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Research Output

2019

Engineering T cell response to cancer antigens by choice of focal therapeutic conditions

Shao, Q., O'Flanagan, S., Lam, T., Roy, P., Pelaez, F., Burbach, B. J., Azarin, S. M., Shimizu, Y. & Bischof, J. C., Jan 1 2019, In : International Journal of Hyperthermia. 36, 1, p. 130-138 9 p.

Research output: Contribution to journalArticle

8 Scopus citations
2018

Role of afferent and efferent renal nerves in the development of AngII-salt hypertension in rats

Foss, J. D., Fiege, J., Shimizu, Y., Collister, J. P., Mayerhofer, T., Wood, L. & Osborn, J. W., Feb 1 2018, In : Physiological Reports. 6, 3, e13602.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
2017

Cytokine-mediated activation of human ex vivo-expanded Vγ9Vδ2 T cells

Domae, E., Hirai, Y., Ikeo, T., Goda, S. & Shimizu, Y., Jan 1 2017, In : Oncotarget. 8, 28, p. 45928-45942 15 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

QuARCC: The Quality Assurance Research Reproducibility Collaborative

Davies, R. L., Laube, K. L., Bakker, C. J., Sayre, F. D. & Shimizu, Y., 2017.

Research output: Contribution to conferencePoster

Open Access

Signaling to and from T cell integrins

Shimizu, Y., Jan 1 2017, Integrins: The Biological Problems. CRC Press, p. 101-132 32 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations
2016
4 Scopus citations

CD28/B7 deficiency attenuates systolic overload-induced congestive heart failure, myocardial and pulmonary inflammation, and activated T cell accumulation in the heart and lungs

Wang, H., Kwak, D., Fassett, J., Hou, L., Xu, X., Burbach, B. J., Thenappan, T., Xu, Y., Ge, J. B., Shimizu, Y., Bache, R. J. & Chen, Y., Sep 1 2016, In : Hypertension. 68, 3, p. 688-696 9 p.

Research output: Contribution to journalArticle

21 Scopus citations

Renal Denervation Normalizes Arterial Pressure with No Effect on Glucose Metabolism or Renal Inflammation in Obese Hypertensive Mice

Asirvatham-Jeyaraj, N., Fiege, J. K., Han, R., Foss, J., Banek, C. T., Burbach, B. J., Razzoli, M., Bartolomucci, A., Shimizu, Y., Panoskaltsis-Mortari, A. & Osborn, J. W., Oct 1 2016, In : Hypertension. 68, 4, p. 929-936 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Resting Afferent Renal Nerve Discharge and Renal Inflammation: Elucidating the Role of Afferent and Efferent Renal Nerves in Deoxycorticosterone Acetate Salt Hypertension

Banek, C. T., Knuepfer, M. M., Foss, J. D., Fiege, J. K., Asirvatham-Jeyaraj, N., Van Helden, D., Shimizu, Y. & Osborn, J. W., Dec 1 2016, In : Hypertension. 68, 6, p. 1415-1423 9 p.

Research output: Contribution to journalArticle

27 Scopus citations
2015
4 Scopus citations
2013

ICAM-1-dependent homotypic aggregates regulate CD8 T cell effector function and differentiation during T cell activation

Zumwalde, N. A., Domae, E., Mescher, M. F. & Shimizu, Y., Oct 1 2013, In : Journal of Immunology. 191, 7, p. 3681-3693 13 p.

Research output: Contribution to journalArticle

27 Scopus citations
11 Scopus citations
2012
12 Scopus citations
2011
16 Scopus citations

β1 integrin is critical for the maintenance of antigen-specific CD4 T cells in the bone marrow but not long-term immunological memory

DeNucci, C. C. & Shimizu, Y., Apr 1 2011, In : Journal of Immunology. 186, 7, p. 4019-4026 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

β-Actin specifically controls cell growth, migration, and the G-actin pool

Bunnell, T. M., Burbach, B. J., Shimizu, Y. & Ervasti, J. M., Nov 1 2011, In : Molecular biology of the cell. 22, 21, p. 4047-4058 12 p.

