William C Pomerantz

20022022
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Research Output 2002 2019

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2019
1 Citation (Scopus)

Selectivity, ligand deconstruction, and cellular activity analysis of a BPTF bromodomain inhibitor

Kirberger, S. E., Ycas, P. D., Johnson, J. A., Chen, C., Ciccone, M. F., Woo, R. W. L., Urick, A. K., Zahid, H., Shi, K., Aihara, H., McAllister, S. D., Kashani-Sabet, M., Shi, J., Dickson, A., Dos Santos, C. O. & Pomerantz, W. C. K., Jan 1 2019, In : Organic and Biomolecular Chemistry. 17, 7, p. 2020-2027 8 p.

Research output: Contribution to journalArticle

inhibitors
selectivity
Ligands
ligands
proteins

Systematically Mitigating the p38α Activity of Triazole-based BET Inhibitors

Carlson, A. S., Cui, H., Divakaran, A., Johnson, J. A., Brunner, R. M., Pomerantz, W. C. & Topczewski, J. J., Sep 12 2019, In : ACS Medicinal Chemistry Letters. 10, 9, p. 1296-1301 6 p.

Research output: Contribution to journalArticle

Triazoles
Phosphotransferases
Lysine
Polypharmacology
Proteins
2018
1 Citation (Scopus)

Design, Synthesis, and Characterization of a Fluorescence Polarization Pan-BET Bromodomain Probe

Paulson, C. N., Guan, X., Ayoub, A. M., Chan, A., Karim, R. M., Pomerantz, W. C., Schönbrunn, E., Georg, G. & Hawkinson, J. E., Dec 13 2018, In : ACS Medicinal Chemistry Letters. 9, 12, p. 1223-1229 7 p.

Research output: Contribution to journalArticle

Fluorescence Polarization
Assays
Screening
Fluorescence
Polarization
3 Citations (Scopus)

Dual Labeling of the CBP/p300 KIX Domain for 19F NMR Leads to Identification of a New Small-Molecule Binding Site

Gee, C. T., Arntson, K. E., Koleski, E. J., Staebell, R. L. & Pomerantz, W. C., May 4 2018, In : ChemBioChem. 19, 9, p. 963-969 7 p.

Research output: Contribution to journalArticle

Labeling
Binding Sites
Nuclear magnetic resonance
Ligands
Molecules
6 Citations (Scopus)

Molecular Basis for the N-Terminal Bromodomain-and-Extra-Terminal-Family Selectivity of a Dual Kinase-Bromodomain Inhibitor

Divakaran, A., Talluri, S. K., Ayoub, A. M., Mishra, N. K., Cui, H., Widen, J. C., Berndt, N., Zhu, J. Y., Carlson, A. S., Topczewski, J. J., Schonbrunn, E. K., Harki, D. A. & Pomerantz, W. C., Oct 25 2018, In : Journal of Medicinal Chemistry. 61, 20, p. 9316-9334 19 p.

Research output: Contribution to journalArticle

Lysine
Phosphotransferases
Post Translational Protein Processing
Interleukin-8
Epigenomics
2017
18 Citations (Scopus)

BET Bromodomain Inhibitors with One-Step Synthesis Discovered from Virtual Screen

Ayoub, A. M., Hawk, L. M. L., Herzig, R. J., Jiang, J., Wisniewski, A. J., Gee, C. T., Zhao, P., Zhu, J. Y., Berndt, N., Offei-Addo, N. K., Scott, T. G., Qi, J., Bradner, J. E., Ward, T. R., Schönbrunn, E., Georg, G. I. & Pomerantz, W. C. K., Jun 22 2017, In : Journal of Medicinal Chemistry. 60, 12, p. 4805-4817 13 p.

Research output: Contribution to journalArticle

Open Access
Ligands
Fluorescence Polarization
Uracil
Structure-Activity Relationship
Contraception
12 Citations (Scopus)

BPTF Maintains Chromatin Accessibility and the Self-Renewal Capacity of Mammary Gland Stem Cells

Frey, W. D., Chaudhry, A., Slepicka, P. F., Ouellette, A. M., Kirberger, S. E., Pomerantz, W. C., Hannon, G. J. & dos Santos, C. O., Jul 11 2017, In : Stem Cell Reports. 9, 1, p. 23-31 9 p.

