William Mantyh

2025

Identifying progression subphenotypes of Alzheimer's disease from large-scale electronic health records with machine learning

Zhou, M., Tang, A. S., Zhang, H., Xu, Z., Ke, A. M. C., Su, C., Huang, Y., Mantyh, W. G., Jaffee, M. S., Rankin, K. P., DeKosky, S. T., Zhou, J., Guo, Y., Bian, J., Sirota, M. & Wang, F., May 2025, In: Journal of Biomedical Informatics. 165, 104820.

Research output: Contribution to journal › Article › peer-review

Open Access

sTREM2 in discordant CSF Aβ₄₂ and p-tau181

for the Alzheimer's Disease Neuroimaging Initiative, Jan 1 2025, In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 17, 1, e70072.

Research output: Contribution to journal › Article › peer-review

Open Access

2024

APOE «4 Allele Frequency Among Cognitively Healthy Members of an Ojibwe Tribal Nation

Block, A. D., Castro, M. R., Hansen, A., Strong, C., Hanes, E., Schomaker, M. L., Matheson, M. J., Hill, A., Peterson, A., Henderson, J. N. & Mantyh, W. G., Feb 13 2024, In: Neurology: Genetics. 10, 2, e200130.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Care needs assessment of older adults with dementia in a semi-rural district in Vietnam: A community-based cross-sectional study

Nguyen, A. N., Nguyen, B. T., Nguyen, B. T., Nguyen, B. T. T., Nguyen, N. T. A., Dang, N. T. K., Nguyen, A. T. P., Nguyen, A. T., Pham, T., Mantyh, W. G., Tran, D., Le, O. T. P. & Park, V. M. T., Mar 2024, In: Psychogeriatrics. 24, 2, p. 249-258 10 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Cognitive Decline and Other Late-Stage Neurologic Complications in Cockayne Syndrome

Rajamani, G., Stafki, S. A., Daugherty, A. L., Mantyh, W. G., Littel, H. R., Bruels, C. C., Pacak, C. A., Robbins, P. D., Niedernhofer, L. J., Abiona, A., Giunti, P., Mohammed, S., Laugel, V. & Kang, P. B., May 16 2024, In: Neurology: Clinical Practice. 14, 4, e200309.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Repurposing non-pharmacological interventions for Alzheimer's disease through link prediction on biomedical literature

Xiao, Y., Hou, Y., Zhou, H., Diallo, G., Fiszman, M., Wolfson, J., Zhou, L., Kilicoglu, H., Chen, Y., Su, C., Xu, H., Mantyh, W. G. & Zhang, R., Dec 2024, In: Scientific reports. 14, 1, 8693.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

The Era of Early Detection and Treatment of Brain Amyloid Deposition in Asymptomatic Individuals?

Li, D. & Mantyh, W. G., Sep 1 2024, In: Clinical chemistry. 70, 9, p. 1096-1098 3 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

2023

Alzheimer’s pathology is associated with altered cognition, brain volume, and plasma biomarker patterns in traumatic encephalopathy syndrome

Asken, B. M., Tanner, J. A., Gaynor, L. S., VandeVrede, L., Mantyh, W. G., Casaletto, K. B., Staffaroni, A. M., Fonseca, C., Shankar, R., Grant, H., Smith, K., Lago, A. L., Xu, H., La Joie, R., Cobigo, Y., Rosen, H., Perry, D. C., Rojas, J. C., Miller, B. L. & Gardner, R. C. & 3 others, Wang, K. K. W., Kramer, J. H. & Rabinovici, G. D., Dec 2023, In: Alzheimer's Research and Therapy. 15, 1, 126.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

Characteristics of Recurrent Visions of the Nonphysical World Among Cognitively Unimpaired Elders of the Ojibwe Tribal Nation

Mantyh, W. G., Block, A. D., Castro, M. R., Hansen, A., Matheson, M. J., Strong, C., Hill, A., Cayci, Z. & Henderson, J. N., Oct 18 2023, In: JAMA Network Open. 6, 10, e2338221.

Research output: Contribution to journal › Article › peer-review

Open Access

Early-onset Alzheimer's disease explained by polygenic risk of late-onset disease?

Mantyh, W. G., Cochran, J. N., Taylor, J. W., Broce, I. J., Geier, E. G., Bonham, L. W., Anderson, A. G., Sirkis, D. W., Joie, R. L., Iaccarino, L., Chaudhary, K., Edwards, L., Strom, A., Grant, H., Allen, I. E., Miller, Z. A., Gorno-Tempini, M. L., Kramer, J. H., Miller, B. L. & Desikan, R. S. & 2 others, Rabinovici, G. D. & Yokoyama, J. S., Oct 1 2023, In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 15, 4, e12482.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

2022

Deep phenotyping of Alzheimer’s disease leveraging electronic medical records identifies sex-specific clinical associations

Tang, A. S., Oskotsky, T., Havaldar, S., Mantyh, W. G., Bicak, M., Solsberg, C. W., Woldemariam, S., Zeng, B., Hu, Z., Oskotsky, B., Dubal, D., Allen, I. E., Glicksberg, B. S. & Sirota, M., Dec 2022, In: Nature communications. 13, 1, 675.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

