β-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors

Lauren M. Slosky; Yushi Bai; Krisztian Toth; Caroline Ray; Lauren K. Rochelle; Alexandra Badea; Rahul Chandrasekhar; Vladimir M. Pogorelov; Dennis M. Abraham; Namratha Atluri; Satyamaheshwar Peddibhotla; Michael P. Hedrick; Paul Hershberger; Patrick Maloney; Hong Yuan; Zibo Li; William C. Wetsel; Anthony B. Pinkerton; Lawrence S. Barak; Marc G. Caron

doi:10.1016/j.cell.2020.04.053

β-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors

Lauren M. Slosky
, Yushi Bai
, Krisztian Toth
, Caroline Ray
, Lauren K. Rochelle
, Alexandra Badea
, Rahul Chandrasekhar
, Vladimir M. Pogorelov
, Dennis M. Abraham
, Namratha Atluri
, Satyamaheshwar Peddibhotla
, Michael P. Hedrick
, Paul Hershberger
, Patrick Maloney
, Hong Yuan
, Zibo Li
, William C. Wetsel
, Anthony B. Pinkerton
, Lawrence S. Barak
, Marc G. Caron

Research output: Contribution to journal › Article › peer-review

116 Scopus citations

Abstract

An ago-allosteric modulator that biases neurotensin receptor 1 signaling toward β-arrestin shows promise as a means of treating psychostimulant addictions and avoiding G protein-mediated side effects.

Original language	English (US)
Pages (from-to)	1364-1379.e14
Journal	Cell
Volume	181
Issue number	6
DOIs	https://doi.org/10.1016/j.cell.2020.04.053
State	Published - Jun 11 2020
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2020 Elsevier Inc.

Keywords

G protein-coupled recpetor
GPCR
NTSR1
PET
addiction
allosteric modulator
cocaine
dopamine
methamphetamine
neurotensin receptor 1
positron emission tomography
self-administration
β-arrestin

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Publisher link

10.1016/j.cell.2020.04.053

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Slosky, L. M., Bai, Y., Toth, K., Ray, C., Rochelle, L. K., Badea, A., Chandrasekhar, R., Pogorelov, V. M., Abraham, D. M., Atluri, N., Peddibhotla, S., Hedrick, M. P., Hershberger, P., Maloney, P., Yuan, H., Li, Z., Wetsel, W. C., Pinkerton, A. B., Barak, L. S., & Caron, M. G. (2020). β-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors. Cell, 181(6), 1364-1379.e14. https://doi.org/10.1016/j.cell.2020.04.053

Slosky, LM, Bai, Y, Toth, K, Ray, C, Rochelle, LK, Badea, A, Chandrasekhar, R, Pogorelov, VM, Abraham, DM, Atluri, N, Peddibhotla, S, Hedrick, MP, Hershberger, P, Maloney, P, Yuan, H, Li, Z, Wetsel, WC, Pinkerton, AB, Barak, LS & Caron, MG 2020, 'β-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors', Cell, vol. 181, no. 6, pp. 1364-1379.e14. https://doi.org/10.1016/j.cell.2020.04.053

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title = "β-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors",

abstract = "An ago-allosteric modulator that biases neurotensin receptor 1 signaling toward β-arrestin shows promise as a means of treating psychostimulant addictions and avoiding G protein-mediated side effects.",

keywords = "G protein-coupled recpetor, GPCR, NTSR1, PET, addiction, allosteric modulator, cocaine, dopamine, methamphetamine, neurotensin receptor 1, positron emission tomography, self-administration, β-arrestin",

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month = jun,

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doi = "10.1016/j.cell.2020.04.053",

language = "English (US)",

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AU - Slosky, Lauren M.

AU - Bai, Yushi

AU - Toth, Krisztian

AU - Ray, Caroline

AU - Rochelle, Lauren K.

AU - Badea, Alexandra

AU - Chandrasekhar, Rahul

AU - Pogorelov, Vladimir M.

AU - Abraham, Dennis M.

AU - Atluri, Namratha

AU - Peddibhotla, Satyamaheshwar

AU - Hedrick, Michael P.

AU - Hershberger, Paul

AU - Maloney, Patrick

AU - Yuan, Hong

AU - Li, Zibo

AU - Wetsel, William C.

AU - Pinkerton, Anthony B.

AU - Barak, Lawrence S.

AU - Caron, Marc G.

PY - 2020/6/11

Y1 - 2020/6/11

N2 - An ago-allosteric modulator that biases neurotensin receptor 1 signaling toward β-arrestin shows promise as a means of treating psychostimulant addictions and avoiding G protein-mediated side effects.

AB - An ago-allosteric modulator that biases neurotensin receptor 1 signaling toward β-arrestin shows promise as a means of treating psychostimulant addictions and avoiding G protein-mediated side effects.

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KW - GPCR

KW - NTSR1

KW - PET

KW - addiction

KW - allosteric modulator

KW - cocaine

KW - dopamine

KW - methamphetamine

KW - neurotensin receptor 1

KW - positron emission tomography

KW - self-administration

KW - β-arrestin

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JO - Cell

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ER -

β-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors

Abstract

Bibliographical note

Keywords

UN SDGs

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