Research output: Contribution to journalArticle

Human Mammary Glands
Stem cells
Chromatin
Breast
Stem Cells
1 Citation (Scopus)

Meeting Proceedings ICBS2016 - Translating the Power of Chemical Biology to Clinical Advances

Kuriki, Y., Komatsu, T., Ycas, P. D., Coulup, S. K., Carlson, E. J. & Pomerantz, W. C., Apr 21 2017, In : ACS Chemical Biology. 12, 4, p. 869-877 9 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Oxygen Sensing with Perfluorocarbon-Loaded Ultraporous Mesostructured Silica Nanoparticles

Lee, A. L., Gee, C. T., Weegman, B. P., Einstein, S. A., Juelfs, A. R., Ring, H. L., Hurley, K. R., Egger, S. M., Swindlehurst, G., Garwood, M., Pomerantz, W. C. K. & Haynes, C. L., Jun 27 2017, In : ACS Nano. 11, 6, p. 5623-5632 10 p.

Research output: Contribution to journalArticle

Open Access
Fluorocarbons
Silicon Dioxide
Silica
Oxygen
Nanoparticles
13 Citations (Scopus)

Quantifying Protein Concentrations Using Smartphone Colorimetry: A New Method for an Established Test

Gee, C. T., Kehoe, E., Pomerantz, W. C. & Penn, L., Jul 11 2017, In : Journal of Chemical Education. 94, 7, p. 941-945 5 p.

Research output: Contribution to journalArticle

Colorimetry
Smartphones
laboratory experiment
experiment
Biuret
5 Citations (Scopus)

Specific Acetylation Patterns of H2A.Z Form Transient Interactions with the BPTF Bromodomain

Perell, G. T., Mishra, N. K., Sudhamalla, B., Ycas, P. D., Islam, K. & Pomerantz, W. C. K., Sep 5 2017, In : Biochemistry. 56, 35, p. 4607-4615 9 p.

Research output: Contribution to journalArticle

Open Access
Acetylation
Lysine
Transcription Factors
Histones
Transcription
11 Citations (Scopus)

Synthesis of Intrinsically Disordered Fluorinated Peptides for Modular Design of High-Signal 19 F MRI Agents

Kirberger, S. E., Maltseva, S. D., Manulik, J. C., Einstein, S. A., Weegman, B. P., Garwood, M. & Pomerantz, W. C. K., Jan 1 2017, In : Angewandte Chemie - International Edition. 56, 23, p. 6440-6444 5 p.

Research output: Contribution to journalArticle

Open Access
Magnetic resonance imaging
Peptides
Molecular imaging
Imaging techniques
Fluorine
8 Citations (Scopus)

Tuning Sulfur Oxidation States on Thioether-Bridged Peptide Macrocycles for Modulation of Protein Interactions

Perell, G. T., Staebell, R. L., Hairani, M., Cembran, A. & Pomerantz, W. C., Sep 19 2017, In : ChemBioChem. 18, 18, p. 1836-1844 9 p.

Research output: Contribution to journalArticle

Sulfides
Sulfur
Myeloid-Lymphoid Leukemia Protein
Tuning
Modulation
2016
27 Citations (Scopus)

Oxidation increases the strength of the methionine-aromatic interaction

Lewis, A. K., Dunleavy, K. M., Senkow, T. L., Her, C., Horn, B. T., Jersett, M. A., Mahling, R., McCarthy, M. R., Perell, G. T., Valley, C. C., Karim, C. B., Gao, J., Pomerantz, W. C. K., Thomas, D. D., Cembran, A., Hinderliter, A. & Sachs, J. N., Oct 1 2016, In : Nature Chemical Biology. 12, 10, p. 860-866 7 p.

Research output: Contribution to journalArticle

Methionine
Proteins
Databases
Lymphotoxin-alpha
Protein Folding
6 Citations (Scopus)

Paramagnetic relaxation enhancement for protein-observed 19F NMR as an enabling approach for efficient fragment screening

Hawk, L., Gee, C. T., Urick, A. K., Hu, H. & Pomerantz, W. C., Jan 1 2016, In : RSC Advances. 6, 98, p. 95715-95721 7 p.

Research output: Contribution to journalArticle

Screening
Ligands
Nuclear magnetic resonance
Proteins
Relaxation time
10 Citations (Scopus)

Prediction of 19F NMR chemical shifts in labeled proteins: Computational protocol and case study

Isley, W. C., Urick, A. K., Pomerantz, W. C. & Cramer, C., Jul 5 2016, In : Molecular Pharmaceutics. 13, 7, p. 2376-2386 11 p.

