Abstract
The dystrophin-glycoprotein complex was examined in dystrophin-deficient dogs with golden retriever muscular dystrophy (GRMD) using immunoblot and immunofluorescence analysis. The dystrophin-associated proteins were substantially reduced in muscle from dogs with GRMD. Interestingly, regression analysis revealed a strong correlation between the amount of α-dystroglycan and serum creatine kinase levels and the contraction tension measured for a given peroneus longus muscle.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 173-176 |
| Number of pages | 4 |
| Journal | FEBS Letters |
| Volume | 350 |
| Issue number | 2-3 |
| DOIs | |
| State | Published - Aug 22 1994 |
Bibliographical note
Funding Information:Acknowledgements: We gratefully acknowledgeD avid Zoloto and Michael Mullinix for preparationo f the skeletaml uscleh omogenates and membranesu sed in this study. K.P.C. is an investigatoro f the Howard HughesM edical Institute.T his work was also supportedb y grants from the Muscular Dystrophy Association (J.M.E., S.L.R., J.N.K. and K.P.C.) and the WisconsinA ffiliate of the AmericanH eart Association( J.M.E.).
Keywords
- Dystroglycan
- Dystrophin
- Dystrophin-associated protein
- Dystrophin-glycoprotein complex
- Golden retriever muscular dystrophy
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