If you made any changes in Pure, your changes will be visible here soon.

Research Output 1986 2019

2019
1 Citation (Scopus)

Engineering T cell response to cancer antigens by choice of focal therapeutic conditions

Shao, Q., O'Flanagan, S., Lam, T. S., Roy, P., Pelaez, F., Burbach, B. J., Azarin, S. M., Shimizu, Y. & Bischof, J. C., Jan 1 2019, In : International Journal of Hyperthermia. 36, 1, p. 130-138 9 p.

Research output: Contribution to journalArticle

Cryosurgery
Electroporation
Hot Temperature
T-Lymphocytes
Antigens
2018
1 Citation (Scopus)

Role of afferent and efferent renal nerves in the development of AngII-salt hypertension in rats

Foss, J. D., Fiege, J. K., Shimizu, Y., Collister, J. P., Mayerhofer, T., Wood, L. & Osborn Jr, J. W., Feb 1 2018, In : Physiological Reports. 6, 3, e13602.

Research output: Contribution to journalArticle

Open Access
Angiotensin II
Salts
Hypertension
Kidney
Denervation
2017
3 Citations (Scopus)

Cytokine-mediated activation of human ex vivo-expanded Vγ9Vδ2 T cells

Domae, E., Hirai, Y., Ikeo, T., Goda, S. & Shimizu, Y., Jan 1 2017, In : Oncotarget. 8, 28, p. 45928-45942 15 p.

Research output: Contribution to journalArticle

Open Access
Interleukin-18
Interleukin-12
Cytokines
T-Lymphocytes
Interleukins

QuARCC: The Quality Assurance Research Reproducibility Collaborative

Davies, R. L., Laube, K. L., Bakker, C. J., Sayre, F. D. & Shimizu, Y., 2017.

Research output: Contribution to conferencePoster

Open Access
3 Citations (Scopus)

Signaling to and from T cell integrins

Shimizu, Y., Jan 1 2017, Integrins: The Biological Problems. CRC Press, p. 101-132 32 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

T-cells
Lymphocytes
Integrins
T-Lymphocytes
Adhesion
2016
2 Citations (Scopus)
Cell Differentiation
T-Lymphocytes
Infection
Proteins
NK Cell Lectin-Like Receptors
20 Citations (Scopus)

CD28/B7 deficiency attenuates systolic overload-induced congestive heart failure, myocardial and pulmonary inflammation, and activated T cell accumulation in the heart and lungs

Wang, H., Kwak, D., Fassett, J., Hou, L., Xu, X., Burbach, B. J., Thenappan, T., Xu, Y., Ge, J. B., Shimizu, Y., Bache, R. J. & Chen, Y., Sep 1 2016, In : Hypertension. 68, 3, p. 688-696 9 p.

Research output: Contribution to journalArticle

Pneumonia
Heart Failure
T-Lymphocytes
Lung
Constriction
9 Citations (Scopus)

Renal Denervation Normalizes Arterial Pressure with No Effect on Glucose Metabolism or Renal Inflammation in Obese Hypertensive Mice

Asirvatham Jeyaraj, N. M. J., Fiege, J. K., Han, R., Foss, J., Banek, C. T., Burbach, B. J., Razzoli, M., Bartolomucci, A., Shimizu, Y., Panoskaltsis-Mortari, A. & Osborn Jr, J. W., Oct 1 2016, In : Hypertension. 68, 4, p. 929-936 8 p.

Research output: Contribution to journalArticle

Obese Mice
Denervation
Arterial Pressure
Inflammation
Kidney
22 Citations (Scopus)

Resting Afferent Renal Nerve Discharge and Renal Inflammation: Elucidating the Role of Afferent and Efferent Renal Nerves in Deoxycorticosterone Acetate Salt Hypertension

Banek, C. T., Knuepfer, M. M., Foss, J. D., Fiege, J. K., Asirvatham-Jeyaraj, N., Van Helden, D., Shimizu, Y. & Osborn, J. W., Dec 1 2016, In : Hypertension. 68, 6, p. 1415-1423 9 p.

