ß-Funaltrexamine (ß-FNA) decreases deprivation and opioid-induced feeding

A. S. Levine; M. Grace; C. J. Billington

doi:10.1016/0006-8993(91)90632-6

ß-Funaltrexamine (ß-FNA) decreases deprivation and opioid-induced feeding

A. S. Levine, M. Grace, C. J. Billington

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

We studied the effect of the μ antagonist, ß-funaltrexamine (ß-FNA) on deprivation and opioid-induced feeding. Intracerebroventricular pre-treatment of 20 h deprived rats with 0.1, 1, 10 and 20 nmol of ß-FNA decreased feeding by 24%, 50%, 50% and 38% during the first hour. Central administration of ß-FNA (0.1, 1 and 10 nmol) also decreased feeding induced by the μ opioid agonist, DAMGO by 57%, 60% and 71%. Feeding induced by the δ agonist, DSLET, was decreased by pre-treatment with ß-FNA; but only during the 1-2 h time points, a time when relatively little food was ingested. Intraventricular injection of ß-FNA failed to alter feeding stimulated by the κ opioid agonist, U-50,488H. These data further substantiate a role for the opioid receptor in deprivation and opioid-induced feeding.

Original language	English (US)
Pages (from-to)	281-284
Number of pages	4
Journal	Brain Research
Volume	562
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(91)90632-6
State	Published - Oct 25 1991

Bibliographical note

Funding Information:
Acknowledgements. This work was supported by NIDA ROI DA03999 and the Department of Veterans Affairs. We thank Wcndy Welch for her excellent technical assistance.

Keywords

Feeding
Opioid
ß-Funaltrexamine

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10.1016/0006-8993(91)90632-6

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title = "{\ss}-Funaltrexamine ({\ss}-FNA) decreases deprivation and opioid-induced feeding",

abstract = "We studied the effect of the μ antagonist, {\ss}-funaltrexamine ({\ss}-FNA) on deprivation and opioid-induced feeding. Intracerebroventricular pre-treatment of 20 h deprived rats with 0.1, 1, 10 and 20 nmol of {\ss}-FNA decreased feeding by 24%, 50%, 50% and 38% during the first hour. Central administration of {\ss}-FNA (0.1, 1 and 10 nmol) also decreased feeding induced by the μ opioid agonist, DAMGO by 57%, 60% and 71%. Feeding induced by the δ agonist, DSLET, was decreased by pre-treatment with {\ss}-FNA; but only during the 1-2 h time points, a time when relatively little food was ingested. Intraventricular injection of {\ss}-FNA failed to alter feeding stimulated by the κ opioid agonist, U-50,488H. These data further substantiate a role for the opioid receptor in deprivation and opioid-induced feeding.",

keywords = "Feeding, Opioid, {\ss}-Funaltrexamine",

author = "Levine, {A. S.} and M. Grace and Billington, {C. J.}",

note = "Funding Information: Acknowledgements. This work was supported by NIDA ROI DA03999 and the Department of Veterans Affairs. We thank Wcndy Welch for her excellent technical assistance.",

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AU - Levine, A. S.

AU - Grace, M.

AU - Billington, C. J.

N1 - Funding Information: Acknowledgements. This work was supported by NIDA ROI DA03999 and the Department of Veterans Affairs. We thank Wcndy Welch for her excellent technical assistance.

PY - 1991/10/25

Y1 - 1991/10/25

N2 - We studied the effect of the μ antagonist, ß-funaltrexamine (ß-FNA) on deprivation and opioid-induced feeding. Intracerebroventricular pre-treatment of 20 h deprived rats with 0.1, 1, 10 and 20 nmol of ß-FNA decreased feeding by 24%, 50%, 50% and 38% during the first hour. Central administration of ß-FNA (0.1, 1 and 10 nmol) also decreased feeding induced by the μ opioid agonist, DAMGO by 57%, 60% and 71%. Feeding induced by the δ agonist, DSLET, was decreased by pre-treatment with ß-FNA; but only during the 1-2 h time points, a time when relatively little food was ingested. Intraventricular injection of ß-FNA failed to alter feeding stimulated by the κ opioid agonist, U-50,488H. These data further substantiate a role for the opioid receptor in deprivation and opioid-induced feeding.

AB - We studied the effect of the μ antagonist, ß-funaltrexamine (ß-FNA) on deprivation and opioid-induced feeding. Intracerebroventricular pre-treatment of 20 h deprived rats with 0.1, 1, 10 and 20 nmol of ß-FNA decreased feeding by 24%, 50%, 50% and 38% during the first hour. Central administration of ß-FNA (0.1, 1 and 10 nmol) also decreased feeding induced by the μ opioid agonist, DAMGO by 57%, 60% and 71%. Feeding induced by the δ agonist, DSLET, was decreased by pre-treatment with ß-FNA; but only during the 1-2 h time points, a time when relatively little food was ingested. Intraventricular injection of ß-FNA failed to alter feeding stimulated by the κ opioid agonist, U-50,488H. These data further substantiate a role for the opioid receptor in deprivation and opioid-induced feeding.

KW - Feeding

KW - Opioid

KW - ß-Funaltrexamine

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ß-Funaltrexamine (ß-FNA) decreases deprivation and opioid-induced feeding

Abstract

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