Yingjie Chen

19992022

Research output per year

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Article
2020

Kidney failure, arterial hypertension and left ventricular hypertrophy in rats with loss of function mutation of SOD3

Guo, H., Xu, D., Kuroki, M., Lu, Z., Xu, X., Geurts, A., Osborn, J. W. & Chen, Y., Jan 1 2020, (Accepted/In press) In : Free Radical Biology and Medicine.

Research output: Contribution to journalArticle

1 Scopus citations
2019

Adenosine kinase attenuates cardiomyocyte microtubule stabilization and protects against pressure overload-induced hypertrophy and LV dysfunction

Fassett, J., Xu, X., Kwak, D., Zhu, G., Fassett, E. K., Zhang, P., Wang, H., Mayer, B., Bache, R. J. & Chen, Y., May 2019, In : Journal of Molecular and Cellular Cardiology. 130, p. 49-58 10 p.

Research output: Contribution to journalArticle

1 Scopus citations
1 Scopus citations
1 Scopus citations

Isolevuglandin scavenger attenuates pressure overload-induced cardiac oxidative stress, cardiac hypertrophy, heart failure and lung remodeling

Shang, L., Weng, X., Wang, D., Yue, W., Mernaugh, R., Amarnath, V., Weir, E. K., Dudley, S., Xu, Y., Hou, M. & Chen, Y., Sep 2019, In : Free Radical Biology and Medicine. 141, p. 291-298 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Profound Increase of Lung Airway Resistance in Heart Failure: a Potential Important Contributor for Dyspnea

Liu, X., Yang, L., Kwak, D., Hou, L., Shang, R., Meyer, C., Panoskaltsis-Mortari, A., Xu, X., Weir, E. K. & Chen, Y., Aug 15 2019, In : Journal of cardiovascular translational research. 12, 4, p. 271-279 9 p.

Research output: Contribution to journalArticle

Short term Pm2.5 exposure caused a robust lung inflammation, vascular remodeling, and exacerbated transition from left ventricular failure to right ventricular hypertrophy

Yue, W., Tong, L., Liu, X., Weng, X., Chen, X., Wang, D., Dudley, S., Weir, E. K., Ding, W., Lu, Z., Xu, Y. & Chen, Y., Apr 2019, In : Redox Biology. 22, 101161.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations
2018

AMPKα2 deficiency exacerbates long-term PM 2.5 exposure-induced lung injury and cardiac dysfunction

Wang, H., Shen, X., Tian, G., Shi, X., Huang, W., Wu, Y., Sun, L., Peng, C., Liu, S., Huang, Y., Chen, X., Zhang, F., Chen, Y., Ding, W. & Lu, Z., Jun 2018, In : Free Radical Biology and Medicine. 121, p. 202-214 13 p.

Research output: Contribution to journalArticle

16 Scopus citations
2017

Cardiomyocyte dimethylarginine dimethylaminohydrolase-1 (DDAH1) plays an important role in attenuating ventricular hypertrophy and dysfunction

Xu, X., Zhang, P., Kwak, D., Fassett, J., Yue, W., Atzler, D., Hu, X., Liu, X., Wang, H., Lu, Z., Guo, H., Schwedhelm, E., Böger, R. H., Chen, P. & Chen, Y., Sep 1 2017, In : Basic Research in Cardiology. 112, 5, 55.

Research output: Contribution to journalArticle

11 Scopus citations

Repetitive ischemia increases myocardial dimethylarginine dimethylaminohydrolase 1 expression

Zhang, P., Fassett, J. T., Zhu, G., Li, J., Hu, X., Xu, X., Chen, Y. & Bache, R. J., Jan 1 2017, In : Vascular Medicine (United Kingdom). 22, 3, p. 179-188 10 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Role of bone marrow-derived CD11c+ dendritic cells in systolic overload-induced left ventricular inflammation, fibrosis and hypertrophy

Wang, H., Kwak, D., Fassett, J., Liu, X., Yao, W., Weng, X., Xu, X., Xu, Y., Bache, R. J., Mueller, D. L. & Chen, Y., May 1 2017, In : Basic research in cardiology. 112, 3, 25.

Research output: Contribution to journalArticle

14 Scopus citations
2016

CD28/B7 deficiency attenuates systolic overload-induced congestive heart failure, myocardial and pulmonary inflammation, and activated T cell accumulation in the heart and lungs

Wang, H., Kwak, D., Fassett, J., Hou, L., Xu, X., Burbach, B. J., Thenappan, T., Xu, Y., Ge, J. B., Shimizu, Y., Bache, R. J. & Chen, Y., Sep 1 2016, In : Hypertension. 68, 3, p. 688-696 9 p.

