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2020

Evolutionarily conserved resistance to phagocytosis observed in melanoma cells is insensitive to upregulation of pro-phagocytic signals and to CD47 blockade

Anderson, K. L., Snyder, K. M., Ito, D., Lins, D. C., Mills, L. J., Weiskopf, K., Ring, N. G., Ring, A. M., Shimizu, Y., Mescher, M. F., Weissman, I. L. & Modiano, J. F., Apr 1 2020, In : Melanoma research. p. 147-158 12 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2019

Engineering T cell response to cancer antigens by choice of focal therapeutic conditions

Shao, Q., O'Flanagan, S., Lam, T., Roy, P., Pelaez, F., Burbach, B. J., Azarin, S. M., Shimizu, Y. & Bischof, J. C., Jan 1 2019, In : International Journal of Hyperthermia. 36, 1, p. 130-138 9 p.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations
2018

Role of afferent and efferent renal nerves in the development of AngII-salt hypertension in rats

Foss, J. D., Fiege, J., Shimizu, Y., Collister, J. P., Mayerhofer, T., Wood, L. & Osborn, J. W., Feb 1 2018, In : Physiological Reports. 6, 3, e13602.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
2017

Cytokine-mediated activation of human ex vivo-expanded Vγ9Vδ2 T cells

Domae, E., Hirai, Y., Ikeo, T., Goda, S. & Shimizu, Y., Jan 1 2017, In : Oncotarget. 8, 28, p. 45928-45942 15 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations
2016
Open Access
4 Scopus citations

CD28/B7 deficiency attenuates systolic overload-induced congestive heart failure, myocardial and pulmonary inflammation, and activated T cell accumulation in the heart and lungs

Wang, H., Kwak, D., Fassett, J., Hou, L., Xu, X., Burbach, B. J., Thenappan, T., Xu, Y., Ge, J. B., Shimizu, Y., Bache, R. J. & Chen, Y., Sep 1 2016, In : Hypertension. 68, 3, p. 688-696 9 p.

Research output: Contribution to journalArticle

Open Access
22 Scopus citations

Renal Denervation Normalizes Arterial Pressure with No Effect on Glucose Metabolism or Renal Inflammation in Obese Hypertensive Mice

Asirvatham-Jeyaraj, N., Fiege, J. K., Han, R., Foss, J., Banek, C. T., Burbach, B. J., Razzoli, M., Bartolomucci, A., Shimizu, Y., Panoskaltsis-Mortari, A. & Osborn, J. W., Oct 1 2016, In : Hypertension. 68, 4, p. 929-936 8 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Resting Afferent Renal Nerve Discharge and Renal Inflammation: Elucidating the Role of Afferent and Efferent Renal Nerves in Deoxycorticosterone Acetate Salt Hypertension

Banek, C. T., Knuepfer, M. M., Foss, J. D., Fiege, J. K., Asirvatham-Jeyaraj, N., Van Helden, D., Shimizu, Y. & Osborn, J. W., Dec 1 2016, In : Hypertension. 68, 6, p. 1415-1423 9 p.

Research output: Contribution to journalArticle

Open Access
30 Scopus citations
2015
4 Scopus citations
2013

ICAM-1-dependent homotypic aggregates regulate CD8 T cell effector function and differentiation during T cell activation

Zumwalde, N. A., Domae, E., Mescher, M. F. & Shimizu, Y., Oct 1 2013, In : Journal of Immunology. 191, 7, p. 3681-3693 13 p.

Research output: Contribution to journalArticle

29 Scopus citations
11 Scopus citations
2012
12 Scopus citations
2011
16 Scopus citations

β1 integrin is critical for the maintenance of antigen-specific CD4 T cells in the bone marrow but not long-term immunological memory

DeNucci, C. C. & Shimizu, Y., Apr 1 2011, In : Journal of Immunology. 186, 7, p. 4019-4026 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

β-Actin specifically controls cell growth, migration, and the G-actin pool

Bunnell, T. M., Burbach, B. J., Shimizu, Y. & Ervasti, J. M., Nov 1 2011, In : Molecular biology of the cell. 22, 21, p. 4047-4058 12 p.

