Timothy D O'Connell

19942019

Research output per year

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Research Output

1,25-Dihydroxyvitamin D3-regulated binding of nuclear proteins to a c- myc intron element

Pan, Q., Martell, R. E., O'Connell, T. D. & Simpson, R. U., 1996, In : Endocrinology. 137, 10, p. 4154-4160 7 p.

Research output: Contribution to journalArticle

14 Scopus citations

1,25-Dihydroxyvitamin D3 regulation of cardiac myocyte proliferation and hypertrophy

O'Connell, T. D., Berry, J. E., Jarvis, A. K., Somerman, M. J. & Simpson, R. U., Jan 1 1997, In : American Journal of Physiology - Heart and Circulatory Physiology. 272, 4 41-4, p. H1751-H1758

Research output: Contribution to journalArticle

89 Scopus citations

1, 25-Dihydroxyvitamin D3 regulation of cardiac myocyte proliferation and hypertrophy

O'Connell, T. D., Berry, J. E., Jarvis, A. K., Somerman, M. J. & Simpson, R. U., Dec 1 1997, In : American Journal of Physiology. 272, 4 PART 2, p. H1759-H1769

Research output: Contribution to journalArticle

74 Scopus citations

1,25-Dihydroxyvitamin D3 Regulation of Myocardial Growth and c-myc Levels in the Rat Heart

Oconnell, T. D. & Simpson, R. U., Aug 1995, In : Biochemical and Biophysical Research Communications. 213, 1, p. 59-65 7 p.

Research output: Contribution to journalArticle

31 Scopus citations

Abnormal myocardial contraction in α1A- and α 1B-adrenoceptor double-knockout mice

mccloskey, D. T., Turnbull, L., Swigart, P., O'Connell, T. D., Simpson, P. C. & Baker, A. J., Oct 1 2003, In : Journal of Molecular and Cellular Cardiology. 35, 10, p. 1207-1216 10 p.

Research output: Contribution to journalArticle

34 Scopus citations

Aldosterone directly stimulates cardiac myocyte hypertrophy

Okoshi, M. P., Yan, X., Okoshi, K., Nakayama, M., Schuldt, A. J. T., O'Connell, T. D., Simpson, P. C. & Lorell, B. H., Dec 2004, In : Journal of cardiac failure. 10, 6, p. 511-518 8 p.

Research output: Contribution to journalArticle

67 Scopus citations

Alpha-1-adrenergic receptors: Targets for agonist drugs to treat heart failure

Jensen, B. C., O'Connell, T. D. & Simpson, P. C., Oct 1 2011, In : Journal of Molecular and Cellular Cardiology. 51, 4, p. 518-528 11 p.

Research output: Contribution to journalReview article

80 Scopus citations

Alpha-1-adrenergic receptors in heart failure: The adaptive arm of the cardiac response to chronic catecholamine stimulation

Jensen, B. C., O'Connell, T. D. & Simpson, P. C., Apr 2014, In : Journal of Cardiovascular Pharmacology. 63, 4, p. 291-301 11 p.

Research output: Contribution to journalReview article

36 Scopus citations

An association between gene expression and better survival in female mice following myocardial infarction

Chen, Q., Williams, R., Healy, C. L., Wright, C. D., Wu, S. C. & O'Connell, T. D., Nov 2010, In : Journal of Molecular and Cellular Cardiology. 49, 5, p. 801-811 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Antisense oligonucleotides targeted against protein kinase Cβ and CβII block 1,25-(OH)2D3-induced differentiation

Simpson, R. U., O'Connell, T. D., Pan, Q., Newhouse, J. & Somerman, M. J., Jul 31 1998, In : Journal of Biological Chemistry. 273, 31, p. 19587-19591 5 p.

Research output: Contribution to journalArticle

22 Scopus citations

An α1A-adrenergic-extracellular signal-regulated kinase survival signaling pathway in cardiac myocytes

Huang, Y., Wright, C. D., Merkwan, C. L., Baye, N. L., Liang, Q., Simpson, P. C. & O'Connell, T. D., Feb 2007, In : Circulation. 115, 6, p. 763-772 10 p.

