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Research Output 1986 2019

Article
148 Citations (Scopus)

Accessory cell function of keratinocytes for superantigens: Dependence on lymphocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction

Nickoloff, B. J., Mitra, R. S., Green, J., Zheng, X. G., Shimizu, Y., Thompson, C. & Turka, L. A., Jan 1 1993, In : Journal of Immunology. 150, 6, p. 2148-2159 12 p.

Research output: Contribution to journalArticle

Superantigens
Lymphocyte Function-Associated Antigen-1
Intercellular Adhesion Molecule-1
Keratinocytes
T-Lymphocytes
24 Citations (Scopus)

Activated keratinocytes present bacterial-derived superantigens to T lymphocytes: relevance to psoriasis

Nickoloff, B. J., Mitra, R. S., Green, J., Shimizu, Y., Thompson, C. & Turka, L. A., Jan 1 1993, In : Journal of Dermatological Science. 6, 2, p. 127-133 7 p.

Research output: Contribution to journalArticle

Superantigens
T-cells
Keratinocytes
Psoriasis
T-Lymphocytes
105 Citations (Scopus)

Activated T-cell adhesion to thrombospondin is mediated by the α4β1 (VLA-4) and α5β1 (VLA-5) integrins

Yabkowitz, R., Dixit, V. M., Guo, N., Roberts, D. D. & Shimizu, Y., Jul 1 1993, In : Journal of Immunology. 151, 1, p. 149-158 10 p.

Research output: Contribution to journalArticle

Integrin alpha4beta1
Thrombospondins
Cell Adhesion
Integrins
T-Lymphocytes
31 Citations (Scopus)
T-Lymphocyte Epitopes
Fibronectins
Cell Adhesion
Integrins
Cell Movement
299 Citations (Scopus)

Activation-independent binding of human memory T cells to adhesion molecule ELAM-1

Shimizu, Y., Shaw, S., Graber, N., Gopal, T. V., Morgan, K. J., Seventer, G. A. V. & Newman, W., Jan 1 1991, In : Nature. 349, 6312, p. 799-802 4 p.

Research output: Contribution to journalArticle

E-Selectin
Cell Adhesion Molecules
T-Lymphocytes
Endothelial Cells
Cell Adhesion
16 Citations (Scopus)

ADAP is dispensable for NK cell development and function

Fostel, L. V., Dluzniewska, J., Shimizu, Y., Burbach, B. J. & Peterson, E. J., Aug 1 2006, In : International Immunology. 18, 8, p. 1305-1314 10 p.

Research output: Contribution to journalArticle

Natural Killer Cells
Cytokine Receptors
Immunoreceptor Tyrosine-Based Activation Motif
Lymphokines
Innate Immunity
11 Citations (Scopus)
Cyclin-Dependent Kinase 2
Cyclin E
Cell Cycle Proteins
T-Lymphocytes
Proteins
27 Citations (Scopus)

Adhesion and degranulation-promoting adapter protein (ADAP) positively regulates T cell sensitivity to antigen and T cell survival

Mueller, K. L., Thomas, M. S., Burbach, B. J., Peterson, E. J. & Shimizu, Y., Sep 15 2007, In : Journal of Immunology. 179, 6, p. 3559-3569 11 p.

Research output: Contribution to journalArticle

Cell Survival
T-Lymphocytes
Antigens
Proteins
Cell Communication
3 Citations (Scopus)
Cell Differentiation
T-Lymphocytes
Infection
Proteins
NK Cell Lectin-Like Receptors
259 Citations (Scopus)

Adhesion through the LFA-1 (CD11a/CD18)-ICAM-1 (CD54) and the VLA-4 (CD49d)-VCAM-1 (CD106) pathways prevents apoptosis of germinal center B cells

Koopman, G., Keehnen, R. M. J., Lindhout, E., Newman, W., Shimizu, Y., Van Seventer, G. A., De Groot, C. & Pals, S. T., Apr 15 1994, In : Journal of Immunology. 152, 8, p. 3760-3767 8 p.