Research output: Contribution to journalArticle

126 Scopus citations
2010

Control of α4β7 integrin expression and CD4 T cell homing by the β1 integrin subunit

DeNucci, C. C., Pagán, A. J., Mitchell, J. S. & Shimizu, Y., Mar 1 2010, In : Journal of Immunology. 184, 5, p. 2458-2467 10 p.

Research output: Contribution to journalArticle

39 Scopus citations
25 Scopus citations
2008

Distinct regulation of integrin-dependent T cell conjugate formation and NF-κB activation by the adapter protein ADAP

Burbach, B. J., Srivastava, R., Medeiros, R. B., O'Gorman, W. E., Peterson, E. J. & Shimizu, Y., Oct 1 2008, In : Journal of Immunology. 181, 7, p. 4840-4851 12 p.

Research output: Contribution to journalArticle

Open Access
23 Scopus citations

Selective regulation of CD8 effector T cell migration by the p110γ isoform of phosphatidylinositol 3-kinase

Martin, A. L., Schwartz, M. D., Jameson, S. C. & Shimizu, Y., Feb 15 2008, In : Journal of Immunology. 180, 4, p. 2081-2088 8 p.

Research output: Contribution to journalArticle

Open Access
58 Scopus citations

The p110γ isoform of phosphatidylinositol 3-kinase regulates migration of effector CD4 T lymphocytes into peripheral inflammatory sites

Thomas, M. S., Mitchell, J. S., Denucci, C. C., Martin, A. L. & Shimizu, Y., Sep 1 2008, In : Journal of Leukocyte Biology. 84, 3, p. 814-823 10 p.

Research output: Contribution to journalArticle

36 Scopus citations

The WAVE2 complex regulates T cell receptor signaling to integrins via Abl- and CrkL-C3G-mediated activation of Rap1

Nolz, J. C., Nacusi, L. P., Segovis, C. M., Medeiros, R. B., Mitchell, J. S., Shimizu, Y. & Billadeau, D. D., Sep 22 2008, In : Journal of Cell Biology. 182, 6, p. 1231-1244 14 p.

Research output: Contribution to journalArticle

67 Scopus citations
2007

Adhesion and degranulation-promoting adapter protein (ADAP) positively regulates T cell sensitivity to antigen and T cell survival

Mueller, K. L., Thomas, M. S., Burbach, B. J., Peterson, E. J. & Shimizu, Y., Sep 15 2007, In : Journal of Immunology. 179, 6, p. 3559-3569 11 p.

Research output: Contribution to journalArticle

29 Scopus citations

Formins Regulate the Actin-Related Protein 2/3 Complex-Independent Polarization of the Centrosome to the Immunological Synapse

Gomez, T. S., Kumar, K., Medeiros, R. B., Shimizu, Y., Leibson, P. J. & Billadeau, DD. D., Feb 23 2007, In : Immunity. 26, 2, p. 177-190 14 p.

Research output: Contribution to journalArticle

185 Scopus citations

MHC class II deprivation impairs CD4 T cell motility and responsiveness to antigen-bearing dendritic cells in vivo

Fischer, U. B., Jacovetty, E. L., Medeiros, R. B., Goudy, B. D., Zell, T., Swanson, J. B., Lorenz, E., Shimizu, Y., Miller, M. J., Khoruts, A. & Ingulli, E., Apr 24 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 17, p. 7181-7186 6 p.

Research output: Contribution to journalArticle

52 Scopus citations

Regulation of NF-κB activation in T cells via association of the adapter proteins ADAP and CARMA1

Medeiros, R. B., Burbach, B. J., Mueller, K. L., Srivastava, R., Moon, J. J., Highfill, S., Peterson, E. J. & Shimizu, Y., May 4 2007, In : Science. 316, 5825, p. 754-758 5 p.

Research output: Contribution to journalArticle

70 Scopus citations

WAVE2 regulates high-affinity integrin binding by recruiting vinculin and talin to the immunological synapse

Nolz, J. C., Medeiros, R. B., Mitchell, J. S., Zhu, P., Freedman, B. D., Shimizu, Y. & Billadeau, D. D., Sep 1 2007, In : Molecular and cellular biology. 27, 17, p. 5986-6000 15 p.