Research output: Contribution to journalArticle

Proteins
Drug Design
Epigenomics
Molecular Weight
Ligands
34 Citations (Scopus)

Protein-observed 19F-NMR for fragment screening, affinity quantification and druggability assessment

Gee, C. T., Arntson, K. E., Urick, A. K., Mishra, N. K., Hawk, L., Wisniewski, A. J. & Pomerantz, W. C., Aug 1 2016, In : Nature Protocols. 11, 8, p. 1414-1427 14 p.

Research output: Contribution to journalArticle

Screening
Nuclear magnetic resonance
Proteins
Molecules
CREB-Binding Protein
17 Citations (Scopus)

Protein-observed fluorine NMR is a complementary ligand discovery method to 1 H CPMG ligand-observed NMR

Urick, A. K., Calle, L. P., Espinosa, J. F., Hu, H. & Pomerantz, W. C. K., Nov 18 2016, In : ACS Chemical Biology. 11, 11, p. 3154-3164 11 p.

Research output: Contribution to journalArticle

Fluorine
Nuclear magnetic resonance
Ligands
Proteins
Chemical shift
2015
38 Citations (Scopus)

Dual Screening of BPTF and Brd4 Using Protein-Observed Fluorine NMR Uncovers New Bromodomain Probe Molecules

Urick, A. K., Hawk, L. M. L., Cassel, M. K., Mishra, N. K., Liu, S., Adhikari, N., Zhang, W., Dos Santos, C. O., Hall, J. L. & Pomerantz, W. C. K., Oct 16 2015, In : ACS Chemical Biology. 10, 10, p. 2246-2256 11 p.

Research output: Contribution to journalArticle

Fluorine
Screening
Nuclear magnetic resonance
Molecules
Proteins
31 Citations (Scopus)

Fragment screening and druggability assessment for the CBP/p300 KIX domain through protein-observed 19F NMR spectroscopy

Gee, C. T., Koleski, E. J. & Pomerantz, W. C., Mar 16 2015, In : Angewandte Chemie - International Edition. 54, 12, p. 3735-3739 5 p.

Research output: Contribution to journalArticle

CREB-Binding Protein
Nuclear magnetic resonance spectroscopy
Screening
Proteins
Molecules
2014
39 Citations (Scopus)

Fluorinated aromatic amino acids are sensitive 19 f NMR probes for bromodomain-ligand interactions

Mishra, N. K., Urick, A. K., Ember, S. W. J., Schonbrunn, E. & Pomerantz, W. C., Dec 19 2014, In : ACS Chemical Biology. 9, 12, p. 2755-2760 6 p.

Research output: Contribution to journalArticle

Aromatic Amino Acids
Nuclear magnetic resonance
Ligands
Fluorine
Calorimetry
21 Citations (Scopus)

FP tethering: A screening technique to rapidly identify compounds that disrupt protein-protein interactions

Lodge, J. M., Justin Rettenmaier, T., Wells, J. A., Pomerantz, W. C. & Mapp, A. K., Jan 1 2014, In : MedChemComm. 5, 3, p. 370-375 6 p.

Research output: Contribution to journalArticle

Fluorescence Polarization
Disulfides
Screening
Fluorescence
Polarization
2013
37 Citations (Scopus)

Ordering a dynamic protein Via a small-molecule stabilizer

Wang, N., Majmudar, C. Y., Pomerantz, W. C., Gagnon, J. K., Sadowsky, J. D., Meagher, J. L., Johnson, T. K., Stuckey, J. A., Brooks, C. L., Wells, J. A. & Mapp, A. K., Mar 6 2013, In : Journal of the American Chemical Society. 135, 9, p. 3363-3366 4 p.

Research output: Contribution to journalArticle

p300-CBP Transcription Factors
Molecular Dynamics Simulation
Binding Sites
Ligands
Proteins
2012
35 Citations (Scopus)

Profiling the dynamic interfaces of fluorinated transcription complexes for ligand discovery and characterization

Pomerantz, W. C., Wang, N., Lipinski, A. K., Wang, R., Cierpicki, T. & Mapp, A. K., Aug 17 2012, In : ACS Chemical Biology. 7, 8, p. 1345-1350 6 p.

Research output: Contribution to journalArticle

Transcription
Ligands
Aromatic Amino Acids
p300-CBP Transcription Factors
Proteins
36 Citations (Scopus)

Sekikaic acid and lobaric acid target a dynamic interface of the coactivator CBP/p300

Majmudar, C. Y., Højfeldt, J. W., Arevang, C. J., Pomerantz, W. C., Gagnon, J. K., Schultz, P. J., Cesa, L. C., Doss, C. H., Rowe, S. P., Vásquez, V., Tamayo-Castillo, G., Cierpicki, T., Brooks, C. L., Sherman, D. H. & Mapp, A. K., Nov 5 2012, In : Angewandte Chemie - International Edition. 51, 45, p. 11258-11262 5 p.

