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Research Output 1986 2019

2001
248 Citations (Scopus)

Coupling of the TCR to integrin activation by SLAP-130/Fyb

Peterson, E. J., Woods, M. L., Dmowski, S. A., Derimanov, G., Jordan, M. S., Wu, J. N., Myung, P. S., Liu, Q. H., Pribila, J. T., Freedman, B. D., Shimizu, Y. & Koretzky, G. A., Sep 21 2001, In : Science. 293, 5538, p. 2263-2265 3 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Integrins
Phosphoproteins
Actins
T-Lymphocytes
78 Citations (Scopus)

Cutting edge: T cell migration regulated by CXCR4 chemokine receptor signaling to ZAP-70 tyrosine kinase

Ottoson, N. C., Pribila, J. T., Chan, A. S. H. & Shimizu, Y., Aug 15 2001, In : Journal of Immunology. 167, 4, p. 1857-1861 5 p.

Research output: Contribution to journalArticle

ZAP-70 Protein-Tyrosine Kinase
CXCR4 Receptors
Chemokine Receptors
Jurkat Cells
Protein-Tyrosine Kinases
5 Citations (Scopus)

Measurement of cellular adhesion under static conditions.

Mobley, J. L. & Shimizu, Y., Jan 1 2001, In : Current protocols in immunology / edited by John E. Coligan ... [et al.]. Chapter 7

Research output: Contribution to journalArticle

Ligands
Cell Adhesion
Lymphocyte Activation
Adhesives
Suspensions
125 Citations (Scopus)

Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain

Chen, R., Kim, O., Li, M., Xiong, X., Guan, J. L., Kung, H. J., Chen, H., Shimizu, Y. & Qiu, Y., May 21 2001, In : Nature Cell Biology. 3, 5, p. 439-444 6 p.

Research output: Contribution to journalArticle

Focal Adhesion Protein-Tyrosine Kinases
Integrins
Protein-Tyrosine Kinases
Cell Movement
Carcinoma
44 Citations (Scopus)

Signaling networks regulating β1 integrin-mediated adhesion of T lymphocytes to extracellular matrix

Woods, M. L. & Shimizu, Y., Jul 7 2001, In : Journal of Leukocyte Biology. 69, 6, p. 874-880 7 p.

Research output: Contribution to journalArticle

Integrins
Extracellular Matrix
T-Cell Antigen Receptor
T-Lymphocytes
Phosphatidylinositol 3-Kinase
20 Citations (Scopus)

The T lymphocyte structure CD60 contains a sialylated carbohydrate epitope that is expressed on both gangliosides and glycoproteins

Fox, D. A., He, X., Abe, A., Hollander, T., Li, L. L., Kan, L., Friedman, A. W., Shimizu, Y., Shayman, J. A. & Kozarsky, K., Jul 28 2001, In : Immunological Investigations. 30, 2, p. 67-85 19 p.

Research output: Contribution to journalArticle

Gangliosides
Epitopes
Glycoproteins
Carbohydrates
T-Lymphocytes
2 Citations (Scopus)

Tuning the function of ZAP-70 in vivo

Shimizu, Y., Oct 1 2001, In : Trends in Immunology. 22, 10, p. 541-542 2 p.

Research output: Contribution to journalShort survey

2000
31 Citations (Scopus)
T-Lymphocyte Epitopes
Fibronectins
Cell Adhesion
Integrins
Cell Movement
59 Citations (Scopus)

Cutting edge: A novel function for the SLAP-130/FYB adapter protein in β1 integrin signaling and T lymphocyte migration

Hunter, A. J., Ottoson, N., Boerth, N., Koretzky, G. A. & Shimizu, Y., Feb 1 2000, In : Journal of Immunology. 164, 3, p. 1143-1147 5 p.

Research output: Contribution to journalArticle

Phosphoproteins
Integrins
T-Lymphocytes
Proteins
Tyrosine
16 Citations (Scopus)

From the ECM to the cytoskeleton and back: How integrins orchestrate T cell action

Epler, J. A., Liu, R. & Shimizu, Y., Jan 1 2000, In : Developmental Immunology. 7, 2-4, p. 155-170 16 p.