Research output: Contribution to journalArticle

21 Scopus citations

Genetic and Pharmacologic Inhibition of the Chemokine Receptor CXCR2 Prevents Experimental Hypertension and Vascular Dysfunction

Wang, L., Zhao, X. C., Cui, W., Ma, Y. Q., Ren, H. L., Zhou, X., Fassett, J., Yang, Y. Z., Chen, Y., Xia, Y. L., Du, J. & Li, H. H., Nov 1 2016, In : Circulation. 134, 18, p. 1353-1368 16 p.

Research output: Contribution to journalArticle

Open Access
42 Scopus citations

Increasing Regulatory T Cells With Interleukin-2 and Interleukin-2 Antibody Complexes Attenuates Lung Inflammation and Heart Failure Progression

Wang, H., Hou, L., Kwak, D., Fassett, J., Xu, X., Chen, A., Chen, W., Blazar, B. R., Xu, Y., Hall, J. L., Ge, J. B., Bache, R. J. & Chen, Y., Jul 1 2016, In : Hypertension. 68, 1, p. 114-122 9 p.

Research output: Contribution to journalArticle

29 Scopus citations
2015

S-nitrosylation of PDE5 increases its ubiquitin-proteasomal degradation

Wang, Y., Zhang, P., Xu, Z., Yue, W., Zhuang, Y., Chen, Y. & Lu, Z., Jul 25 2015, In : Free Radical Biology and Medicine. 86, p. 343-351 9 p., 12452.

Research output: Contribution to journalArticle

9 Scopus citations
2014

Double-stranded RNA-dependent protein kinase deficiency protects the heart from systolic overload-induced congestive heart failure

Wang, H., Xu, X., Fassett, J., Kwak, D., Liu, X., Hu, X., Falls, T. J., Bell, J. C., Li, H., Bitterman, P., Bache, R. J. & Chen, Y., Apr 1 2014, In : Circulation. 129, 13, p. 1397-1406 10 p.

Research output: Contribution to journalArticle

26 Scopus citations

Endoplasmic reticulum stress sensor protein kinase R-like endoplasmic reticulum kinase (PERK) protects against pressure overload-induced heart failure and lung remodeling

Liu, X., Kwak, D., Lu, Z., Xu, X., Fassett, J., Wang, H., Wei, Y., Cavener, D. R., Hu, X., Hall, J., Bache, R. J. & Chen, Y., Jan 1 2014, In : Hypertension. 64, 4, p. 738-744 7 p.

Research output: Contribution to journalArticle

38 Scopus citations

Inducible nitric oxide synthase inhibits oxygen consumption in collateral-dependent myocardium

Chen, Y., Zhang, P., Li, J., Xu, X. & Bache, R. J., Feb 1 2014, In : American Journal of Physiology - Heart and Circulatory Physiology. 306, 3, p. H356-H362

Research output: Contribution to journalArticle

2 Scopus citations

Interferon regulatory factor 1 is required for cardiac remodeling in response to pressure overload

Jiang, D. S., Li, L., Huang, L., Gong, J., Xia, H., Liu, X., Wan, N., Wei, X., Zhu, X., Chen, Y., Chen, X., Zhang, X. D. & Li, H., Jul 2014, In : Hypertension. 64, 1, p. 77-86 10 p.

Research output: Contribution to journalArticle

52 Scopus citations

Interferon regulatory factor 7 functions as a novel negative regulator of pathological cardiac hypertrophy

Jiang, D. S., Liu, Y., Zhou, H., Zhang, Y., Zhang, X. D., Zhang, X. F., Chen, K., Gao, L., Peng, J., Gong, H., Chen, Y., Yang, Q., Liu, P. P., Fan, G. C., Zou, Y. & Li, H., Apr 2014, In : Hypertension. 63, 4, p. 713-722 10 p.

Research output: Contribution to journalArticle

51 Scopus citations

Loss of the eukaryotic initiation factor 2α kinase general control nonderepressible 2 protects mice from pressure overload-induced congestive heart failure without affecting ventricular hypertrophy

Lu, Z., Xu, X., Fassett, J., Kwak, D., Liu, X., Hu, X., Wang, H., Guo, H., Xu, D., Yan, S., Mcfalls, E. O., Lu, F., Bache, R. J. & Chen, Y., Jan 1 2014, In : Hypertension. 63, 1, p. 128-135 8 p.