Research output: Contribution to journalArticle

Integrin alpha4beta1
Lymphocyte Function-Associated Antigen-1
Germinal Center
Vascular Cell Adhesion Molecule-1
Intercellular Adhesion Molecule-1
260 Citations (Scopus)

Analysis of t cell stimulation by superantigen plus major histocompatibility complex class ii molecules or by cd3 monoclonal antibody: Costimulation by purified adhesion ligands vcam-1, icam-1, but not elam-1

van Seventer, G. A., Newman, W., Shimizu, Y., Nutman, T. B., Tanaka, Y., Horgan, K. J., Gopal, T. V., Ennis, E., O'sullivan, D., Grey, H. & Shaw, S., Oct 1 1991, In : Journal of Experimental Medicine. 174, 4, p. 901-913 13 p.

Research output: Contribution to journalArticle

Superantigens
Vascular Cell Adhesion Molecule-1
Major Histocompatibility Complex
Monoclonal Antibodies
Intercellular Adhesion Molecule-1
88 Citations (Scopus)

A novel function for the Tec family tyrosine kinase Itk in activation of β1 integrins by the T-cell receptor

Woods, M. L., Kivens, W. J., Adelsman, M. A., Qiu, Y., August, A. & Shimizu, Y., Mar 15 2001, In : EMBO Journal. 20, 6, p. 1232-1244 13 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Integrins
Phosphatidylinositol 3-Kinase
Protein-Tyrosine Kinases
Chemical activation
107 Citations (Scopus)

A role for phosphatidylinositol 3-kinase in the regulation of β1 integrin activity by the CD2 antigen

Shimizu, Y., Mobley, J. L., Finkelstein, L. D. & Chan, A. S. H., Dec 1 1995, In : Journal of Cell Biology. 131, 6 II, p. 1867-1880 14 p.

Research output: Contribution to journalArticle

CD2 Antigens
Phosphatidylinositol 3-Kinase
Integrins
Up-Regulation
Vascular Cell Adhesion Molecule-1
21 Citations (Scopus)

CD28/B7 deficiency attenuates systolic overload-induced congestive heart failure, myocardial and pulmonary inflammation, and activated T cell accumulation in the heart and lungs

Wang, H., Kwak, D., Fassett, J., Hou, L., Xu, X., Burbach, B. J., Thenappan, T., Xu, Y., Ge, J. B., Shimizu, Y., Bache, R. J. & Chen, Y., Sep 1 2016, In : Hypertension. 68, 3, p. 688-696 9 p.

Research output: Contribution to journalArticle

Pneumonia
Heart Failure
T-Lymphocytes
Lung
Constriction
87 Citations (Scopus)

CD28-mediated up-regulation of β1-integrin adhesion involves phosphatidylinositol 3-kinase

Zell, T., Hunt, S. W., Mobley, J. L., Finkelstein, L. D. & Shimizu, Y., Feb 1 1996, In : Journal of Immunology. 156, 3, p. 883-886 4 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Integrins
Up-Regulation
Fibronectins
HL-60 Cells
324 Citations (Scopus)

CD31 expressed on distinctive T cell subsets is a preferential amplifier of β1 integrin-mediated adhesion

Tanaka, Y., Albelda, S. M., Horgan, K. J., Van Seventer, G. A., Shimizu, Y., Newman, W., Hallam, J., Newman, P. J., Buck, C. A. & Shaw, S., Jul 1 1992, In : Journal of Experimental Medicine. 176, 1, p. 245-253 9 p.

