19952020

Research output per year

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Research Output

A comparison of two single-stranded DNA binding models by mutational analysis of APOBEC3G

Shindo, K., Li, M., Gross, P. J., Brown, W. L., Harjes, E., Lu, Y., Matsuo, H. & Harris, R. S., Aug 2 2012, In : Biology. 1, 2, p. 260-276 17 p.

Research output: Contribution to journalArticle

14 Scopus citations

A fluorescent reporter for quantification and enrichment of DNA editing by APOBEC-Cas9 or cleavage by Cas9 in living cells

St Martin, A., Salamango, D., Serebrenik, A., Shaban, N. M., Brown, W. L., Donati, F., Munagala, U., Conticello, S. G. & Harris, R., Aug 21 2018, In : Nucleic acids research. 46, 14, p. e84

Research output: Contribution to journalArticle

Open Access
17 Scopus citations

A lentivirus-based system for Cas9/gRNA expression and subsequent removal by Cre-mediated recombination

Carpenter, M. A., Law, E. K., Serebrenik, A., Brown, W. L. & Harris, R. S., Mar 1 2019, In : Methods. 156, p. 79-84 6 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

A panel of eGFP reporters for single base editing by APOBEC-Cas9 editosome complexes

Martin, A. S., Salamango, D. J., Serebrenik, A. A., Shaban, N. M., Brown, W. L. & Harris, R. S., Dec 1 2019, In : Scientific reports. 9, 1, 497.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

APOBEC3B and AID have similar nuclear import mechanisms

Lackey, L., Demorest, Z. L., Land, A. M., Hultquist, J. F., Brown, W. L. & Harris, R. S., Jun 22 2012, In : Journal of Molecular Biology. 419, 5, p. 301-314 14 p.

Research output: Contribution to journalArticle

50 Scopus citations

APOBEC3B is an enzymatic source of mutation in breast cancer

Burns, M. B., Lackey, L., Carpenter, M. A., Rathore, A., Land, A. M., Leonard, B., Refsland, E. W., Kotandeniya, D., Tretyakova, N., Nikas, J. B., Yee, D., Temiz, N. A., Donohue, D. E., Mcdougle, R. M., Brown, W. L., Law, E. K. & Harris, R. S., Feb 21 2013, In : Nature. 494, 7437, p. 366-370 5 p.

Research output: Contribution to journalArticle

449 Scopus citations

APOBEC3B Nuclear Localization Requires Two Distinct N-Terminal Domain Surfaces

Salamango, D. J., McCann, J. L., Demir, Ö., Brown, W. L., Amaro, R. E. & Harris, R. S., Aug 17 2018, In : Journal of Molecular Biology. 430, 17, p. 2695-2708 14 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

APOBEC3B upregulation and genomic mutation patterns in serous ovarian carcinoma

Leonard, B., Hart, S. N., Burns, M. B., Carpenter, M. A., Temiz, N. A., Rathore, A., Vogel, R. I., Nikas, J. B., Law, E. K., Brown, W. L., Li, Y., Zhang, Y., Maurer, M. J., Oberg, A. L., Cunningham, J. M., Shridhar, V., Bell, D. A., April, C., Bentley, D., Bibikova, M. & 14 others, Cheetham, R. K., Fan, J. B., Grocock, R., Humphray, S., Kingsbury, Z., Peden, J., Chien, J., Swisher, E. M., Hartmann, L. C., Kalli, K. R., Goode, E. L., Sicotte, H., Kaufmann, S. H. & Harris, R. S., Dec 15 2013, In : Cancer Research. 73, 24, p. 7222-7231 10 p.

Research output: Contribution to journalArticle

102 Scopus citations

APOBEC3F properties and hypermutation preferences indicate activity against HIV-1 in vivo

Liddament, M. T., Brown, W. L., Schumacher, A. J. & Harris, R. S., Aug 10 2004, In : Current Biology. 14, 15, p. 1385-1391 7 p.

