William C Pomerantz

20022020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

Filter
Article
2020

2-Fluorotyrosine is a valuable but understudied amino acid for protein-observed 19F NMR

Ycas, P. D., Wagner, N., Olsen, N. M., Fu, R. & Pomerantz, W. C. K., Jan 1 2020, In : Journal of biomolecular NMR. 74, 1, p. 61-69 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Multidimensional Nanoparticle Characterization through Ion Mobility-Mass Spectrometry

Li, C., Lee, A. L., Chen, X., Pomerantz, W. C. K., Haynes, C. L. & Hogan, C. J., Feb 4 2020, In : Analytical chemistry. 92, 3, p. 2503-2510 8 p.

Research output: Contribution to journalArticle

1 Scopus citations
2019

Evaluating the Advantages of Using 3D-Enriched Fragments for Targeting BET Bromodomains

Johnson, J. A., Nicolaou, C. A., Kirberger, S. E., Pandey, A. K., Hu, H. & Pomerantz, W. C. K., Dec 12 2019, In : ACS Medicinal Chemistry Letters. 10, 12, p. 1648-1654 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

SAR by (Protein-Observed) 19F NMR

Divakaran, A., Kirberger, S. E. & Pomerantz, W. C. K., Dec 17 2019, In : Accounts of Chemical Research. 52, 12, p. 3407-3418 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

Selectivity, ligand deconstruction, and cellular activity analysis of a BPTF bromodomain inhibitor

Kirberger, S. E., Ycas, P. D., Johnson, J. A., Chen, C., Ciccone, M. F., Woo, R. W. L., Urick, A. K., Zahid, H., Shi, K., Aihara, H., McAllister, S. D., Kashani-Sabet, M., Shi, J., Dickson, A., Dos Santos, C. O. & Pomerantz, W. C. K., Jan 1 2019, In : Organic and Biomolecular Chemistry. 17, 7, p. 2020-2027 8 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Systematically Mitigating the p38α Activity of Triazole-based BET Inhibitors

Carlson, A. S., Cui, H., Divakaran, A., Johnson, J. A., Brunner, R. M., Pomerantz, W. C. K. & Topczewski, J. J., Sep 12 2019, In : ACS Medicinal Chemistry Letters. 10, 9, p. 1296-1301 6 p.

Research output: Contribution to journalArticle

2 Scopus citations
2018

Design, Synthesis, and Characterization of a Fluorescence Polarization Pan-BET Bromodomain Probe

Paulson, C. N., Guan, X., Ayoub, A. M., Chan, A., Karim, R. M., Pomerantz, W. C. K., Schönbrunn, E., Georg, G. I. & Hawkinson, J. E., Dec 13 2018, In : ACS Medicinal Chemistry Letters. 9, 12, p. 1223-1229 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Dual Labeling of the CBP/p300 KIX Domain for 19F NMR Leads to Identification of a New Small-Molecule Binding Site

Gee, C. T., Arntson, K. E., Koleski, E. J., Staebell, R. L. & Pomerantz, W. C., May 4 2018, In : ChemBioChem. 19, 9, p. 963-969 7 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Molecular Basis for the N-Terminal Bromodomain-and-Extra-Terminal-Family Selectivity of a Dual Kinase-Bromodomain Inhibitor

Divakaran, A., Talluri, S. K., Ayoub, A. M., Mishra, N. K., Cui, H., Widen, J. C., Berndt, N., Zhu, J. Y., Carlson, A. S., Topczewski, J. J., Schonbrunn, E. K., Harki, D. A. & Pomerantz, W. C. K., Oct 25 2018, In : Journal of medicinal chemistry. 61, 20, p. 9316-9334 19 p.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations
2017

BET Bromodomain Inhibitors with One-Step Synthesis Discovered from Virtual Screen

Ayoub, A. M., Hawk, L. M. L., Herzig, R. J., Jiang, J., Wisniewski, A. J., Gee, C. T., Zhao, P., Zhu, J. Y., Berndt, N., Offei-Addo, N. K., Scott, T. G., Qi, J., Bradner, J. E., Ward, T. R., Schönbrunn, E., Georg, G. I. & Pomerantz, W. C. K., Jun 22 2017, In : Journal of medicinal chemistry. 60, 12, p. 4805-4817 13 p.

