20032020

Research output per year

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Research Output

2020

Emerging roles for human glycolipid transfer protein superfamily members in the regulation of autophagy, inflammation, and cell death

Mishra, S. K., Gao, Y. G., Zou, X., Stephenson, D. J., Malinina, L., Hinchcliffe, E. H., Chalfant, C. E. & Brown, R. E., Apr 2020, In : Progress in Lipid Research. 78, 101031.

Research output: Contribution to journalReview article

Measuring Lipid Transfer Protein Activity Using Bicelle-Dilution Model Membranes

Gao, Y-G., Le, T. M. L., Zhai, X., Boldyrev, I. A., Mishra, S. K., Tischer, A., Murayama, T., Nishida, A., Molotkovsky, J. G., Alam, A. & Brown, R. E., Feb 18 2020, In : Analytical Chemistry. 92, 4, p. 3417-3425 9 p.

Research output: Contribution to journalArticle

1 Scopus citations
2019

Structural basis of phosphatidylcholine recognition by the C2-domain of cytosolic phospholipase A2α

Hirano, Y., Gao, Y-G., Stephenson, D. J., Vu, N. T., Malinina, L., Simanshu, D. K., Chalfant, C. E., Patel, D. J. & Brown, R. E., May 3 2019, In : eLife. 8, 28 p., e44760.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
2018

CPTP: A sphingolipid transfer protein that regulates autophagy and inflammasome activation

Mishra, S. K., Gao, Y-G., Deng, Y., Chalfant, C. E., Hinchcliffe, E. H. & Brown, R. E., May 4 2018, In : Autophagy. 14, 5

Research output: Contribution to journalArticle

12 Scopus citations

Structural analyses of 4-phosphate adaptor protein 2 yield mechanistic insights into sphingolipid recognition by the glycolipid transfer protein family

Ochoa-Lizarralde, B., Gao, Y. G., Popov, A. N., Samygina, V. R., Zhai, X., Mishra, S. K., Boldyrev, I. A., Molotkovsky, J. G., Simanshu, D. K., Patel, D. J., Brown, R. E. & Malinina, L., Jan 1 2018, In : Journal of Biological Chemistry. 293, 43, p. 16709-16723 15 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
2017

HSP90 recognizes the N-terminus of huntingtin involved in regulation of huntingtin aggregation by USP19

He, W. T., Xue, W., Gao, Y. G., Hong, J. Y., Yue, H. W., Jiang, L. L. & Hu, H. Y., Dec 1 2017, In : Scientific reports. 7, 1, 14797.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Phosphatidylserine stimulates ceramide 1-phosphate (C1P) intermembrane transfer by C1P transfer proteins

Zhai, X., Gao, Y. G., Mishra, S. K., Simanshu, D. K., Boldyrev, I. A., Benson, L. M., Bergen, H. R., Malinina, L., Mundy, J., Molotkovsky, J. G., Patel, D. J. & Brown, R. E., Feb 10 2017, In : Journal of Biological Chemistry. 292, 6, p. 2531-2541 11 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations
2016

Cytoplasmic ubiquitin-specific protease 19 (USP19) modulates aggregation of polyglutamine-expanded Ataxin-3 and Huntingtin through the HSP90 chaperone

He, W. T., Zheng, X. M., Zhang, Y. H., Gao, Y-G., Song, A. X. & Hu, H. Y., Jan 25 2016, In : PLoS One. 11, 1

Research output: Contribution to journalArticle

10 Scopus citations
2014

A ubiquitin shuttle DC-UbP/UBTD2 reconciles protein ubiquitination and deubiquitination via linking UbE1 and USP5 enzymes

Song, A. X., Yang, H., Gao, Y. G., Zhou, C. J., Zhang, Y. H. & Hu, H. Y., Sep 2014, In : PloS one. 9, 9, e0107509.

Research output: Contribution to journalArticle

Autoinhibitory structure of the WW domain of HYPB/SETD2 regulates its interaction with the proline-rich region of huntingtin

Gao, Y. G., Yang, H., Zhao, J., Jiang, Y. J. & Hu, H. Y., Mar 4 2014, In : Structure. 22, 3, p. 378-386 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

Structural insights into the interaction between a potent anti-inflammatory protein, viral CC chemokine inhibitor (vCCI), and the human CC chemokine, eotaxin-1

Kuo, N. W., Gao, Y. G., Schill, M. S., Isern, N., Dupureur, C. M. & Li Wang, P. J., Mar 7 2014, In : Journal of Biological Chemistry. 289, 10, p. 6592-6603 12 p.

Research output: Contribution to journalArticle

7 Scopus citations
2013

The glycolipid transfer protein (GLTP) domain of phosphoinositol 4-phosphate adaptor protein-2 (FAPP2): Structure drives preference for simple neutral glycosphingolipids

Kamlekar, R. K., Simanshu, D. K., Gao, Y-G., Kenoth, R., Pike, H. M., Prendergast, F. G., Malinina, L., Molotkovsky, J. G., Venyaminov, S. Y., Patel, D. J. & Brown, R. E., Feb 1 2013, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1831, 2, p. 417-427 11 p.