Research output: Contribution to journalArticle

Cytoskeleton
Integrins
T-Lymphocytes
Viral Tumor Antigens
Cellular Structures
35 Citations (Scopus)

Regulation of β1 integrin-mediated adhesion by T cell receptor signaling involves ZAP-70 but differs from signaling events that regulate transciptional activity

Epler, J. A., Liu, R., Chung, H., Ottoson, N. C. & Shimizu, Y., Nov 1 2000, In : Journal of Immunology. 165, 9, p. 4941-4949 9 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Integrins
T-Lymphocytes
ZAP-70 Protein-Tyrosine Kinase
Adhesives
20 Citations (Scopus)

Role of phosphoinositide 3-kinase and the Cbl adaptor protein in coupling the α4β1 integrin to mitogen-activated protein kinase signalling

Finkelstein, L. D. & Shimizu, Y., Jan 15 2000, In : Biochemical Journal. 345, 2, p. 385-392 8 p.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Phosphatidylinositols
Mitogen-Activated Protein Kinases
Integrins
Phosphotransferases
1999
80 Citations (Scopus)

High affinity very late antigen-4 subsets expressed on T cells are mandatory for spontaneous adhesion strengthening but not for rolling on VCAM- 1 in shear flow

Chen, C., Mobley, J. L., Dwir, O., Shimron, F., Grabovsky, V., Lobb, R. R., Shimizu, Y. & Alon, R., Jan 15 1999, In : Journal of Immunology. 162, 2, p. 1084-1095 12 p.

Research output: Contribution to journalArticle

Integrin alpha4beta1
Vascular Cell Adhesion Molecule-1
T-Lymphocytes
Ligands
Jurkat Cells
97 Citations (Scopus)

Integrins in the immune system

Shimizu, Y., Rose, D. M. & Ginsberg, M. H., Jan 1 1999, In : Advances in Immunology. 72, 72, p. 325-380 56 p.

Research output: Contribution to journalArticle

Integrins
Immune System
25 Citations (Scopus)

Regulation of integrin function by T cell activation: Points of convergence and divergence

Zell, T., Kivens, W. J., Kellermann, S. A. & Shimizu, Y., Dec 1 1999, In : Immunologic Research. 20, 2, p. 127-145 19 p.

Research output: Contribution to journalReview article

Integrins
Phosphatidylinositols
T-Lymphocytes
Phosphotransferases
Leukocytes
80 Citations (Scopus)
Neuregulin-1
Phosphatidylinositols
Epidermal Growth Factor
Integrins
Phosphotransferases
1998
40 Citations (Scopus)

Identification of a proline-rich sequence in the CD2 cytoplasmic domain critical for regulation of integrin-mediated adhesion and activation of phosphoinositide 3-kinase

Kivens, W. J., Hunt, S. W., Mobley, J. L., Zell, T., Dell, C. L., Bierer, B. E. & Shimizu, Y., Jan 1 1998, In : Molecular and cellular biology. 18, 9, p. 5291-5307 17 p.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Proline
Integrins
Mitogen-Activated Protein Kinases
Mutation
48 Citations (Scopus)

Regulation of β1-integrin-mediated cell adhesion by the Cbl adaptor protein

Zell, T., Warden, C. S., Chan, A. S. H., Cook, M. E., Dell, C. L., Hunt, S. W. & Shimizu, Y., Jul 2 1998, In : Current Biology. 8, 14, p. 814-822 9 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Cell adhesion
integrins
phosphatidylinositol 3-kinase
cell adhesion
39 Citations (Scopus)

Use of a β1 integrin-deficient human T cell to identify β1 integrin cytoplasmic domain sequences critical for integrin function

Romzek, N. C., Harris, E. S., Dell, C. L., Skronek, J., Hasse, E., Reynolds, P. J., Hunt, S. W. & Shimizu, Y., Oct 1 1998, In : Molecular biology of the cell. 9, 10, p. 2715-2727 13 p.

Research output: Contribution to journalArticle

Integrins
T-Lymphocytes
Fibronectins
Amino Acids
Cell Line
1997
47 Citations (Scopus)

CD7-Mediated Regulation of Integrin Adhesiveness on Human T Cells Involves Tyrosine Phosphorylation-Dependent Activation of Phosphatidylinositol 3-Kinase

Chan, A. S. H., Mobley, J. L., Fields, G. B. & Shimizu, Y., Jul 15 1997, In : Journal of Immunology. 159, 2, p. 934-942 9 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Adhesiveness
Integrins
Tyrosine
Phosphorylation
7 Citations (Scopus)

Structural Requirements for β1 Integrin-Mediated Tyrosine Phosphorylation in Human T Cells

Finkelstein, L. D., Reynolds, P. J., Hunt, S. W. & Shimizu, Y., Dec 1 1997, In : Journal of Immunology. 159, 11, p. 5355-5363 9 p.

