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Personal profile

Research interests

The Hays’ lab studies the structural and regulatory mechanisms that drive intracellular transport. At a basic level the regulation of microtubule-based transport within cells is dependent on the cytoplasmic motor proteins (dyneins and kinesins) that translocate along the microtubule lattice. These unidirectional motors, in combination with the assembly of polarized arrays of microtubules within cells, provide a mechanism to partition cellular organelles and molecules within a cell's cytoplasmic compartment. Malfunctions in motor function influence global aspects of cell biology including the establishment of cell polarities, the maintenance of genomic stability, and cell-cell communication an underlie a growing list of medical maladies including cancer and neurodegeneration. The Hays’ laboratory is applying genetic, molecular and biochemical approaches in Drosophila to study the molecular regulation of motor proteins and intercellular transport.

Research interests

  • molecular genetics (e.g.
  • protein biochemistry
  • isolation of mutations)
  • classical genetics (e.g.
  • confocal and conventional light microscopy
  • transgenic organisms)
  • molecular cytology

Fingerprint The Fingerprint is created by mining the titles and abstracts of the person's research outputs and projects/funding awards to create an index of weighted terms from discipline-specific thesauri.

  • 14 Similar Profiles
Dyneins Medicine & Life Sciences
Cytoplasmic Dyneins Medicine & Life Sciences
Drosophila Medicine & Life Sciences
Microtubules Medicine & Life Sciences
Kinetochores Medicine & Life Sciences
Kinesin Medicine & Life Sciences
Mutation Medicine & Life Sciences
Axonal Transport Medicine & Life Sciences

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Projects 2003 2023

Research Output 1982 2018

1 Citation (Scopus)

Kinesin-5 Mediated Chromosome Congression in Insect Spindles

Tubman, E., He, Y., Hays, T. S. & Odde, D. J., Feb 1 2018, In : Cellular and Molecular Bioengineering. 11, 1, p. 25-36 12 p.

Research output: Contribution to journalArticle

Kinesin
Chromosomes, Human, Pair 5
Microtubules
Chromosomes
Chromosome

Single Molecule Studies Enabled by Model-Based Controller Design

Bhaban, S., Talukdar, S., Li, M-G., Hays, T. S., Seiler Jr, P. J. & salapaka, M. V., Aug 1 2018, In : IEEE/ASME Transactions on Mechatronics. 23, 4, p. 1532-1542 11 p., 8401903.

Research output: Contribution to journalArticle

Controllers
Molecules
Optical tweezers
Proteins
Thermal noise
13 Citations (Scopus)
Axonal Transport
Secretory Vesicles
Phosphoric Monoester Hydrolases
Phosphotransferases
Transcription Factor AP-1
1 Citation (Scopus)

Drosophila cytoplasmic dynein: Mutations, tools, and developmental functions

Neisch, A. L., Avery, A. W., Li, M-G. & Hays, T. S., Nov 22 2017, Dyneins: The Biology of Dynein Motors: Second Edition. Elsevier Inc., p. 569-627 59 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Cytoplasmic Dyneins
Dyneins
Drosophila
Mutation
Germ Cells
3 Citations (Scopus)

Structural basis for high-affinity actin binding revealed by a β-III-spectrin SCA5 missense mutation

Avery, A. W., Fealey, M. E., Wang, F., Orlova, A., Thompson, A. R., Thomas, D. D., Hays, T. S. & Egelman, E. H., Dec 1 2017, In : Nature communications. 8, 1, 1350.

Research output: Contribution to journalArticle

Open Access
ataxia
Spinocerebellar Ataxias
Spectrin
Missense Mutation
mutations