Research output: Contribution to journalArticle

Open Access
19 Scopus citations

BPTF Maintains Chromatin Accessibility and the Self-Renewal Capacity of Mammary Gland Stem Cells

Frey, W. D., Chaudhry, A., Slepicka, P. F., Ouellette, A. M., Kirberger, S. E., Pomerantz, W. C. K., Hannon, G. J. & dos Santos, C. O., Jul 11 2017, In : Stem Cell Reports. 9, 1, p. 23-31 9 p.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations

Meeting Proceedings ICBS2016 - Translating the Power of Chemical Biology to Clinical Advances

Kuriki, Y., Komatsu, T., Ycas, P. D., Coulup, S. K., Carlson, E. J. & Pomerantz, W. C. K., Apr 21 2017, In : ACS Chemical Biology. 12, 4, p. 869-877 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Oxygen Sensing with Perfluorocarbon-Loaded Ultraporous Mesostructured Silica Nanoparticles

Lee, A. L., Gee, C. T., Weegman, B. P., Einstein, S. A., Juelfs, A. R., Ring, H. L., Hurley, K. R., Egger, S. M., Swindlehurst, G., Garwood, M., Pomerantz, W. C. K. & Haynes, C. L., Jun 27 2017, In : ACS nano. 11, 6, p. 5623-5632 10 p.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

Quantifying Protein Concentrations Using Smartphone Colorimetry: A New Method for an Established Test

Gee, C. T., Kehoe, E., Pomerantz, W. C. & Penn, L., Jul 11 2017, In : Journal of Chemical Education. 94, 7, p. 941-945 5 p.

Research output: Contribution to journalArticle

14 Scopus citations

Specific Acetylation Patterns of H2A.Z Form Transient Interactions with the BPTF Bromodomain

Perell, G. T., Mishra, N. K., Sudhamalla, B., Ycas, P. D., Islam, K. & Pomerantz, W. C. K., Sep 5 2017, In : Biochemistry. 56, 35, p. 4607-4615 9 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Synthesis of Intrinsically Disordered Fluorinated Peptides for Modular Design of High-Signal 19 F MRI Agents

Kirberger, S. E., Maltseva, S. D., Manulik, J. C., Einstein, S. A., Weegman, B. P., Garwood, M. & Pomerantz, W. C. K., Jan 1 2017, In : Angewandte Chemie - International Edition. 56, 23, p. 6440-6444 5 p.

Research output: Contribution to journalArticle

Open Access
15 Scopus citations

Tuning Sulfur Oxidation States on Thioether-Bridged Peptide Macrocycles for Modulation of Protein Interactions

Perell, G. T., Staebell, R. L., Hairani, M., Cembran, A. & Pomerantz, W. C. K., Sep 19 2017, In : ChemBioChem. 18, 18, p. 1836-1844 9 p.

Research output: Contribution to journalArticle

9 Scopus citations
2016

Oxidation increases the strength of the methionine-aromatic interaction

Lewis, A. K., Dunleavy, K. M., Senkow, T. L., Her, C., Horn, B. T., Jersett, M. A., Mahling, R., McCarthy, M. R., Perell, G. T., Valley, C. C., Karim, C. B., Gao, J., Pomerantz, W. C. K., Thomas, D. D., Cembran, A., Hinderliter, A. & Sachs, J. N., Oct 1 2016, In : Nature Chemical Biology. 12, 10, p. 860-866 7 p.

