Yingjie Chen

19992020

Research output per year

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Research Output

Article

A comparative study of discriminating human heart failure etiology using gene expression profiles

Huang, X., Pan, W., Grindle, S., Han, X., Chen, Y., Park, S. J., Miller, L. W. & Hall, J. L., Aug 24 2005, In : BMC bioinformatics. 6, 205.

Research output: Contribution to journalArticle

44 Scopus citations

Acute effects of febuxostat, a nonpurine selective inhibitor of xanthine oxidase, in pacing induced heart failure

Hou, M., Hu, Q., Chen, Y., Zhao, L., Zhang, J. J. & Bache, R. J., Nov 1 2006, In : Journal of Cardiovascular Pharmacology. 48, 5, p. 255-263 9 p.

Research output: Contribution to journalArticle

17 Scopus citations

Adenosine A3 receptor deficiency exerts unanticipated protective effects on the pressure-overloaded left ventricle

Lu, Z., Fassett, J., Xu, X., Hu, X., Zhu, G., French, J., Zhang, P., Schnermann, J., Bache, R. J. & Chen, Y., Oct 21 2008, In : Circulation. 118, 17, p. 1713-1721 9 p.

Research output: Contribution to journalArticle

32 Scopus citations

Adenosine kinase attenuates cardiomyocyte microtubule stabilization and protects against pressure overload-induced hypertrophy and LV dysfunction

Fassett, J., Xu, X., Kwak, D., Zhu, G., Fassett, E. K., Zhang, P., Wang, H., Mayer, B., Bache, R. J. & Chen, Y., May 2019, In : Journal of Molecular and Cellular Cardiology. 130, p. 49-58 10 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Adenosine kinase regulation of cardiomyocyte hypertrophy

Fassett, J. T., Hu, X., Xu, X., Lu, Z., Zhang, P., Chen, Y. & Bache, R. J., May 1 2011, In : American Journal of Physiology - Heart and Circulatory Physiology. 300, 5, p. H1722-H1732

Research output: Contribution to journalArticle

13 Scopus citations

Adenosine regulation of microtubule dynamics in cardiac hypertrophy

Fassett, J. T., Xu, X., Hu, X., Zhu, G., French, J., Chen, Y. & Bache, R. J., Aug 1 2009, In : American Journal of Physiology - Heart and Circulatory Physiology. 297, 2, p. H523-H532

Research output: Contribution to journalArticle

16 Scopus citations
10 Scopus citations

Alterations of gene expression in failing myocardium following left ventricular assist device support

Chen, Y., Park, S., Li, Y., Missov, E., Hou, M., Han, X., Hall, J. L., Miller, L. W. & Bache, R. J., Oct 2003, In : Physiological genomics. 14, p. 251-260 10 p.

Research output: Contribution to journalArticle

90 Scopus citations

AMP-activated protein kinase α1 protects against diet-induced insulin resistance and obesity

Zhang, W., Zhang, X., Wang, H., Guo, X., Li, H., Wang, Y., Xu, X., Tan, L., Mashek, M. T., Zhang, C., Chen, Y., Mashek, D., Foretz, M., Zhu, C., Zhou, H., Liu, X., Viollet, B., Wu, C. & Huo, Y., Dec 1 2012, In : Diabetes. 61, 12, p. 3114-3125 12 p.

Research output: Contribution to journalArticle

32 Scopus citations

AMP activated protein kinase-α2 deficiency exacerbates pressure-overload-induced left ventricular hypertrophy and dysfunction in mice

Zhang, P., Hu, X., Xu, X., Fassett, J., Zhu, G., Viollet, B., Xu, W., Wiczer, B., Bernlohr, D. A., Bache, R. J. & Chen, Y., Nov 1 2008, In : Hypertension. 52, 5, p. 918-924 7 p.

Research output: Contribution to journalArticle

122 Scopus citations

AMP activated protein kinase-α2 regulates expression of estrogen-related receptor-α, a metabolic transcription factor related to heart failure development

Hu, X., Xu, X., Lu, Z., Zhang, P., Fassett, J., Zhang, Y., Xin, Y., Hall, J. L., Viollet, B., Bache, R. J., Huang, Y. & Chen, Y., Oct 1 2011, In : Hypertension. 58, 4, p. 696-703 8 p.