Plasma P-tau181 and P-tau217 in Patients with Traumatic Encephalopathy Syndrome with and Without Evidence of Alzheimer Disease Pathology

Asken, B. M., Tanner, J. A., Vandevrede, L., Mantyh, W. G., Casaletto, K. B., Staffaroni, A. M., La Joie, R., Iaccarino, L., Soleimani-Meigooni, D., Rojas, J. C., Gardner, R. C., Miller, B. L., Grinberg, L. T., Boxer, A. L., Kramer, J. H. & Rabinovici, G. D., Aug 9 2022, In: Neurology. 99, 6, p. E594-E604

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

2021

Association of remote mild traumatic brain injury with cortical amyloid burden in clinically normal older adults

Asken, B. M., Mantyh, W. G., La Joie, R., Strom, A., Casaletto, K. B., Staffaroni, A. M., Apple, A. C., Lindbergh, C. A., Iaccarino, L., You, M., Grant, H., Fonseca, C., Windon, C., Younes, K., Tanner, J., Rabinovici, G. D., Kramer, J. H. & Gardner, R. C., Oct 2021, In: Brain Imaging and Behavior. 15, 5, p. 2417-2425 9 p.

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Heterogeneous distribution of tau pathology in the behavioural variant of Alzheimer's disease

Singleton, E., Hansson, O., Pijnenburg, Y. A. L., La Joie, R., Mantyh, W. G., Tideman, P., Stomrud, E., Leuzy, A., Johansson, M., Strandberg, O., Smith, R., Berendrecht, E., Miller, B. L., Iaccarino, L., Edwards, L., Strom, A., Wolters, E. E., Coomans, E., Visser, D. & Golla, S. S. V. & 9 others, Tuncel, H., Bouwman, F., Van Swieten, J. C., Papma, J. M., Van Berckel, B., Scheltens, P., Dijkstra, A. A., Rabinovici, G. D. & Ossenkoppele, R., Aug 1 2021, In: Journal of Neurology, Neurosurgery and Psychiatry. 92, 8, p. 872-880 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

21 Scopus citations

2020

Progressive dysexecutive syndrome due to Alzheimer's disease: a description of 55 cases and comparison to other phenotypes

Townley, R. A., Graff-Radford, J., Mantyh, W. G., Botha, H., Polsinelli, A. J., Przybelski, S. A., Machulda, M. M., Makhlouf, A. T., Senjem, M. L., Murray, M. E., Reichard, R. R., Savica, R., Boeve, B. F., Drubach, D. A., Josephs, K. A., Knopman, D. S., Lowe, V. J., Jack, C. R., Petersen, R. C. & Jones, D. T., 2020, In: Brain Communications. 2, 1, fcaa068.

Research output: Contribution to journal › Article › peer-review

Open Access

97 Scopus citations

Tau Positron Emission Tomographic Findings in a Former US Football Player with Pathologically Confirmed Chronic Traumatic Encephalopathy

Mantyh, W. G., Spina, S., Lee, A., Iaccarino, L., Soleimani-Meigooni, D., Tsoy, E., Mellinger, T. J., Grant, H., Vandevrede, L., La Joie, R., Lesman-Segev, O., Gaus, S., Possin, K. L., Grinberg, L. T., Miller, B. L., Seeley, W. W. & Rabinovici, G. D., Apr 2020, In: JAMA Neurology. 77, 4, p. 517-521 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

46 Scopus citations

2019

Teaching Video NeuroImages: Foix-Chavany-Marie syndrome

Mantyh, W. G., Chandregowda, A., Fulgham, J. R., Flemming, K. D., Laughlin, R. S. & Jones, D. T., May 28 2019, In: Neurology. 92, 22, p. E2620-E2621

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

2018

FDG-PET in tau-negative amnestic dementia resembles that of autopsy-proven hippocampal sclerosis

Botha, H., Mantyh, W. G., Murray, M. E., Knopman, D. S., Przybelski, S. A., Wiste, H. J., Graff-Radford, J., Josephs, K. A., Schwarz, C. G., Kremers, W. K., Boeve, B. F., Petersen, R. C., Machulda, M. M., Parisi, J. E., Dickson, D. W., Lowe, V., Jack, C. R. & Jones, D. T., Apr 2018, In: Brain. 141, 4, p. 1201-1217 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

84 Scopus citations

Spontaneous posterior spinal artery infarction

Zalewski, N. L., Rabinstein, A. A., Wijdicks, E. F. M., Petty, G. W., Pittock, S. J., Mantyh, W. G. & Flanagan, E. P., Aug 28 2018, In: Neurology. 91, 9, p. 414-417 4 p.

