Projects per year
Personal profile
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Mitochondrial Transplantation for Repair in Traumatic Brain Injury
Low, W. C. (PI), O'Brien, T. D. (CoI), Phelan, G. (Graduate Student) & Vegoe, A. L. (Other Role)
MINNESOTA OFFICE OF HIGHER EDUCATION
1/29/25 → 12/31/26
Project: Research project
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Development of a Brain Organoid-Derived Exosome Product for the Treatment of Traumatic Brain Injury
O'Brien, T. D. (PI) & Vegoe, A. L. (Other Role)
MINNESOTA OFFICE OF HIGHER EDUCATION
12/23/24 → 6/30/26
Project: Research project
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Center for Multiparametric Imaging of Tumor Immune Microenvironments
Provenzano, P. (PI), Akkin, T. (CoI), Gordon, W. R. (CoI), Largaespada, D. A. (CoI), Marques, G. (CoI), Moriarity, B. S. (CoI), O'Brien, T. D. (CoI), Odde, D. J. (CoI), Parker, L. L. (CoI), Sanders, M. A. (CoI), Sloan, L. (CoI), Stromnes, I. M. (CoI) & Wood, D. K. (CoI)
12/9/21 → 11/30/24
Project: Research project
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Brain Organoid-Derived Exosomes for Treatment of Traumatic Brain Injury
O'Brien, T. D. (PI), Crane, A. T. (CoI) & Ramachandran, S. (CoI)
MINNESOTA OFFICE OF HIGHER EDUCATION
4/23/21 → 6/30/24
Project: Research project
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Multilineage 3-dimensional Brain Organoids to Model Intracranial Pressure Linked to Chronic Traumatic Encephalopathy
Crane, A. T. (PI) & O'Brien, T. D. (CoI)
MINNESOTA OFFICE OF HIGHER EDUCATION
7/23/19 → 6/30/22
Project: Research project
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A bioengineered artificial interstitium supports long-term islet xenograft survival in nonhuman primates without immunosuppression
Oppler, S. H., Stone, L. L. H., Leishman, D. J., Janecek, J. L., Moore, M. E. G., Rangarajan, P., Willenberg, B. J., O'Brien, T. D., Modiano, J., Pheil, N., Dalton, J., Dalton, M., Ramachandran, S. & Graham, M. L., Jan 2024, In: Science Advances. 10, 1, eadi4919.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Hemangiosarcoma Cells Promote Conserved Host-derived Hematopoietic Expansion
Kim, J. H., Schulte, A. J., Sarver, A. L., Lee, D., Angelos, M. G., Frantz, A. M., Forster, C. L., O’Brien, T. D., Cornax, I., O’Sullivan, M. G., Cheng, N., Lewellen, M., Oseth, L. A., Kumar, S., Bullman, S., Pedamallu, C. S., Goyal, S. M., Meyerson, M., Lund, T. C. & Breen, M. & 4 others, , Jun 2024, In: Cancer Research Communications. 4, 6, p. 1467-1480 14 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Targeted mapping and utilization of the perihepatic surface for therapeutic beta cell replacement and retrieval in diabetic non-human primates
Leishman, D. J., Oppler, S. H., Stone, L. L. H., O’Brien, T. D., Ramachandran, S., Willenberg, B. J., Adams, A. B., Hering, B. J. & Graham, M. L., 2024, In: Frontiers in Transplantation. 3, 1352777.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Hypoxia within subcutaneously implanted macroencapsulation devices limits the viability and functionality of densely loaded islets
Einstein, S. A., Steyn, L. V., Weegman, B. P., Suszynski, T. M., Sambanis, A., O’Brien, T. D., Avgoustiniatos, E. S., Firpo, M. T., Graham, M. L., Janecek, J., Eberly, L. E., Garwood, M., Putnam, C. W. & Papas, K. K., 2023, In: Frontiers in Transplantation. 2, 1257029.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Clinically available immunosuppression averts rejection but not systemic inflammation after porcine islet xenotransplant in cynomolgus macaques
Graham, M. L., Ramachandran, S., Singh, A., Moore, M. E. G., Flanagan, E. B., Azimzadeh, A., Burlak, C., Mueller, K., Martins, K., Anazawa, T., Appakalai, B. N., Bansal-Pakala, P., Murtaugh, M. P., O'Brien, T. D., Papas, K. K., Spizzo, T., Schuurman, H. J., Hancock, W. W. & Hering, B. J., Mar 2022, In: American Journal of Transplantation. 22, 3, p. 745-760 16 p.Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations