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Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Projects
- 1 Active
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Microglial P2Y6 Receptor Calcium Signaling as a Core Regulator of Epileptogenesis
Umpierre, T. (PI)
NATIONAL INSTITUTES OF HEALTH (NIH)
9/1/24 → 8/31/27
Project: Research project
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Chemogenetic activation of microglial Gi signaling decreases microglial surveillance and impairs neuronal synchronization
Zhao, S., Wang, L., Kleidonas, D., Qi, F., Liang, Y., Zheng, J., Umpierre, A. D. & Wu, L. J., Feb 28 2025, In: Science Advances. 11, 9, eado7829.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
In vivo calcium extrusion from accumbal astrocytes reduces anxiety-like behaviors but increases compulsive-like responses and compulsive ethanol drinking in mice
Peyton, L., Haroon, H., Umpierre, A., Essa, H., Bruce, R., Wu, L. J. & Choi, D. S., May 1 2025, In: Neuropharmacology. 268, 110320.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Rod-shaped microglia interact with neuronal dendrites to attenuate cortical excitability during TDP-43-related neurodegeneration
Xie, M., Liang, Y., Miller, A. S., Pallegar, P. N., Umpierre, A. D., Wang, N., Zhang, S., Nagaraj, N. K., Fogarty, Z. C., Ghayal, N. B., Oskarsson, B., Zhao, S., Zheng, J., Shi, W., Akter, M., Qi, F., Nguyen, A. T., Dickson, D. W. & Wu, L. J., 2025, (Accepted/In press) In: Immunity.Research output: Contribution to journal › Article › peer-review
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Microglia enhance post-anesthesia neuronal activity by shielding inhibitory synapses
Haruwaka, K., Ying, Y., Liang, Y., Umpierre, A. D., Yi, M. H., Kremen, V., Chen, T., Xie, T., Qi, F., Zhao, S., Zheng, J., Liu, Y. U., Dong, H., Worrell, G. A. & Wu, L. J., Mar 2024, In: Nature neuroscience. 27, 3, p. 449-461 13 p.Research output: Contribution to journal › Article › peer-review
Open Access36 Scopus citations -
Microglial P2Y6 calcium signaling promotes phagocytosis and shapes neuroimmune responses in epileptogenesis
Umpierre, A. D., Li, B., Ayasoufi, K., Simon, W. L., Zhao, S., Xie, M., Thyen, G., Hur, B., Zheng, J., Liang, Y., Bosco, D. B., Maynes, M. A., Wu, Z., Yu, X., Sung, J., Johnson, A. J., Li, Y. & Wu, L. J., Jun 19 2024, In: Neuron. 112, 12, p. 1959-1977.e10Research output: Contribution to journal › Article › peer-review
Open Access31 Scopus citations