Research output: Contribution to journalArticle

Desoxycorticosterone
Acetates
Salts
Hypertension
Inflammation
2015
2 Citations (Scopus)
Cell Degranulation
Cell Adhesion
T-Lymphocytes
Phenotype
Proteins
2013
25 Citations (Scopus)

ICAM-1-dependent homotypic aggregates regulate CD8 T cell effector function and differentiation during T cell activation

Zumwalde, N. A., Domae, E., Mescher, M. F. & Shimizu, Y., Oct 1 2013, In : Journal of Immunology. 191, 7, p. 3681-3693 13 p.

Research output: Contribution to journalArticle

Intercellular Adhesion Molecule-1
T-Lymphocytes
Cluster Analysis
Lymphocyte Function-Associated Antigen-1
Granzymes
10 Citations (Scopus)
src-Family Kinases
Phosphoproteins
Cell Communication
Dendritic Cells
Protein Kinases
2012
11 Citations (Scopus)
Cyclin-Dependent Kinase 2
Cyclin E
Cell Cycle Proteins
T-Lymphocytes
Proteins
2011
15 Citations (Scopus)
src-Family Kinases
Phosphoproteins
Integrins
Proteins
Lymphocyte Function-Associated Antigen-1
12 Citations (Scopus)

β1 integrin is critical for the maintenance of antigen-specific CD4 T cells in the bone marrow but not long-term immunological memory

DeNucci, C. C. & Shimizu, Y., Apr 1 2011, In : Journal of Immunology. 186, 7, p. 4019-4026 8 p.

Research output: Contribution to journalArticle

Immunologic Memory
CD4 Antigens
Long-Term Memory
Integrins
Bone Marrow
110 Citations (Scopus)

β-Actin specifically controls cell growth, migration, and the G-actin pool

Bunnell, T. M., Burbach, B. J., Shimizu, Y. & Ervasti, J. M., Nov 1 2011, In : Molecular biology of the cell. 22, 21, p. 4047-4058 12 p.

Research output: Contribution to journalArticle

Cell Movement
Actins
Growth
Fibroblasts
Knockout Mice
2010
37 Citations (Scopus)

Control of α4β7 integrin expression and CD4 T cell homing by the β1 integrin subunit

DeNucci, C. C., Pagán, A. J., Mitchell, J. S. & Shimizu, Y., Mar 1 2010, In : Journal of Immunology. 184, 5, p. 2458-2467 10 p.

Research output: Contribution to journalArticle

Integrins
T-Lymphocytes
Peyer's Patches
Listeriosis
Cell Adhesion Molecules
23 Citations (Scopus)
Phosphorylation
T-cells
Ubiquitination
Phosphotransferases
Chemical activation
2009

Corrigendum to "Quantitative measurement of nuclear translocation events using similarity analysis of multispectral cellular images obtained in flow" [J. Immunol. Methods 311 (2006) 117-29] (DOI:10.1016/j.jim.2006.01.018)

George, T. C., Fanning, S. L., Fitzgerald-Bocarsly, P., Medeiros, R. B., Highfill, S., Shimizu, Y., Hall, B. E., Frost, K., Basiji, D., Ortyn, W. E., Morrissey, P. J. & Lynch, D. H., May 15 2009, In : Journal of Immunological Methods. 344, 1, 1 p.

Research output: Contribution to journalComment/debate

corrigendum
78 Citations (Scopus)

Integrin function in T-Cell homing to lymphoid and nonlymphoid sites: Getting there and staying there

Denucci, C. C., Mitchell, J. S. & Shimizu, Y., Jun 15 2009, In : Critical Reviews in Immunology. 29, 2, p. 87-109 23 p.

Research output: Contribution to journalReview article

Integrins
T-Lymphocytes
Chemokine Receptors
Adaptive Immunity
Immunity
2008
21 Citations (Scopus)

Distinct regulation of integrin-dependent T cell conjugate formation and NF-κB activation by the adapter protein ADAP

Burbach, B. J., Srivastava, R., Medeiros, R. B., O'Gorman, W. E., Peterson, E. J. & Shimizu, Y., Oct 1 2008, In : Journal of Immunology. 181, 7, p. 4840-4851 12 p.