Research output: Contribution to journalArticle

Open Access
28 Scopus citations

Paramagnetic relaxation enhancement for protein-observed 19F NMR as an enabling approach for efficient fragment screening

Hawk, L. M. L., Gee, C. T., Urick, A. K., Hu, H. & Pomerantz, W. C. K., Jan 1 2016, In : RSC Advances. 6, 98, p. 95715-95721 7 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Prediction of 19F NMR chemical shifts in labeled proteins: Computational protocol and case study

Isley, W. C., Urick, A. K., Pomerantz, W. C. & Cramer, C., Jul 5 2016, In : Molecular Pharmaceutics. 13, 7, p. 2376-2386 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

Protein-observed 19F-NMR for fragment screening, affinity quantification and druggability assessment

Gee, C. T., Arntson, K. E., Urick, A. K., Mishra, N. K., Hawk, L., Wisniewski, A. J. & Pomerantz, W. C., Aug 1 2016, In : Nature Protocols. 11, 8, p. 1414-1427 14 p.

Research output: Contribution to journalArticle

44 Scopus citations

Protein-observed fluorine NMR is a complementary ligand discovery method to 1H CPMG ligand-observed NMR

Urick, A. K., Calle, L. P., Espinosa, J. F., Hu, H. & Pomerantz, W. C. K., Nov 18 2016, In : ACS Chemical Biology. 11, 11, p. 3154-3164 11 p.

Research output: Contribution to journalArticle

22 Scopus citations
2015

Dual Screening of BPTF and Brd4 Using Protein-Observed Fluorine NMR Uncovers New Bromodomain Probe Molecules

Urick, A. K., Hawk, L. M. L., Cassel, M. K., Mishra, N. K., Liu, S., Adhikari, N., Zhang, W., Dos Santos, C. O., Hall, J. L. & Pomerantz, W. C. K., Oct 16 2015, In : ACS Chemical Biology. 10, 10, p. 2246-2256 11 p.

Research output: Contribution to journalArticle

44 Scopus citations

Fragment screening and druggability assessment for the CBP/p300 KIX domain through protein-observed 19F NMR spectroscopy

Gee, C. T., Koleski, E. J. & Pomerantz, W. C. K., Mar 16 2015, In : Angewandte Chemie - International Edition. 54, 12, p. 3735-3739 5 p.

Research output: Contribution to journalArticle

32 Scopus citations
2014

Fluorinated aromatic amino acids are sensitive 19 f NMR probes for bromodomain-ligand interactions

Mishra, N. K., Urick, A. K., Ember, S. W. J., Schonbrunn, E. & Pomerantz, W. C., Dec 19 2014, In : ACS Chemical Biology. 9, 12, p. 2755-2760 6 p.

Research output: Contribution to journalArticle

42 Scopus citations

FP tethering: A screening technique to rapidly identify compounds that disrupt protein-protein interactions

Lodge, J. M., Justin Rettenmaier, T., Wells, J. A., Pomerantz, W. C. & Mapp, A. K., Mar 2014, In : MedChemComm. 5, 3, p. 370-375 6 p.

Research output: Contribution to journalArticle

21 Scopus citations
2013

Ordering a dynamic protein Via a small-molecule stabilizer

Wang, N., Majmudar, C. Y., Pomerantz, W. C., Gagnon, J. K., Sadowsky, J. D., Meagher, J. L., Johnson, T. K., Stuckey, J. A., Brooks, C. L., Wells, J. A. & Mapp, A. K., Mar 6 2013, In : Journal of the American Chemical Society. 135, 9, p. 3363-3366 4 p.

Research output: Contribution to journalArticle

39 Scopus citations
2012

Profiling the dynamic interfaces of fluorinated transcription complexes for ligand discovery and characterization

Pomerantz, W. C., Wang, N., Lipinski, A. K., Wang, R., Cierpicki, T. & Mapp, A. K., Aug 17 2012, In : ACS Chemical Biology. 7, 8, p. 1345-1350 6 p.

