William C Pomerantz

20022022
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Peptides Chemical Compounds
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Nuclear magnetic resonance Chemical Compounds
Screening Chemical Compounds
Proteins Chemical Compounds
Molecules Chemical Compounds
Liquid Crystals Chemical Compounds

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Projects 2014 2022

Melanoma
Therapeutics
Epigenomics
Neoplasms
Magnetic resonance imaging
Peptides
Proteins
Organic Chemistry

Research Output 2002 2019

Selectivity, ligand deconstruction, and cellular activity analysis of a BPTF bromodomain inhibitor

Kirberger, S. E., Ycas, P. D., Johnson, J. A., Chen, C., Ciccone, M. F., Woo, R. W. L., Urick, A. K., Zahid, H., Shi, K., Aihara, H., McAllister, S. D., Kashani-Sabet, M., Shi, J., Dickson, A., Dos Santos, C. O. & Pomerantz, W. C., Jan 1 2019, In : Organic and Biomolecular Chemistry. 17, 7, p. 2020-2027 8 p.

Research output: Contribution to journalArticle

inhibitors
selectivity
Ligands
ligands
proteins

Systematically Mitigating the p38α Activity of Triazole-based BET Inhibitors

Carlson, A. S., Cui, H., Divakaran, A., Johnson, J. A., Brunner, R. M., Pomerantz, W. C. & Topczewski, J. J., Sep 12 2019, In : ACS Medicinal Chemistry Letters. 10, 9, p. 1296-1301 6 p.

Research output: Contribution to journalArticle

Triazoles
Phosphotransferases
Lysine
Polypharmacology
Proteins
1 Citation (Scopus)

Design, Synthesis, and Characterization of a Fluorescence Polarization Pan-BET Bromodomain Probe

Paulson, C. N., Guan, X., Ayoub, A. M., Chan, A., Karim, R. M., Pomerantz, W. C., Schönbrunn, E., Georg, G. & Hawkinson, J. E., Dec 13 2018, In : ACS Medicinal Chemistry Letters. 9, 12, p. 1223-1229 7 p.

Research output: Contribution to journalArticle

Fluorescence Polarization
Assays
Screening
Fluorescence
Polarization
1 Citation (Scopus)

Dual Labeling of the CBP/p300 KIX Domain for 19F NMR Leads to Identification of a New Small-Molecule Binding Site

Gee, C. T., Arntson, K. E., Koleski, E. J., Staebell, R. L. & Pomerantz, W. C., May 4 2018, In : ChemBioChem. 19, 9, p. 963-969 7 p.

Research output: Contribution to journalArticle

Labeling
Binding Sites
Nuclear magnetic resonance
Ligands
Molecules
5 Citations (Scopus)

Molecular Basis for the N-Terminal Bromodomain-and-Extra-Terminal-Family Selectivity of a Dual Kinase-Bromodomain Inhibitor

Divakaran, A., Talluri, S. K., Ayoub, A. M., Mishra, N. K., Cui, H., Widen, J. C., Berndt, N., Zhu, J. Y., Carlson, A. S., Topczewski, J. J., Schonbrunn, E. K., Harki, D. A. & Pomerantz, W. C., Oct 25 2018, In : Journal of Medicinal Chemistry. 61, 20, p. 9316-9334 19 p.

Research output: Contribution to journalArticle

Lysine
Phosphotransferases
Post Translational Protein Processing
Interleukin-8
Epigenomics