Research output: Contribution to journalArticle

Integrins
T-Lymphocytes
src-Family Kinases
Phosphoproteins
Proline-Rich Protein Domains
56 Citations (Scopus)

Selective regulation of CD8 effector T cell migration by the p110γ isoform of phosphatidylinositol 3-kinase

Martin, A. L., Schwartz, M. D., Jameson, S. C. & Shimizu, Y., Feb 15 2008, In : Journal of Immunology. 180, 4, p. 2081-2088 8 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Cell Movement
Protein Isoforms
T-Lymphocytes
Vaccinia virus
34 Citations (Scopus)

The p110γ isoform of phosphatidylinositol 3-kinase regulates migration of effector CD4 T lymphocytes into peripheral inflammatory sites

Thomas, M. S., Mitchell, J. S., Denucci, C. C., Martin, A. L. & Shimizu, Y., Sep 1 2008, In : Journal of Leukocyte Biology. 84, 3, p. 814-823 10 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Protein Isoforms
T-Lymphocytes
Antigens
Phosphatidylinositol 3-Kinases
64 Citations (Scopus)

The WAVE2 complex regulates T cell receptor signaling to integrins via Abl- and CrkL-C3G-mediated activation of Rap1

Nolz, J. C., Nacusi, L. P., Segovis, C. M., Medeiros, R. B., Mitchell, J. S., Shimizu, Y. & Billadeau, D. D., Sep 22 2008, In : Journal of Cell Biology. 182, 6, p. 1231-1244 14 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Integrins
Cluster Analysis
Immunological Synapses
Talin
2007
27 Citations (Scopus)

Adhesion and degranulation-promoting adapter protein (ADAP) positively regulates T cell sensitivity to antigen and T cell survival

Mueller, K. L., Thomas, M. S., Burbach, B. J., Peterson, E. J. & Shimizu, Y., Sep 15 2007, In : Journal of Immunology. 179, 6, p. 3559-3569 11 p.

Research output: Contribution to journalArticle

Cell Survival
T-Lymphocytes
Antigens
Proteins
Cell Communication
175 Citations (Scopus)

Formins Regulate the Actin-Related Protein 2/3 Complex-Independent Polarization of the Centrosome to the Immunological Synapse

Gomez, T. S., Kumar, K., Medeiros, R. B., Shimizu, Y., Leibson, P. J. & Billadeau, DD. D., Feb 23 2007, In : Immunity. 26, 2, p. 177-190 14 p.

Research output: Contribution to journalArticle

Actin-Related Protein 2-3 Complex
Immunological Synapses
Centrosome
Actins
T-Cell Antigen Receptor
51 Citations (Scopus)

MHC class II deprivation impairs CD4 T cell motility and responsiveness to antigen-bearing dendritic cells in vivo

Fischer, U. B., Jacovetty, E. L., Medeiros, R. B., Goudy, B. D., Zell, T., Swanson, J. B., Lorenz, E., Shimizu, Y., Miller, M. J., Khoruts, A. & Ingulli, E., Apr 24 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 17, p. 7181-7186 6 p.

Research output: Contribution to journalArticle

Dendritic Cells
Cell Movement
T-Lymphocytes
Antigens
Ligands
66 Citations (Scopus)

Regulation of NF-κB activation in T cells via association of the adapter proteins ADAP and CARMA1

Medeiros, R. B., Burbach, B. J., Mueller, K. L., Srivastava, R., Moon, J. J., Highfill, S., Peterson, E. J. & Shimizu, Y., May 4 2007, In : Science. 316, 5825, p. 754-758 5 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
T-Lymphocytes
Proteins
Lymphocyte Activation
Transcription Factors

Signal Transduction Events Regulating Integrin Function and T Cell Migration in the Mouse

Nagarajan, L. R. & Shimizu, Y., Dec 1 2007, The Mouse in Biomedical Research. Elsevier Inc., Vol. 4. p. 195-206 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

integrins
cell movement
Integrins
Cell Movement
signal transduction
96 Citations (Scopus)

T-cell receptor signaling to integrins

Burbach, B. J., Medeiros, R. B., Mueller, K. L. & Shimizu, Y., Aug 1 2007, In : Immunological Reviews. 218, 1, p. 65-81 17 p.

Research output: Contribution to journalReview article

T-Cell Antigen Receptor
Integrins
T-Lymphocytes
Proteins
Talin
70 Citations (Scopus)

WAVE2 regulates high-affinity integrin binding by recruiting vinculin and talin to the immunological synapse

Nolz, J. C., Medeiros, R. B., Mitchell, J. S., Zhu, P., Freedman, B. D., Shimizu, Y. & Billadeau, D. D., Sep 1 2007, In : Molecular and cellular biology. 27, 17, p. 5986-6000 15 p.

