If you made any changes in Pure, your changes will be visible here soon.

Research Output 1986 2019

1986
47 Citations (Scopus)

Transfer of cloned human class I major histocompatibility complex genes into HLA mutant human lymphoblastoid cells

Shimizu, Y., Koller, B., Geraghty, D., Orr, H., Shaw, S., Kavathas, P. & DeMars, R., Jan 1 1986, In : Molecular and cellular biology. 6, 4, p. 1074-1087 14 p.

Research output: Contribution to journalArticle

Major Histocompatibility Complex
MHC Class I Genes
HLA-A2 Antigen
Genes
Human Herpesvirus 4
1987
39 Citations (Scopus)

Insulin binding to human B lymphoblasts is a function of HLA haplotype

Kittur, D., Shimizu, Y., DeMars, R. & Edidin, M., Jan 1 1987, In : Proceedings of the National Academy of Sciences of the United States of America. 84, 5, p. 1351-1355 5 p.

Research output: Contribution to journalArticle

Haplotypes
Insulin
HLA Antigens
HLA-A1 Antigen
HLA-C Antigens
39 Citations (Scopus)

Organization of the human class I major histocompatibility complex genes

Koller, B. H., Geraghty, D., Orr, H. T., Shimizu, Y. & DeMars, R., Mar 1 1987, In : Immunologic Research. 6, 1-2, p. 1-10 10 p.

Research output: Contribution to journalArticle

Nucleic Acid Sequence Homology
Molecular Cloning
Multigene Family
HLA Antigens
Major Histocompatibility Complex
1988
192 Citations (Scopus)

HLA-E: A novel HLA class I gene expressed in resting T lymphocytes

Koller, B. H., Geraghty, D. E., Shimizu, Y., DeMars, R. & Orr, H. T., Jan 1 1988, In : Journal of Immunology. 141, 3, p. 897-904 8 p.

Research output: Contribution to journalArticle

MHC Class I Genes
T-Lymphocytes
RNA
HLA-C Antigens
Genes
49 Citations (Scopus)

Specific associations of fluorescent β-2-microglobulin with cell surfaces. The affinity of different H-2 and HLA antigens for β-2-microglobulin

Hochman, J. H., Shimizu, Y., DeMars, R. & Edidin, M., Jan 1 1988, In : Journal of Immunology. 140, 7, p. 2322-2329 8 p.

Research output: Contribution to journalArticle

H-2 Antigens
HLA Antigens
Fluorescein-5-isothiocyanate
Cell Line
Viral Antigens
176 Citations (Scopus)
MHC Class I Genes
Major Histocompatibility Complex
HLA-A Antigens
HLA-B Antigens
beta 2-Microglobulin
18 Citations (Scopus)

Two molecular pathways of human T cell adhesion: establishment of receptor-ligand relationship

Shaw, S. & Shimizu, Y., Jan 1 1988, In : Current Opinion in Immunology. 1, 1, p. 92-97 6 p.

Research output: Contribution to journalArticle

Immunologic Receptors
Leukocyte-Adhesion Receptors
CD2 Antigens
Immunologic Surveillance
T Lymphocyte Differentiation Antigens
1989
112 Citations (Scopus)
MHC Class I Genes
Histocompatibility Antigens Class I
HLA Antigens
Natural Killer Cells
Antigens
254 Citations (Scopus)

Production of human cells expressing individual transferred HLA-A,-B,-C genes using an HLA-A,-B,-C null human cell line

Shimizu, Y. & DeMars, R., Jan 1 1989, In : Journal of Immunology. 142, 9, p. 3320-3328 9 p.

Research output: Contribution to journalArticle

Null Lymphocytes
HLA-A Antigens
HLA-B Antigens
MHC Class I Genes
Cell Line
4 Citations (Scopus)

T lymphocyte adhesion molecules.

Shimizu, Y. & Shaw, S., Dec 1 1989, In : The Year in immunology. 6, p. 69-94 26 p.

Research output: Contribution to journalReview article

Immunologic Receptors
Leukocyte-Adhesion Receptors
CD2 Antigens
Lymphocyte Homing Receptors
T Lymphocyte Differentiation Antigens
1990
325 Citations (Scopus)

Costimulation of proliferative responses of resting CD4+ T cells by the interaction of VLA-4 and VLA-5 with fibronectin or VLA-6 with laminin

Shimizu, Y., Van Seventer, G. A., Horgan, K. J. & Shaw, S., Jul 1 1990, In : Journal of Immunology. 145, 1, p. 59-67 9 p.