Research output: Contribution to journalArticle

103 Scopus citations

Cardiac alpha1-adrenergic receptors: Novel aspects of expression, signaling mechanisms, physiologic function, and clinical importance

O'Connell, T. D., Jensen, B. C., Baker, A. J. & Simpson, P. C., Jan 2014, In : Pharmacological Reviews. 66, 1, p. 308-333 26 p.

Research output: Contribution to journalArticle

87 Scopus citations
17 Scopus citations

Derivation and high engraftment of patient-specific cardiomyocyte sheet using induced pluripotent stem cells generated from adult cardiac fibroblast

Zhang, L., Guo, J., Zhang, P., Xiong, Q., Wu, S. C., Xia, L., Roy, S. S., Tolar, J., O'Connell, T. D., Kyba, M., Liao, K. & Zhang, J., 2015, In : Circulation: Heart Failure. 8, 1, p. 156-166 11 p.

Research output: Contribution to journalArticle

43 Scopus citations

Diminished GATA4 protein levels contribute to hyperglycemia-induced cardiomyocyte injury

Kobayashi, S., Mao, K., Zheng, H., Wang, X., Patterson, C., O'Connell, T. D. & Liang, Q., Jul 27 2007, In : Journal of Biological Chemistry. 282, 30, p. 21945-21952 8 p.

Research output: Contribution to journalArticle

42 Scopus citations

Efficacy and safety of dofetilide in the treatment of frequent ventricular tachyarrhythmias after amiodarone intolerance or failure

Pinter, A., Akhtari, S., O'Connell, T., O'Donnell, S., Mangat, I., Korley, V., Ahmad, K., Posan, E., Newman, D. & Dorian, P., Jan 18 2011, In : Journal of the American College of Cardiology. 57, 3, p. 380-381 2 p.

Research output: Contribution to journalLetter

Open Access
16 Scopus citations

EPA, not DHA, prevents fibrosis in pressure overload-induced heart failure: Potential role of free fatty acid receptor 4

Eclov, J. A., Qian, Q., Redetzke, R., Chen, Q., Wu, S. C., Healy, C. L., Ortmeier, S. B., Harmon, E., Shearer, G. C. & O'Connell, T. D., Dec 1 2015, In : Journal of lipid research. 56, 12, p. 2297-2308 12 p.

Research output: Contribution to journalArticle

20 Scopus citations
1 Scopus citations

GATA4 is a survival factor in adult cardiac myocytes but is not required for α1A-adrenergic receptor survival signaling

Huang, Y., Wright, C. D., Kobayashi, S., Healy, C. L., Elgethun, M., Cypher, A., Liang, Q. & O'Connell, T. D., Aug 2008, In : American Journal of Physiology - Heart and Circulatory Physiology. 295, 2, p. H699-H707

Research output: Contribution to journalArticle

14 Scopus citations

Immunochemical identification of the 1,25-dihydroxyvitamin D3 receptor protein in human heart

O'Connell, T. D. & Simpson, R. U., Sep 1996, In : Cell Biology International. 20, 9, p. 621-624 4 p.

Research output: Contribution to journalArticle

64 Scopus citations

Inhibition of cardiac myocyte maturation by 1, 25-dihydroxyvitamin D3

O’connell, T. D., Giacherio, D. A., Jarvis, A. K. & Simpson, R. U., Feb 1995, In : Endocrinology. 136, 2, p. 482-488 7 p.

Research output: Contribution to journalArticle

24 Scopus citations

Isolation and culture of adult mouse cardiac myocytes

O'Connell, T. D., Rodrigo, M. C. & Simpson, P. C., Feb 5 2007, Cardiovascular Proteomics: Methods and Protocols. Vivanco, F. (ed.). p. 271-296 26 p. (Methods in Molecular Biology; vol. 357).