Research output: Contribution to journalArticle

Immunological Synapses
Talin
Vinculin
Integrins
T-Cell Antigen Receptor
2006
15 Citations (Scopus)

ADAP is dispensable for NK cell development and function

Fostel, L. V., Dluzniewska, J., Shimizu, Y., Burbach, B. J. & Peterson, E. J., Aug 1 2006, In : International Immunology. 18, 8, p. 1305-1314 10 p.

Research output: Contribution to journalArticle

Natural Killer Cells
Cytokine Receptors
Immunoreceptor Tyrosine-Based Activation Motif
Lymphokines
Innate Immunity
27 Citations (Scopus)

Matrix metalloproteinase-1 produced by human CXCL12-stimulated natural killer cells

Goda, S., Inoue, H., Umehara, H., Miyaji, M., Nagano, Y., Harakawa, N., Imai, H., Lee, P., Macarthy, J. B., Ikeo, T., Domae, N., Shimizu, Y. & Iida, J., Jan 1 2006, In : American Journal of Pathology. 169, 2, p. 445-458 14 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 1
Natural Killer Cells
Integrins
Membrane-Associated Matrix Metalloproteinases
Lymphocytes
178 Citations (Scopus)

Quantitative measurement of nuclear translocation events using similarity analysis of multispectral cellular images obtained in flow

George, T. C., Fanning, S. L., Fitzgeral-Bocarsly, P., Medeiros, R. B., Highfill, S., Shimizu, Y., Hall, B. E., Frost, K., Basiji, D., Ortyn, W. E., Morrissey, P. J. & Lynch, D. H., Apr 20 2006, In : Journal of Immunological Methods. 311, 1-2, p. 117-129 13 p.

Research output: Contribution to journalArticle

Cytoplasm
Dendritic Cells
Population
Genes
160 Citations (Scopus)

The WAVE2 complex regulates actin cytoskeletal reorganization and CRAC-mediated calcium entry during T cell activation

Nolz, J. C., Gomez, T. S., Zhu, P., Li, S., Medeiros, R. B., Shimizu, Y., Burkhardt, J. K., Freedman, B. D. & Billadeau, D. D., Jan 10 2006, In : Current Biology. 16, 1, p. 24-34 11 p.

Research output: Contribution to journalArticle

T-cells
actin
Actins
T-lymphocytes
Chemical activation
2005
10 Citations (Scopus)

Influence of β1 integrin intracytoplasmic domains in the regulation of VLA-4-mediated adhesion of human T cells to VCAM-1 under flow conditions

Rosenthal-Allieri, M. A., Ticchioni, M., Breittmayer, J. P., Shimizu, Y. & Bernard, A., Jul 15 2005, In : Journal of Immunology. 175, 2, p. 1214-1223 10 p.

Research output: Contribution to journalArticle

Integrin alpha4beta1
Vascular Cell Adhesion Molecule-1
Integrins
T-Lymphocytes
Tyrosine
69 Citations (Scopus)

Protein kinase D1 and the β1 integrin cytoplasmic domain control β1 integrin function via regulation of Rap1 activation

Medeiros, R. B., Dickey, D. M., Chung, H., Quale, A. C., Nagarajan, L. R., Billadeau, D. D. & Shimizu, Y., Aug 1 2005, In : Immunity. 23, 2, p. 213-226 14 p.

Research output: Contribution to journalArticle

Integrins
Protein Kinases
Protein Kinase C
T-Lymphocytes
Membranes
40 Citations (Scopus)

Tec kinases regulate TCR-mediated recruitment of signaling molecules and integrin-dependent cell adhesion

Finkelstein, L. D., Shimizu, Y. & Schwartzberg, P. L., Nov 1 2005, In : Journal of Immunology. 175, 9, p. 5923-5930 8 p.

Research output: Contribution to journalArticle

Cell Adhesion
Integrins
T-Lymphocytes
Lymphocyte Function-Associated Antigen-1
Protein Kinase C
2004
36 Citations (Scopus)

Control of TCR-Mediated Activation of β1 Integrins by the ZAP-70 Tyrosine Kinase Interdomain B Region and the Linker for Activation of T Cells Adapter Protein

Goda, S., Quale, A. C., Woods, M. L., Felthauser, A. & Shimizu, Y., May 1 2004, In : Journal of Immunology. 172, 9, p. 5379-5387 9 p.