Research output: Contribution to journalArticle

118 Scopus citations
2010

Control of α4β7 integrin expression and CD4 T cell homing by the β1 integrin subunit

DeNucci, C. C., Pagán, A. J., Mitchell, J. S. & Shimizu, Y., Mar 1 2010, In : Journal of Immunology. 184, 5, p. 2458-2467 10 p.

Research output: Contribution to journalArticle

39 Scopus citations
25 Scopus citations
2009

Corrigendum to "Quantitative measurement of nuclear translocation events using similarity analysis of multispectral cellular images obtained in flow" [J. Immunol. Methods 311 (2006) 117-29] (DOI:10.1016/j.jim.2006.01.018)

George, T. C., Fanning, S. L., Fitzgerald-Bocarsly, P., Medeiros, R. B., Highfill, S., Shimizu, Y., Hall, B. E., Frost, K., Basiji, D., Ortyn, W. E., Morrissey, P. J. & Lynch, D. H., May 15 2009, In : Journal of Immunological Methods. 344, 1, 1 p.

Research output: Contribution to journalComment/debate

Integrin function in T-Cell homing to lymphoid and nonlymphoid sites: Getting there and staying there

Denucci, C. C., Mitchell, J. S. & Shimizu, Y., Jun 15 2009, In : Critical Reviews in Immunology. 29, 2, p. 87-109 23 p.

Research output: Contribution to journalReview article

81 Scopus citations
2008

Distinct regulation of integrin-dependent T cell conjugate formation and NF-κB activation by the adapter protein ADAP

Burbach, B. J., Srivastava, R., Medeiros, R. B., O'Gorman, W. E., Peterson, E. J. & Shimizu, Y., Oct 1 2008, In : Journal of Immunology. 181, 7, p. 4840-4851 12 p.

Research output: Contribution to journalArticle

23 Scopus citations

Selective regulation of CD8 effector T cell migration by the p110γ isoform of phosphatidylinositol 3-kinase

Martin, A. L., Schwartz, M. D., Jameson, S. C. & Shimizu, Y., Feb 15 2008, In : Journal of Immunology. 180, 4, p. 2081-2088 8 p.

Research output: Contribution to journalArticle

58 Scopus citations

The p110γ isoform of phosphatidylinositol 3-kinase regulates migration of effector CD4 T lymphocytes into peripheral inflammatory sites

Thomas, M. S., Mitchell, J. S., Denucci, C. C., Martin, A. L. & Shimizu, Y., Sep 1 2008, In : Journal of Leukocyte Biology. 84, 3, p. 814-823 10 p.

Research output: Contribution to journalArticle

36 Scopus citations

The WAVE2 complex regulates T cell receptor signaling to integrins via Abl- and CrkL-C3G-mediated activation of Rap1

Nolz, J. C., Nacusi, L. P., Segovis, C. M., Medeiros, R. B., Mitchell, J. S., Shimizu, Y. & Billadeau, D. D., Sep 22 2008, In : Journal of Cell Biology. 182, 6, p. 1231-1244 14 p.

Research output: Contribution to journalArticle

65 Scopus citations
2007

Adhesion and degranulation-promoting adapter protein (ADAP) positively regulates T cell sensitivity to antigen and T cell survival

Mueller, K. L., Thomas, M. S., Burbach, B. J., Peterson, E. J. & Shimizu, Y., Sep 15 2007, In : Journal of Immunology. 179, 6, p. 3559-3569 11 p.

Research output: Contribution to journalArticle

28 Scopus citations

Formins Regulate the Actin-Related Protein 2/3 Complex-Independent Polarization of the Centrosome to the Immunological Synapse

Gomez, T. S., Kumar, K., Medeiros, R. B., Shimizu, Y., Leibson, P. J. & Billadeau, DD. D., Feb 23 2007, In : Immunity. 26, 2, p. 177-190 14 p.