Research output: Chapter in Book/Report/Conference proceedingChapter

205 Scopus citations

Navigating the signalling network in mouse cardiac myocytes

Sambrano, G. R., Frasert, I., Han, H., Ni, Y., O'Connell, T., Yan, Z. & Stull, J. T., Dec 12 2002, In : Nature. 420, 6916, p. 712-714 3 p.

Research output: Contribution to journalReview article

72 Scopus citations
15 Scopus citations

Nuclear localization drives α1-adrenergic receptor oligomerization and signaling in cardiac myocytes

Wright, C. D., Wu, S. C., Dahl, E. F., Sazama, A. J. & O'Connell, T. D., Mar 1 2012, In : Cellular Signalling. 24, 3, p. 794-802 9 p.

Research output: Contribution to journalArticle

32 Scopus citations
18 Scopus citations

Nuclear α1-adrenergic receptors signal activated ERK localization to caveolae in adult cardiac myocytes

Wright, C. D., Chen, Q., Baye, N. L., Huang, Y., Healy, C. L., Kasinathan, S. & O'Connell, T. D., Oct 24 2008, In : Circulation research. 103, 9, p. 992-1000 9 p.

Research output: Contribution to journalArticle

71 Scopus citations

Omega-3 fatty acids prevent pressure overload-induced cardiac fibrosis through activation of cyclic GMP/protein kinase g signaling in cardiac fibroblasts

Chen, J., Shearer, G. C., Chen, Q., Healy, C. L., Beyer, A. J., Nareddy, V. B., Gerdes, A. M., Harris, W. S., O'Connell, T. D. & Wang, D., Feb 15 2011, In : Circulation. 123, 6, p. 584-593 10 p.

Research output: Contribution to journalArticle

98 Scopus citations

Overview of the alliance for cellular signaling

Gilman, A. G., Simon, M. I., Bourne, H. R., Harris, B. A., Long, R., Ross, E. M., Stull, J. T., Taussig, R., Arkin, A. P., Cobb, M. H., Cyster, J. G., Devreotes, P. N., Ferrell, J. E., Fruman, D., Gold, M., Weiss, A., Berridge, M. J., Cantley, L. C., Catterall, W. A., Coughlin, S. R. & 57 others, Olson, E. N., Smith, T. F., Brugge, J. S., Botstein, D., Dixon, J. E., Hunter, T., Lefkowitz, R. J., Pawson, A. J., Sternberg, P. W., Varmus, H., Subramaniam, S., Sinkovits, R. S., Li, J., Mock, D., Ning, Y., Saunders, B., Sternweis, P. C., Hilgemann, D., Scheuermann, R. H., DeCamp, D., Hsueh, R., Lin, K. M., Ni, Y., Seaman, W. E., Simpson, P. C., O'Connell, T. D., Roach, T., Choi, S., Eversole-Cire, P., Fraser, I., Mumby, M. C., Zhao, Y., Brekken, D., Shu, H., Meyer, T., Chandy, G., Heo, W. D., Liou, J., O'Rourke, N., Verghese, M., Mumby, S. M., Han, H., Brown, H. A., Forrester, J. S., Ivanova, P., Milne, S. B., Casey, P. J., Harden, T. K., Doyle, J., Gray, M. L., Michnick, S., Schmidt, M. A., Toner, M., Tsien, R. Y., Natarajan, M., Ranganathan, R. & Sambrano, G. R., Dec 12 2002, In : Nature. 420, 6916, p. 703-706 4 p.

Research output: Contribution to journalReview article

109 Scopus citations

Predicting Risk for Incident Heart Failure With Omega-3 Fatty Acids: From MESA

Block, R. C., Liu, L., Herrington, D. M., Huang, S., Tsai, M. Y., O'Connell, T. D. & Shearer, G. C., Aug 2019, In : JACC: Heart Failure. 7, 8, p. 651-661 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Promotion of HL-60 cell differentiation by 1,25-dihydroxyvitamin D3 regulation of protein kinase C levels and activity

Quintin, P., Granger, J., O'Connell, T. D., Somerman, M. J. & Simpson, R. U., Oct 15 1997, In : Biochemical Pharmacology. 54, 8, p. 909-915 7 p.