Research output: Contribution to journalArticle

Integrin alpha6beta1
Integrin alpha5beta1
Integrin alpha4beta1
Laminin
Fibronectins
113 Citations (Scopus)

Hyporesponsiveness of “naive” (CD45RA+) human T cells to multiple receptor‐mediated stimuli but augmentation of responses by co‐stimuli

Horgan, K. J., Van Seventer, G. A., Shimizu, Y. & Shaw, S., Jan 1 1990, In : European Journal of Immunology. 20, 5, p. 1111-1118 8 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Superantigens
Monocytes
Interleukin-1
Interleukin-6
265 Citations (Scopus)

LFA-3, CD44, AND CD45: Physiologic triggers of human monocyte TNF and IL-1 release

Webb, D. S. A., Shimizu, Y., Van Seventer, G. A., Shaw, S. & Gerrard, T. L., Jan 1 1990, In : Science. 249, 4974, p. 1295-1297 3 p.

Research output: Contribution to journalArticle

CD58 Antigens
Interleukin-1
Monocytes
Tumor Necrosis Factor-alpha
Monokines
522 Citations (Scopus)

Regulated expression and binding of three VLA (β1) integrin receptors on T cells

Shimizu, Y., Van Seventer, G. A., Horgan, K. J. & Shaw, S., Jan 1 1990, In : Nature. 345, 6272, p. 250-253 4 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Integrins
Antigens
T-Lymphocytes
Integrin alpha4beta1
270 Citations (Scopus)
Integrin alpha6beta1
CD Antigens
Integrin alpha5beta1
Integrin alpha4beta1
Lymphocyte Function-Associated Antigen-1
708 Citations (Scopus)

The LFA-1 ligand ICAM-1 provides an important costimulatory signal for T cell receptor-mediated activation of resting T cells

Van Seventer, G. A., Shimizu, Y., Horgan, K. J. & Shaw, S., Jun 15 1990, In : Journal of Immunology. 144, 12, p. 4579-4586 8 p.

Research output: Contribution to journalArticle

Costimulatory and Inhibitory T-Cell Receptors
Lymphocyte Function-Associated Antigen-1
Intercellular Adhesion Molecule-1
Ligands
T-Lymphocytes
1991
299 Citations (Scopus)

Activation-independent binding of human memory T cells to adhesion molecule ELAM-1

Shimizu, Y., Shaw, S., Graber, N., Gopal, T. V., Morgan, K. J., Seventer, G. A. V. & Newman, W., Jan 1 1991, In : Nature. 349, 6312, p. 799-802 4 p.

Research output: Contribution to journalArticle

E-Selectin
Cell Adhesion Molecules
T-Lymphocytes
Endothelial Cells
Cell Adhesion
260 Citations (Scopus)

Analysis of t cell stimulation by superantigen plus major histocompatibility complex class ii molecules or by cd3 monoclonal antibody: Costimulation by purified adhesion ligands vcam-1, icam-1, but not elam-1

van Seventer, G. A., Newman, W., Shimizu, Y., Nutman, T. B., Tanaka, Y., Horgan, K. J., Gopal, T. V., Ennis, E., O'sullivan, D., Grey, H. & Shaw, S., Oct 1 1991, In : Journal of Experimental Medicine. 174, 4, p. 901-913 13 p.

Research output: Contribution to journalArticle

Superantigens
Vascular Cell Adhesion Molecule-1
Major Histocompatibility Complex
Monoclonal Antibodies
Intercellular Adhesion Molecule-1
301 Citations (Scopus)

Four molecular pathways of T cell adhesion to endothelial cells: Roles of LFA-1, VCAM-1, and ELAM-1 and changes in pathway hierarchy under different activation conditions

Shimizu, Y., Newman, W., Gopal, T. V., Horgan, K. J., Graber, N., Beall, L. D., Van Seventer, G. A. & Shaw, S., Jan 1 1991, In : Journal of Cell Biology. 113, 5, p. 1203-1212 10 p.

Research output: Contribution to journalArticle

Lymphocyte Function-Associated Antigen-1
E-Selectin
Vascular Cell Adhesion Molecule-1
Cell Adhesion
Human Umbilical Vein Endothelial Cells
7 Citations (Scopus)

Lymphocyte adhesion mediated by VLA (beta 1) integrins. Functional roles of multiple extracellular matrix and cell-surface ligands

Shimizu, Y. & Shaw, S., Jan 1 1991, In : Chemical Immunology. 50, p. 34-54 21 p.