Research output: Contribution to journalArticle

74 Scopus citations
2006

ADAP is dispensable for NK cell development and function

Fostel, L. V., Dluzniewska, J., Shimizu, Y., Burbach, B. J. & Peterson, E. J., Aug 1 2006, In : International Immunology. 18, 8, p. 1305-1314 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Matrix metalloproteinase-1 produced by human CXCL12-stimulated natural killer cells

Goda, S., Inoue, H., Umehara, H., Miyaji, M., Nagano, Y., Harakawa, N., Imai, H., Lee, P., Macarthy, J. B., Ikeo, T., Domae, N., Shimizu, Y. & Iida, J., Aug 2006, In : American Journal of Pathology. 169, 2, p. 445-458 14 p.

Research output: Contribution to journalArticle

28 Scopus citations

Quantitative measurement of nuclear translocation events using similarity analysis of multispectral cellular images obtained in flow

George, T. C., Fanning, S. L., Fitzgeral-Bocarsly, P., Medeiros, R. B., Highfill, S., Shimizu, Y., Hall, B. E., Frost, K., Basiji, D., Ortyn, W. E., Morrissey, P. J. & Lynch, D. H., Apr 20 2006, In : Journal of Immunological Methods. 311, 1-2, p. 117-129 13 p.

Research output: Contribution to journalArticle

190 Scopus citations

The WAVE2 complex regulates actin cytoskeletal reorganization and CRAC-mediated calcium entry during T cell activation

Nolz, J. C., Gomez, T. S., Zhu, P., Li, S., Medeiros, R. B., Shimizu, Y., Burkhardt, J. K., Freedman, B. D. & Billadeau, D. D., Jan 10 2006, In : Current Biology. 16, 1, p. 24-34 11 p.

Research output: Contribution to journalArticle

166 Scopus citations
2005

Influence of β1 integrin intracytoplasmic domains in the regulation of VLA-4-mediated adhesion of human T cells to VCAM-1 under flow conditions

Rosenthal-Allieri, M. A., Ticchioni, M., Breittmayer, J. P., Shimizu, Y. & Bernard, A., Jul 15 2005, In : Journal of Immunology. 175, 2, p. 1214-1223 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Protein kinase D1 and the β1 integrin cytoplasmic domain control β1 integrin function via regulation of Rap1 activation

Medeiros, R. B., Dickey, D. M., Chung, H., Quale, A. C., Nagarajan, L. R., Billadeau, D. D. & Shimizu, Y., Aug 1 2005, In : Immunity. 23, 2, p. 213-226 14 p.

Research output: Contribution to journalArticle

69 Scopus citations

Tec kinases regulate TCR-mediated recruitment of signaling molecules and integrin-dependent cell adhesion

Finkelstein, L. D., Shimizu, Y. & Schwartzberg, P. L., Nov 1 2005, In : Journal of Immunology. 175, 9, p. 5923-5930 8 p.

Research output: Contribution to journalArticle

41 Scopus citations
2004

Control of TCR-Mediated Activation of β1 Integrins by the ZAP-70 Tyrosine Kinase Interdomain B Region and the Linker for Activation of T Cells Adapter Protein

Goda, S., Quale, A. C., Woods, M. L., Felthauser, A. & Shimizu, Y., May 1 2004, In : Journal of Immunology. 172, 9, p. 5379-5387 9 p.

Research output: Contribution to journalArticle

36 Scopus citations

Cutting edge: LFA-1 integrin-dependent T cell adhesion is regulated by both Ag specificity and sensitivity

Mueller, K. L., Daniels, M. A., Felthauser, A., Kao, C., Jameson, S. C. & Shimizu, Y., Aug 15 2004, In : Journal of Immunology. 173, 4, p. 2222-2226 5 p.

Research output: Contribution to journalArticle

25 Scopus citations

The α1β1 and αEβ 7 Integrins Define a Subset of Dendritic Cells in Peripheral Lymph Nodes with Unique Adhesive and Antigen Uptake Properties

Pribila, J. T., Itano, A. A., Mueller, K. L. & Shimizu, Y., Jan 1 2004, In : Journal of Immunology. 172, 1, p. 282-291 10 p.

Research output: Contribution to journalArticle

29 Scopus citations
2003

LFA-1: More than just T cell Velcro

Shimizu, Y., Nov 1 2003, In : Nature immunology. 4, 11, p. 1052-1054 3 p.

Research output: Contribution to journalArticle

25 Scopus citations
2002

Let's Rap: Making a functional integrin

Shimizu, Y., Nov 1 2002, In : Trends in Immunology. 23, 11, p. 522-523 2 p.