Research output: Contribution to journalArticle

35 Scopus citations

Quantification of Catecholamine Uptake in Adult Cardiac Myocytes

Dahl, E. F., Wright, C. D. & O’connell, T. D., Jan 1 2015, In : Methods in Molecular Biology. 1234, p. 43-52 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Rapamycin prevents thyroid hormone-induced cardiac hypertrophy

Kuzman, J. A., O'Connell, T. D. & Gerdes, A. M., Jul 2007, In : Endocrinology. 148, 7, p. 3477-3484 8 p.

Research output: Contribution to journalArticle

88 Scopus citations

Regulation of myosin isozyme expression by vitamin D3 deficiency and 1,25-dihydroxyvitamin D3 in the rat heart

O′connell, T. D., Weishaar, R. E. & Simpson, R. U., Feb 1994, In : Endocrinology. 134, 2, p. 899-905 7 p.

Research output: Contribution to journalArticle

33 Scopus citations

Subcellular compartmentalization of proximal Gq-receptor signaling produces unique hypertrophic phenotypes in adult cardiac myocytes

Dahl, E. F., Wu, S. C., Healy, C. L., Harsch, B. A., Shearer, G. C. & O’Connell, T. D., Jun 8 2018, In : Journal of Biological Chemistry. 293, 23, p. 8734-8749 16 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

The α1A/C- and α1B-adrenergic receptors are required for physiological cardiac hypertrophy in the double-knockout mouse

O'Connell, T. D., Ishizaka, S., Nakamura, A., Swigart, P. M., Rodrigo, M. C., Simpson, G. L., Cotecchia, S., Rokosh, D. G., Grossman, W., Foster, E. & Simpson, P. C., Jun 2003, In : Journal of Clinical Investigation. 111, 11, p. 1783-1791 9 p.

Research output: Contribution to journalArticle

150 Scopus citations

With or Without Langendorff: A New Method for Adult Myocyte Isolation to Be Tested with Time

Chen, X., O'Connell, T. D. & Xiang, Y. K., Sep 30 2016, In : Circulation research. 119, 8, p. 888-890 3 p.

Research output: Contribution to journalEditorial

Open Access
4 Scopus citations

α1-adrenergic receptor responses in α1AB-AR knockout mouse hearts suggest the presence of α1D-AR

Turnbull, L., McCloskey, D. T., O'Connell, T. D., Simpson, P. C. & Baker, A. J., Apr 1 2003, In : American Journal of Physiology - Heart and Circulatory Physiology. 284, 4 53-4, p. H1104-H1109

Research output: Contribution to journalArticle

48 Scopus citations

α1-Adrenergic receptors prevent a maladaptive cardiac response to pressure overload

O'Connell, T. D., Swigart, P. M., Rodrigo, M. C., Ishizaka, S., Joho, S., Turnbull, L., Tecott, L. H., Baker, A. J., Foster, E., Grossman, W. & Simpson, P. C., Apr 1 2006, In : Journal of Clinical Investigation. 116, 4, p. 1005-1015 11 p.

Research output: Contribution to journalArticle

104 Scopus citations

α1-adrenoceptor subtypes mediate negative inotropy in myocardium from α1A/C-knockout and wild type mice

McCloskey, D. T., Gregg Rokosh, D., O'Connell, T. D., Keung, E. C., Simpson, P. C. & Baker, A. J., Aug 1 2002, In : Journal of Molecular and Cellular Cardiology. 34, 8, p. 1007-1017 11 p.

Research output: Contribution to journalArticle

30 Scopus citations

ω3-Polyunsaturated fatty acids for heart failure: Effects of dose on efficacy and novel signaling through free fatty acid receptor 4

O'Connell, T. D., Block, R. C., Huang, S. P. & Shearer, G. C., Feb 1 2017, In : Journal of Molecular and Cellular Cardiology. 103, p. 74-92 19 p.

Research output: Contribution to journalReview article

Open Access
26 Scopus citations