Research output: Contribution to journalArticle

17 Scopus citations
2012

The role of individual carbohydrate-binding sites in the function of the potent anti-HIV lectin griffithsin

Xue, J., Gao, Y-G., Hoorelbeke, B., Kagiampakis, I., Zhao, B., Demeler, B., Balzarini, J. & LiWang, P., Aug 21 2012, In : Molecular Pharmaceutics. 9, 9

Research output: Contribution to journalArticle

25 Scopus citations
2011

Conformational folding and stability of the HET-C2 glycolipid transfer protein fold: Does a molten globule-like state regulate activity?

Kenoth, R., Kamlekar, R. K., Simanshu, D. K., Gao, Y-G., Malinina, L., Prendergast, F. G., Molotkovsky, J. G., Patel, D. J., Venyaminov, S. Y. & Brown, R. E., Jun 14 2011, In : Biochemistry. 50, 23, p. 5163-5171 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Human glycolipid transfer protein (GLTP) expression modulates cell shape

Gao, Y., Chung, T., Zou, X., Pike, H. M. & Brown, R. E., May 24 2011, In : PloS one. 6, 5, e19990.

Research output: Contribution to journalArticle

10 Scopus citations

Human glycolipid transfer protein gene (GLTP) expression is regulated by Sp1 and Sp3: Involvement of the bioactive sphingolipid ceramide

Zou, X., Gao, Y-G., Ruvolo, V. R., Gardner, T. L., Ruvolo, P. P. & Brown, R. E., Jan 14 2011, In : Journal of Biological Chemistry. 286, 2, p. 1301-1311 11 p.

Research output: Contribution to journalArticle

15 Scopus citations
2010

Human GLTP: Three distinct functions for the three tryptophans in a novel peripheral amphitropic fold

Kamlekar, R. K., Gao, Y-G., Kenoth, R., Molotkovsky, J. G., Prendergast, F. G., Malinina, L., Patel, D. J., Wessels, W. S., Venyaminov, S. Y. & Brown, R. E., Oct 20 2010, In : Biophysical journal. 99, 8, p. 2626-2635 10 p.

Research output: Contribution to journalArticle

19 Scopus citations
2006

Crystal structures of E. coli CcmG and its mutants reveal key roles of the N-terminal β-sheet and the fingerprint region

Ouyang, N., Gao, Y. G., Hu, H. Y. & Xia, Z. X., Dec 1 2006, In : Proteins: Structure, Function and Genetics. 65, 4, p. 1021-1031 11 p.

Research output: Contribution to journalArticle

22 Scopus citations

Determination of the three-dimensional structure of anemoside A3 in solution by NMR and molecular simulation

Li, Q., Shi, Y. H., Gao, Y. G., Ye, W. C. & Yao, X. S., Apr 1 2006, In : Journal of China Pharmaceutical University. 37, 2, p. 123-126 4 p.

Research output: Contribution to journalArticle

1 Scopus citations

Highly efficient expression and purification system of small-size protein domains in Escherichia coli for biochemical characterization

Bao, W. J., Gao, Y. G., Chang, Y. G., Zhang, T. Y., Lin, X. J., Yan, X. Z. & Hu, H. Y., Jun 1 2006, In : Protein Expression and Purification. 47, 2, p. 599-606 8 p.

Research output: Contribution to journalArticle

51 Scopus citations

Solution structure of the ubiquitin-associated domain of human BMSC-UbP and its complex with ubiquitin

Chang, Y. G., Song, A. X., Gao, Y. G., Shi, Y. H., Lin, X. J., Cao, X. T., Lin, D. H. & Hu, H. Y., Jun 1 2006, In : Protein Science. 15, 6, p. 1248-1259 12 p.

Research output: Contribution to journalArticle

42 Scopus citations

Structural Insights into the Specific Binding of Huntingtin Proline-Rich Region with the SH3 and WW Domains

Gao, Y. G., Yan, X. Z., Song, A. X., Chang, Y. G., Gao, X. C., Jiang, N., Zhang, Q. & Hu, H. Y., Dec 1 2006, In : Structure. 14, 12, p. 1755-1765 11 p.

Research output: Contribution to journalArticle

29 Scopus citations
2005

Identification, expression, and purification of a unique stable domain from human HSPC144 protein

Song, A. X., Chang, Y. G., Gao, Y. G., Lin, X. J., Shi, Y. H., Lin, D. H., Hang, Q. H. & Hu, H. Y., Jul 1 2005, In : Protein Expression and Purification. 42, 1, p. 146-152 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Solution structure of the ubiquitin-like domain of human DC-UbP from dendritic cells

Gao, Y. G., Song, A. I. X., Shi, Y. H., Chang, Y. G., Liu, S. X., Yu, Y. I. Z. I., Cao, X. T., Lin, D. H. & Hu, H. Y., Aug 1 2005, In : Protein Science. 14, 8, p. 2044-2050 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

Studies on aggregation-propensities and secondary structural transformations of proteins

Ji, L. N., Gao, Y. G., Zhang, F., Li, H. T., Hu, H. Y. & Hu, J., Feb 1 2005, In : Nuclear Science and Techniques/Hewuli. 16, 1, p. 6-11 6 p.

Research output: Contribution to journalArticle

2003

Crystallization and preliminary crystallographic studies of Escherichia coli CcmG/DsbE protein

Ouyang, N., Chen, W. Y., Li, Q., Gao, Y. G., Hu, H. Y. & Xia, Z. X., Sep 1 2003, In : Acta Crystallographica - Section D Biological Crystallography. 59, 9, p. 1674-1675 2 p.

Research output: Contribution to journalArticle

1 Scopus citations