Research output: Contribution to journalArticle

359 Scopus citations

APOBEC3G expression correlates with T-cell infiltration and improved clinical outcomes in high-grade serous ovarian carcinoma

Leonard, B., Starrett, G. J., Maurer, M. J., Oberg, A. L., Van Bockstal, M., Van Dorpe, J., De Wever, O., Helleman, J., Sieuwerts, A. M., Berns, E. M. J. J., Martens, J. W. M., Anderson, B. D., Brown, W. L., Kalli, K. R., Kaufmann, S. H. & Harris, R. S., Sep 15 2016, In : Clinical Cancer Research. 22, 18, p. 4746-4755 10 p.

Research output: Contribution to journalArticle

Open Access
16 Scopus citations

Apobec3H subcellular localization determinants define zipcode for targeting HIV-1 for restriction

Salamango, D. J., Becker, J. T., McCann, J. L., Cheng, A. Z., Demir, Ö., Amaro, R. E., Brown, W. L., Shaban, N. M. & Harrisa, R. S., Dec 1 2018, In : Molecular and cellular biology. 38, 23, e00356.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

A single amino acid in human APOBEC3F alters susceptibility to HIV-1 Vif

Albin, J. S., LaRue, R. S., Weaver, J. A., Brown, W. L., Shindo, K., Harjes, E., Matsuo, H. & Harris, R. S., Dec 24 2010, In : Journal of Biological Chemistry. 285, 52, p. 40785-40792 8 p.

Research output: Contribution to journalArticle

44 Scopus citations

Catalytic activity of APOBEC3F is required for efficient restriction of Vif-deficient human immunodeficiency virus

Albin, J. S., Brown, W. L. & Harris, R. S., Feb 1 2014, In : Virology. 450-451, p. 49-54 6 p.

Research output: Contribution to journalArticle

17 Scopus citations

Cell-Specific Delivery of Bacteriophage-Encapsidated Ricin a Chain

Wu, M., Brown, W. L. & Stockley, P. G., Jan 1 1995, In : Bioconjugate Chemistry. 6, 5, p. 587-595 9 p.

Research output: Contribution to journalArticle

68 Scopus citations

Delivery of antisense oligonucleotides to leukemia cells by RNA bacteriophage capsids

Wu, M., Sherwin, T., Brown, W. L. & Stockley, P. G., Mar 1 2005, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 1, 1, p. 67-76 10 p.

Research output: Contribution to journalArticle

59 Scopus citations

Development of a novel drug-delivery system using bacteriophage MS2 capsids

Wu, M., Brown, W. L., Hill, H. R. & Stockley, P. G., 1996, In : Biochemical Society transactions. 24, 3, p. 413S

Research output: Contribution to journalArticle

4 Scopus citations

Dynein and star interact in EGFR signaling and ligand trafficking

Iyadurai, S. J. P., Robinson, J. T., Ma, L., He, Y., Mische, S., Li, M. G., Brown, W., Guichard, A., Bier, E. & Hays, T. S., Aug 15 2008, In : Journal of cell science. 121, 16, p. 2643-2651 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Endogenous APOBEC3A DNA cytosine deaminase is cytoplasmic and nongenotoxic

Land, A. M., Law, E. K., Carpenter, M. A., Lackey, L., Brown, W. L. & Harris, R. S., Jun 14 2013, In : Journal of Biological Chemistry. 288, 24, p. 17253-17260 8 p.

Research output: Contribution to journalArticle

44 Scopus citations

Epstein–Barr virus BORF2 inhibits cellular APOBEC3B to preserve viral genome integrity

Cheng, A. Z., Yockteng-Melgar, J., Jarvis, M. C., Malik-Soni, N., Borozan, I., Carpenter, M. A., McCann, J. L., Ebrahimi, D., Shaban, N. M., Marcon, E., Greenblatt, J., Brown, W. L., Frappier, L. & Harris, R., Jan 1 2019, In : Nature Microbiology. 4, 1, p. 78-88 11 p.

