1996 …2023
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Fingerprint The Fingerprint is created by mining the titles and abstracts of the person's research outputs and projects/funding awards to create an index of weighted terms from discipline-specific thesauri.

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Ribonuclease H Medicine & Life Sciences
HIV Reverse Transcriptase Medicine & Life Sciences
Integrases Medicine & Life Sciences
Antiviral Agents Medicine & Life Sciences
RNA-Directed DNA Polymerase Medicine & Life Sciences
Human Immunodeficiency Virus Ribonuclease H Medicine & Life Sciences
Viruses Chemical Compounds
Scaffolds Chemical Compounds

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Projects 2012 2023

Taking aim at HBV eradication using novel NRTIs and caps

Wang, Z. & Xie, J.

Emory University

11/1/175/31/19

Project: Research project

Capsid
Capsid
Antiviral Agents
HIV
Ribonuclease H
Capsid
Capsid
Antiviral Agents
HIV

Research Output 1996 2019

1 Citation (Scopus)

5-Aminothiophene-2,4-dicarboxamide analogues as hepatitis B virus capsid assembly effectors

TANG, JING., Huber, A. D., Pineda, D. L., Boschert, K. N., Wolf, J. J., Kankanala, J., Xie, J., Sarafianos, S. G. & Wang, Z., Feb 15 2019, In : European Journal of Medicinal Chemistry. 164, p. 179-192 14 p.

Research output: Contribution to journalArticle

Virus Assembly
Capsid
Viruses
Hepatitis B virus
Viral Core Proteins

Challenges and Opportunities in Hepatitis B Research

Wang, Z., May 10 2019, In : ACS Infectious Diseases. 5, 5, p. 652-654 3 p.

Research output: Contribution to journalEditorial

Hepatitis B
Research

Novel Deazaflavin Analogues Potently Inhibited Tyrosyl DNA Phosphodiesterase 2 (TDP2) and Strongly Sensitized Cancer Cells toward Treatment with Topoisomerase II (TOP2) Poison Etoposide

Kankanala, J., Ribeiro, C. J. A., Kiselev, E., Ravji, A., Williams, J., Xie, J., Aihara, H., Pommier, Y. & Wang, Z., May 9 2019, In : Journal of Medicinal Chemistry. 62, 9, p. 4669-4682 14 p.

Research output: Contribution to journalArticle

Type II DNA Topoisomerase
Poisons
Etoposide
Phosphodiesterase Inhibitors
Permeability

Novel Hepatitis B Virus Capsid-Targeting Antiviral That Aggregates Core Particles and Inhibits Nuclear Entry of Viral Cores

Huber, A. D., Pineda, D. L., Liu, D., Boschert, K. N., Gres, A. T., Wolf, J. J., Coonrod, E. M., Tang, J., Laughlin, T. G., Yang, Q., Puray-Chavez, M. N., Ji, J., Singh, K., Kirby, K. A., Wang, Z. & Sarafianos, S. G., Jan 1 2019, (Accepted/In press) In : ACS Infectious Diseases. 5, 5, p. 750-758 9 p.

Research output: Contribution to journalArticle

Capsid
Hepatitis B virus
Antiviral Agents
Virus Replication
High-Throughput Screening Assays
1 Citation (Scopus)

Pharmacophore-based design of novel 3-hydroxypyrimidine-2,4-dione subtypes as inhibitors of HIV reverse transcriptase-associated RNase H: Tolerance of a nonflexible linker

Tang, J., Do, H. T., Huber, A. D., Casey, M. C., Kirby, K. A., Wilson, D. J., Kankanala, J., Parniak, M. A., Sarafianos, S. G. & Wang, Z., Mar 15 2019, In : European Journal of Medicinal Chemistry. 166, p. 390-399 10 p.

Research output: Contribution to journalArticle

Ribonuclease H
HIV Reverse Transcriptase
Catalytic Domain
Integrases
RNA-Directed DNA Polymerase