Research output: Contribution to journalArticle

179 Scopus citations

MHC class II deprivation impairs CD4 T cell motility and responsiveness to antigen-bearing dendritic cells in vivo

Fischer, U. B., Jacovetty, E. L., Medeiros, R. B., Goudy, B. D., Zell, T., Swanson, J. B., Lorenz, E., Shimizu, Y., Miller, M. J., Khoruts, A. & Ingulli, E., Apr 24 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 17, p. 7181-7186 6 p.

Research output: Contribution to journalArticle

52 Scopus citations

Regulation of NF-κB activation in T cells via association of the adapter proteins ADAP and CARMA1

Medeiros, R. B., Burbach, B. J., Mueller, K. L., Srivastava, R., Moon, J. J., Highfill, S., Peterson, E. J. & Shimizu, Y., May 4 2007, In : Science. 316, 5825, p. 754-758 5 p.

Research output: Contribution to journalArticle

70 Scopus citations

Signal Transduction Events Regulating Integrin Function and T Cell Migration in the Mouse

Nagarajan, L. R. & Shimizu, Y., Dec 1 2007, The Mouse in Biomedical Research. Elsevier Inc., Vol. 4. p. 195-206 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

T-cell receptor signaling to integrins

Burbach, B. J., Medeiros, R. B., Mueller, K. L. & Shimizu, Y., Aug 1 2007, In : Immunological Reviews. 218, 1, p. 65-81 17 p.

Research output: Contribution to journalReview article

96 Scopus citations

WAVE2 regulates high-affinity integrin binding by recruiting vinculin and talin to the immunological synapse

Nolz, J. C., Medeiros, R. B., Mitchell, J. S., Zhu, P., Freedman, B. D., Shimizu, Y. & Billadeau, D. D., Sep 1 2007, In : Molecular and cellular biology. 27, 17, p. 5986-6000 15 p.

Research output: Contribution to journalArticle

73 Scopus citations
2006

ADAP is dispensable for NK cell development and function

Fostel, L. V., Dluzniewska, J., Shimizu, Y., Burbach, B. J. & Peterson, E. J., Aug 1 2006, In : International Immunology. 18, 8, p. 1305-1314 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Matrix metalloproteinase-1 produced by human CXCL12-stimulated natural killer cells

Goda, S., Inoue, H., Umehara, H., Miyaji, M., Nagano, Y., Harakawa, N., Imai, H., Lee, P., Macarthy, J. B., Ikeo, T., Domae, N., Shimizu, Y. & Iida, J., Aug 2006, In : American Journal of Pathology. 169, 2, p. 445-458 14 p.

Research output: Contribution to journalArticle

27 Scopus citations

Quantitative measurement of nuclear translocation events using similarity analysis of multispectral cellular images obtained in flow

George, T. C., Fanning, S. L., Fitzgeral-Bocarsly, P., Medeiros, R. B., Highfill, S., Shimizu, Y., Hall, B. E., Frost, K., Basiji, D., Ortyn, W. E., Morrissey, P. J. & Lynch, D. H., Apr 20 2006, In : Journal of Immunological Methods. 311, 1-2, p. 117-129 13 p.

Research output: Contribution to journalArticle

180 Scopus citations

The WAVE2 complex regulates actin cytoskeletal reorganization and CRAC-mediated calcium entry during T cell activation

Nolz, J. C., Gomez, T. S., Zhu, P., Li, S., Medeiros, R. B., Shimizu, Y., Burkhardt, J. K., Freedman, B. D. & Billadeau, D. D., Jan 10 2006, In : Current Biology. 16, 1, p. 24-34 11 p.

Research output: Contribution to journalArticle

163 Scopus citations
2005

Influence of β1 integrin intracytoplasmic domains in the regulation of VLA-4-mediated adhesion of human T cells to VCAM-1 under flow conditions

Rosenthal-Allieri, M. A., Ticchioni, M., Breittmayer, J. P., Shimizu, Y. & Bernard, A., Jul 15 2005, In : Journal of Immunology. 175, 2, p. 1214-1223 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Protein kinase D1 and the β1 integrin cytoplasmic domain control β1 integrin function via regulation of Rap1 activation

Medeiros, R. B., Dickey, D. M., Chung, H., Quale, A. C., Nagarajan, L. R., Billadeau, D. D. & Shimizu, Y., Aug 1 2005, In : Immunity. 23, 2, p. 213-226 14 p.

