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Research Output 1994 2019

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Article
2019

Computational and psychophysical experiments on the Pacinian corpuscle's ability to discriminate complex stimuli

Senkow, T. L., Theis, N., Quindlen-Hotek, J. & Barocas, V. H., Jan 1 2019, (Accepted/In press) In : IEEE Transactions on Haptics.

Research output: Contribution to journalArticle

Experiments

Emergent structure-dependent relaxation spectra in viscoelastic fiber networks in extension

Dhume, R. Y. & Barocas, V. H., Mar 15 2019, In : Acta Biomaterialia. 87, p. 245-255 11 p.

Research output: Contribution to journalArticle

Tissue
Fibers
Bearings (structural)
Viscoelasticity
Weight-Bearing

Image-based multi-scale mechanical analysis of strain amplification in neurons embedded in collagen gel

Chan, V. W. L., Tobin, W. R., Zhang, S., Winkelstein, B. A., Barocas, V. H., Shephard, M. S. & Picu, C. R., Jan 25 2019, In : Computer Methods in Biomechanics and Biomedical Engineering. 22, 2, p. 113-129 17 p.

Research output: Contribution to journalArticle

Collagen
Neurons
Amplification
Gels
Geometry

Multiscale model of fatigue of collagen gels

Dhume, R. Y., Shih, E. D. & Barocas, V. H., Feb 15 2019, In : Biomechanics and Modeling in Mechanobiology. 18, 1, p. 175-187 13 p.

Research output: Contribution to journalArticle

Multiscale Model
Collagen
Fatigue
Gels
Fatigue of materials
2018

A finite-element model of mechanosensation by a Pacinian corpuscle cluster in human skin

Quindlen-Hotek, J. C. & Barocas, V. H., Aug 1 2018, In : Biomechanics and Modeling in Mechanobiology. 17, 4, p. 1053-1067 15 p.

Research output: Contribution to journalArticle

Pacinian Corpuscles
Phase Shift
Phase shift
Finite Element Model
Skin
2 Citations (Scopus)

Dicer1 deficiency in the idiopathic pulmonary fibrosis fibroblastic focus promotes fibrosis by suppressing MicroRNA biogenesis

Herrera, J., Beisang, D. J., Peterson, M., Forster, C., Gilbertsen, A. J., Benyumov, A., Smith, K., Korenczuk, C. E., Barocas, V. H., Guenther, K., Hite, R., Zhang, L., Henke, C. A. & Bitterman, P. B., Aug 15 2018, In : American journal of respiratory and critical care medicine. 198, 4, p. 486-496 11 p.

Research output: Contribution to journalArticle

Idiopathic Pulmonary Fibrosis
MicroRNAs
Extracellular Matrix
Fibrosis
Fibroblasts

Mechanics of a two-fiber model with one nested fiber network, as applied to the collagen-fibrin system

Nedrelow, D., Bankwala, D., Hyypio, J. D., Lai, V. & Barocas, V. H., May 1 2018, In : Acta Biomaterialia. 72, p. 306-315 10 p.

Research output: Contribution to journalArticle

Mechanics
Fibrin
Collagen
Gels
Fibers
2 Citations (Scopus)

Multiscale mechanics of the cervical facet capsular ligament, with particular emphasis on anomalous fiber realignment prior to tissue failure

Zhang, S., Zarei, V., Winkelstein, B. A. & Barocas, V. H., Jan 1 2018, In : Biomechanics and Modeling in Mechanobiology. 17, 1, p. 133-145 13 p.

Research output: Contribution to journalArticle

Ligaments
Stretch
Mechanics
Facet
Anomalous
Ligaments
Neurons
Joints
Low Back Pain
Microtubules

The role of the facet capsular ligament in providing spinal stability

Bermel, E. A., Barocas, V. H. & Ellingson, A. M., Oct 3 2018, In : Computer Methods in Biomechanics and Biomedical Engineering. 21, 13, p. 712-721 10 p.

