Sylvain E Lesne

PhD

Accepting PhD Students

20002024
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Research Output 2000 2019

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Article
2019
2 Citations (Scopus)

Tau is required for progressive synaptic and memory deficits in a transgenic mouse model of α-synucleinopathy

Singh, B., Covelo, A., Martell-Martínez, H., Nanclares, C., Sherman, M. A., Okematti, E., Meints, J., Teravskis, P. J., Gallardo, C., Savonenko, A. V., Benneyworth, M. A., Lesne, S. E., Liao, D., Araque, A. & Lee, M. K., Oct 1 2019, In : Acta Neuropathologica. 138, 4, p. 551-574 24 p.

Research output: Contribution to journalArticle

Memory Disorders
Transgenic Mice
Lewy Body Disease
Parkinson Disease
Dementia
2018
4 Citations (Scopus)

Bidirectional modulation of Alzheimer phenotype by alpha-synuclein in mice and primary neurons

Khan, S. S., LaCroix, M., Boyle, G., Sherman, M. A., Brown, J. L., Amar, F., Aldaco, J., Lee, M. K., Bloom, G. S. & Lesne, S. E., Oct 1 2018, In : Acta Neuropathologica. 136, 4, p. 589-605 17 p.

Research output: Contribution to journalArticle

Open Access
Synucleins
Phenotype
Neurons
Alzheimer Disease
Amyloid
4 Citations (Scopus)

Discrete Pools of Oligomeric Amyloid-β Track with Spatial Learning Deficits in a Mouse Model of Alzheimer Amyloidosis

Chiang, A. C. A., Fowler, S. W., Reddy, R., Pletnikova, O., Troncoso, J. C., Sherman, M. A., Lesne, S. E. & Jankowsky, J. L., Mar 1 2018, In : American Journal of Pathology. 188, 3, p. 739-756 18 p.

Research output: Contribution to journalArticle

Open Access
Amyloidosis
Amyloid
Detergents
Trans-Activators
Amyloid beta-Protein Precursor
2017
20 Citations (Scopus)

Selective lowering of synapsins induced by oligomeric α-synuclein exacerbates memory deficits

Larson, M. E., Greimel, S. J., Amar, F., LaCroix, M., Boyle, G., Sherman, M. A., Schley, H., Miel, C., Schneider, J. A., Kayed, R., Benfenati, F., Lee, M. K., Bennett, D. A. & Lesné, S. E., Jun 6 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 23, p. E4648-E4657

Research output: Contribution to journalArticle

Open Access
Synucleins
Synapsins
Memory Disorders
Amyloidogenic Proteins
Brain
27 Citations (Scopus)

The amyloid-β oligomer Aβ∗56 induces specific alterations in neuronal signaling that lead to tau phosphorylation and aggregation

Amar, F., Sherman, M. A., Rush, T., Larson, M., Boyle, G., Chang, L., Götz, J., Buisson, A. & Lesne, S. E., May 9 2017, In : Science signaling. 10, 478, aal2021.

Research output: Contribution to journalArticle

Open Access
Phosphorylation
Oligomers
Amyloid
Alzheimer Disease
Agglomeration
2016
31 Citations (Scopus)

Gain-of-function mutations in protein kinase Cα (PKCα) may promote synaptic defects in Alzheimer's disease

Alfonso, S. I., Callender, J. A., Hooli, B., Antal, C. E., Mullin, K., Sherman, M. A., Lesné, S. E., Leitges, M., Newton, A. C., Tanzi, R. E. & Malinow, R., May 10 2016, In : Science signaling. 9, 427, ra47.

Research output: Contribution to journalArticle

Protein Kinase C
Alzheimer Disease
Defects
Mutation
Synapses
23 Citations (Scopus)

Soluble conformers of Aβ and tau alter selective proteins governing axonal transport

Sherman, M. A., LaCroix, M., Amar, F., Larson, M. E., Forster, C., Aguzzi, A., Bennett, D. A., Ramsden, M. & Lesné, S. E., Sep 14 2016, In : Journal of Neuroscience. 36, 37, p. 9647-9658 12 p.

Research output: Contribution to journalArticle

Axonal Transport
Proteins
Kinesin
Neurofibrillary Tangles
Antibodies
2014
54 Citations (Scopus)

Genetic modulation of soluble Aβ rescues cognitive and synaptic impairment in a mouse model of Alzheimer's disease

Fowler, S. W., Chiang, A. C. A., Savjani, R. R., Larson, M. E., Sherman, M. A., Schuler, D. R., Cirrito, J. R., Lesné, S. E. & Jankowsky, J. L., Jan 1 2014, In : Journal of Neuroscience. 34, 23, p. 7871-7885 15 p.