Research output: Contribution to journalArticle

69 Scopus citations

Tec kinases regulate TCR-mediated recruitment of signaling molecules and integrin-dependent cell adhesion

Finkelstein, L. D., Shimizu, Y. & Schwartzberg, P. L., Nov 1 2005, In : Journal of Immunology. 175, 9, p. 5923-5930 8 p.

Research output: Contribution to journalArticle

40 Scopus citations
2004

Control of TCR-Mediated Activation of β1 Integrins by the ZAP-70 Tyrosine Kinase Interdomain B Region and the Linker for Activation of T Cells Adapter Protein

Goda, S., Quale, A. C., Woods, M. L., Felthauser, A. & Shimizu, Y., May 1 2004, In : Journal of Immunology. 172, 9, p. 5379-5387 9 p.

Research output: Contribution to journalArticle

36 Scopus citations

Cutting edge: LFA-1 integrin-dependent T cell adhesion is regulated by both Ag specificity and sensitivity

Mueller, K. L., Daniels, M. A., Felthauser, A., Kao, C., Jameson, S. C. & Shimizu, Y., Aug 15 2004, In : Journal of Immunology. 173, 4, p. 2222-2226 5 p.

Research output: Contribution to journalArticle

24 Scopus citations

Integrins and T cell-mediated immunity

Pribila, J. T., Quale, A. C., Mueller, K. L. & Shimizu, Y., Jun 7 2004, In : Annual Review of Immunology. 22, p. 157-180 24 p.

Research output: Contribution to journalReview article

173 Scopus citations

The α1β1 and αEβ 7 Integrins Define a Subset of Dendritic Cells in Peripheral Lymph Nodes with Unique Adhesive and Antigen Uptake Properties

Pribila, J. T., Itano, A. A., Mueller, K. L. & Shimizu, Y., Jan 1 2004, In : Journal of Immunology. 172, 1, p. 282-291 10 p.

Research output: Contribution to journalArticle

29 Scopus citations
2003

Disabling multiple integrins from the inside out

Shimizu, Y., Jan 2003, In : Journal of Clinical Investigation. 111, 1, p. 23-24 2 p.

Research output: Contribution to journalComment/debate

2 Scopus citations

LFA-1: More than just T cell Velcro

Shimizu, Y., Nov 1 2003, In : Nature immunology. 4, 11, p. 1052-1054 3 p.

Research output: Contribution to journalArticle

25 Scopus citations

Signal transduction events regulating integrin function and T cell migration new functions and complexity

Pribila, J. T. & Shimizu, Y., Apr 1 2003, In : Immunologic Research. 27, 1, p. 107-128 22 p.

Research output: Contribution to journalReview article

15 Scopus citations
2002

Adapting to one less tyrosine

Shimizu, Y., Aug 1 2002, In : Trends in Immunology. 23, 8, 1 p.

Research output: Contribution to journalShort survey

Adhesion in the immune system

Shimizu, Y., Aug 1 2002, In : Immunological Reviews. 186, p. 5-7 3 p.

Research output: Contribution to journalEditorial

Genetic analysis of integrin activation in T lymphocytes

Kellermann, S. A., Dell, C. L., Hunt, S. W. & Shimizu, Y., Aug 1 2002, In : Immunological Reviews. 186, p. 172-188 17 p.

Research output: Contribution to journalReview article

12 Scopus citations

Let's Rap: Making a functional integrin

Shimizu, Y., Nov 1 2002, In : Trends in Immunology. 23, 11, p. 522-523 2 p.

Research output: Contribution to journalArticle

2001

A novel function for the Tec family tyrosine kinase Itk in activation of β1 integrins by the T-cell receptor

Woods, M. L., Kivens, W. J., Adelsman, M. A., Qiu, Y., August, A. & Shimizu, Y., Mar 15 2001, In : EMBO Journal. 20, 6, p. 1232-1244 13 p.

Research output: Contribution to journalArticle

88 Scopus citations