Research output: Contribution to journalArticle

2001

A novel function for the Tec family tyrosine kinase Itk in activation of β1 integrins by the T-cell receptor

Woods, M. L., Kivens, W. J., Adelsman, M. A., Qiu, Y., August, A. & Shimizu, Y., Mar 15 2001, In : EMBO Journal. 20, 6, p. 1232-1244 13 p.

Research output: Contribution to journalArticle

88 Scopus citations

Coupling of the TCR to integrin activation by SLAP-130/Fyb

Peterson, E. J., Woods, M. L., Dmowski, S. A., Derimanov, G., Jordan, M. S., Wu, J. N., Myung, P. S., Liu, Q. H., Pribila, J. T., Freedman, B. D., Shimizu, Y. & Koretzky, G. A., Sep 21 2001, In : Science. 293, 5538, p. 2263-2265 3 p.

Research output: Contribution to journalArticle

251 Scopus citations

Cutting edge: T cell migration regulated by CXCR4 chemokine receptor signaling to ZAP-70 tyrosine kinase

Ottoson, N. C., Pribila, J. T., Chan, A. S. H. & Shimizu, Y., Aug 15 2001, In : Journal of Immunology. 167, 4, p. 1857-1861 5 p.

Research output: Contribution to journalArticle

80 Scopus citations

Measurement of cellular adhesion under static conditions.

Mobley, J. L. & Shimizu, Y., May 2001, In : Current protocols in immunology / edited by John E. Coligan ... [et al.]. Chapter 7

Research output: Contribution to journalArticle

5 Scopus citations

Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain

Chen, R., Kim, O., Li, M., Xiong, X., Guan, J. L., Kung, H. J., Chen, H., Shimizu, Y. & Qiu, Y., May 21 2001, In : Nature Cell Biology. 3, 5, p. 439-444 6 p.

Research output: Contribution to journalArticle

126 Scopus citations

Signaling networks regulating β1 integrin-mediated adhesion of T lymphocytes to extracellular matrix

Woods, M. L. & Shimizu, Y., Jul 7 2001, In : Journal of Leukocyte Biology. 69, 6, p. 874-880 7 p.

Research output: Contribution to journalArticle

44 Scopus citations

The T lymphocyte structure CD60 contains a sialylated carbohydrate epitope that is expressed on both gangliosides and glycoproteins

Fox, D. A., He, X., Abe, A., Hollander, T., Li, L. L., Kan, L., Friedman, A. W., Shimizu, Y., Shayman, J. A. & Kozarsky, K., Jul 28 2001, In : Immunological Investigations. 30, 2, p. 67-85 19 p.

Research output: Contribution to journalArticle

20 Scopus citations
2000
31 Scopus citations

Cutting edge: A novel function for the SLAP-130/FYB adapter protein in β1 integrin signaling and T lymphocyte migration

Hunter, A. J., Ottoson, N., Boerth, N., Koretzky, G. A. & Shimizu, Y., Feb 1 2000, In : Journal of Immunology. 164, 3, p. 1143-1147 5 p.

Research output: Contribution to journalArticle

Open Access
59 Scopus citations

From the ECM to the cytoskeleton and back: How integrins orchestrate T cell action

Epler, J. A., Liu, R. & Shimizu, Y., Jan 1 2000, In : Developmental Immunology. 7, 2-4, p. 155-170 16 p.

Research output: Contribution to journalArticle

16 Scopus citations

Regulation of β1 integrin-mediated adhesion by T cell receptor signaling involves ZAP-70 but differs from signaling events that regulate transciptional activity

Epler, J. A., Liu, R., Chung, H., Ottoson, N. C. & Shimizu, Y., Nov 1 2000, In : Journal of Immunology. 165, 9, p. 4941-4949 9 p.

Research output: Contribution to journalArticle

Open Access
35 Scopus citations

Role of phosphoinositide 3-kinase and the Cbl adaptor protein in coupling the α4β1 integrin to mitogen-activated protein kinase signalling

Finkelstein, L. D. & Shimizu, Y., Jan 15 2000, In : Biochemical Journal. 345, 2, p. 385-392 8 p.

Research output: Contribution to journalArticle

21 Scopus citations