Research output: Contribution to journalArticle

35 Scopus citations

Sekikaic acid and lobaric acid target a dynamic interface of the coactivator CBP/p300

Majmudar, C. Y., Højfeldt, J. W., Arevang, C. J., Pomerantz, W. C., Gagnon, J. K., Schultz, P. J., Cesa, L. C., Doss, C. H., Rowe, S. P., Vásquez, V., Tamayo-Castillo, G., Cierpicki, T., Brooks, C. L., Sherman, D. H. & Mapp, A. K., Nov 5 2012, In : Angewandte Chemie - International Edition. 51, 45, p. 11258-11262 5 p.

Research output: Contribution to journalArticle

36 Scopus citations
2011

Lyotropic liquid crystalline phases from helical β-peptides as alignment media

Thiele, C. M., Pomerantz, W. C., Abbott, N. L. & Gellman, S. H., Jan 7 2011, In : Chemical Communications. 47, 1, p. 502-504 3 p.

Research output: Contribution to journalArticle

21 Scopus citations

Lyotropic liquid crystals formed from ACHC-Rich β-peptides

Pomerantz, W. C., Yuwono, V. M., Drake, R., Hartgerink, J. D., Abbott, N. L. & Gellman, S. H., Aug 31 2011, In : Journal of the American Chemical Society. 133, 34, p. 13604-13613 10 p.

Research output: Contribution to journalArticle

39 Scopus citations

Transcriptional tools: Small molecules for modulating CBP KIX-dependent transcriptional activators

Bates, C. A., Pomerantz, W. C. & Mapp, A. K., Jan 1 2011, In : Biopolymers. 95, 1, p. 17-23 7 p.

Research output: Contribution to journalArticle

14 Scopus citations
2009

A rationally designed aldolase foldamer

Müller, M. M., Windsor, M. A., Pomerantz, W. C., Gellman, S. H. & Hilvert, D., Jan 19 2009, In : Angewandte Chemie - International Edition. 48, 5, p. 922-925 4 p.

Research output: Contribution to journalArticle

114 Scopus citations

Effect of sequence and structural properties on 14-helical β-peptide activity against Candida albicans planktonic cells and biofilms

Karlsson, A. J., Pomerantz, W. C., Neilsen, K. J., Gellman, S. H. & Palecek, S. P., Jul 17 2009, In : ACS Chemical Biology. 4, 7, p. 567-579 13 p.

Research output: Contribution to journalArticle

61 Scopus citations

In situ monitoring of backbone thioester exchange by 19F NMR

Pomerantz, W. C., Hadley, E. B., Fry, C. G. & Gellman, S. H., Sep 4 2009, In : ChemBioChem. 10, 13, p. 2177-2181 5 p.

Research output: Contribution to journalArticle

6 Scopus citations

Preclinical development of a bifunctional cancer cell homing, PKCε inhibitory peptide for the treatment of head and neck cancer

Bao, L., Gorin, M. A., Zhang, M., Ventura, A. C., Pomerantz, W. C., Merajver, S. D., Teknos, T. N., Mapp, A. K. & Pan, Q., Jul 15 2009, In : Cancer Research. 69, 14, p. 5829-5834 6 p.

Research output: Contribution to journalArticle

16 Scopus citations
2008

Characterization of nanofibers formed by self-assembly of Β-peptide oligomers using small angle x-ray scattering

Pizzey, C. L., Pomerantz, W. C., Sung, B. J., Yuwono, V. M., Gellman, S. H., Hartgerink, J. D., Yethiraj, A. & Abbott, N. L., Sep 15 2008, In : Journal of Chemical Physics. 129, 9, 095103.

Research output: Contribution to journalArticle

33 Scopus citations

Comparison of design strategies for promotion of β-peptide 14-helix stability in water

Vaz, E., Pomerantz, W. C., Geyer, M., Gellman, S. H. & Brunsveld, L., Sep 22 2008, In : ChemBioChem. 9, 14, p. 2254-2259 6 p.