Research output: Contribution to journalArticle

T-Lymphocyte Subsets
Integrins
T-Lymphocytes
Endothelial Cells
Adhesives
47 Citations (Scopus)

CD7-Mediated Regulation of Integrin Adhesiveness on Human T Cells Involves Tyrosine Phosphorylation-Dependent Activation of Phosphatidylinositol 3-Kinase

Chan, A. S. H., Mobley, J. L., Fields, G. B. & Shimizu, Y., Jul 15 1997, In : Journal of Immunology. 159, 2, p. 934-942 9 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Adhesiveness
Integrins
Tyrosine
Phosphorylation

Cell-specific differences in a4βl integrin-mediated signal transduction

Finkelstein, L. D., Hunt, S. W. & Shimizu, Y., Dec 1 1996, In : FASEB Journal. 10, 6

Research output: Contribution to journalArticle

Signal transduction
Phosphorylation
integrins
Integrins
Tyrosine
36 Citations (Scopus)

Control of TCR-Mediated Activation of β1 Integrins by the ZAP-70 Tyrosine Kinase Interdomain B Region and the Linker for Activation of T Cells Adapter Protein

Goda, S., Quale, A. C., Woods, M. L., Felthauser, A. & Shimizu, Y., May 1 2004, In : Journal of Immunology. 172, 9, p. 5379-5387 9 p.

Research output: Contribution to journalArticle

ZAP-70 Protein-Tyrosine Kinase
Integrins
Protein-Tyrosine Kinases
T-Lymphocytes
Tyrosine
37 Citations (Scopus)

Control of α4β7 integrin expression and CD4 T cell homing by the β1 integrin subunit

DeNucci, C. C., Pagán, A. J., Mitchell, J. S. & Shimizu, Y., Mar 1 2010, In : Journal of Immunology. 184, 5, p. 2458-2467 10 p.

Research output: Contribution to journalArticle

Integrins
T-Lymphocytes
Peyer's Patches
Listeriosis
Cell Adhesion Molecules
325 Citations (Scopus)

Costimulation of proliferative responses of resting CD4+ T cells by the interaction of VLA-4 and VLA-5 with fibronectin or VLA-6 with laminin

Shimizu, Y., Van Seventer, G. A., Horgan, K. J. & Shaw, S., Jul 1 1990, In : Journal of Immunology. 145, 1, p. 59-67 9 p.

Research output: Contribution to journalArticle

Integrin alpha6beta1
Integrin alpha5beta1
Integrin alpha4beta1
Laminin
Fibronectins
22 Citations (Scopus)

Costimulation of Superantigen-Activated T Lymphocytes by Autologous Dendritic Cells Is Dependent on B7

Nestle, F. O., Thompson, C., Shimizu, Y., Turka, L. A. & Nickoloff, B. J., Jan 1 1994, In : Cellular Immunology. 156, 1, p. 220-229 10 p.

Research output: Contribution to journalArticle

Superantigens
Dendritic Cells
T-Lymphocytes
Antigen-Presenting Cells
Isoantigens
248 Citations (Scopus)

Coupling of the TCR to integrin activation by SLAP-130/Fyb

Peterson, E. J., Woods, M. L., Dmowski, S. A., Derimanov, G., Jordan, M. S., Wu, J. N., Myung, P. S., Liu, Q. H., Pribila, J. T., Freedman, B. D., Shimizu, Y. & Koretzky, G. A., Sep 21 2001, In : Science. 293, 5538, p. 2263-2265 3 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Integrins
Phosphoproteins
Actins
T-Lymphocytes
182 Citations (Scopus)

Crosslinking of the T cell-specific accessory molecules CD7 and CD28 modulates T cell adhesion

Shimizu, Y., Van Seventer, G. A., Ennis, E., Newman, W., Horgan, K. J. & Shaw, S., Feb 1 1992, In : Journal of Experimental Medicine. 175, 2, p. 577-582 6 p.

Research output: Contribution to journalArticle

Cell Adhesion
T-Lymphocytes
Calcimycin
Integrins
Protein Kinase C
78 Citations (Scopus)

Cutting edge: T cell migration regulated by CXCR4 chemokine receptor signaling to ZAP-70 tyrosine kinase

Ottoson, N. C., Pribila, J. T., Chan, A. S. H. & Shimizu, Y., Aug 15 2001, In : Journal of Immunology. 167, 4, p. 1857-1861 5 p.