Research output: Contribution to journalArticle

ZAP-70 Protein-Tyrosine Kinase
Integrins
Protein-Tyrosine Kinases
T-Lymphocytes
Tyrosine
23 Citations (Scopus)

Cutting edge: LFA-1 integrin-dependent T cell adhesion is regulated by both Ag specificity and sensitivity

Mueller, K. L., Daniels, M. A., Felthauser, A., Kao, C., Jameson, S. C. & Shimizu, Y., Aug 15 2004, In : Journal of Immunology. 173, 4, p. 2222-2226 5 p.

Research output: Contribution to journalArticle

Lymphocyte Function-Associated Antigen-1
Cell Adhesion
Integrins
T-Lymphocytes
Sensitivity and Specificity
171 Citations (Scopus)

Integrins and T cell-mediated immunity

Pribila, J. T., Quale, A. C., Mueller, K. L. & Shimizu, Y., Jun 7 2004, In : Annual Review of Immunology. 22, p. 157-180 24 p.

Research output: Contribution to journalReview article

Integrins
Cellular Immunity
T-Lymphocytes
Antigen-Presenting Cells
Viral Tumor Antigens
29 Citations (Scopus)

The α1β1 and αEβ 7 Integrins Define a Subset of Dendritic Cells in Peripheral Lymph Nodes with Unique Adhesive and Antigen Uptake Properties

Pribila, J. T., Itano, A. A., Mueller, K. L. & Shimizu, Y., Jan 1 2004, In : Journal of Immunology. 172, 1, p. 282-291 10 p.

Research output: Contribution to journalArticle

Integrins
Dendritic Cells
Lymph Nodes
Antigens
Collagen
2003
2 Citations (Scopus)

Disabling multiple integrins from the inside out

Shimizu, Y., Jan 1 2003, In : Journal of Clinical Investigation. 111, 1, p. 23-24 2 p.

Research output: Contribution to journalComment/debate

Immunologic Deficiency Syndromes
Thrombasthenia
Integrins
Signal Transduction
Neutrophils
25 Citations (Scopus)

LFA-1: More than just T cell Velcro

Shimizu, Y., Nov 1 2003, In : Nature Immunology. 4, 11, p. 1052-1054 3 p.

Research output: Contribution to journalArticle

Lymphocyte Function-Associated Antigen-1
T-Lymphocytes
Viral Tumor Antigens
Antigen-Presenting Cells
Integrins
15 Citations (Scopus)

Signal transduction events regulating integrin function and T cell migration new functions and complexity

Pribila, J. T. & Shimizu, Y., Apr 1 2003, In : Immunologic Research. 27, 1, p. 107-128 22 p.

Research output: Contribution to journalReview article

Integrins
Cell Movement
Signal Transduction
T-Lymphocytes
T-Cell Antigen Receptor
2002

Adapting to one less tyrosine

Shimizu, Y., Aug 1 2002, In : Trends in Immunology. 23, 8, 1 p.

Research output: Contribution to journalShort survey

Tyrosine

Adhesion in the immune system

Shimizu, Y., Aug 1 2002, In : Immunological Reviews. 186, p. 5-7 3 p.

Research output: Contribution to journalEditorial

Immune System
12 Citations (Scopus)

Genetic analysis of integrin activation in T lymphocytes

Kellermann, S. A., Dell, C. L., Hunt, S. W. & Shimizu, Y., Aug 1 2002, In : Immunological Reviews. 186, p. 172-188 17 p.

Research output: Contribution to journalReview article

Activation Analysis
T-Cell Antigen Receptor
Integrins
T-Lymphocytes
Cell Adhesion

Let's Rap: Making a functional integrin

Shimizu, Y., Nov 1 2002, In : Trends in Immunology. 23, 11, p. 522-523 2 p.

Research output: Contribution to journalArticle

Integrins
2001
88 Citations (Scopus)

A novel function for the Tec family tyrosine kinase Itk in activation of β1 integrins by the T-cell receptor

Woods, M. L., Kivens, W. J., Adelsman, M. A., Qiu, Y., August, A. & Shimizu, Y., Mar 15 2001, In : EMBO Journal. 20, 6, p. 1232-1244 13 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Integrins
Phosphatidylinositol 3-Kinase
Protein-Tyrosine Kinases
Chemical activation