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Tau-negative amnestic dementia masquerading as Alzheimer disease dementia

Botha, H., Mantyh, W. G., Graff-Radford, J., Machulda, M. M., Przybelski, S. A., Wiste, H. J., Senjem, M. L., Parisi, J. E., Petersen, R. C., Murray, M. E., Boeve, B. F., Lowe, V. J., Knopman, D. S., Jack, C. R. & Jones, D. T., Mar 13 2018, In: Neurology. 90, 11, p. e940-e946

Research output: Contribution to journal › Article › peer-review

Open Access

32 Scopus citations

2017

Epidermal nerve fiber quantification in patients with erythromelalgia

Mantyh, W. G., Dyck, P. J. B., Dyck, P. J., Engelstad, J. K., Litchy, W. J., Sandroni, P. & Davis, M. D. P., Feb 1 2017, In: JAMA Dermatology. 153, 2, p. 162-167 6 p.

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

2016

Examining the frequency of stimulant misuse among patients with primary disorders of hypersomnolence: A retrospective cohort study

Mantyh, W. G., Auger, R. R., Morgenthaler, T. I., Silber, M. H. & Moore, W. R., 2016, In: Journal of Clinical Sleep Medicine. 12, 5, p. 659-662 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

2012

The effect of aging on the density of the sensory nerve fiber innervation of bone and acute skeletal pain

Jimenez-Andrade, J. M., Mantyh, W. G., Bloom, A. P., Freeman, K. T., Ghilardi, J. R., Kuskowski, M. A. & Mantyh, P. W., May 2012, In: Neurobiology of Aging. 33, 5, p. 921-932 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

44 Scopus citations

2011

Quantifying the reduction in nonmedical costs after the introduction of a rural county hospital in Ecuador

Gaus, D. P., Herrera, D. F., Mantyh, W. G., Girdhari, R. P. & Kuskowski, M. A., Jun 2011, In: Revista Panamericana de Salud Publica/Pan American Journal of Public Health. 29, 6, p. 423-427 5 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Sustained blockade of neurotrophin receptors TrkA, TrkB and TrkC reduces non-malignant skeletal pain but not the maintenance of sensory and sympathetic nerve fibers

Ghilardi, J. R., Freeman, K. T., Jimenez-Andrade, J. M., Mantyh, W. G., Bloom, A. P., Bouhana, K. S., Trollinger, D., Winkler, J., Lee, P., Andrews, S. W., Kuskowski, M. A. & Mantyh, P. W., Feb 1 2011, In: Bone. 48, 2, p. 389-398 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

53 Scopus citations

The majority of myelinated and unmyelinated sensory nerve fibers that innervate bone express the tropomyosin receptor kinase A

Castañeda-Corral, G., Jimenez-Andrade, J. M., Bloom, A. P., Taylor, R. N., Mantyh, W. G., Kaczmarska, M. J., Ghilardi, J. R. & Mantyh, P. W., Mar 31 2011, In: Neuroscience. 178, p. 196-207 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

168 Scopus citations

2010

Administration of a tropomyosin receptor kinase inhibitor attenuates sarcoma-induced nerve sprouting, neuroma formation and bone cancer pain

Ghilardi, J. R., Freeman, K. T., Jimenez-Andrade, J. M., Mantyh, W. G., Bloom, A. P., Kuskowski, M. A. & Mantyh, P. W., Dec 7 2010, In: Molecular Pain. 6, 87.

Research output: Contribution to journal › Article › peer-review

93 Scopus citations

A phenotypically restricted set of primary afferent nerve fibers innervate the bone versus skin: Therapeutic opportunity for treating skeletal pain

Jimenez-Andrade, J. M., Mantyh, W. G., Bloom, A. P., Xu, H., Ferng, A. S., Dussor, G., Vanderah, T. W. & Mantyh, P. W., Feb 2010, In: Bone. 46, 2, p. 306-313 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

138 Scopus citations

Blockade of nerve sprouting and neuroma formation markedly attenuates the development of late stage cancer pain

Mantyh, W. G., Jimenez-Andrade, J. M., Stake, J. I., Bloom, A. P., Kaczmarska, M. J., Taylor, R. N., Freeman, K. T., Ghilardi, J. R., Kuskowski, M. A. & Mantyh, P. W., Dec 1 2010, In: Neuroscience. 171, 2, p. 588-598 11 p.

Research output: Contribution to journal › Article › peer-review

162 Scopus citations

Pathological sprouting of adult nociceptors in chronic prostate cancer-induced bone pain

Jimenez-Andrade, J. M., Bloom, A. P., Stake, J. I., Mantyh, W. G., Taylor, R. N., Freeman, K. T., Ghilardi, J. R., Kuskowski, M. A. & Mantyh, P. W., Nov 3 2010, In: Journal of Neuroscience. 30, 44, p. 14649-14656 8 p.

Research output: Contribution to journal › Article › peer-review

169 Scopus citations

2009

Capsaicin-sensitive sensory nerve fibers contribute to the generation and maintenance of skeletal fracture pain

Jimenez-Andrade, J. M., Bloom, A. P., Mantyh, W. G., Koewler, N. J., Freeman, K. T., Delong, D., Ghilardi, J. R., Kuskowski, M. A. & Mantyh, P. W., Sep 15 2009, In: Neuroscience. 162, 4, p. 1244-1254 11 p.

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

William Mantyh

Research output

Search results