Research output: Contribution to journalReview article

Integrin alpha1beta1
Integrin beta Chains
Lymphocyte Activation
Cell Adhesion
Integrins
290 Citations (Scopus)

Lymphocyte interactions with extracellular matrix

Shimizu, Y. & Shaw, S., Dec 1 1991, In : FASEB Journal. 5, 9, p. 2292-2299 8 p.

Research output: Contribution to journalArticle

Lymphocytes
extracellular matrix
Extracellular Matrix
lymphocytes
receptors
94 Citations (Scopus)

Remote T cell co‐stimulation via LFA‐1/ICAM‐1 and CD2/LFA‐3: Demonstration with immobilized ligand/mAb and implication in monocyte‐mediated co‐stimulation

Van Seventer, G. A., Shimizu, Y., Horgan, K. J., Luce, G. E. G., Webb, D. & Shaw, S., Jan 1 1991, In : European Journal of Immunology. 21, 7, p. 1711-1718 8 p.

Research output: Contribution to journalArticle

Monoclonal Antibodies
Ligands
T-Lymphocytes
Monocytes
Interleukin-1
150 Citations (Scopus)

Roles of multiple accessory molecules in T-cell activation

van Seventer, G. A., Shimizu, Y. & Shaw, S., Jan 1 1991, In : Current Opinion in Immunology. 3, 3, p. 294-303 10 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Antigen-Presenting Cells
Viral Tumor Antigens
Extracellular Matrix
Ligands
1992
324 Citations (Scopus)

CD31 expressed on distinctive T cell subsets is a preferential amplifier of β1 integrin-mediated adhesion

Tanaka, Y., Albelda, S. M., Horgan, K. J., Van Seventer, G. A., Shimizu, Y., Newman, W., Hallam, J., Newman, P. J., Buck, C. A. & Shaw, S., Jul 1 1992, In : Journal of Experimental Medicine. 176, 1, p. 245-253 9 p.

Research output: Contribution to journalArticle

T-Lymphocyte Subsets
Integrins
T-Lymphocytes
Endothelial Cells
Adhesives
182 Citations (Scopus)

Crosslinking of the T cell-specific accessory molecules CD7 and CD28 modulates T cell adhesion

Shimizu, Y., Van Seventer, G. A., Ennis, E., Newman, W., Horgan, K. J. & Shaw, S., Feb 1 1992, In : Journal of Experimental Medicine. 175, 2, p. 577-582 6 p.

Research output: Contribution to journalArticle

Cell Adhesion
T-Lymphocytes
Calcimycin
Integrins
Protein Kinase C
40 Citations (Scopus)

Differential expression of VLA-α4 and VLA-β1 discriminates multiple subsets of CD4+CD45R0+ 'memory' T cells

Horgan, K. J., Ginther Luce, G. E., Tanaka, Y., Schweighoffer, T., Shimizu, Y., Sharrow, S. O. & Shaw, S., Dec 1 1992, In : Journal of Immunology. 149, 12, p. 4082-4087 6 p.

Research output: Contribution to journalArticle

Integrin alpha1beta1
Integrin alpha4beta1
T-Lymphocytes
Integrins
Integrin alpha3beta1
9 Citations (Scopus)

HUT 78 T cells bind to noncytokine-stimulated keratinocytes using a non- CD18-dependent adhesion pathway

Nickoloff, B. J., Mitra, R. S., Shimizu, Y., Barker, J. N. W. N., Karabin, G., Stoof, T. & Stoolman, L. M., Jan 1 1992, In : American Journal of Pathology. 140, 6, p. 1365-1374 10 p.

Research output: Contribution to journalArticle

Keratinocytes
T-Lymphocytes
Melanocytes
Phorbol Esters
Fibroblasts
639 Citations (Scopus)

Lymphocyte interactions with endothelial cells

Shimizu, Y., Newman, W., Tanaka, Y. & Shaw, S., Jan 1 1992, In : Immunology Today. 13, 3, p. 106-112 7 p.

Research output: Contribution to journalReview article

Endothelial Cells
Lymphocytes
Endothelium
Lymphoid Tissue
Cell Adhesion
1993
148 Citations (Scopus)

Accessory cell function of keratinocytes for superantigens: Dependence on lymphocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction

Nickoloff, B. J., Mitra, R. S., Green, J., Zheng, X. G., Shimizu, Y., Thompson, C. & Turka, L. A., Jan 1 1993, In : Journal of Immunology. 150, 6, p. 2148-2159 12 p.

