TY - JOUR
T1 - α-Melanocyte stimulating hormone and ghrelin
T2 - Central interaction in feeding control
AU - Olszewski, Pawel K.
AU - Bomberg, Eric M
AU - Grace, Martha K.
AU - Levine, Allen S
N1 - Funding Information:
This work was supported by the Dept. of Veterans Affairs, by the NIDA Grant DA-03999, and the NIH grant P30 DK-50456.
PY - 2007/10
Y1 - 2007/10
N2 - α-Melanocyte stimulating hormone (α-MSH) and ghrelin play significant yet opposite roles in the regulation of feeding: α-MSH inhibits, whereas ghrelin stimulates consumption. The two peptidergic systems may interact in the process of food intake control. A single report published thus far has shown that a synthetic agonist of the melanocortin receptors, MTII, injected in the hypothalamic paraventricular nucleus (PVN) decreases feeding generated by ghrelin. We found that very low doses of α-MSH and MTII administered ICV significantly reduced ghrelin-dependent hyperphagia. However, an endogenous molecule, α-MSH, infused in the PVN did not exert an inhibitory effect on ghrelin-induced consumption, whereas the effective dose of PVN MTII exceeded that necessary to decrease short-term deprivation-induced feeding. We conclude that it is likely that in feeding regulation α-MSH and ghrelin "interact" at the central nervous system level, but the involvement of the PVN in this interaction appears questionable.
AB - α-Melanocyte stimulating hormone (α-MSH) and ghrelin play significant yet opposite roles in the regulation of feeding: α-MSH inhibits, whereas ghrelin stimulates consumption. The two peptidergic systems may interact in the process of food intake control. A single report published thus far has shown that a synthetic agonist of the melanocortin receptors, MTII, injected in the hypothalamic paraventricular nucleus (PVN) decreases feeding generated by ghrelin. We found that very low doses of α-MSH and MTII administered ICV significantly reduced ghrelin-dependent hyperphagia. However, an endogenous molecule, α-MSH, infused in the PVN did not exert an inhibitory effect on ghrelin-induced consumption, whereas the effective dose of PVN MTII exceeded that necessary to decrease short-term deprivation-induced feeding. We conclude that it is likely that in feeding regulation α-MSH and ghrelin "interact" at the central nervous system level, but the involvement of the PVN in this interaction appears questionable.
UR - http://www.scopus.com/inward/record.url?scp=34548694082&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34548694082&partnerID=8YFLogxK
U2 - 10.1016/j.peptides.2007.07.017
DO - 10.1016/j.peptides.2007.07.017
M3 - Article
C2 - 17719137
AN - SCOPUS:34548694082
SN - 0196-9781
VL - 28
SP - 2084
EP - 2089
JO - Peptides
JF - Peptides
IS - 10
ER -