Research output: Contribution to journalArticle

p300-CBP Transcription Factors
Biological Products
Throughput
Molecules
Acids
2011
20 Citations (Scopus)

Lyotropic liquid crystalline phases from helical β-peptides as alignment media

Thiele, C. M., Pomerantz, W. C., Abbott, N. L. & Gellman, S. H., Jan 7 2011, In : Chemical Communications. 47, 1, p. 502-504 3 p.

Research output: Contribution to journalArticle

Peptides
Crystalline materials
Liquids
Chain length
Water
37 Citations (Scopus)

Lyotropic liquid crystals formed from ACHC-Rich β-peptides

Pomerantz, W. C., Yuwono, V. M., Drake, R., Hartgerink, J. D., Abbott, N. L. & Gellman, S. H., Aug 31 2011, In : Journal of the American Chemical Society. 133, 34, p. 13604-13613 10 p.

Research output: Contribution to journalArticle

Liquid Crystals
Liquid crystals
Peptides
Nanofibers
Acids
14 Citations (Scopus)

Transcriptional tools: Small molecules for modulating CBP KIX-dependent transcriptional activators

Bates, C. A., Pomerantz, W. C. & Mapp, A. K., Jan 1 2011, In : Biopolymers. 95, 1, p. 17-23 7 p.

Research output: Contribution to journalArticle

CREB-Binding Protein
Transcription
Transcriptional Activation
Molecules
Pathologic Processes
2009
109 Citations (Scopus)

A rationally designed aldolase foldamer

Müller, M. M., Windsor, M. A., Pomerantz, W. C., Gellman, S. H. & Hilvert, D., Jan 19 2009, In : Angewandte Chemie - International Edition. 48, 5, p. 922-925 4 p.

Research output: Contribution to journalArticle

Fructose-Bisphosphate Aldolase
Imines
Ammonium Compounds
Peptides
Enzymes
60 Citations (Scopus)

Effect of sequence and structural properties on 14-helical β-peptide activity against Candida albicans planktonic cells and biofilms

Karlsson, A. J., Pomerantz, W. C., Neilsen, K. J., Gellman, S. H. & Palecek, S. P., Jul 17 2009, In : ACS Chemical Biology. 4, 7, p. 567-579 13 p.

Research output: Contribution to journalArticle

Candida
Biofilms
Candida albicans
Structural properties
Peptides
6 Citations (Scopus)

In situ monitoring of backbone thioester exchange by 19F NMR

Pomerantz, W. C., Hadley, E. B., Fry, C. G. & Gellman, S. H., Sep 4 2009, In : ChemBioChem. 10, 13, p. 2177-2181 5 p.

Research output: Contribution to journalArticle

Molecular Sequence Data
Magnetic resonance spectroscopy
Protein folding
Fluorine
Protein Folding
16 Citations (Scopus)

Preclinical development of a bifunctional cancer cell homing, PKCε inhibitory peptide for the treatment of head and neck cancer

Bao, L., Gorin, M. A., Zhang, M., Ventura, A. C., Pomerantz, W. C., Merajver, S. D., Teknos, T. N., Mapp, A. K. & Pan, Q., Jul 15 2009, In : Cancer Research. 69, 14, p. 5829-5834 6 p.

Research output: Contribution to journalArticle

Head and Neck Neoplasms
Protein Kinase C
Peptides
Neoplasms
Therapeutics
2008
31 Citations (Scopus)

Characterization of nanofibers formed by self-assembly of Β-peptide oligomers using small angle x-ray scattering

Pizzey, C. L., Pomerantz, W. C., Sung, B. J., Yuwono, V. M., Gellman, S. H., Hartgerink, J. D., Yethiraj, A. & Abbott, N. L., Sep 15 2008, In : Journal of Chemical Physics. 129, 9, 095103.

Research output: Contribution to journalArticle

x ray scattering
Nanofibers
oligomers
Oligomers
Self assembly
33 Citations (Scopus)

Comparison of design strategies for promotion of β-peptide 14-helix stability in water

Vaz, E., Pomerantz, W. C., Geyer, M., Gellman, S. H. & Brunsveld, L., Sep 22 2008, In : ChemBioChem. 9, 14, p. 2254-2259 6 p.