Research output: Contribution to journalArticle

42 Scopus citations

AMPK attenuates microtubule proliferation in cardiac hypertrophy

Fassett, J. T., Hu, X., Xu, X., Lu, Z., Zhang, P., Chen, Y. & Bache, R. J., Mar 11 2013, In : American Journal of Physiology - Heart and Circulatory Physiology. 304, 5, p. H749-H758

Research output: Contribution to journalArticle

28 Scopus citations

AMPKα2 deficiency exacerbates long-term PM 2.5 exposure-induced lung injury and cardiac dysfunction

Wang, H., Shen, X., Tian, G., Shi, X., Huang, W., Wu, Y., Sun, L., Peng, C., Liu, S., Huang, Y., Chen, X., Zhang, F., Chen, Y., Ding, W. & Lu, Z., Jun 2018, In : Free Radical Biology and Medicine. 121, p. 202-214 13 p.

Research output: Contribution to journalArticle

18 Scopus citations
1 Scopus citations

Borrowing information from relevant microarray studies for sample classification using weighted partial least squares

Huang, X., Pan, W., Han, X., Chen, Y., Miller, L. W. & Hall, J. L., Jun 1 2005, In : Computational Biology and Chemistry. 29, 3, p. 204-211 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Cardiac-specific mindin overexpression attenuates cardiac hypertrophy via blocking AKT/GSK3β and TGF-β1Smad signalling

Yan, L., Wei, X., Tang, Q. Z., Feng, J., Zhang, Y., Liu, C., Bian, Z. Y., Zhang, L. F., Chen, M., Bai, X., Wang, A. B., Fassett, J., Chen, Y., He, Y. W., Yang, Q., Liu, P. P. & Li, H., Oct 1 2011, In : Cardiovascular Research. 92, 1, p. 85-94 10 p.

Research output: Contribution to journalArticle

54 Scopus citations

Cardiac troponin T alterations in myocardium and serum of rats after stressful, prolonged intense exercise

Chen, Y., Serfass, R. C., Mackey-Bojack, S. M., Kelly, K. L., Titus, J. L. & Apple, F. S., May 1 2000, In : Journal of applied physiology. 88, 5, p. 1749-1755 7 p.

Research output: Contribution to journalArticle

109 Scopus citations

Cardiomyocyte dimethylarginine dimethylaminohydrolase-1 (DDAH1) plays an important role in attenuating ventricular hypertrophy and dysfunction

Xu, X., Zhang, P., Kwak, D., Fassett, J., Yue, W., Atzler, D., Hu, X., Liu, X., Wang, H., Lu, Z., Guo, H., Schwedhelm, E., Böger, R. H., Chen, P. & Chen, Y., Sep 1 2017, In : Basic Research in Cardiology. 112, 5, 55.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

CD28/B7 deficiency attenuates systolic overload-induced congestive heart failure, myocardial and pulmonary inflammation, and activated T cell accumulation in the heart and lungs

Wang, H., Kwak, D., Fassett, J., Hou, L., Xu, X., Burbach, B. J., Thenappan, T., Xu, Y., Ge, J. B., Shimizu, Y., Bache, R. J. & Chen, Y., Sep 1 2016, In : Hypertension. 68, 3, p. 688-696 9 p.

Research output: Contribution to journalArticle

21 Scopus citations

Cyclic nucleotide phosphodiesterase type 5 activity limits blood flow to hypoperfused myocardium during exercise

Traverse, J. H., Chen, Y., Du, R. & Bache, R. J., Dec 12 2000, In : Circulation. 102, 24, p. 2997-3002 6 p.

Research output: Contribution to journalArticle

47 Scopus citations

DDAH1 deficiency attenuates endothelial cell cycle progression and angiogenesis

Zhang, P., Xu, X., Hu, X., Wang, H., Fassett, J., Huo, Y., Chen, Y. & Bache, R. J., Nov 18 2013, In : PloS one. 8, 11, e79444.