Research output: Contribution to journalLetter

Open Access
21 Scopus citations

Erratum: APOBEC3B is an enzymatic source of mutation in breast cancer (Nature (2013) 494 (366-370) DOI: 10.1038/nature11881)

Burns, M. B., Lackey, L., Carpenter, M. A., Rathore, A., Land, A. M., Leonard, B., Refsland, E. W., Kotandeniya, D., Tretyakova, N., Nikas, J. B., Yee, D., Temiz, N. A., Donohue, D. E., McDougle, R. M., Brown, W. L., Law, E. K. & Harris, R. S., Nov 7 2013, In : Nature. 502, 7472, 1 p.

Research output: Contribution to journalComment/debate

First-in-class small molecule inhibitors of the single-strand DNA cytosine deaminase APOBEC3G

Li, M., Shandilya, S. M. D., Carpenter, M. A., Rathore, A., Brown, W. L., Perkins, A. L., Harki, D. A., Solberg, J., Hook, D. J., Pandey, K. K., Parniak, M. A., Johnson, J. R., Krogan, N. J., Somasundaran, M., Ali, A., Schiffer, C. A. & Harris, R. S., Mar 16 2012, In : ACS Chemical Biology. 7, 3, p. 506-517 12 p.

Research output: Contribution to journalArticle

77 Scopus citations

Genetic and mechanistic basis for APOBEC3H alternative splicing, retrovirus restriction, and counteraction by HIV-1 protease

Ebrahimi, D., Richards, C. M., Carpenter, M. A., Wang, J., Ikeda, T., Becker, J. T., Cheng, A. Z., McCann, J. L., Shaban, N. M., Salamango, D. J., Starrett, G. J., Lingappa, J. R., Yong, J., Brown, W. L. & Harris, R. S., Dec 1 2018, In : Nature communications. 9, 1, 4137.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

HIV-1 restriction by endogenous APOBEC3G in the myeloid cell line THP-1

Ikeda, T., Molan, A. M., Jarvis, M. C., Carpenter, M. A., Salamango, D. J., Brown, W. L. & Harris, R., Jul 2019, In : Journal of General Virology. 100, 7, p. 1140-1152 13 p., 001276.

Research output: Contribution to journalArticle

2 Scopus citations

HIV-1 Vif Triggers Cell Cycle Arrest by Degrading Cellular PPP2R5 Phospho-regulators

Salamango, D. J., Ikeda, T., Moghadasi, S. A., Wang, J., McCann, J. L., Serebrenik, A. A., Ebrahimi, D., Jarvis, M. C., Brown, W. L. & Harris, R. S., Oct 29 2019, In : Cell reports. 29, 5, p. 1057-1065.e4

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-Deficient HIV-1

Hultquist, J. F., Lengyel, J. A., Refsland, E. W., LaRue, R. S., Lackey, L., Brown, W. L. & Harris, R., Nov 2011, In : Journal of virology. 85, 21, p. 11220-11234 15 p.

Research output: Contribution to journalArticle

216 Scopus citations

Human immunodeficiency virus type 1 cDNAs produced in the presence of APOBEC3G exhibit defects in plus-strand DNA transfer and integration

Mbisa, J. L., Barr, R., Thomas, J. A., Vandegraaff, N., Dorweiler, I. J., Svarovskaia, E. S., Brown, W. L., Mansky, L. M., Gorelick, R. J., Harris, R. S., Engelman, A. & Pathak, V. K., Jul 2007, In : Journal of virology. 81, 13, p. 7099-7110 12 p.