Research output: Contribution to journalArticle

Integrins
Tyrosine
Phosphorylation
T-Lymphocytes
Amino Acids
31 Citations (Scopus)
Crk-Associated Substrate Protein
Integrins
Tyrosine
Phosphorylation
T-Lymphocytes
1996
87 Citations (Scopus)

CD28-mediated up-regulation of β1-integrin adhesion involves phosphatidylinositol 3-kinase

Zell, T., Hunt, S. W., Mobley, J. L., Finkelstein, L. D. & Shimizu, Y., Feb 1 1996, In : Journal of Immunology. 156, 3, p. 883-886 4 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Integrins
Up-Regulation
Fibronectins
HL-60 Cells

Cell-specific differences in a4βl integrin-mediated signal transduction

Finkelstein, L. D., Hunt, S. W. & Shimizu, Y., Dec 1 1996, In : FASEB Journal. 10, 6, p. A1449

Research output: Contribution to journalArticle

Signal transduction
Phosphorylation
integrins
Integrins
Tyrosine
10 Citations (Scopus)

Intracellular signaling pathways and the regulation of cell adhesion.

Shimizu, Y., Jan 1 1996, In : Human cell : official journal of Human Cell Research Society. 9, 3, p. 175-180 6 p.

Research output: Contribution to journalReview article

Cell Adhesion
Integrins
T-Lymphocytes
Adhesives
Leukocyte-Adhesion Receptors
22 Citations (Scopus)
Integrins
Protein Kinase C
T-Lymphocytes
Cell Line
Mutation
103 Citations (Scopus)

Regulating integrin-mediated adhesion: One more function of PI 3-kinase?

Shimizu, Y. & Hunt, S. W., Jan 1 1996, In : Immunology Today. 17, 12, p. 565-573 9 p.

Research output: Contribution to journalReview article

Phosphatidylinositol 3-Kinases
Integrins

Regulation of adhesion molecule expression by t cell activation in vivo

Kellermann, S. A., Jenkins, M. & Shimizu, Y., Dec 1 1996, In : FASEB Journal. 10, 6

Research output: Contribution to journalArticle

T-cells
adhesion
Adhesion
T-lymphocytes
Chemical activation
16 Citations (Scopus)

T-lymphocyte interactions with endothelium and extracellular matrix

Hunt, S. W., Harris, E. S., Kellermann, S. A. & Shimizu, Y., Jan 1 1996, In : Critical Reviews in Oral Biology and Medicine. 7, 1, p. 59-86 28 p.

Research output: Contribution to journalReview article

Endothelium
Extracellular Matrix
T-Lymphocytes
Transendothelial and Transepithelial Migration
Immunologic Monitoring
1995
107 Citations (Scopus)

A role for phosphatidylinositol 3-kinase in the regulation of β1 integrin activity by the CD2 antigen

Shimizu, Y., Mobley, J. L., Finkelstein, L. D. & Chan, A. S. H., Dec 1 1995, In : Journal of Cell Biology. 131, 6 II, p. 1867-1880 14 p.

Research output: Contribution to journalArticle

CD2 Antigens
Phosphatidylinositol 3-Kinase
Integrins
Up-Regulation
Vascular Cell Adhesion Molecule-1
1994
259 Citations (Scopus)

Adhesion through the LFA-1 (CD11a/CD18)-ICAM-1 (CD54) and the VLA-4 (CD49d)-VCAM-1 (CD106) pathways prevents apoptosis of germinal center B cells

Koopman, G., Keehnen, R. M. J., Lindhout, E., Newman, W., Shimizu, Y., Van Seventer, G. A., De Groot, C. & Pals, S. T., Apr 15 1994, In : Journal of Immunology. 152, 8, p. 3760-3767 8 p.

Research output: Contribution to journalArticle

Integrin alpha4beta1
Lymphocyte Function-Associated Antigen-1
Germinal Center
Vascular Cell Adhesion Molecule-1
Intercellular Adhesion Molecule-1
22 Citations (Scopus)

Costimulation of Superantigen-Activated T Lymphocytes by Autologous Dendritic Cells Is Dependent on B7

Nestle, F. O., Thompson, C., Shimizu, Y., Turka, L. A. & Nickoloff, B. J., Jan 1 1994, In : Cellular Immunology. 156, 1, p. 220-229 10 p.