Research output: Contribution to journalArticle

33 Scopus citations

Distinctive circular dichroism signature for 14-helix-bundle formation by ß-peptides

Pomerantz, W. C., Grygiel, T. L. R., Lai, J. R. & Gellman, S. H., May 1 2008, In : Organic Letters. 10, 9, p. 1799-1802 4 p.

Research output: Contribution to journalArticle

26 Scopus citations

Nanofibers and lyotropic liquid crystals from a class of self-assembling β-peptides

Pomerantz, W. C., Yuwono, V. M., Pizzey, C. L., Hartgerink, J. D., Abbott, N. L. & Gellman, S. H., Feb 1 2008, In : Angewandte Chemie - International Edition. 47, 7, p. 1241-1244 4 p.

Research output: Contribution to journalArticle

69 Scopus citations
2007

Origins of the high 14-helix propensity of cyclohexyl-rigidified residues in β-peptides

Lee, M. R., Raguse, T. L., Schinnerl, M., Pomerantz, W. C., Wang, X., Wipf, P. & Gellman, S. H., Apr 26 2007, In : Organic Letters. 9, 9, p. 1801-1804 4 p.

Research output: Contribution to journalArticle

37 Scopus citations

Practical synthesis of enantiomerically pure β2-amino acids via proline-catalyzed diastereoselective aminomethylation of aldehydes

Chi, Y., English, E. P., Pomerantz, W. C., Horne, W. S., Joyce, L. A., Alexander, L. R., Fleming, W. S., Hopkins, E. A. & Gellman, S. H., May 9 2007, In : Journal of the American Chemical Society. 129, 18, p. 6050-6055 6 p.

Research output: Contribution to journalArticle

56 Scopus citations

Sequence dependent behavior of amphiphilic β-peptides on gold surfaces

Pomerantz, W. C., Cadwell, K. D., Hsu, Y. J., Gellman, S. H. & Abbott, N. L., Sep 4 2007, In : Chemistry of Materials. 19, 18, p. 4436-4441 6 p.

Research output: Contribution to journalArticle

22 Scopus citations
2006

Antifungal activity from 14-helical β-peptides

Karlsson, A. J., Pomerantz, W. C., Weisblum, B., Gellman, S. H. & Palecek, S. P., Oct 4 2006, In : Journal of the American Chemical Society. 128, 39, p. 12630-12631 2 p.

Research output: Contribution to journalArticle

121 Scopus citations

Lyotropic liquid crystals from designed helical β-peptides

Pomerantz, W. C., Abbott, N. L. & Gellman, S. H., Jul 12 2006, In : Journal of the American Chemical Society. 128, 27, p. 8730-8731 2 p.

Research output: Contribution to journalArticle

61 Scopus citations
2005

Donor-substituted cyanoethynylethenes: π-conjugation and band-gap tuning in strong charge-transfer chromophores

Moonen, N. N. P., Pomerantz, W. C., Gist, R., Boudon, C., Gisselbrecht, J. P., Kawai, T., Kishioka, A., Gross, M., Irie, M. & Diederich, F., May 20 2005, In : Chemistry - A European Journal. 11, 11, p. 3325-3341 17 p.

Research output: Contribution to journalArticle

88 Scopus citations
2002

Comparing isotope effects and rates for the methanolic sodium methoxide reactions of 9-r-fluorene to those for p-CF3C6H4CHClR (R = CH2Cl, CH2F and CF3)

Koch, H. F., Pomerantz, W. C., Ruggles, E. L., Van Laren, M. & Van Roon, A. M., Oct 1 2002, In : Collection of Czechoslovak Chemical Communications. 67, 10, p. 1505-1516 12 p.

Research output: Contribution to journalArticle

2 Scopus citations