Abstract
The environmental carcinogens N-nitrosopyrrolidine (NPYR) and N′-nitrosonornicotine (NNN) were incubated with human liver microsomes to test for the presence of enzymes catalyzing α-hydroxylation, which is likely to be an activation mechanism for these compounds. Both nitrosamines underwent α-hydroxylation; rates were higher for NPYR than for NNN, as observed in rats. The results indicate that both NPYR and NNN can be metabolically activated by human liver microsomes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 35-41 |
| Number of pages | 7 |
| Journal | Cancer Letters |
| Volume | 8 |
| Issue number | 1 |
| DOIs | |
| State | Published - Nov 1979 |
Bibliographical note
Funding Information:This study was supported by National Cancer Institute Grants CA 21393 and CA 23901. Stephen S. Hecht is recipient of National Cancer Institute Research Career Development Award 5K04-CA 00124.
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