Research output: Contribution to journalArticle

Peptides
Water
Cyclization
Ionic strength
Osmolar Concentration
25 Citations (Scopus)

Distinctive circular dichroism signature for 14-helix-bundle formation by ß-peptides

Pomerantz, W. C., Grygiel, T. L. R., Lai, J. R. & Gellman, S. H., May 1 2008, In : Organic Letters. 10, 9, p. 1799-1802 4 p.

Research output: Contribution to journalArticle

Dichroism
Circular Dichroism
helices
dichroism
bundles
68 Citations (Scopus)

Nanofibers and lyotropic liquid crystals from a class of self-assembling β-peptides

Pomerantz, W. C., Yuwono, V. M., Pizzey, C. L., Hartgerink, J. D., Abbott, N. L. & Gellman, S. H., Feb 1 2008, In : Angewandte Chemie - International Edition. 47, 7, p. 1241-1244 4 p.

Research output: Contribution to journalArticle

Liquid Crystals
Nanofibers
Liquid crystals
Peptides
Transmission electron microscopy
2007
36 Citations (Scopus)

Origins of the high 14-helix propensity of cyclohexyl-rigidified residues in β-peptides

Lee, M. R., Raguse, T. L., Schinnerl, M., Pomerantz, W. C., Wang, X., Wipf, P. & Gellman, S. H., Apr 26 2007, In : Organic Letters. 9, 9, p. 1801-1804 4 p.

Research output: Contribution to journalArticle

Hydrophobic and Hydrophilic Interactions
helices
peptides
Peptides
rings
53 Citations (Scopus)

Practical synthesis of enantiomerically pure β2-amino acids via proline-catalyzed diastereoselective aminomethylation of aldehydes

Chi, Y., English, E. P., Pomerantz, W. C., Horne, W. S., Joyce, L. A., Alexander, L. R., Fleming, W. S., Hopkins, E. A. & Gellman, S. H., May 9 2007, In : Journal of the American Chemical Society. 129, 18, p. 6050-6055 6 p.

Research output: Contribution to journalArticle

Aldehydes
Proline
Amino alcohols
Amino Alcohols
Amino acids
22 Citations (Scopus)

Sequence dependent behavior of amphiphilic β-peptides on gold surfaces

Pomerantz, W. C., Cadwell, K. D., Hsu, Y. J., Gellman, S. H. & Abbott, N. L., Sep 4 2007, In : Chemistry of Materials. 19, 18, p. 4436-4441 6 p.

Research output: Contribution to journalArticle

Gold
Peptides
Self assembled monolayers
Sulfhydryl Compounds
Isomers
2006
117 Citations (Scopus)

Antifungal activity from 14-helical β-peptides

Karlsson, A. J., Pomerantz, W. C., Weisblum, B., Gellman, S. H. & Palecek, S. P., Oct 4 2006, In : Journal of the American Chemical Society. 128, 39, p. 12630-12631 2 p.

Research output: Contribution to journalArticle

Peptides
Candida albicans
Cells
Candida
Pathogens
61 Citations (Scopus)

Lyotropic liquid crystals from designed helical β-peptides

Pomerantz, W. C., Abbott, N. L. & Gellman, S. H., Jul 12 2006, In : Journal of the American Chemical Society. 128, 27, p. 8730-8731 2 p.

Research output: Contribution to journalArticle

Liquid Crystals
Liquid crystals
Peptides
Crystalline materials
Liquids
2005
88 Citations (Scopus)

Donor-substituted cyanoethynylethenes: π-conjugation and band-gap tuning in strong charge-transfer chromophores

Moonen, N. N. P., Pomerantz, W. C., Gist, R., Boudon, C., Gisselbrecht, J. P., Kawai, T., Kishioka, A., Gross, M., Irie, M. & Diederich, F., May 20 2005, In : Chemistry - A European Journal. 11, 11, p. 3325-3341 17 p.

Research output: Contribution to journalArticle

Chromophores
Charge transfer
Energy gap
Tuning
Electrochemistry
2002
2 Citations (Scopus)

Comparing isotope effects and rates for the methanolic sodium methoxide reactions of 9-r-fluorene to those for p-CF3C6H4CHClR (R = CH2Cl, CH2F and CF3)

Koch, H. F., Pomerantz, W. C., Ruggles, E. L., Van Laren, M. & Van Roon, A. M., Oct 1 2002, In : Collection of Czechoslovak Chemical Communications. 67, 10, p. 1505-1516 12 p.

Research output: Contribution to journalArticle

Isotopes
Methanol
Chemical activation
Ion exchange
Entropy