Research output: Contribution to journalArticle

Superantigens
Lymphocyte Function-Associated Antigen-1
Intercellular Adhesion Molecule-1
Keratinocytes
T-Lymphocytes
24 Citations (Scopus)

Activated keratinocytes present bacterial-derived superantigens to T lymphocytes: relevance to psoriasis

Nickoloff, B. J., Mitra, R. S., Green, J., Shimizu, Y., Thompson, C. & Turka, L. A., Jan 1 1993, In : Journal of Dermatological Science. 6, 2, p. 127-133 7 p.

Research output: Contribution to journalArticle

Superantigens
T-cells
Keratinocytes
Psoriasis
T-Lymphocytes
105 Citations (Scopus)

Activated T-cell adhesion to thrombospondin is mediated by the α4β1 (VLA-4) and α5β1 (VLA-5) integrins

Yabkowitz, R., Dixit, V. M., Guo, N., Roberts, D. D. & Shimizu, Y., Jul 1 1993, In : Journal of Immunology. 151, 1, p. 149-158 10 p.

Research output: Contribution to journalArticle

Integrin alpha4beta1
Thrombospondins
Cell Adhesion
Integrins
T-Lymphocytes
93 Citations (Scopus)

Discordant expression of CD28 ligands, BB-1, and B7 on keratinocytes in vitro and psoriatic cells in vivo

Nickoloff, B. J., Mitra, R. S., Lee, K., Turka, L. A., Green, J., Thompson, C. & Shimizu, Y., Dec 1 1993, In : American Journal of Pathology. 142, 4, p. 1029-1040 12 p.

Research output: Contribution to journalArticle

CD80 Antigens
Keratinocytes
Monoclonal Antibodies
T-Cell Antigen Receptor
T-Lymphocytes
48 Citations (Scopus)

Distinct divalent cation requirements for integrin-mediated CD4+ T lymphocyte adhesion to ICAM-1, fibronectin, VCAM-1, and invasin

Shimizu, Y. & Mobley, J. L., Jan 1 1993, In : Journal of Immunology. 151, 8, p. 4106-4115 10 p.

Research output: Contribution to journalArticle

Vascular Cell Adhesion Molecule-1
Divalent Cations
Intercellular Adhesion Molecule-1
Fibronectins
Integrins
35 Citations (Scopus)
Keratinocytes
Histamine
Tumors
Necrosis
Adhesion
169 Citations (Scopus)

Mucins in the mainstream

Shimizu, Y. & Shaw, S., Jan 1 1993, In : Nature. 366, 6456, p. 630-631 2 p.

Research output: Contribution to journalShort survey

Mucoproteins
L-Selectin
Cell Adhesion Molecules
Mucins
Cell Adhesion
16 Citations (Scopus)

Regulatory mechanisms underlying t cell integrin receptor function

Mobley, J. L., Reynolds, P. J. & Shimizu, Y., Aug 1993, In : Seminars in Immunology. 5, 4, p. 227-236 10 p.

Research output: Contribution to journalArticle

Integrins
Lymphocytes
Ligands
52 Citations (Scopus)

Very late antigen 4-dependent adhesion and costimulation of resting human T cells by the bacterial β1 integrin ligand invasin

Ennis, E., Isberg, R. R. & Shimizu, Y., Jan 1 1993, In : Journal of Experimental Medicine. 177, 1, p. 207-212 6 p.

Research output: Contribution to journalArticle

Integrin alpha4beta1
Integrins
Ligands
T-Lymphocytes
Antigens
1994
259 Citations (Scopus)

Adhesion through the LFA-1 (CD11a/CD18)-ICAM-1 (CD54) and the VLA-4 (CD49d)-VCAM-1 (CD106) pathways prevents apoptosis of germinal center B cells

Koopman, G., Keehnen, R. M. J., Lindhout, E., Newman, W., Shimizu, Y., Van Seventer, G. A., De Groot, C. & Pals, S. T., Apr 15 1994, In : Journal of Immunology. 152, 8, p. 3760-3767 8 p.

Research output: Contribution to journalArticle

Integrin alpha4beta1
Lymphocyte Function-Associated Antigen-1
Germinal Center
Vascular Cell Adhesion Molecule-1
Intercellular Adhesion Molecule-1
22 Citations (Scopus)

Costimulation of Superantigen-Activated T Lymphocytes by Autologous Dendritic Cells Is Dependent on B7

Nestle, F. O., Thompson, C., Shimizu, Y., Turka, L. A. & Nickoloff, B. J., Jan 1 1994, In : Cellular Immunology. 156, 1, p. 220-229 10 p.

