ß-Endorphin as a potent analgesic by intravenous injection

Liann Fu Tseng, Horace H. Loh, Choh Hao Li

Research output: Contribution to journalArticle

193 Scopus citations

Abstract

AN untriakontapeptide1 with significant opiate activity from camel pituitary glands was shown to have an amino acid sequence identical to the carboxyl-terminal 31 amino acids of β-lipotropins2,3. The peptide, designated as β-endorphin, has recently been synthesised 4, and when administered directly into the brain, it was found 5 to be considerably more potent than morphine in molar basis, and its actions were blocked by naloxone. Other peptides related to β-lipotropins have also been shown to possess in vitro opiate-like activity6-9. We report here the analgesic effects of β-endorphin when it is injected intravenously.

Original languageEnglish (US)
Pages (from-to)239-240
Number of pages2
JournalNature
Volume263
Issue number5574
DOIs
StatePublished - Dec 1 1976

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