Research output: Contribution to journalArticle

220 Scopus citations

Lineage-Specific Viral Hijacking of Non-canonical E3Ubiquitin Ligase Cofactors in the Evolution of Vif Anti-APOBEC3 Activity

Kane, J. R., Stanley, D. J., Hultquist, J. F., Johnson, J. R., Mietrach, N., Binning, J. M., Jónsson, S. R., Barelier, S., Newton, B. W., Johnson, T. L., Franks-Skiba, K. E., Li, M., Brown, W. L., Gunnarsson, H. I., Adalbjornsdóttir, A., Fraser, J. S., Harris, R. S., Andrésdóttir, V., Gross, J. D. & Krogan, N. J., May 26 2015, In : Cell reports. 11, 8, p. 1236-1250 15 p.

Research output: Contribution to journalArticle

32 Scopus citations

Long-term restriction by APOBEC3F selects human immunodeficiency virus type 1 variants with restored vif function

Albin, J. S., Haché, G., Hultquist, J. F., Brown, W. L. & Harris, R. S., Oct 2010, In : Journal of virology. 84, 19, p. 10209-10219 11 p.

Research output: Contribution to journalArticle

38 Scopus citations

MagnEdit-interacting factors that recruit DNA-editing enzymes to single base targets

McCann, J. L., Salamango, D., Law, E. K., Brown, W. L. & Harris, R. S., Feb 24 2020, In : Life science alliance. 3, 4, LSA.201900606.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Methylcytosine and normal cytosine deamination by the foreign DNA restriction enzyme APOBEC3A

Carpenter, M. A., Li, M., Rathore, A., Lackey, L., Law, E. K., Land, A. M., Leonard, B., Shandilya, S. M. D., Bohn, M. F., Schiffer, C. A., Brown, W. L. & Harris, R. S., Oct 5 2012, In : Journal of Biological Chemistry. 287, 41, p. 34801-34808 8 p.

Research output: Contribution to journalArticle

80 Scopus citations

Natural APOBEC3C variants can elicit differential HIV-1 restriction activity

Anderson, B. D., Ikeda, T., Moghadasi, S. A., Martin, A. S., Brown, W. L. & Harris, R. S., Dec 17 2018, In : Retrovirology. 15, 1, 78.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Natural Polymorphisms in Human APOBEC3H and HIV-1 Vif Combine in Primary T Lymphocytes to Affect Viral G-to-A Mutation Levels and Infectivity

Refsland, E. W., Hultquist, J. F., Luengas, E. M., Ikeda, T., Shaban, N. M., Law, E. K., Brown, W. L., Reilly, C., Emerman, M. & Harris, R. S., Nov 1 2014, In : PLoS genetics. 10, 11

Research output: Contribution to journalArticle

55 Scopus citations

Quantitative profiling of the full APOBEC3 mRNA repertoire in lymphocytes and tissues: Implications for HIV-1 restriction

Refsland, E. W., Stenglein, M. D., Shindo, K., Albin, J. S., Brown, W. L. & Harris, R. S., Mar 20 2010, In : Nucleic acids research. 38, 13, p. 4274-4284 11 p., gkq174.

Research output: Contribution to journalArticle

233 Scopus citations

RNA bacteriophage capsid-mediated drug delivery and epitope presentation

Brown, W. L., Mastico, R. A., Wu, M., Heal, K. G., Adams, C. J., Murray, J. B., Simpson, J. C., Lord, J. M., Taylor-Robinson, A. W. & Stockley, P. G., Dec 1 2002, In : Intervirology. 45, 4-6, p. 371-380 10 p.

Research output: Contribution to journalArticle

69 Scopus citations

Simian immunodeficiency virus Vif and human APOBEC3B interactions resemble those between HIV-1 Vif and human APOBEC3G

Wang, J., Shaban, N. M., Land, A. M., Brown, W. L. & Harris, R. S., Jun 1 2018, In : Journal of virology. 92, 12, e00447-18.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Subcellular localization of the APOBEC3 proteins during mitosis and implications for genomic DNA deamination

Lackey, L., Law, E. K., Brown, W. L. & Harris, R., Mar 1 2013, In : Cell Cycle. 12, 5, p. 762-772 11 p.

