Long-term use of opioids to treat pain can create a need for the person to take increasing doses of medication to get the same pain relief. We suspect that giving long-acting buprenorphine (an opioid) to animals creates the same problem instead of providing long-acting pain relief.
Mice and rats develop acute tolerance to the analgesic effects of sustained-release buprenorphine. Currently evaluating other species.
|Short title||SRB and acute opioid tolerance|
|Effective start/end date||7/15/16 → …|