Research output: Contribution to journalArticle

19 Scopus citations

Delayed treatment effects of xanthine oxidase inhibition on systolic overload-induced left ventricular hypertrophy and dysfunction

Xu, X., Zhao, L., Hu, X., Zhang, P., Wessale, J., Bache, R. & Chen, Y., Jun 1 2010, In : Nucleosides, Nucleotides and Nucleic Acids. 29, 4-6, p. 306-313 8 p.

Research output: Contribution to journalArticle

13 Scopus citations
80 Scopus citations
1 Scopus citations

Dimethylarginine dimethylaminohydrolase-1 is the critical enzyme for degrading the cardiovascular risk factor asymmetrical dimethylarginine

Hu, X., Atzler, D., Xu, X., Zhang, P., Guo, H., Lu, Z., Fassett, J., Schwedhelm, E., Böger, R. H., Bache, R. J. & Chen, Y., Jul 1 2011, In : Arteriosclerosis, thrombosis, and vascular biology. 31, 7, p. 1540-1546 7 p.

Research output: Contribution to journalArticle

90 Scopus citations

Dimethylarginine dimethylaminohydrolase 1 modulates endothelial cell growth through nitric oxide and Akt

Zhang, P., Hu, X., Xu, X., Chen, Y. & Bache, R. J., Apr 1 2011, In : Arteriosclerosis, thrombosis, and vascular biology. 31, 4, p. 890-897 8 p.

Research output: Contribution to journalArticle

30 Scopus citations

Dimethylarginine dimethylaminohydrolase and endothelial dysfunction in failing hearts

Chen, Y., Li, Y., Zhang, P., Traverse, J. H., Hou, M., Xu, X., Kimoto, M. & Bache, R. J., Nov 1 2005, In : American Journal of Physiology - Heart and Circulatory Physiology. 289, 5 58-5, p. H2212-H2219

Research output: Contribution to journalArticle

54 Scopus citations

Disruption of mindin exacerbates cardiac hypertrophy and fibrosis

Bian, Z. Y., Wei, X., Deng, S., Tang, Q. Z., Feng, J., Zhang, Y., Liu, C., Jiang, D. S., Yan, L., Zhang, L. F., Chen, M., Fassett, J., Chen, Y., He, Y. W., Yang, Q., Liu, P. P. & Li, H., Aug 2012, In : Journal of Molecular Medicine. 90, 8, p. 895-910 16 p.

Research output: Contribution to journalArticle

22 Scopus citations

Disruption of sarcolemmal atp-sensitive potassium channel activity impairs the cardiac response to systolic overload

Hu, X., Xu, X., Huang, Y., Fassett, J., Flagg, T. P., Zhang, Y., Nichols, C. G., Bache, R. J. & Chen, Y., Oct 24 2008, In : Circulation research. 103, 9, p. 1009-1017 9 p.

Research output: Contribution to journalArticle

35 Scopus citations

Double-stranded RNA-dependent protein kinase deficiency protects the heart from systolic overload-induced congestive heart failure

Wang, H., Xu, X., Fassett, J., Kwak, D., Liu, X., Hu, X., Falls, T. J., Bell, J. C., Li, H., Bitterman, P., Bache, R. J. & Chen, Y., Apr 1 2014, In : Circulation. 129, 13, p. 1397-1406 10 p.

Research output: Contribution to journalArticle

26 Scopus citations

Ecto-5′ -nucleotidase deficiency exacerbates pressure-overload- induced left ventricular hypertrophy and dysfunction

Xu, X., Fassett, J., Hu, X., Zhu, G., Lu, Z., Li, Y., Schnermann, J., Bache, R. J. & Chen, Y., Jun 1 2008, In : Hypertension. 51, 6, p. 1557-1564 8 p.

Research output: Contribution to journalArticle

32 Scopus citations

Effect of K+ATP channel and adenosine receptor blockade during rest and exercise in congestive heart failure

Traverse, J. H., Chen, Y., Hou, M. X., Li, Y. & Bache, R. J., Jun 1 2007, In : Circulation research. 100, 11, p. 1643-1649 7 p.

