19922013
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Research Output 1992 2013

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Article
2013
14 Citations (Scopus)
Epidermal Growth Factor Receptor
Epidermal Growth Factor
Breast Neoplasms
Ligands
Estrogen Receptors
2010
71 Citations (Scopus)

The type i insulin-like growth factor receptor regulates cancer metastasis independently of primary tumor growth by promoting invasion and survival

Sachdev, D., Zhang, X., Matise, I., Gaillard-Kelly, M. & Yee, D., Jan 1 2010, In : Oncogene. 29, 2, p. 251-262 12 p.

Research output: Contribution to journalArticle

Somatomedin Receptors
Neoplasm Metastasis
Growth
Neoplasms
Anoikis
2006
91 Citations (Scopus)

Insulin receptor substrates mediate distinct biological responses to insulin-like growth factor receptor activation in breast cancer cells

Byron, S. A., Horwitz, K. B., Richer, J. K., Lange, C. A., Zhang, X. & Yee, D., Nov 6 2006, In : British Journal of Cancer. 95, 9, p. 1220-1228 9 p.

Research output: Contribution to journalArticle

Somatomedin Receptors
Insulin Receptor
Insulin Receptor Substrate Proteins
Breast Neoplasms
Phenotype
2005
55 Citations (Scopus)

Multiple signaling pathways are activated during insulin-like growth factor-I (IGF-I) stimulated breast cancer cell migration

Zhang, X., Lin, M., Van Golen, K. L., Yoshioka, K., Itoh, K. & Yee, D., Sep 1 2005, In : Breast Cancer Research and Treatment. 93, 2, p. 159-168 10 p.

Research output: Contribution to journalArticle

Insulin-Like Growth Factor I
Cell Movement
Breast Neoplasms
Focal Adhesion Protein-Tyrosine Kinases
IGF Type 1 Receptor
2004
132 Citations (Scopus)

A Dominant Negative Type I Insulin-like Growth Factor Receptor Inhibits Metastasis of Human Cancer Cells

Sachdev, D., Hartell, J. S., Lee, A. V., Zhang, X. & Yee, D., Feb 6 2004, In : Journal of Biological Chemistry. 279, 6, p. 5017-5024 8 p.

Research output: Contribution to journalArticle

IGF Type 1 Receptor
Insulin-Like Growth Factor I
Cells
Neoplasm Metastasis
Heterografts
41 Citations (Scopus)

Motility response to insulin-like growth factor-I (IGF-I) in MCF-7 cells is associated with IRS-2 activation and integrin expression

Zhang, X., Kamaraju, S., Hakuno, F., Kabuta, T., Takahashi, S. I., Sachdev, D. & Yee, D., Jan 1 2004, In : Breast Cancer Research and Treatment. 83, 2, p. 161-170 10 p.

Research output: Contribution to journalArticle

MCF-7 Cells
Insulin-Like Growth Factor I
Integrins
Insulin Receptor Substrate Proteins
Cell Culture Techniques
61 Citations (Scopus)

Selective activation of insulin receptor substrate-1 and -2 in pleural mesothelioma cells: Association with distinct malignant phenotypes

Hoang, C. D., Zhang, X., Scott, P. D., Guillaume, T. J., Maddaus, M. A., Yee, D. & Kratzke, R. A., Oct 15 2004, In : Cancer Research. 64, 20, p. 7479-7485 7 p.

Research output: Contribution to journalArticle

Insulin Receptor Substrate Proteins
Mesothelioma
Somatomedins
Phenotype
Insulin-Like Growth Factor I
2003
18 Citations (Scopus)

The α2 and α3 integrins are required for morphologic differentiation of an intestinal epithelial cell line

Zhang, X., Cromwell, J. W., Kunjummen, B. D., Yee, D. & Garcia-Aguilar, J., Apr 1 2003, In : Surgery. 133, 4, p. 429-437 9 p.

Research output: Contribution to journalArticle

Integrins
Epithelial Cells
Cell Line
Caco-2 Cells
Antisense DNA
2002
67 Citations (Scopus)

Insulin-like growth factor binding protein-1 (IGFBP-1) inhibits breast cancer cell motility

Zhang, X. & Yee, D., Aug 1 2002, In : Cancer Research. 62, 15, p. 4369-4375 7 p.

Research output: Contribution to journalArticle

Insulin-Like Growth Factor Binding Protein 1
Integrins
Cell Movement
Breast Neoplasms
Insulin-Like Growth Factor I
2001
104 Citations (Scopus)

Regulation of breast cancer cell motility by insulin receptor substrate-2 (IRS-2) in metastatic variants of human breast cancer cell lines

Jackson, J. G., Zhang, X., Yoneda, T. & Yee, D., Nov 1 2001, In : Oncogene. 20, 50, p. 7318-7325 8 p.

Research output: Contribution to journalArticle

Insulin Receptor Substrate Proteins
Cell Movement
Breast Neoplasms
Cell Line
Somatomedins
1996
62 Citations (Scopus)

Mutation of a conserved serine in TM4 of opioid receptors confers full agonistic properties to classical antagonists

Claude, P. A., Wotta, D. R., Zhang, X., Prather, P. L., McGinn, T. M., Erickson, L. J., Loh, H. H. & Law, P-Y., Jun 27 1996, In : Proceedings of the National Academy of Sciences of the United States of America. 93, 12, p. 5715-5719 5 p.

Research output: Contribution to journalArticle

Opioid Receptors
Serine
Mutation
Narcotic Antagonists
CHO Cells
1995
61 Citations (Scopus)

Distribution of Neuropeptide Receptors: New Views of Peptidergic Neurotransmission Made Possible by Antibodies to Opioid Receptors

ELDE, ROBERT., ARVIDSSON, ULF., RIEDL, MAUREEN., VULCHANOVA, LUCY., LEE, JANGHERN. H., DADO, ROBERT., NAKANO, ALBERT., CHAKRABARTI, SUMITA., ZHANG, XU., LOH, HORACE. H., LAW, PING. Y., HÖKFELT, TOMAS. & WESSENDORF, MARTIN., May 1995, In : Annals of the New York Academy of Sciences. 757, 1, p. 390-404 15 p.

Research output: Contribution to journalArticle

Neuropeptide Receptors
kappa Opioid Receptor
mu Opioid Receptor
Opioid Receptors
Synaptic Transmission
1993
11 Citations (Scopus)

Transfection of NG108-15 cells with antisense opioid-binding cell adhesion molecule cDNA alters opioid receptor-G-protein interaction

Govitrapong, P., Zhang, X., Loh, H. H. & Lee, N. M., Jan 1 1993, In : Journal of Biological Chemistry. 268, 24, p. 18280-18285 6 p.

Research output: Contribution to journalArticle

Cell Adhesion Molecules
Opioid Receptors
GTP-Binding Proteins
Opioid Analgesics
Transfection
1992
6 Citations (Scopus)

Antisense proenkephalin cDNA transfection decreases opioid binding in NG 108-15 cells

Arany, I., Zhang, X., Loh, H. H. & Lee, N. M., Dec 1992, In : Molecular Brain Research. 16, 3-4, p. 295-302 8 p.

Research output: Contribution to journalArticle

Opioid Analgesics
Transfection
Complementary DNA
Opioid Receptors
Methionine Enkephalin