Research output: Contribution to journalArticle

Superantigens
Dendritic Cells
T-Lymphocytes
Antigen-Presenting Cells
Isoantigens
48 Citations (Scopus)

Differential activation-dependent regulation of integrin function in cultured human T-leukemic cell lines

Mobley, J. L., Ennis, E. & Shimizu, Y., Feb 15 1994, In : Blood. 83, 4, p. 1039-1050 12 p.

Research output: Contribution to journalArticle

Integrins
Chemical activation
Cells
T-cells
Cell Line
107 Citations (Scopus)

Novel allele-specific, post-translational reduction in HLA class I surface expression in a mutant human B cell line

Greenwood, R., Shimizu, Y., Sekhon, G. S. & DeMars, R., Dec 15 1994, In : Journal of Immunology. 153, 12, p. 5525-5536 12 p.

Research output: Contribution to journalArticle

HLA-A1 Antigen
HLA-B8 Antigen
B-Lymphocytes
Alleles
Cell Line
28 Citations (Scopus)

T cell receptor stimulation, but not CD28 costimulation, is dependent on LFA‐1‐mediated events

Green, J. M., Zheng, XG. G., Shimizu, Y., Thompson, C. B. & Turka, L. A., Jan 1 1994, In : European Journal of Immunology. 24, 1, p. 265-272 8 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Immobilized Antibodies
T-Lymphocytes
Mixed Lymphocyte Culture Test
CHO Cells
23 Citations (Scopus)

Tyrosine kinase activity associated with the CD7 antigen: correlation with regulation of T cell integrin function

Chan, A. S. H., Reynolds, P. J. & Shimizu, Y., Nov 1994, In : European Journal of Immunology. 24, 11, p. 2602-2608 7 p.

Research output: Contribution to journalArticle

CD7 Antigens
Integrins
Protein-Tyrosine Kinases
T-Lymphocytes
Up-Regulation
1993
148 Citations (Scopus)

Accessory cell function of keratinocytes for superantigens: Dependence on lymphocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction

Nickoloff, B. J., Mitra, R. S., Green, J., Zheng, X. G., Shimizu, Y., Thompson, C. & Turka, L. A., Jan 1 1993, In : Journal of Immunology. 150, 6, p. 2148-2159 12 p.

Research output: Contribution to journalArticle

Superantigens
Lymphocyte Function-Associated Antigen-1
Intercellular Adhesion Molecule-1
Keratinocytes
T-Lymphocytes
24 Citations (Scopus)

Activated keratinocytes present bacterial-derived superantigens to T lymphocytes: relevance to psoriasis

Nickoloff, B. J., Mitra, R. S., Green, J., Shimizu, Y., Thompson, C. & Turka, L. A., Jan 1 1993, In : Journal of Dermatological Science. 6, 2, p. 127-133 7 p.

Research output: Contribution to journalArticle

Superantigens
T-cells
Keratinocytes
Psoriasis
T-Lymphocytes
105 Citations (Scopus)

Activated T-cell adhesion to thrombospondin is mediated by the α4β1 (VLA-4) and α5β1 (VLA-5) integrins

Yabkowitz, R., Dixit, V. M., Guo, N., Roberts, D. D. & Shimizu, Y., Jul 1 1993, In : Journal of Immunology. 151, 1, p. 149-158 10 p.

Research output: Contribution to journalArticle

Integrin alpha4beta1
Thrombospondins
Cell Adhesion
Integrins
T-Lymphocytes
93 Citations (Scopus)

Discordant expression of CD28 ligands, BB-1, and B7 on keratinocytes in vitro and psoriatic cells in vivo

Nickoloff, B. J., Mitra, R. S., Lee, K., Turka, L. A., Green, J., Thompson, C. & Shimizu, Y., Dec 1 1993, In : American Journal of Pathology. 142, 4, p. 1029-1040 12 p.