Research output: Contribution to journalArticle

Open Access
Ligaments
Stiffness
Bending moments
2017

A finite-element model of granular serotonin exocytosis

Datta, A., Haynes, C. L. & Barocas, V. H., Mar 1 2017, In : Integrative Biology (United Kingdom). 9, 3, p. 248-256 9 p.

Research output: Contribution to journalArticle

Exocytosis
Platelets
Serotonin
Blood Platelets
Microstructure

Biomechanics of human parietal pleura in uniaxial extension

Tenorio, L. E. M., Devine, K. J., Lee, J., Kowalewski, T. M. & Barocas, V. H., Nov 1 2017, In : Journal of the Mechanical Behavior of Biomedical Materials. 75, p. 330-335 6 p.

Research output: Contribution to journalArticle

Biomechanics
Needles
Simulators
Tissue
Medical problems
1 Citation (Scopus)

Cellular Microbiaxial Stretching to Measure a Single-Cell Strain Energy Density Function

Win, Z., Buksa, J. M., Steucke, K. E., Gant Luxton, G. W., Barocas, V. H. & Alford, P. W., Jul 1 2017, In : Journal of Biomechanical Engineering. 139, 7, 071006.

Research output: Contribution to journalArticle

Strain energy
Probability density function
Stretching
Muscle
Vascular Smooth Muscle
12 Citations (Scopus)

Collagen organization in facet capsular ligaments varies with spinal region and with ligament deformation

Ban, E., Zhang, S., Zarei, V., Barocas, V. H., Winkelstein, B. A. & Picu, C. R., Jul 1 2017, In : Journal of Biomechanical Engineering. 139, 7, 071009.

Research output: Contribution to journalArticle

Ligaments
Collagen
Fibers
Lumbosacral Region
Spatial Analysis
1 Citation (Scopus)

Computational parametric analysis of the mechanical response of structurally varying pacinian corpuscles

Quindlen, J. C., Güçlü, B., Schepis, E. A. & Barocas, V. H., Jul 1 2017, In : Journal of Biomechanical Engineering. 139, 7, 071012.

Research output: Contribution to journalArticle

Pacinian Corpuscles
Amplification
Fluids
Vibration
Viscosity
5 Citations (Scopus)

Computer simulation of lumbar flexion shows shear of the facet capsular ligament

Claeson, A. A. & Barocas, V. H., Jan 1 2017, In : Spine Journal. 17, 1, p. 109-119 11 p.

Research output: Contribution to journalArticle

Ligaments
Computer Simulation
Zygapophyseal Joint
Biomechanical Phenomena
Joint Capsule
8 Citations (Scopus)

Failure of the porcine ascending aorta: Multidirectional experiments and a unifying microstructural model

Witzenburg, C. M., Dhume, R. Y., Shah, S. B., Korenczuk, C. E., Wagner, H. P., Alford, P. W. & Barocas, V. H., Mar 1 2017, In : Journal of Biomechanical Engineering. 139, 3, 031005.

Research output: Contribution to journalArticle

Aorta
Swine
Dissection
Mechanics
Experiments
6 Citations (Scopus)

Image-based multiscale mechanical modeling shows the importance of structural heterogeneity in the human lumbar facet capsular ligament

Zarei, V., Liu, C. J., Claeson, A. A., Akkin, T. & Barocas, V. H., Aug 1 2017, In : Biomechanics and Modeling in Mechanobiology. 16, 4, p. 1425-1438 14 p.

Research output: Contribution to journalArticle

Ligaments
Facet
Fiber
Fibers
Biaxial
2 Citations (Scopus)

Isotropic failure criteria are not appropriate for anisotropic fibrous biological tissues

Korenczuk, C. E., Votava, L. E., Dhume, R. Y., Kizilski, S. B., Brown, G. E., Narain, R. & Barocas, V. H., Jul 1 2017, In : Journal of Biomechanical Engineering. 139, 7, 4036316.

