Tanya S Freedman

20032023
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  • 17 Similar Profiles
ras-GRF1 Medicine & Life Sciences
src-Family Kinases Medicine & Life Sciences
Nucleotides Medicine & Life Sciences
Macrophages Chemical Compounds
T-Cell Antigen Receptor Medicine & Life Sciences
Immunoreceptor Tyrosine-Based Activation Motif Medicine & Life Sciences
ZAP-70 Protein-Tyrosine Kinase Medicine & Life Sciences
Catalytic Domain Medicine & Life Sciences

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Projects 2017 2023

Clustered Regularly Interspaced Short Palindromic Repeats
Gene Editing

Research Output 2003 2019

Unique-region phosphorylation targets LynA for rapid degradation, tuning its expression and signaling in myeloid cells

Brian, B. F., Jolicoeur, A. S., Guerrero, C. R., Nunez, M. G., Sychev, Z. E., Hegre, S. A., Sætrom, P., Habib, N., Drake, J. M., Schwertfeger, K. L. & Freedman, T. S., Jul 2019, In : eLife. 8, e46043.

Research output: Contribution to journalArticle

Open Access
Phosphorylation
src-Family Kinases
Macrophages
Myeloid Cells
Tuning
6 Citations (Scopus)

LynA regulates an inflammation-sensitive signaling checkpoint in macrophages

Freedman, T. S., Tan, Y. X., Skrzypczynska, K. M., Manz, B. N., Sjaastad, F. V., Goodridge, H. S., Lowell, C. A. & Weiss, A., Oct 30 2015, In : eLife. 4, OCTOBER2015, e09183.

Research output: Contribution to journalArticle

Immunoreceptor Tyrosine-Based Activation Motif
src-Family Kinases
Macrophages
Cluster Analysis
Inflammation
51 Citations (Scopus)

Inhibition of the kinase Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full TCR signaling

Tan, Y. X., Manz, B. N., Freedman, T. S., Zhang, C., Shokat, K. M. & Weiss, A., Feb 1 2014, In : Nature immunology. 15, 2, p. 186-194 9 p.

Research output: Contribution to journalArticle

Thymocytes
T-Cell Antigen Receptor
Actins
Phosphotransferases
src-Family Kinases
78 Citations (Scopus)

STIM1, PKC-δ and RasGRP set a threshold for proapoptotic Erk signaling during B cell development

Limnander, A., Depeille, P., Freedman, T. S., Liou, J., Leitges, M., Kurosaki, T., Roose, J. P. & Weiss, A., May 1 2011, In : Nature immunology. 12, 5, p. 425-433 9 p.

Research output: Contribution to journalArticle

Protein Kinase C
B-Lymphocytes
Autoimmunity
Clonal Deletion
Guanine Nucleotide Exchange Factors
156 Citations (Scopus)

ZAP-70: an essential kinase in T-cell signaling.

Wang, H., Kadlecek, T. A., Au-Yeung, B. B., Goodfellow, H. E. S., Hsu, L. Y., Freedman, T. S. & Weiss, A., Jan 1 2010, In : Cold Spring Harbor perspectives in biology. 2, 5

Research output: Contribution to journalReview article

ZAP-70 Protein-Tyrosine Kinase
Cell signaling
Antigen Receptors
T-cells
T-Cell Antigen Receptor