Research output: Contribution to journalArticle

ZAP-70 Protein-Tyrosine Kinase
CXCR4 Receptors
Chemokine Receptors
Jurkat Cells
Protein-Tyrosine Kinases
23 Citations (Scopus)

Cutting edge: LFA-1 integrin-dependent T cell adhesion is regulated by both Ag specificity and sensitivity

Mueller, K. L., Daniels, M. A., Felthauser, A., Kao, C., Jameson, S. C. & Shimizu, Y., Aug 15 2004, In : Journal of Immunology. 173, 4, p. 2222-2226 5 p.

Research output: Contribution to journalArticle

Lymphocyte Function-Associated Antigen-1
Cell Adhesion
Integrins
T-Lymphocytes
Sensitivity and Specificity
59 Citations (Scopus)

Cutting edge: A novel function for the SLAP-130/FYB adapter protein in β1 integrin signaling and T lymphocyte migration

Hunter, A. J., Ottoson, N., Boerth, N., Koretzky, G. A. & Shimizu, Y., Feb 1 2000, In : Journal of Immunology. 164, 3, p. 1143-1147 5 p.

Research output: Contribution to journalArticle

Phosphoproteins
Integrins
T-Lymphocytes
Proteins
Tyrosine
3 Citations (Scopus)

Cytokine-mediated activation of human ex vivo-expanded Vγ9Vδ2 T cells

Domae, E., Hirai, Y., Ikeo, T., Goda, S. & Shimizu, Y., Jan 1 2017, In : Oncotarget. 8, 28, p. 45928-45942 15 p.

Research output: Contribution to journalArticle

Open Access
Interleukin-18
Interleukin-12
Cytokines
T-Lymphocytes
Interleukins
112 Citations (Scopus)
MHC Class I Genes
Histocompatibility Antigens Class I
HLA Antigens
Natural Killer Cells
Antigens
48 Citations (Scopus)

Differential activation-dependent regulation of integrin function in cultured human T-leukemic cell lines

Mobley, J. L., Ennis, E. & Shimizu, Y., Feb 15 1994, In : Blood. 83, 4, p. 1039-1050 12 p.

Research output: Contribution to journalArticle

Integrins
Chemical activation
Cells
T-cells
Cell Line
40 Citations (Scopus)

Differential expression of VLA-α4 and VLA-β1 discriminates multiple subsets of CD4+CD45R0+ 'memory' T cells

Horgan, K. J., Ginther Luce, G. E., Tanaka, Y., Schweighoffer, T., Shimizu, Y., Sharrow, S. O. & Shaw, S., Dec 1 1992, In : Journal of Immunology. 149, 12, p. 4082-4087 6 p.

Research output: Contribution to journalArticle

Integrin alpha1beta1
Integrin alpha4beta1
T-Lymphocytes
Integrins
Integrin alpha3beta1
93 Citations (Scopus)

Discordant expression of CD28 ligands, BB-1, and B7 on keratinocytes in vitro and psoriatic cells in vivo

Nickoloff, B. J., Mitra, R. S., Lee, K., Turka, L. A., Green, J., Thompson, C. & Shimizu, Y., Dec 1 1993, In : American Journal of Pathology. 142, 4, p. 1029-1040 12 p.

Research output: Contribution to journalArticle

CD80 Antigens
Keratinocytes
Monoclonal Antibodies
T-Cell Antigen Receptor
T-Lymphocytes
48 Citations (Scopus)

Distinct divalent cation requirements for integrin-mediated CD4+ T lymphocyte adhesion to ICAM-1, fibronectin, VCAM-1, and invasin

Shimizu, Y. & Mobley, J. L., Jan 1 1993, In : Journal of Immunology. 151, 8, p. 4106-4115 10 p.

