Abstract
AN untriakontapeptide1 with significant opiate activity from camel pituitary glands was shown to have an amino acid sequence identical to the carboxyl-terminal 31 amino acids of β-lipotropins2,3. The peptide, designated as β-endorphin, has recently been synthesised 4, and when administered directly into the brain, it was found 5 to be considerably more potent than morphine in molar basis, and its actions were blocked by naloxone. Other peptides related to β-lipotropins have also been shown to possess in vitro opiate-like activity6-9. We report here the analgesic effects of β-endorphin when it is injected intravenously.
Original language | English (US) |
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Pages (from-to) | 239-240 |
Number of pages | 2 |
Journal | Nature |
Volume | 263 |
Issue number | 5574 |
DOIs | |
State | Published - Dec 1 1976 |