Research output: Contribution to journalArticle

Amyloid Plaques
Amyloid
Alzheimer Disease
Amyloid beta-Protein Precursor
Cognition
16 Citations (Scopus)

Toxic oligomer species of amyloid-β in Alzheimer's disease, a timing issue

Lesné, S. E., Jan 1 2014, In : Swiss Medical Weekly. 144, 14021.

Research output: Contribution to journalArticle

Poisons
Amyloid
Alzheimer Disease
Aptitude
Brain
2013
241 Citations (Scopus)

Brain amyloid-β oligomers in ageing and Alzheimer's disease

Lesné, S. E., Sherman, M. A., Grant, M., Kuskowski, M., Schneider, J. A., Bennett, D. A. & Ashe, K. H., May 2013, In : Brain. 136, 5, p. 1383-1398 16 p.

Research output: Contribution to journalArticle

Amyloid
Alzheimer Disease
Brain
Microtubule Proteins
tau Proteins
2012
73 Citations (Scopus)

Soluble α-synuclein is a novel modulator of alzheimer's disease pathophysiology

Larson, M. E., Sherman, M. A., Greimel, S., Kuskowski, M., Schneider, J. A., Bennett, D. A. & Lesné, S. E., Jul 25 2012, In : Journal of Neuroscience. 32, 30, p. 10253-10266 14 p.

Research output: Contribution to journalArticle

Synucleins
Alzheimer Disease
Synaptic Vesicles
Transgenic Mice
Lewy Bodies
160 Citations (Scopus)

The complex PrPc-Fyn couples human oligomeric Aβ with pathological tau changes in Alzheimer's disease

Larson, M., Sherman, M. A., Amar, F., Nuvolone, M., Schneider, J. A., Bennett, D. A., Aguzzi, A. & Lesné, S. E., Nov 21 2012, In : Journal of Neuroscience. 32, 47, p. 16857-16871 15 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Dendritic Spines
Genetically Modified Animals
Gene Dosage
src-Family Kinases
2011
91 Citations (Scopus)

Cognitive effects of cell-derived and synthetically derived Aβ oligomers

Reed, M. N., Hofmeister, J. J., Jungbauer, L., Welzel, A. T., Yu, C., Sherman, M. A., Lesne, S. E., LaDu, M. J., Walsh, D. M., Ashe, K. H. & Cleary, J. P., Oct 1 2011, In : Neurobiology of Aging. 32, 10, p. 1784-1794 11 p.

Research output: Contribution to journalArticle

Brain
Amyloid
Cognition
Transgenic Mice
Uncertainty

Detecting aβ*56 oligomers in brain tissues.

Sherman, M. A. & Lesné, S. E., May 11 2011, In : Methods in molecular biology (Clifton, N.J.). 670, p. 45-56 12 p.

Research output: Contribution to journalArticle

Neurofibrillary Tangles
Amyloid beta-Peptides
Amyloid Plaques
Brain
Transgenic Mice
2008
159 Citations (Scopus)

Cyclooxygenase-2 inhibition improves amyloid-β-mediated suppression of memory and synaptic plasticity

Kotilinek, L. A., Westerman, M. A., Wang, Q., Panizzon, K., Lim, G. P., Simonyi, A., Lesne, S., Falinska, A., Younkin, L. H., Younkin, S. G., Rowan, M., Cleary, J., Wallis, R. A., Sun, G. Y., Cole, G., Frautschy, S., Anwyl, R. & Ashe, K. H., Mar 1 2008, In : Brain. 131, 3, p. 651-664 14 p.

Research output: Contribution to journalArticle

Neuronal Plasticity
Non-Steroidal Anti-Inflammatory Agents
Cyclooxygenase 2
Amyloid
Serum Amyloid A Protein
65 Citations (Scopus)

Oligomers of the amyloid-β protein disrupt working memory: Confirmation with two behavioral procedures

Poling, A., Morgan-Paisley, K., Panos, J. J., Kim, E. M., O'Hare, E., Cleary, J. P., Lesne, S. E., Ashe, K. H., Porritt, M. & Baker, L. E., Nov 21 2008, In : Behavioural Brain Research. 193, 2, p. 230-234 5 p.

Research output: Contribution to journalArticle

Amyloidogenic Proteins
Short-Term Memory
Amyloid
Culture Media
Alzheimer Disease
123 Citations (Scopus)

Plaque-bearing mice with reduced levels of oligomeric amyloid-β assemblies have intact memory function

Lesne, S. E., Kotilinek, L. & Ashe, K. H., Feb 6 2008, In : Neuroscience. 151, 3, p. 745-749 5 p.