Research output: Contribution to journalArticle

Vascular Cell Adhesion Molecule-1
Divalent Cations
Intercellular Adhesion Molecule-1
Fibronectins
Integrins
21 Citations (Scopus)

Distinct regulation of integrin-dependent T cell conjugate formation and NF-κB activation by the adapter protein ADAP

Burbach, B. J., Srivastava, R., Medeiros, R. B., O'Gorman, W. E., Peterson, E. J. & Shimizu, Y., Oct 1 2008, In : Journal of Immunology. 181, 7, p. 4840-4851 12 p.

Research output: Contribution to journalArticle

Integrins
T-Lymphocytes
src-Family Kinases
Phosphoproteins
Proline-Rich Protein Domains
2 Citations (Scopus)

Engineering T cell response to cancer antigens by choice of focal therapeutic conditions

Shao, Q., O'flanagan, S. D., Lam, T. S., Roy, P., Pelaez, F., Burbach, B. J., Azarin, S. M., Shimizu, Y. & Bischof, J. C., Jan 1 2019, In : International Journal of Hyperthermia. 36, 1, p. 130-138 9 p.

Research output: Contribution to journalArticle

Cryosurgery
Electroporation
Hot Temperature
T-Lymphocytes
Antigens
175 Citations (Scopus)

Formins Regulate the Actin-Related Protein 2/3 Complex-Independent Polarization of the Centrosome to the Immunological Synapse

Gomez, T. S., Kumar, K., Medeiros, R. B., Shimizu, Y., Leibson, P. J. & Billadeau, DD. D., Feb 23 2007, In : Immunity. 26, 2, p. 177-190 14 p.

Research output: Contribution to journalArticle

Actin-Related Protein 2-3 Complex
Immunological Synapses
Centrosome
Actins
T-Cell Antigen Receptor
301 Citations (Scopus)

Four molecular pathways of T cell adhesion to endothelial cells: Roles of LFA-1, VCAM-1, and ELAM-1 and changes in pathway hierarchy under different activation conditions

Shimizu, Y., Newman, W., Gopal, T. V., Horgan, K. J., Graber, N., Beall, L. D., Van Seventer, G. A. & Shaw, S., Jan 1 1991, In : Journal of Cell Biology. 113, 5, p. 1203-1212 10 p.

Research output: Contribution to journalArticle

Lymphocyte Function-Associated Antigen-1
E-Selectin
Vascular Cell Adhesion Molecule-1
Cell Adhesion
Human Umbilical Vein Endothelial Cells
16 Citations (Scopus)

From the ECM to the cytoskeleton and back: How integrins orchestrate T cell action

Epler, J. A., Liu, R. & Shimizu, Y., Jan 1 2000, In : Developmental Immunology. 7, 2-4, p. 155-170 16 p.

Research output: Contribution to journalArticle

Cytoskeleton
Integrins
T-Lymphocytes
Viral Tumor Antigens
Cellular Structures
80 Citations (Scopus)

High affinity very late antigen-4 subsets expressed on T cells are mandatory for spontaneous adhesion strengthening but not for rolling on VCAM- 1 in shear flow

Chen, C., Mobley, J. L., Dwir, O., Shimron, F., Grabovsky, V., Lobb, R. R., Shimizu, Y. & Alon, R., Jan 15 1999, In : Journal of Immunology. 162, 2, p. 1084-1095 12 p.

Research output: Contribution to journalArticle

Integrin alpha4beta1
Vascular Cell Adhesion Molecule-1
T-Lymphocytes
Ligands
Jurkat Cells
35 Citations (Scopus)
Keratinocytes
Histamine
Tumors
Necrosis
Adhesion
192 Citations (Scopus)

HLA-E: A novel HLA class I gene expressed in resting T lymphocytes

Koller, B. H., Geraghty, D. E., Shimizu, Y., DeMars, R. & Orr, H. T., Jan 1 1988, In : Journal of Immunology. 141, 3, p. 897-904 8 p.