Research output: Contribution to journalArticle

24 Scopus citations

Metformin protects against systolic overload-induced heart failure independent of AMP-activated protein kinase α2

Xu, X., Lu, Z., Fassett, J., Zhang, P., Hu, X., Liu, X., Kwak, D., Li, J., Zhu, G., Tao, Y., Hou, M., Wang, H., Guo, H., Viollet, B., McFalls, E. O., Bache, R. J. & Chen, Y., Apr 2014, In : Hypertension. 63, 4, p. 723-728 6 p.

Research output: Contribution to journalArticle

36 Scopus citations

Toll-interacting protein (Tollip) negatively regulates pressure overload-induced ventricular hypertrophy in mice

Liu, Y., Jiang, X. L., Liu, Y., Jiang, D. S., Zhang, Y., Zhang, R., Chen, Y., Yang, Q., Zhang, X. D., Fan, G. C. & Li, H., Jan 1 2014, In : Cardiovascular Research. 101, 1, p. 87-96 10 p.

Research output: Contribution to journalArticle

31 Scopus citations
2013

AMPK attenuates microtubule proliferation in cardiac hypertrophy

Fassett, J. T., Hu, X., Xu, X., Lu, Z., Zhang, P., Chen, Y. & Bache, R. J., Mar 11 2013, In : American Journal of Physiology - Heart and Circulatory Physiology. 304, 5, p. H749-H758

Research output: Contribution to journalArticle

28 Scopus citations

DDAH1 deficiency attenuates endothelial cell cycle progression and angiogenesis

Zhang, P., Xu, X., Hu, X., Wang, H., Fassett, J., Huo, Y., Chen, Y. & Bache, R. J., Nov 18 2013, In : PloS one. 8, 11, e79444.

Research output: Contribution to journalArticle

17 Scopus citations

Interferon regulatory factor 3 is a negative regulator of pathological cardiac hypertrophy

Lu, J., Bian, Z. Y., Zhang, R., Zhang, Y., Liu, C., Yan, L., Zhang, S. M., Jiang, D. S., Wei, X., Zhu, X. H., Chen, M., Wang, A. B., Chen, Y., Yang, Q., Liu, P. P. & Li, H., Jan 1 2013, In : Basic research in cardiology. 108, 2, 326.

Research output: Contribution to journalArticle

60 Scopus citations

Interferon regulatory factor 9 protects against hepatic insulin resistance and steatosis in male mice

Wang, X. A., Zhang, R., Jiang, D., Deng, W., Zhang, S., Deng, S., Zhong, J., Wang, T., Zhu, L. H., Yang, L., Hong, S., Guo, S., Chen, K., Zhang, X. F., She, Z., Chen, Y., Yang, Q., Zhang, X. D. & Li, H., Aug 1 2013, In : Hepatology. 58, 2, p. 603-616 14 p.

Research output: Contribution to journalArticle

55 Scopus citations

Microtubule Actin Cross-Linking Factor 1 Regulates Cardiomyocyte Microtubule Distribution and Adaptation to Hemodynamic Overload

Fassett, J. T., Xu, X., Kwak, D., Wang, H., Liu, X., Hu, X., Bache, R. J. & Chen, Y., Sep 26 2013, In : PloS one. 8, 9, e73887.

Research output: Contribution to journalArticle

28 Scopus citations

Reduced expression of mitochondrial electron transport chain proteins from hibernating hearts relative to ischemic preconditioned hearts in the second window of protection

Cabrera, J. A., Butterick, T. A., Long, E. K., Ziemba, E. A., Anderson, L. B., Duffy, C. M., Sluiter, W., Duncker, D. J., Zhang, J., Chen, Y., Ward, H. B., Kelly, R. F. & McFalls, E. O., Jul 1 2013, In : Journal of Molecular and Cellular Cardiology. 60, 1, p. 90-96 7 p.

Research output: Contribution to journalArticle

15 Scopus citations

Regulation of DDAH1 as a potential therapeutic target for treating cardiovascular diseases

Liu, X., Fassett, J., Wei, Y. & Chen, Y., Jul 19 2013, In : Evidence-based Complementary and Alternative Medicine. 2013, 619207.

Research output: Contribution to journalArticle

6 Scopus citations

Role of interferon regulatory factor 4 in the regulation of pathological cardiac hypertrophy

Jiang, D. S., Bian, Z. Y., Zhang, Y., Zhang, S. M., Liu, Y., Zhang, R., Chen, Y., Yang, Q., Zhang, X. D., Fan, G. C. & Li, H., Apr 18 2013, In : Hypertension. 61, 6, p. 1193-1202 10 p.