Research output: Contribution to journalArticle

10 Scopus citations

Effect of PDE5 inhibition on coronary hemodynamics in pacing-induced heart failure

Chen, Y., Traverse, J. H., Hou, M., Li, Y., Du, R. & Bache, R. J., May 1 2003, In : American Journal of Physiology - Heart and Circulatory Physiology. 284, 5 53-5

Research output: Contribution to journalArticle

31 Scopus citations

Effect of sildenafil on coronary active and reactive hyperemia

Chen, Y., Du, R., Traverse, J. H. & Bache, R. J., Jan 1 2000, In : American Journal of Physiology - Heart and Circulatory Physiology. 279, 5 48-5, p. H2319-H2325

Research output: Contribution to journalArticle

27 Scopus citations

Endoplasmic reticulum stress sensor protein kinase R-like endoplasmic reticulum kinase (PERK) protects against pressure overload-induced heart failure and lung remodeling

Liu, X., Kwak, D., Lu, Z., Xu, X., Fassett, J., Wang, H., Wei, Y., Cavener, D. R., Hu, X., Hall, J., Bache, R. J. & Chen, Y., Jan 1 2014, In : Hypertension. 64, 4, p. 738-744 7 p.

Research output: Contribution to journalArticle

38 Scopus citations

ET-A receptor activity restrains coronary blood flow in the failing heart

Hou, M., Chen, Y., Traverse, J. H., Li, Y., Barsoum, M. & Bache, R. J., Jun 1 2004, In : Journal of Cardiovascular Pharmacology. 43, 6, p. 764-769 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

Exacerbated pulmonary arterial hypertension and right ventricular hypertrophy in animals with loss of function of extracellular superoxide dismutase

Xu, D., Guo, H., Xu, X., Lu, Z., Fassett, J., Hu, X., Xu, Y., Tang, Q., Hu, D., Somani, A., Geurts, A. M., Ostertag, E., Bache, R. J., Weir, E. K. & Chen, Y., Aug 1 2011, In : Hypertension. 58, 2, p. 303-309 7 p.

Research output: Contribution to journalArticle

45 Scopus citations

Extracellular superoxide dismutase deficiency exacerbates pressure overload-induced left ventricular hypertrophy and dysfunction

Lu, Z., Xu, X., Hu, X., Zhu, G., Zhang, P., Van Deel, E. D., French, J. P., Fassett, J. T., Oury, T. D., Bache, R. J. & Chen, Y., Jan 1 2008, In : Hypertension. 51, 1, p. 19-25 7 p.

Research output: Contribution to journalArticle

73 Scopus citations

Extracellular superoxide dismutase protects the heart against oxidative stress and hypertrophy after myocardial infarction

van Deel, E. D., Lu, Z., Xu, X., Zhu, G., Hu, X., Oury, T. D., Bache, R. J., Duncker, D. J. & Chen, Y., Apr 1 2008, In : Free Radical Biology and Medicine. 44, 7, p. 1305-1313 9 p.

Research output: Contribution to journalArticle

67 Scopus citations

Genetic and Pharmacologic Inhibition of the Chemokine Receptor CXCR2 Prevents Experimental Hypertension and Vascular Dysfunction

Wang, L., Zhao, X. C., Cui, W., Ma, Y. Q., Ren, H. L., Zhou, X., Fassett, J., Yang, Y. Z., Chen, Y., Xia, Y. L., Du, J. & Li, H. H., Nov 1 2016, In : Circulation. 134, 18, p. 1353-1368 16 p.

Research output: Contribution to journalArticle

Open Access
42 Scopus citations

Genomic profiling of the human heart before and after mechanical support with a ventricular assist device reveals alterations in vascular signaling networks

Hall, J. L., Grindle, S., Han, X., Fermin, D., Park, S., Chen, Y., Bache, R. J., Mariash, A., Guan, Z., Ormaza, S., Thompson, J., Graziano, J., De Sam Lazaro, S. E., Pan, S., Simari, R. D. & Miller, L. W., Jul 1 2004, In : Physiological genomics. 17, p. 283-291 9 p.

