Projects per year
Personal profile
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Center for Multiparametric Imaging of Tumor Immune Microenvironments
Provenzano, P. (PI), Akkin, T. (CoI), Gordon, W. R. (CoI), Largaespada, D. A. (CoI), Marques, G. (CoI), Moriarity, B. S. (CoI), O'Brien, T. D. (CoI), Odde, D. J. (CoI), Parker, L. L. (CoI), Sanders, M. A. (CoI), Sloan, L. (CoI), Stromnes, I. M. (CoI) & Wood, D. K. (CoI)
NIH NATIONAL CANCER INSTITUTE (NCI)
12/9/21 → 11/30/24
Project: Research project
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Brain Organoid-Derived Exosomes for Treatment of Traumatic Brain Injury
O'Brien, T. D. (PI), Crane, A. T. (CoI) & Ramachandran, S. (CoI)
4/23/21 → 6/30/24
Project: Research project
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Multilineage 3-dimensional Brain Organoids to Model Intracranial Pressure Linked to Chronic Traumatic Encephalopathy
Crane, A. T. (PI) & O'Brien, T. D. (CoI)
7/23/19 → 6/30/22
Project: Research project
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Brain Organoid Cell Products for Research and Therapeuti
O'Brien, T. D. (PI) & Molnar, G. F. (CoI)
THE NATIONAL SCIENCE FOUNDATION
1/1/18 → 12/31/18
Project: Research project
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Targeted engineering of the perihepatic surface using
Graham, M. L. (PI), Hering, B. J. (CoI) & O'Brien, T. D. (CoI)
8/1/16 → 7/31/19
Project: Research project
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A bioengineered artificial interstitium supports long-term islet xenograft survival in nonhuman primates without immunosuppression
Oppler, S. H., Stone, L. L. H., Leishman, D. J., Janecek, J. L., Moore, M. E. G., Rangarajan, P., Willenberg, B. J., O'Brien, T. D., Modiano, J., Pheil, N., Dalton, J., Dalton, M., Ramachandran, S. & Graham, M. L., Jan 2024, In: Science Advances. 10, 1, eadi4919.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Hemangiosarcoma Cells Promote Conserved Host-derived Hematopoietic Expansion
Kim, J. H., Schulte, A. J., Sarver, A. L., Lee, D., Angelos, M. G., Frantz, A. M., Forster, C. L., O’Brien, T. D., Cornax, I., O’Sullivan, M. G., Cheng, N., Lewellen, M., Oseth, L. A., Kumar, S., Bullman, S., Pedamallu, C. S., Goyal, S. M., Meyerson, M., Lund, T. C. & Breen, M. & 4 others, , Jun 2024, In: Cancer Research Communications. 4, 6, p. 1467-1480 14 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Clinically available immunosuppression averts rejection but not systemic inflammation after porcine islet xenotransplant in cynomolgus macaques
Graham, M. L., Ramachandran, S., Singh, A., Moore, M. E. G., Flanagan, E. B., Azimzadeh, A., Burlak, C., Mueller, K., Martins, K., Anazawa, T., Appakalai, B. N., Bansal-Pakala, P., Murtaugh, M. P., O'Brien, T. D., Papas, K. K., Spizzo, T., Schuurman, H. J., Hancock, W. W. & Hering, B. J., Mar 2022, In: American Journal of Transplantation. 22, 3, p. 745-760 16 p.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
Development of an exosomal gene signature to detect residual disease in dogs with osteosarcoma using a novel xenograft platform and machine learning
Makielski, K. M., Donnelly, A. J., Khammanivong, A., Scott, M. C., Ortiz, A. R., Galvan, D. C., Tomiyasu, H., Amaya, C., Ward, K. A., Montoya, A., Garbe, J. R., Mills, L. J., Cutter, G. R., Fenger, J. M., Kisseberth, W. C., O’Brien, T. D., Weigel, B. J., Spector, L. G., Bryan, B. A. & Subramanian, S. & 1 others, , Sep 6 2021, In: Laboratory Investigation. 101, 12, p. 1585-1596 12 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
A novel MCT1 and MCT4 dual inhibitor reduces mitochondrial metabolism and inhibits tumour growth of feline oral squamous cell carcinoma
Khammanivong, A., Saha, J., Spartz, A. K., Sorenson, B. S., Bush, A. G., Korpela, D. M., Gopalakrishnan, R., Jonnalagadda, S., Mereddy, V. R., O'Brien, T. D., Drewes, L. R. & Dickerson, E. B., Sep 1 2020, In: Veterinary and Comparative Oncology. 18, 3, p. 324-341 18 p.Research output: Contribution to journal › Article › peer-review
11 Scopus citations