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Research Output 2001 2018

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Article
2018

Despite high levels of expression in thymic epithelial cells, miR-181a1 and miR-181b1 are not required for thymic development

Stefanski, H. E., Xing, Y., Taylor, P. A., Maio, S., Henao-Meija, J., Williams, A., Flavell, R. A., Hollander, G. A. & Blazar, B. R., Jun 1 2018, In : PloS one. 13, 6, e0198871.

Research output: Contribution to journalArticle

epithelial cells
Epithelial Cells
thymocytes
T-cells
Thymocytes
1 Citation (Scopus)

Thymic epithelial cell support of thymopoiesis does not require Klotho

Xing, Y., Smith, M. J., Goetz, C. A., Mc Elmurry, R. T., Parker, S. L., Min, D., Hollander, G. A., Weinberg, K. I., Tolar, J., Stefanski, H. E. & Blazar, B. R., Dec 1 2018, In : Journal of Immunology. 201, 11, p. 3320-3328 9 p.

Research output: Contribution to journalArticle

Open Access
Vitamin D
Epithelial Cells
Thymus Gland
T-Lymphocytes
Thymocytes
2016
47 Citations (Scopus)

Late stages of T cell maturation in the thymus involve NF-κB and tonic type i interferon signaling

Xing, Y., Wang, X., Jameson, S. C. & Hogquist, K. A., May 1 2016, In : Nature immunology. 17, 5, p. 565-573 9 p.

Research output: Contribution to journalArticle

Thymus Gland
Interferons
T-Lymphocytes
Thymocytes
Phosphotransferases
2015
25 Citations (Scopus)

TCR affinity for thymoproteasome-dependent positively selecting peptides conditions antigen responsiveness in CD8+ T cells

Takada, K., Van Laethem, F., Xing, Y., Akane, K., Suzuki, H., Murata, S., Tanaka, K., Jameson, S. C., Singer, A. & Takahama, Y., Sep 18 2015, In : Nature immunology. 16, 10, p. 1069-1076 8 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
T-Lymphocytes
Antigens
Peptides
Thymus Gland
76 Citations (Scopus)

The TCR's sensitivity to self peptide-MHC dictates the ability of naive CD8 + T cells to respond to foreign antigens

Fulton, R. B., Hamilton Hart, S. E., Xing, Y., Best, J. A., Goldrath, A. W., Hogquist, K. A. & Jameson, S. C., Dec 18 2015, In : Nature immunology. 16, 1, p. 107-117 11 p.

Research output: Contribution to journalArticle

Aptitude
Major Histocompatibility Complex
T-Lymphocytes
Antigens
Peptides
2014
112 Citations (Scopus)

Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells

Mahmud, S. A., Manlove, L. S., Schmitz, H. M., Xing, Y., Wang, Y., Owen, D. L., Schenkel, J. M., Boomer, J. S., Green, J. M., Yagita, H., Chi, H., Hogquist, K. A. & Farrar, M. A., Jan 1 2014, In : Nature immunology. 15, 5, p. 473-481 9 p.

Research output: Contribution to journalArticle

Tumor Necrosis Factor Receptors
Regulatory T-Lymphocytes
T-Cell Antigen Receptor
Receptors, Tumor Necrosis Factor, Type II
Stem Cells
14 Citations (Scopus)
Purification
Thymus
Epithelial Cells
T-cells
Thymus Gland
2013
97 Citations (Scopus)

Murine thymic selection quantified using a unique method to capture deleted T cells

Stritesky, G. L., Xing, Y., Erickson, J. R., Kalekar, L. A., Wang, X., Mueller, D. L., Jameson, S. C. & Hogquist, K. A., Mar 19 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 12, p. 4679-4684 6 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Clonal Deletion
Lymphoid Tissue
Regulatory T-Lymphocytes
Thymocytes
47 Citations (Scopus)
Antigen-Presenting Cells
Peptides
Epithelial Cells
T-Lymphocytes
Clone Cells
2012
117 Citations (Scopus)

T-Cell tolerance: Central and peripheral

Xing, Y. & Hogquist, K. A., Jun 1 2012, In : Cold Spring Harbor Perspectives in Biology. 4, 6, p. 1-15 15 p.