Research output: Contribution to journalArticle

89 Scopus citations

Identification of a gene expression profile that differentiates between ischemic and nonischemic cardiomyopathy

Kittleson, M. M., Ye, S. Q., Irizarry, R. A., Minhas, K. M., Edness, G., Conte, J. V., Parmigiani, G., Miller, L. W., Chen, Y., Hall, J. L., Garcia, J. G. N. & Hare, J. M., Nov 30 2004, In : Circulation. 110, 22, p. 3444-3451 8 p.

Research output: Contribution to journalArticle

99 Scopus citations

Increased extravascular forces limit endothelium-dependent and -independent coronary vasodilation in congestive heart failure

Traverse, J. H., Chen, Y., Crampton, M., Voss, S. & Bache, R. J., Dec 31 2001, In : Cardiovascular Research. 52, 3, p. 454-461 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Increased superoxide production causes coronary endothelial dysfunction and depressed oxygen consumption in the failing heart

Chen, Y., Hou, M., Li, Y., Traverse, J. H., Zhang, P., Salvemini, D., Fukai, T. & Bache, R. J., Jan 1 2005, In : American Journal of Physiology - Heart and Circulatory Physiology. 288, 1 57-1, p. H133-H141

Research output: Contribution to journalArticle

35 Scopus citations

Increasing Regulatory T Cells With Interleukin-2 and Interleukin-2 Antibody Complexes Attenuates Lung Inflammation and Heart Failure Progression

Wang, H., Hou, L., Kwak, D., Fassett, J., Xu, X., Chen, A., Chen, W., Blazar, B. R., Xu, Y., Hall, J. L., Ge, J. B., Bache, R. J. & Chen, Y., Jul 1 2016, In : Hypertension. 68, 1, p. 114-122 9 p.

Research output: Contribution to journalArticle

30 Scopus citations

Inducible nitric oxide synthase deficiency protects the heart from systolic overload-induced ventricular hypertrophy and congestive heart failure

Zhang, P., Xu, X., Hu, X., Van Deel, E. D., Zhu, G. & Chen, Y., Apr 1 2007, In : Circulation research. 100, 7, p. 1089-1098 10 p.

Research output: Contribution to journalArticle

120 Scopus citations

Inducible nitric oxide synthase inhibits oxygen consumption in collateral-dependent myocardium

Chen, Y., Zhang, P., Li, J., Xu, X. & Bache, R. J., Feb 1 2014, In : American Journal of Physiology - Heart and Circulatory Physiology. 306, 3, p. H356-H362

Research output: Contribution to journalArticle

2 Scopus citations

Inhibition of NO production increases myocardial blood flow and oxygen consumption in congestive heart failure

Traverse, J. H., Chen, Y., Hou, M. & Bache, R. J., Jul 2 2002, In : American Journal of Physiology - Heart and Circulatory Physiology. 282, 6 51-6

Research output: Contribution to journalArticle

17 Scopus citations

Interferon regulatory factor 1 is required for cardiac remodeling in response to pressure overload

Jiang, D. S., Li, L., Huang, L., Gong, J., Xia, H., Liu, X., Wan, N., Wei, X., Zhu, X., Chen, Y., Chen, X., Zhang, X. D. & Li, H., Jul 2014, In : Hypertension. 64, 1, p. 77-86 10 p.

Research output: Contribution to journalArticle

52 Scopus citations

Interferon regulatory factor 3 is a negative regulator of pathological cardiac hypertrophy

Lu, J., Bian, Z. Y., Zhang, R., Zhang, Y., Liu, C., Yan, L., Zhang, S. M., Jiang, D. S., Wei, X., Zhu, X. H., Chen, M., Wang, A. B., Chen, Y., Yang, Q., Liu, P. P. & Li, H., Jan 1 2013, In : Basic research in cardiology. 108, 2, 326.

Research output: Contribution to journalArticle

60 Scopus citations