Research output: Contribution to journalArticle

70 Scopus citations

TRAF1 is a critical regulator of cerebral ischaemia-reperfusion injury and neuronal death

Lu, Y. Y., Li, Z. Z., Jiang, D. S., Wang, L., Zhang, Y., Chen, K., Zhang, X. F., Liu, Y., Fan, G. C., Chen, Y., Yang, Q., Zhou, Y., Zhang, X. D., Liu, D. P. & Li, H., Nov 28 2013, In : Nature communications. 4, 2852.

Research output: Contribution to journalArticle

65 Scopus citations

Vinexin-β protects against cardiac hypertrophy by blocking the Akt-dependent signalling pathway

Chen, K., Gao, L., Liu, Y., Zhang, Y., Jiang, D. S., Wei, X., Zhu, X. H., Zhang, R., Chen, Y., Yang, Q., Kioka, N., Zhang, X. D. & Li, H., Jan 1 2013, In : Basic research in cardiology. 108, 2, 338.

Research output: Contribution to journalArticle

32 Scopus citations
2012

AMP-activated protein kinase α1 protects against diet-induced insulin resistance and obesity

Zhang, W., Zhang, X., Wang, H., Guo, X., Li, H., Wang, Y., Xu, X., Tan, L., Mashek, M. T., Zhang, C., Chen, Y., Mashek, D., Foretz, M., Zhu, C., Zhou, H., Liu, X., Viollet, B., Wu, C. & Huo, Y., Dec 1 2012, In : Diabetes. 61, 12, p. 3114-3125 12 p.

Research output: Contribution to journalArticle

32 Scopus citations

Disruption of mindin exacerbates cardiac hypertrophy and fibrosis

Bian, Z. Y., Wei, X., Deng, S., Tang, Q. Z., Feng, J., Zhang, Y., Liu, C., Jiang, D. S., Yan, L., Zhang, L. F., Chen, M., Fassett, J., Chen, Y., He, Y. W., Yang, Q., Liu, P. P. & Li, H., Aug 2012, In : Journal of Molecular Medicine. 90, 8, p. 895-910 16 p.

Research output: Contribution to journalArticle

21 Scopus citations

Left ventricular failure produces profound lung remodeling and pulmonary hypertension in mice: Heart failure causes severe lung disease

Chen, Y., Guo, H., Xu, D., Xu, X., Wang, H., Hu, X., Lu, Z., Kwak, D., Xu, Y., Gunther, R., Huo, Y. & Weir, E. K., Jun 1 2012, In : Hypertension. 59, 6, p. 1170-1178 9 p.

Research output: Contribution to journalArticle

83 Scopus citations
2011

Adenosine kinase regulation of cardiomyocyte hypertrophy

Fassett, J. T., Hu, X., Xu, X., Lu, Z., Zhang, P., Chen, Y. & Bache, R. J., May 1 2011, In : American Journal of Physiology - Heart and Circulatory Physiology. 300, 5, p. H1722-H1732

Research output: Contribution to journalArticle

13 Scopus citations

AMP activated protein kinase-α2 regulates expression of estrogen-related receptor-α, a metabolic transcription factor related to heart failure development

Hu, X., Xu, X., Lu, Z., Zhang, P., Fassett, J., Zhang, Y., Xin, Y., Hall, J. L., Viollet, B., Bache, R. J., Huang, Y. & Chen, Y., Oct 1 2011, In : Hypertension. 58, 4, p. 696-703 8 p.

Research output: Contribution to journalArticle

41 Scopus citations

Cardiac-specific mindin overexpression attenuates cardiac hypertrophy via blocking AKT/GSK3β and TGF-β1Smad signalling

Yan, L., Wei, X., Tang, Q. Z., Feng, J., Zhang, Y., Liu, C., Bian, Z. Y., Zhang, L. F., Chen, M., Bai, X., Wang, A. B., Fassett, J., Chen, Y., He, Y. W., Yang, Q., Liu, P. P. & Li, H., Oct 1 2011, In : Cardiovascular Research. 92, 1, p. 85-94 10 p.

Research output: Contribution to journalArticle

51 Scopus citations

Dimethylarginine dimethylaminohydrolase-1 is the critical enzyme for degrading the cardiovascular risk factor asymmetrical dimethylarginine

Hu, X., Atzler, D., Xu, X., Zhang, P., Guo, H., Lu, Z., Fassett, J., Schwedhelm, E., Böger, R. H., Bache, R. J. & Chen, Y., Jul 1 2011, In : Arteriosclerosis, thrombosis, and vascular biology. 31, 7, p. 1540-1546 7 p.

