Personal profile
Research interests
Will Mantyh MD is a behavioral neurologist specializing in the diagnosis and care for neurodegenerative disease, such as Alzheimer's disease, Lewy body disease, Frontotemporal dementia, or Chronic Traumatic Encephalopathy. His research expertise is the development of blood and imaging biomarkers for neurodegenerative disease. In particular, he currently seeks to expand the applicability of revolutionary new blood tests for Alzheimer's disease to underrepresented patients and 'real world' settings that are more complicated than clinical trial populations.
Education/Academic qualification
MD, University of Minnesota
Award Date: May 10 2014
Fellowship in Behavioral Neurology, University of California at San Francisco
2018 → 2020
Neurology Residency, Mayo Clinic
2015 → 2018
Internal Medicine Internship
2014 → 2015
Research Interest Keywords
- Biomarkers
- Neurodegeneration
- alzheimer's disease
- Health disparities
- Neuroimaging
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being -
SDG 10 Reduced Inequalities
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Collaborations and top research areas from the last five years
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Dementia prevalence, APOE, and blood-based biomarkers of AD in Native American communities
Cayci, Z. (PI), Jacklin, K. (PI), Lakshminarayan, K. (PI), Mantyh, W. (PI), Petersen, A. J. (PI), Johnson, T. M. (CoI) & Smith, B. (CoI)
NIH NATIONAL INSTITUTE ON AGING
8/15/22 → 4/30/27
Project: Research project
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Addressing Alzheimer's Disease and Related Dementias Disparities: The American Indigenous Cognitive Assessment (AMICA) Project
Jacklin, K. (PI), Mantyh, W. (CoI) & Warry, W. (CoI)
NIH NATIONAL INSTITUTE ON AGING
6/1/22 → 5/31/27
Project: Research project
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Detecting synergistic effects of pharmacological and non-pharmacological interventions for AD/ADRD
Li, L. (PI), Mantyh, W. (PI), Wolfson, J. (PI) & Zhang, R. (PI)
NIH NATIONAL INSTITUTE ON AGING
9/1/22 → 5/31/26
Project: Research project
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Linking Connectomics to Biochemical Trajectories of Aging - How the Human Brain Ages Differentially in Key Regions of the Default Mode Network
Hemmy, L. S. (PI), Mangia, S. (PI), McCarten, J. R. (PI), Cayci, Z. (CoI), Mantyh, W. (CoI), Marjanska, M. (CoI) & Michaeli, S. (CoI)
UNIVERSITY OF MISSOURI - COLUMBIA, NATIONAL INSTITUTES OF HEALTH (NIH)
1/19/22 → 7/7/23
Project: Research project
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Bringing Breakthroughs in Alzheimers disease blood-tests and therapies to American Indian communities of Minnesota
Mantyh, W. (PI), Henderson, J. N. (CoI) & Nelson, K. (CoI)
WINSTON & MAXINE WALLIN NEURO DISC FUND
1/1/21 → 12/31/21
Project: Research project
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Blood-based biomarkers and the current landscape of Alzheimer’s disease diagnosis: ethical considerations and practical guidance
Naini, S. M., Mantyh, W. G., Waldron, E. J., Satin, D. J., Basso, M. R., Garland, M., McManimen, S. & Whiteside, D. M., 2026, (Accepted/In press) In: Journal of Clinical and Experimental Neuropsychology.Research output: Contribution to journal › Article › peer-review
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APOE ε4 and Alzheimer's disease risk in Vietnamese populations
Block, A. D., Petersen, A., Hansen, A., Matheson, M., Nguyen, P. A. T., Tran, V. L., Nguyen, B. T., Nguyen, B. T., Nguyen, B. T. T., Tran, H. T., Nguyen, T. A., Pham, T., Hinton, L., Nguyen, H. & Mantyh, W. G., Jan 1 2025, In: Journal of Alzheimer's Disease Reports. 9Research output: Contribution to journal › Article › peer-review
Open Access -
APOE ε4 and ischemic heart disease in American Indian/Indigenous tribal Elders
Labounek, R., Matheson, M. J., Petersen, A. J., Hansen, A., Block, A. D., Strong, C., Hill, A., Kremer, M., Robertson, A. J., Maharaj, V., Lakshminaryan, K., Li, D., Henderson, J. N., Nestrasil, I., Lenglet, C. & Mantyh, W. G., Dec 2025, In: American Heart Journal Plus: Cardiology Research and Practice. 60, 100662.Research output: Contribution to journal › Article › peer-review
Open Access -
Identifying progression subphenotypes of Alzheimer's disease from large-scale electronic health records with machine learning
Zhou, M., Tang, A. S., Zhang, H., Xu, Z., Ke, A. M. C., Su, C., Huang, Y., Mantyh, W. G., Jaffee, M. S., Rankin, K. P., DeKosky, S. T., Zhou, J., Guo, Y., Bian, J., Sirota, M. & Wang, F., May 2025, In: Journal of Biomedical Informatics. 165, 104820.Research output: Contribution to journal › Article › peer-review
Open Access3 Link opens in a new tab Scopus citations -
sTREM2 in discordant CSF Aβ42 and p-tau181
for the Alzheimer's Disease Neuroimaging Initiative, Jan 1 2025, In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 17, 1, e70072.Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Scopus citations