Research output: Contribution to journalArticle

Central Tolerance
Peripheral Tolerance
T-cells
T-Lymphocytes
Thymus
2011
440 Citations (Scopus)

T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse

Moran, A. E., Holzapfel, K. L., Xing, Y., Cunningham, N. R., Maltzman, J. S., Punt, J. & Hogquist, K. A., Jun 1 2011, In : Journal of Experimental Medicine. 208, 6, p. 1279-1289 11 p.

Research output: Contribution to journalArticle

Natural Killer T-Cells
T-Cell Antigen Receptor
Antigen Receptors
Regulatory T-Lymphocytes
Lymphocytes
2009
11 Citations (Scopus)

GANP suppresses the arginine methyltransferase PRMT5 regulating IL-4-mediated STAT6-signaling to IgE production in B cells

Igarashi, H., Kuwahara, K., Yoshida, M., Xing, Y., Maeda, K., Nakajima, K. & Sakaguchi, N., Mar 1 2009, In : Molecular Immunology. 46, 6, p. 1031-1041 11 p.

Research output: Contribution to journalArticle

Interleukin-4
Immunoglobulin E
B-Lymphocytes
Germinal Center
Antibody Affinity
2008
9 Citations (Scopus)

Protein phosphatase subunit G5PR that regulates the JNK-mediated apoptosis signal is essential for the survival of CD4 and CD8 double-positive thymocytes

Xing, Y., Wang, X., Igarashi, H., Kawamoto, H. & Sakaguchi, N., Apr 2008, In : Molecular Immunology. 45, 7, p. 2028-2037 10 p.

Research output: Contribution to journalArticle

Phosphoprotein Phosphatases
Protein Subunits
Thymocytes
Apoptosis
Caspase 3
2005
27 Citations (Scopus)

Increased expression of germinal center-associated nuclear protein RNA-primase is associated with lymphomagenesis

Fujimura, S., Xing, Y., Takeya, M., Yamashita, Y., Ohshima, K., Kuwahara, K. & Sakaguchi, N., Jul 1 2005, In : Cancer Research. 65, 13, p. 5925-5934 10 p.

Research output: Contribution to journalArticle

DNA Primase
Nuclear RNA
Germinal Center
Nuclear Proteins
Hodgkin Disease
16 Citations (Scopus)

Protein phosphatase subunit G5PR is needed for inhibition of B cell receptor-induced apoptosis

Xing, Y., Igarashi, H., Wang, X. & Sakaguchi, N., Sep 5 2005, In : Journal of Experimental Medicine. 202, 5, p. 707-719 13 p.

Research output: Contribution to journalArticle

Phosphoprotein Phosphatases
Protein Subunits
B-Lymphocytes
Apoptosis
Cell Death
2004
10 Citations (Scopus)

The Sac3 homologue shd1 is involved in mitotic progression in mammalian cells

Sefat-E-Khuda, Yoshida, M., Xing, Y., Shimasaki, T., Takeya, M., Kuwahara, K. & Sakaguchi, N., Oct 29 2004, In : Journal of Biological Chemistry. 279, 44, p. 46182-46190 9 p.

Research output: Contribution to journalArticle

Centrosome
Cells
Interference suppression
DNA
Tubulin
2001
35 Citations (Scopus)

Germinal center-associated nuclear protein (GANP) has a phosphorylation-dependent DNA-primase activity that is up-regulated in germinal center regions

Kuwahara, K., Tomiyasu, S., Fujimura, S., Nomura, K., Xing, Y., Nishiyama, N., Ogawa, M., Imajoh-Ohmi, S., Izuta, S. & Sakaguchi, N., Aug 28 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 18, p. 10279-10283 5 p.

Research output: Contribution to journalArticle

DNA Primase
Germinal Center
Nuclear Proteins
Phosphorylation
B-Lymphocytes