Research output: Contribution to journalArticle

88 Scopus citations

Dimethylarginine dimethylaminohydrolase 1 modulates endothelial cell growth through nitric oxide and Akt

Zhang, P., Hu, X., Xu, X., Chen, Y. & Bache, R. J., Apr 1 2011, In : Arteriosclerosis, thrombosis, and vascular biology. 31, 4, p. 890-897 8 p.

Research output: Contribution to journalArticle

29 Scopus citations

Exacerbated pulmonary arterial hypertension and right ventricular hypertrophy in animals with loss of function of extracellular superoxide dismutase

Xu, D., Guo, H., Xu, X., Lu, Z., Fassett, J., Hu, X., Xu, Y., Tang, Q., Hu, D., Somani, A., Geurts, A. M., Ostertag, E., Bache, R. J., Weir, E. K. & Chen, Y., Aug 1 2011, In : Hypertension. 58, 2, p. 303-309 7 p.

Research output: Contribution to journalArticle

45 Scopus citations
2010

Delayed treatment effects of xanthine oxidase inhibition on systolic overload-induced left ventricular hypertrophy and dysfunction

Xu, X., Zhao, L., Hu, X., Zhang, P., Wessale, J., Bache, R. & Chen, Y., Jun 1 2010, In : Nucleosides, Nucleotides and Nucleic Acids. 29, 4-6, p. 306-313 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

Oxidative stress regulates left ventricular PDE5 expression in the failing heart

Lu, Z., Xu, X., Hu, X., Lee, S., Traverse, J. H., Zhu, G., Fassett, J., Tao, Y., Zhang, P., Remedios, C. D., Pritzker, M., Hall, J. L., Garry, D. J. & Chen, Y., Apr 1 2010, In : Circulation. 121, 13, p. 1474-1483 10 p.

Research output: Contribution to journalArticle

108 Scopus citations

PGC-1α regulates expression of myocardial mitochondrial antioxidants and myocardial oxidative stress after chronic systolic overload

Lu, Z., Xu, X., Hu, X., Fassett, J., Zhu, G., Tao, Y., Li, J., Huang, Y., Zhang, P., Zhao, B. & Chen, Y., Oct 1 2010, In : Antioxidants and Redox Signaling. 13, 7, p. 1011-1022 12 p.

Research output: Contribution to journalArticle

136 Scopus citations
2009

Adenosine regulation of microtubule dynamics in cardiac hypertrophy

Fassett, J. T., Xu, X., Hu, X., Zhu, G., French, J., Chen, Y. & Bache, R. J., Aug 1 2009, In : American Journal of Physiology - Heart and Circulatory Physiology. 297, 2, p. H523-H532

Research output: Contribution to journalArticle

16 Scopus citations

Loss of AMPK exacerbates experimental autoimmune encephalomyelitis disease severity

Nath, N., Khan, M., Rattan, R., Mangalam, A., Makkar, R. S., Meester, C. D., Bertrand, L., Singh, I., Chen, Y., Viollet, B. & Giri, S., Aug 14 2009, In : Biochemical and Biophysical Research Communications. 386, 1, p. 16-20 5 p.

Research output: Contribution to journalArticle

49 Scopus citations

NADPH oxidase contributes to coronary endothelial dysfunction in the failing heart

Zhang, P., Hou, M., Li, Y., Xu, X., Barsoum, M., Chen, Y. & Bache, R. J., Mar 1 2009, In : American Journal of Physiology - Heart and Circulatory Physiology. 296, 3, p. H840-H846

Research output: Contribution to journalArticle

31 Scopus citations

Vascular endothelial-specific dimethylarginine dimethylaminohydrolase-1- deficient mice reveal that vascular endothelium plays an important role in removing asymmetric dimethylarginine

Hu, X., Xu, X., Zhu, G., Atzler, D., Kimoto, M., Chen, J., Schwedhelm, E., Lüneburg, N., Böger, R. H., Zhang, P. & Chen, Y., Dec 1 2009, In : Circulation. 120, 22, p. 2222-2229 8 p.

Research output: Contribution to journalArticle

61 Scopus citations
2008

Adenosine A3 receptor deficiency exerts unanticipated protective effects on the pressure-overloaded left ventricle

Lu, Z., Fassett, J., Xu, X., Hu, X., Zhu, G., French, J., Zhang, P., Schnermann, J., Bache, R. J. & Chen, Y., Oct 21 2008, In : Circulation. 118, 17, p. 1713-1721 9 p.

Research output: Contribution to journalArticle

32 Scopus citations