Research output: Contribution to journalArticle

CD80 Antigens
Keratinocytes
Monoclonal Antibodies
T-Cell Antigen Receptor
T-Lymphocytes
48 Citations (Scopus)

Distinct divalent cation requirements for integrin-mediated CD4+ T lymphocyte adhesion to ICAM-1, fibronectin, VCAM-1, and invasin

Shimizu, Y. & Mobley, J. L., Jan 1 1993, In : Journal of Immunology. 151, 8, p. 4106-4115 10 p.

Research output: Contribution to journalArticle

Vascular Cell Adhesion Molecule-1
Divalent Cations
Intercellular Adhesion Molecule-1
Fibronectins
Integrins
35 Citations (Scopus)
Keratinocytes
Histamine
Tumors
Necrosis
Adhesion
169 Citations (Scopus)

Mucins in the mainstream

Shimizu, Y. & Shaw, S., Jan 1 1993, In : Nature. 366, 6456, p. 630-631 2 p.

Research output: Contribution to journalShort survey

Mucoproteins
L-Selectin
Cell Adhesion Molecules
Mucins
Cell Adhesion
16 Citations (Scopus)

Regulatory mechanisms underlying t cell integrin receptor function

Mobley, J. L., Reynolds, P. J. & Shimizu, Y., Aug 1993, In : Seminars in Immunology. 5, 4, p. 227-236 10 p.

Research output: Contribution to journalArticle

Integrins
Lymphocytes
Ligands
52 Citations (Scopus)

Very late antigen 4-dependent adhesion and costimulation of resting human T cells by the bacterial β1 integrin ligand invasin

Ennis, E., Isberg, R. R. & Shimizu, Y., Jan 1 1993, In : Journal of Experimental Medicine. 177, 1, p. 207-212 6 p.

Research output: Contribution to journalArticle

Integrin alpha4beta1
Integrins
Ligands
T-Lymphocytes
Antigens
1992
324 Citations (Scopus)

CD31 expressed on distinctive T cell subsets is a preferential amplifier of β1 integrin-mediated adhesion

Tanaka, Y., Albelda, S. M., Horgan, K. J., Van Seventer, G. A., Shimizu, Y., Newman, W., Hallam, J., Newman, P. J., Buck, C. A. & Shaw, S., Jul 1 1992, In : Journal of Experimental Medicine. 176, 1, p. 245-253 9 p.

Research output: Contribution to journalArticle

T-Lymphocyte Subsets
Integrins
T-Lymphocytes
Endothelial Cells
Adhesives
182 Citations (Scopus)

Crosslinking of the T cell-specific accessory molecules CD7 and CD28 modulates T cell adhesion

Shimizu, Y., Van Seventer, G. A., Ennis, E., Newman, W., Horgan, K. J. & Shaw, S., Feb 1 1992, In : Journal of Experimental Medicine. 175, 2, p. 577-582 6 p.

Research output: Contribution to journalArticle

Cell Adhesion
T-Lymphocytes
Calcimycin
Integrins
Protein Kinase C
40 Citations (Scopus)

Differential expression of VLA-α4 and VLA-β1 discriminates multiple subsets of CD4+CD45R0+ 'memory' T cells

Horgan, K. J., Ginther Luce, G. E., Tanaka, Y., Schweighoffer, T., Shimizu, Y., Sharrow, S. O. & Shaw, S., Dec 1 1992, In : Journal of Immunology. 149, 12, p. 4082-4087 6 p.

Research output: Contribution to journalArticle

Integrin alpha1beta1
Integrin alpha4beta1
T-Lymphocytes
Integrins
Integrin alpha3beta1
9 Citations (Scopus)

HUT 78 T cells bind to noncytokine-stimulated keratinocytes using a non- CD18-dependent adhesion pathway

Nickoloff, B. J., Mitra, R. S., Shimizu, Y., Barker, J. N. W. N., Karabin, G., Stoof, T. & Stoolman, L. M., Jan 1 1992, In : American Journal of Pathology. 140, 6, p. 1365-1374 10 p.

Research output: Contribution to journalArticle

Keratinocytes
T-Lymphocytes
Melanocytes
Phorbol Esters
Fibroblasts
639 Citations (Scopus)

Lymphocyte interactions with endothelial cells

Shimizu, Y., Newman, W., Tanaka, Y. & Shaw, S., 1992, In : Immunology Today. 13, 3, p. 106-112 7 p.

Research output: Contribution to journalReview article

Endothelial Cells
Lymphocytes
Endothelium
Lymphoid Tissue
Cell Adhesion