Research output: Contribution to journalArticle

Tissue
Mechanics
Aorta
Swine
Geometry
1 Citation (Scopus)

Micropipette aspiration of the Pacinian corpuscle

Quindlen, J. C., Bloom, E. T., Ortega, L. E., Moeller, A. & Barocas, V. H., Oct 3 2017, In : Journal of Biomechanics. 63, p. 104-109 6 p.

Research output: Contribution to journalArticle

Pacinian Corpuscles
Elastic moduli
Elastic Modulus
Skin
Feedback
9 Citations (Scopus)
Ligaments
Fibers
Collagen
Elastin
Capsules
5 Citations (Scopus)

Tissue loading and microstructure regulate the deformation of embedded nerve fibres: Predictions from single-scale and multiscale simulations

Zarei, V., Zhang, S., Winkelstein, B. A. & Barocas, V. H., Oct 1 2017, In : Journal of the Royal Society Interface. 14, 135, 20170326.

Research output: Contribution to journalArticle

Nerve Fibers
Axons
Tissue
Microstructure
Fibers
2016

A computational model of flow and species transport in the mesangium

Hunt, S. E., Dorfman, K. D., Segal, Y. & Barocas, V. H., Feb 1 2016, In : American Journal of Physiology - Renal Physiology. 310, 3, p. F222-F229

Research output: Contribution to journalArticle

Immunoglobulin A
Convection
Glomerular Mesangium
IGA Glomerulonephritis
Glomerular Basement Membrane
5 Citations (Scopus)

A multiphysics model of the Pacinian corpuscle

Quindlen, J. C., Stolarski, H. K., Johnson, M. D. & Barocas, V. H., Nov 1 2016, In : Integrative Biology (United Kingdom). 8, 11, p. 1111-1125 15 p.

Research output: Contribution to journalArticle

Pacinian Corpuscles
Touch
Neurites
Frequency response
Mechanics

A nonlinear anisotropic inverse method for computational dissection of inhomogeneous planar tissues

Witzenburg, C. M. & Barocas, V. H., Nov 17 2016, In : Computer Methods in Biomechanics and Biomedical Engineering. 19, 15, p. 1630-1646 17 p.

Research output: Contribution to journalArticle

Dissection
Tissue
Nonlinear analysis
Strain energy
Mechanical properties
1 Citation (Scopus)

A paradigm for materials design for surgical simulators, with specific application to the pleura and needle decompression

Barocas, V., Tenorio, L. M., Devine, K., Lee, J., Sweet, R., Norfleet, J. & Mazzeo, M., Sep 1 2016, In : Journal of Medical Devices, Transactions of the ASME. 10, 3, 030934.

Research output: Contribution to journalArticle

Pleura
Decompression
Needles
Simulators
2 Citations (Scopus)

Automatic Segmentation of Mechanically Inhomogeneous Tissues Based on Deformation Gradient Jump

Witzenburg, C. M., Dhume, R. Y., Lake, S. P. & Barocas, V. H., Jan 1 2016, In : IEEE Transactions on Medical Imaging. 35, 1, p. 29-41 13 p., 7151819.

Research output: Contribution to journalArticle

Tissue
Constitutive equations
Materials properties
Dissection
Rotator Cuff
5 Citations (Scopus)

Cell-matrix interaction during straindependent remodelling of simulated collagen networks

Gyoneva, L., Hovell, C. B., Pewowaruk, R. J., Dorfman, K. D., Segal, Y. & Barocas, V. H., Feb 6 2016, In : Interface Focus. 6, 1, 20150098.

Research output: Contribution to journalArticle

Collagen
Cell Communication
Tissue
Fibers
Mechanical stability
11 Citations (Scopus)

Effect of fiber crimp on the elasticity of random fiber networks with and without embedding matrices

Ban, E., Barocas, V. H., Shephard, M. S. & Picu, C. R., Apr 1 2016, In : Journal of Applied Mechanics, Transactions ASME. 83, 4, 041008.