Research output: Contribution to journalArticle

MHC Class I Genes
T-Lymphocytes
RNA
HLA-C Antigens
Genes
9 Citations (Scopus)

HUT 78 T cells bind to noncytokine-stimulated keratinocytes using a non- CD18-dependent adhesion pathway

Nickoloff, B. J., Mitra, R. S., Shimizu, Y., Barker, J. N. W. N., Karabin, G., Stoof, T. & Stoolman, L. M., Jan 1 1992, In : American Journal of Pathology. 140, 6, p. 1365-1374 10 p.

Research output: Contribution to journalArticle

Keratinocytes
T-Lymphocytes
Melanocytes
Phorbol Esters
Fibroblasts
113 Citations (Scopus)

Hyporesponsiveness of “naive” (CD45RA+) human T cells to multiple receptor‐mediated stimuli but augmentation of responses by co‐stimuli

Horgan, K. J., Van Seventer, G. A., Shimizu, Y. & Shaw, S., Jan 1 1990, In : European Journal of Immunology. 20, 5, p. 1111-1118 8 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Superantigens
Monocytes
Interleukin-1
Interleukin-6
26 Citations (Scopus)

ICAM-1-dependent homotypic aggregates regulate CD8 T cell effector function and differentiation during T cell activation

Zumwalde, N. A., Domae, E., Mescher, M. F. & Shimizu, Y., Oct 1 2013, In : Journal of Immunology. 191, 7, p. 3681-3693 13 p.

Research output: Contribution to journalArticle

Intercellular Adhesion Molecule-1
T-Lymphocytes
Cluster Analysis
Lymphocyte Function-Associated Antigen-1
Granzymes
40 Citations (Scopus)

Identification of a proline-rich sequence in the CD2 cytoplasmic domain critical for regulation of integrin-mediated adhesion and activation of phosphoinositide 3-kinase

Kivens, W. J., Hunt, S. W., Mobley, J. L., Zell, T., Dell, C. L., Bierer, B. E. & Shimizu, Y., Jan 1 1998, In : Molecular and cellular biology. 18, 9, p. 5291-5307 17 p.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Proline
Integrins
Mitogen-Activated Protein Kinases
Mutation
10 Citations (Scopus)

Influence of β1 integrin intracytoplasmic domains in the regulation of VLA-4-mediated adhesion of human T cells to VCAM-1 under flow conditions

Rosenthal-Allieri, M. A., Ticchioni, M., Breittmayer, J. P., Shimizu, Y. & Bernard, A., Jul 15 2005, In : Journal of Immunology. 175, 2, p. 1214-1223 10 p.

Research output: Contribution to journalArticle

Integrin alpha4beta1
Vascular Cell Adhesion Molecule-1
Integrins
T-Lymphocytes
Tyrosine
39 Citations (Scopus)

Insulin binding to human B lymphoblasts is a function of HLA haplotype

Kittur, D., Shimizu, Y., DeMars, R. & Edidin, M., Jan 1 1987, In : Proceedings of the National Academy of Sciences of the United States of America. 84, 5, p. 1351-1355 5 p.

Research output: Contribution to journalArticle

Haplotypes
Insulin
HLA Antigens
HLA-A1 Antigen
HLA-C Antigens
97 Citations (Scopus)

Integrins in the immune system

Shimizu, Y., Rose, D. M. & Ginsberg, M. H., Jan 1 1999, In : Advances in Immunology. 72, 72, p. 325-380 56 p.

Research output: Contribution to journalArticle

Integrins
Immune System
22 Citations (Scopus)
Integrins
Protein Kinase C
T-Lymphocytes
Cell Line
Mutation

Let's Rap: Making a functional integrin

Shimizu, Y., Nov 1 2002, In : Trends in Immunology. 23, 11, p. 522-523 2 p.

Research output: Contribution to journalArticle

Integrins