Research output: Contribution to journalArticle

Superantigens
Dendritic Cells
T-Lymphocytes
Antigen-Presenting Cells
Isoantigens
48 Citations (Scopus)

Differential activation-dependent regulation of integrin function in cultured human T-leukemic cell lines

Mobley, J. L., Ennis, E. & Shimizu, Y., Feb 15 1994, In : Blood. 83, 4, p. 1039-1050 12 p.

Research output: Contribution to journalArticle

Integrins
Chemical activation
Cells
T-cells
Cell Line
107 Citations (Scopus)

Novel allele-specific, post-translational reduction in HLA class I surface expression in a mutant human B cell line

Greenwood, R., Shimizu, Y., Sekhon, G. S. & DeMars, R., Dec 15 1994, In : Journal of Immunology. 153, 12, p. 5525-5536 12 p.

Research output: Contribution to journalArticle

HLA-A1 Antigen
HLA-B8 Antigen
B-Lymphocytes
Alleles
Cell Line
28 Citations (Scopus)

T cell receptor stimulation, but not CD28 costimulation, is dependent on LFA‐1‐mediated events

Green, J. M., Zheng, XG. G., Shimizu, Y., Thompson, C. B. & Turka, L. A., Jan 1 1994, In : European Journal of Immunology. 24, 1, p. 265-272 8 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Immobilized Antibodies
T-Lymphocytes
Mixed Lymphocyte Culture Test
CHO Cells
23 Citations (Scopus)

Tyrosine kinase activity associated with the CD7 antigen: correlation with regulation of T cell integrin function

Chan, A. S. H., Reynolds, P. J. & Shimizu, Y., Jan 1 1994, In : European Journal of Immunology. 24, 11, p. 2602-2608 7 p.

Research output: Contribution to journalArticle

CD7 Antigens
Integrins
Protein-Tyrosine Kinases
T-Lymphocytes
Up-Regulation
1995
107 Citations (Scopus)

A role for phosphatidylinositol 3-kinase in the regulation of β1 integrin activity by the CD2 antigen

Shimizu, Y., Mobley, J. L., Finkelstein, L. D. & Chan, A. S. H., Dec 1 1995, In : Journal of Cell Biology. 131, 6 II, p. 1867-1880 14 p.

Research output: Contribution to journalArticle

CD2 Antigens
Phosphatidylinositol 3-Kinase
Integrins
Up-Regulation
Vascular Cell Adhesion Molecule-1
1996
87 Citations (Scopus)

CD28-mediated up-regulation of β1-integrin adhesion involves phosphatidylinositol 3-kinase

Zell, T., Hunt, S. W., Mobley, J. L., Finkelstein, L. D. & Shimizu, Y., Feb 1 1996, In : Journal of Immunology. 156, 3, p. 883-886 4 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Integrins
Up-Regulation
Fibronectins
HL-60 Cells

Cell-specific differences in a4βl integrin-mediated signal transduction

Finkelstein, L. D., Hunt, S. W. & Shimizu, Y., Dec 1 1996, In : FASEB Journal. 10, 6

Research output: Contribution to journalArticle

Signal transduction
Phosphorylation
integrins
Integrins
Tyrosine
10 Citations (Scopus)

Intracellular signaling pathways and the regulation of cell adhesion.

Shimizu, Y., Jan 1 1996, In : Human cell : official journal of Human Cell Research Society. 9, 3, p. 175-180 6 p.

Research output: Contribution to journalReview article

Cell Adhesion
Integrins
T-Lymphocytes
Adhesives
Leukocyte-Adhesion Receptors
22 Citations (Scopus)
Integrins
Protein Kinase C
T-Lymphocytes
Cell Line
Mutation
103 Citations (Scopus)

Regulating integrin-mediated adhesion: One more function of PI 3-kinase?

Shimizu, Y. & Hunt, S. W., Jan 1 1996, In : Immunology Today. 17, 12, p. 565-573 9 p.

Research output: Contribution to journalReview article

Phosphatidylinositol 3-Kinases
Integrins

Regulation of adhesion molecule expression by t cell activation in vivo

Kellermann, S. A., Jenkins, M. & Shimizu, Y., Dec 1 1996, In : FASEB Journal. 10, 6

Research output: Contribution to journalArticle

T-cells
adhesion
Adhesion
T-lymphocytes
Chemical activation