Research output: Contribution to journalArticle

embedding
Elasticity
elastic properties
fibers
Fibers
24 Citations (Scopus)

Multi-scale Modeling of the Cardiovascular System: Disease Development, Progression, and Clinical Intervention

Zhang, Y., Barocas, V. H., Berceli, S. A., Clancy, C. E., Eckmann, D. M., Garbey, M., Kassab, G. S., Lochner, D. R., McCulloch, A. D., Tran-Son-Tay, R. & Trayanova, N. A., Sep 1 2016, In : Annals of Biomedical Engineering. 44, 9, p. 2642-2660 19 p.

Research output: Contribution to journalArticle

Cardiovascular system
Medicine
Mechanics
Cardiology
Biomechanics
17 Citations (Scopus)

Softening in random networks of non-identical beams

Ban, E., Barocas, V. H., Shephard, M. S. & Picu, R. C., Feb 1 2016, In : Journal of the Mechanics and Physics of Solids. 87, p. 38-50 13 p.

Research output: Contribution to journalArticle

softening
fibers
Fibers
stiffness
Stiffness
12 Citations (Scopus)

Swelling of Collagen-Hyaluronic Acid Co-Gels: An In Vitro Residual Stress Model

Lai, V., Nedrelow, D., Lake, S. P., Kim, B., Weiss, E. M., Tranquillo, R. T. & Barocas, V. H., Oct 1 2016, In : Annals of Biomedical Engineering. 44, 10, p. 2984-2993 10 p.

Research output: Contribution to journalArticle

Hyaluronic acid
Collagen
Swelling
Residual stresses
Gels
2015
3 Citations (Scopus)

Crack propagation versus fiber alignment in collagen gels: Experiments and multiscale simulation

Vanderheiden, S. M., Hadi, M. F. & Barocas, V. H., Dec 1 2015, In : Journal of Biomechanical Engineering. 137, 12, 121002.

Research output: Contribution to journalArticle

Collagen
Crack propagation
Gels
Tissue
Fibers
2 Citations (Scopus)

Effect of Supercoiling on the Mechanical and Permeability Properties of Model Collagen IV Networks

Gyoneva, L., Segal, Y., Dorfman, K. D. & Barocas, V. H., Jul 22 2015, In : Annals of Biomedical Engineering. 43, 7, p. 1695-1705 11 p.

Research output: Contribution to journalArticle

Collagen
Stiffness
Hydrostatic pressure
Blood
Basement Membrane
5 Citations (Scopus)

Marker-Free Tracking of Facet Capsule Motion Using Polarization-Sensitive Optical Coherence Tomography

Claeson, A. A., Yeh, Y. J., Black, A. J., Akkin, T. & Barocas, V. H., Dec 1 2015, In : Annals of Biomedical Engineering. 43, 12, p. 2953-2966 14 p.

Research output: Contribution to journalArticle

Optical tomography
Polarization
Tissue
Power spectrum
Ligaments
5 Citations (Scopus)
Pacinian Corpuscles
indentation
Indentation
Anisotropy
Receptor
2014
8 Citations (Scopus)

Combining displacement field and grip force information to determine mechanical properties of planar tissue with complicated geometry

Nagel, T. M., Hadi, M. F., Claeson, A. A., Nuckley, D. J. & Barocas, V. H., Nov 1 2014, In : Journal of Biomechanical Engineering. 136, 11, 114501.

Research output: Contribution to journalArticle

Hand Strength
Tissue
Mechanical properties
Geometry
Structural Models
15 Citations (Scopus)

Prefailure and failure mechanics of the porcine ascending thoracic aorta: Experiments and a multiscale model

Shah, S. B., Witzenburg, C., Hadi, M. F., Wagner, H. P., Goodrich, J. M., Alford, P. W. & Barocas, V. H., Feb 1 2014, In : Journal of Biomechanical Engineering. 136, 2, 021028.