Research output: Contribution to journalArticle

70 Scopus citations

The Antiviral and Cancer Genomic DNA Deaminase APOBEC3H Is Regulated by an RNA-Mediated Dimerization Mechanism

Shaban, N. M., Shi, K., Lauer, K. V., Carpenter, M. A., Richards, C. M., Salamango, D., Wang, J., Lopresti, M. W., Banerjee, S., Levin-Klein, R., Brown, W. L., Aihara, H. & Harris, R. S., Jan 4 2018, In : Molecular Cell. 69, 1, p. 75-86.e9

Research output: Contribution to journalArticle

Open Access
26 Scopus citations

The deaminase APOBEC3B triggers the death of cells lacking uracil DNA glycosylase

Serebrenik, A. A., Starrett, G. J., Leenen, S., Jarvis, M. C., Shaban, N. M., Salamango, D. J., Nilsen, H., Brown, W. L. & Harris, R. S., Oct 29 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 44, p. 22158-22163 6 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

The DNA Cytosine Deaminase APOBEC3B is a Molecular Determinant of Platinum Responsiveness in Clear Cell Ovarian Cancer

Serebrenik, A. A., Argyris, P. P., Jarvis, M. C., Brown, W. L., Bazzaro, M., Vogel, R. I., Erickson, B. K., Lee, S. H., Goergen, K. M., Maurer, M. J., Heinzen, E. P., Oberg, A. L., Huang, Y., Hou, X., Weroha, S. J., Kaufmann, S. H. & Harris, R. S., Jul 1 2020, In : Clinical cancer research : an official journal of the American Association for Cancer Research. 26, 13, p. 3397-3407 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

The DNA deaminase activity of human APOBEC3G is required for Ty1, MusD, and human immunodeficiency virus type 1 restriction

Schumacher, A. J., Haché, G., MacDuff, D. A., Brown, W. L. & Harris, R. S., Mar 2008, In : Journal of virology. 82, 6, p. 2652-2660 9 p.

Research output: Contribution to journalArticle

130 Scopus citations

The DNA deaminase APOBEC3B interacts with the cell-cycle protein CDK4 and disrupts CDK4-mediated nuclear import of cyclin D1

McCann, J. L., Klein, M. M., Leland, E. M., Law, E. K., Brown, W. L., Salamango, D. J. & Harris, R., Aug 9 2019, In : Journal of Biological Chemistry. 294, 32, p. 12099-12111 13 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

The interaction between AID and CIB1 is nonessential for antibody gene diversification by gene conversion or class switch recombination

Demorest, Z. L., Macduff, D. A., Brown, W. L., Morham, S. G., Parise, L. V. & Harris, R. S., 2010, In : PloS one. 5, 7, e11660.

Research output: Contribution to journalArticle

8 Scopus citations

The local dinucleotide preference of APOBEC3G can be altered from 5′-CC to 5′-TC by a single amino acid substitution

Rathore, A., Carpenter, M. A., Demir, Ö., Ikeda, T., Li, M., Shaban, N. M., Law, E. K., Anokhin, D., Brown, W. L., Amaro, R. E. & Harris, R. S., Nov 15 2013, In : Journal of Molecular Biology. 425, 22, p. 4442-4454 13 p.

Research output: Contribution to journalArticle

50 Scopus citations

The PKC/NF-κB signaling pathway induces APOBEC3B expression in multiple human cancers

Leonard, B., McCann, J. L., Starrett, G. J., Kosyakovsky, L., Luengas, E. M., Molan, A. M., Burns, M. B., McDougle, R. M., Parker, P. J., Brown, W. L. & Harris, R. S., Nov 1 2015, In : Cancer Research. 75, 21, p. 4538-4547 10 p.

Research output: Contribution to journalArticle

62 Scopus citations