Research output: Contribution to journalArticle

Amyloid
Amyloid Plaques
Memory Disorders
Serum Amyloid A Protein
Brain
2007
299 Citations (Scopus)

Accelerating amyloid-β fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models

Cheng, I. H., Scearce-Levie, K., Legleiter, J., Palop, J. J., Gerstein, H., Bien-Ly, N., Puoliväli, J., Lesné, S., Ashe, K. H., Muchowski, P. J. & Mucke, L., Aug 17 2007, In : Journal of Biological Chemistry. 282, 33, p. 23818-23828 11 p.

Research output: Contribution to journalArticle

Oligomers
Amyloid
Alzheimer Disease
Amyloid beta-Protein Precursor
Amyloid Plaques
87 Citations (Scopus)

Involvement of β-site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticity

Huifang, M., Lesné, S., Kotilinek, L., Steidl-Nichols, J. V., Sherman, M., Younkin, L., Younkin, S., Forster, C., Sergeant, N., Delacourte, A., Vassar, R., Citron, M., Kofuji, P., Boland, L. M. & Ashe, K. H., May 8 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 19, p. 8167-8172 6 p.

Research output: Contribution to journalArticle

Neuronal Plasticity
Amyloid beta-Protein Precursor
Enzymes
Alzheimer Disease
Serum Amyloid A Protein
85 Citations (Scopus)

β-amyloid modulation of synaptic transmission and plasticity

Venkitaramani, D. V., Chin, J., Netzer, W. J., Gouras, G. K., Lesne, S., Malinow, R. & Lombroso, P. J., Oct 31 2007, In : Journal of Neuroscience. 27, 44, p. 11832-11837 6 p.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins c-fyn
Neurological Models
Neuronal Plasticity
Amyloid beta-Peptides
Memory Disorders
2006
2154 Citations (Scopus)

A specific amyloid-β protein assembly in the brain impairs memory

Lesne, S. E., Ming, T. K., Kotilinek, L., Kayed, R., Glabe, C. G., Yang, A., Gallagher, M. & Ashe, K. H., Mar 16 2006, In : Nature. 440, 7082, p. 352-357 6 p.

Research output: Contribution to journalArticle

Serum Amyloid A Protein
Alzheimer Disease
Brain
Amyloid
Amyloidogenic Proteins
143 Citations (Scopus)

Orally available compound prevents deficits in memory caused by the Alzheimer amyloid-β oligomers

Townsend, M., Cleary, J. P., Mehta, T., Hofmeister, J., Lesne, S., O'Hare, E., Walsh, D. M. & Selkoe, D. J., Dec 1 2006, In : Annals of Neurology. 60, 6, p. 668-676 9 p.

Research output: Contribution to journalArticle

Memory Disorders
Amyloid
Neuronal Plasticity
Serum Amyloid A Protein
Stereoisomerism
2005
49 Citations (Scopus)

Akt-dependent expression of NAIP-1 protects neurons against amyloid-β toxicity

Lesné, S., Gabrieli, C., Nelson, D. A., White, E., MacKenzie, E. T., Vivien, D. & Buisson, A., Jul 1 2005, In : Journal of Biological Chemistry. 280, 26, p. 24941-24947 7 p.

Research output: Contribution to journalArticle

Neurotrophin 3
Amyloid
Neurons
Toxicity
Phosphatidylinositol 3-Kinase
140 Citations (Scopus)

NMDA receptor activation inhibits α-secretase and promotes neuronal amyloid-β production

Lesné, S., Ali, C., Gabriel, C., Croci, N., MacKenzie, E. T., Glabe, C. G., Plotkine, M., Marchand-Verrecchia, C., Vivien, D. & Buisson, A., Oct 12 2005, In : Journal of Neuroscience. 25, 41, p. 9367-9377 11 p.

Research output: Contribution to journalArticle

Amyloid Precursor Protein Secretases
N-Methyl-D-Aspartate Receptors
Amyloid
Alzheimer Disease
Peptide Hydrolases
35 Citations (Scopus)

Reduced brain tissue perfusion in TGF-β1 transgenic mice showing Alzheimer's disease-like cerebrovascular abnormalities

Gaertner, R. F., Wyss-Coray, T., Von Euw, D., Lesné, S., Vivien, D. & Lacombe, P., Jan 1 2005, In : Neurobiology of Disease. 19, 1-2, p. 38-46 9 p.