Research output: Contribution to journalArticle

Thoracic Aortic Aneurysm
Mechanics
Thoracic Aorta
Aorta
Swine
7 Citations (Scopus)

Quantification of continuous in vivo flexion-extension kinematics and intervertebral strains

Nagel, T. M., Zitnay, J. L., Barocas, V. H. & Nuckley, D. J., Jan 1 2014, In : European Spine Journal. 23, 4, p. 754-761 8 p.

Research output: Contribution to journalArticle

Biomechanical Phenomena
Healthy Volunteers
Fluoroscopy
Spine
3 Citations (Scopus)

Vascular biomechanical properties in mice with smooth muscle specific deletion of Ndst1

Adhikari, N., Billaud, M., Carlson, M., Lake, S. P., Montaniel, K. R. C., Staggs, R., Guan, W., Walek, D., Desir, S., Isakson, B. E., Barocas, V. H. & Hall, J. L., Jan 1 2014, In : Molecular and cellular biochemistry. 385, 1-2, p. 225-238 14 p.

Research output: Contribution to journalArticle

Smooth Muscle
Blood Vessels
Muscle
Aorta
Heparan Sulfate Proteoglycans
2013
23 Citations (Scopus)

A coupled fiber-matrix model demonstrates highly inhomogeneous microstructural interactions in soft tissues under tensile load

Zhang, L., Lake, S. P., Lai, V., Picu, C. R., Barocas, V. H. & Shephard, M. S., Jan 8 2013, In : Journal of Biomechanical Engineering. 135, 1, 011008.

Research output: Contribution to journalArticle

Optical fiber coupling
Tissue
Collagen
Fibers
Stress Fibers
17 Citations (Scopus)
Cytoskeleton
Military electronic countermeasures
Tissue
Fibers
Stiffness
5 Citations (Scopus)
Anterior Chamber
Iris
Pupil
Dilatation
Anatomy
18 Citations (Scopus)

Cross-linked fiber network embedded in an elastic matrix

Zhang, L., Lake, S. P., Barocas, V. H., Shephard, M. S. & Picu, R. C., Jul 28 2013, In : Soft Matter. 9, 28, p. 6398-6405 8 p.

Research output: Contribution to journalArticle

fibers
Fibers
matrices
Consumer products
Stress concentration
8 Citations (Scopus)

Mechanical response of wild-type and Alport murine lens capsules during osmotic swelling

Gyoneva, L., Segal, Y., Dorfman, K. D. & Barocas, V. H., Aug 1 2013, In : Experimental Eye Research. 113, p. 87-91 5 p.

Research output: Contribution to journalArticle

Lenses
Capsules
Hereditary Nephritis
Basement Membrane
Collagen
18 Citations (Scopus)
Collagen
Tissue
Fibers
Hand Strength
Aortic Aneurysm
26 Citations (Scopus)

Multiscale mechanical simulations of cell compacted collagen gels

Aghvami, M., Barocas, V. H. & Sander, E. A., Aug 5 2013, In : Journal of Biomechanical Engineering. 135, 7, 071004.

Research output: Contribution to journalArticle

Collagen
Gels
Extracellular Matrix
Fibers
Tissue
2012

A microscale model for the mechanical interaction of collagen and fibrin networks

Hyypio, J., Hadi, M. F., Lai, V. & Barocas, V. H., Jan 1 2012, In : Journal of Medical Devices, Transactions of the ASME. 6, 1, p. 1 1 p.

Research output: Contribution to journalArticle

Fibrin
Collagen
5 Citations (Scopus)
Glomerular Basement Membrane
Maintenance
Health
Hereditary Nephritis
Pressure drop
7 Citations (Scopus)

Increased iris-lens contact following spontaneous blinking: Mathematical modeling

Amini, R., Jouzdani, S. & Barocas, V. H., Aug 31 2012, In : Journal of Biomechanics. 45, 13, p. 2293-2296 4 p.

Research output: Contribution to journalArticle

Contact lenses
Blinking
Contact Lenses
Iris
Anterior Chamber