Research output: Contribution to journalArticle

Transgenic Mice
Alzheimer Disease
Perfusion
Brain
Blood Vessels
2004
53 Citations (Scopus)

Sp1 and Smad transcription factors co-operate to mediate TGF-β-dependent activation of amyloid-β precursor protein gene transcription

Docagne, F., Gabriel, C., Lebeurrier, N., Lesné, S., Hommet, Y., Plawinski, L., Mackenzie, E. T. & Vivien, D., Oct 15 2004, In : Biochemical Journal. 383, 2, p. 393-399 7 p.

Research output: Contribution to journalArticle

Smad Proteins
Amyloid beta-Protein Precursor
Transforming Growth Factors
Transcription
Transcription Factors
2003
87 Citations (Scopus)

Angiopoietin-1-induced PI3-kinase activation prevents neuronal apoptosis.

Valable, S., Bellail, A., Lesné, S., Liot, G., Mackenzie, E. T., Vivien, D., Bernaudin, M. & Petit, E., Jan 1 2003, In : The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 17, 3, p. 443-445 3 p.

Research output: Contribution to journalArticle

Angiopoietin-1
Phosphatidylinositol 3-Kinases
Chemical activation
Apoptosis
Neuroprotective Agents
44 Citations (Scopus)

Transforming growth factor alpha-induced expression of type 1 plasminogen activator inhibitor in astrocytes rescues neurons from excitotoxicity.

Gabriel, C., Ali, C., Lesné, S., Fernández-Monreal, M., Docagne, F., Plawinski, L., MacKenzie, E. T., Buisson, A. & Vivien, D., Jan 1 2003, In : The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 17, 2, p. 277-279 3 p.

Research output: Contribution to journalArticle

Transforming Growth Factor alpha
Plasminogen Activator Inhibitor 1
Astrocytes
Neurons
N-Methylaspartate
92 Citations (Scopus)

Transforming growth factor-β1 potentiates amyloid-β generation in astrocytes and in transgenic mice

Lesné, S., Docagne, F., Gabriel, C., Liot, G., Lahiri, D. K., Buée, L., Plawinski, L., Delacourte, A., MacKenzie, E. T., Buisson, A. & Vivien, D., May 16 2003, In : Journal of Biological Chemistry. 278, 20, p. 18408-18418 11 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Amyloid
Astrocytes
Transgenic Mice
Amyloid beta-Protein Precursor
2002
64 Citations (Scopus)

Smad3-dependent induction of plasminogen activator inhibitor-1 in astrocytes mediates neuroprotective activity of transforming growth factor-β1 against NMDA-induced necrosis

Docagne, F., Nicole, O., Gabriel, C., Fernández-Monreal, M., Lesné, S., Ali, C., Plawinski, L., Carmeliet, P., MacKenzie, E. T., Buisson, A. & Vivien, D., Jan 1 2002, In : Molecular and Cellular Neuroscience. 21, 4, p. 634-644 11 p.

Research output: Contribution to journalArticle

Plasminogen Activator Inhibitor 1
Transforming Growth Factors
N-Methylaspartate
Astrocytes
Necrosis
16 Citations (Scopus)

Transforming growth factor-β1-modulated cerebral gene expression

Lesné, S., Blanchet, S., Docagne, F., Liot, G., Plawinski, L., MacKenzie, E. T., Auffray, C., Buisson, A., Piétu, G. & Vivien, D., Jan 1 2002, In : Journal of Cerebral Blood Flow and Metabolism. 22, 9, p. 1114-1123 10 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Gene Expression
Astrocytes
Transgenic Mice
Genes
2001
34 Citations (Scopus)

Increased expression of transforming growth factor-β after cerebral ischemia in the baboon: An endogenous marker of neuronal stress?

Ali, C., Docagne, F., Nicole, O., Lesné, S., Toutain, J., Young, A., Chazalviel, L., Divoux, D., Caly, M., Cabal, P., Derlon, J. M., Mackenzie, E. T., Buisson, A. & Vivien, D., Jan 1 2001, In : Journal of Cerebral Blood Flow and Metabolism. 21, 7, p. 820-827 8 p.

Research output: Contribution to journalArticle

Papio
Transforming Growth Factors
Brain Ischemia
Stroke
Primates
2000
155 Citations (Scopus)

Ischemia-induced interleukin-6 as a potential endogenous neuroprotective cytokine against NMDA receptor-mediated excitoxicity in the brain

All, C., Nicole, O., Docagne, F., Lesne, S., MacKenzie, E. T., Nouvelot, A., Buisson, A. & Vivien, D., Jul 10 2000, In : Journal of Cerebral Blood Flow and Metabolism. 20, 6, p. 956-966 11 p.

Research output: Contribution to journalArticle

N-Methyl-D-Aspartate Receptors
Interleukin-6
Ischemia
Cytokines
Brain