Sylvain E Lesne


Accepting PhD Students

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  • 13 Similar Profiles
Amyloid Medicine & Life Sciences
Alzheimer Disease Medicine & Life Sciences
Amyloid Plaques Medicine & Life Sciences
Transforming Growth Factors Medicine & Life Sciences
Brain Medicine & Life Sciences
Transgenic Mice Medicine & Life Sciences
Amyloid beta-Protein Precursor Medicine & Life Sciences
Memory Disorders Medicine & Life Sciences

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Projects 2008 2024

Research Output 2000 2019

2 Citations (Scopus)

Tau is required for progressive synaptic and memory deficits in a transgenic mouse model of α-synucleinopathy

Singh, B., Covelo, A., Martell-Martínez, H., Nanclares, C., Sherman, M. A., Okematti, E., Meints, J., Teravskis, P. J., Gallardo, C., Savonenko, A. V., Benneyworth, M. A., Lesne, S. E., Liao, D., Araque, A. & Lee, M. K., Oct 1 2019, In : Acta Neuropathologica. 138, 4, p. 551-574 24 p.

Research output: Contribution to journalArticle

Memory Disorders
Transgenic Mice
Lewy Body Disease
Parkinson Disease
4 Citations (Scopus)

Bidirectional modulation of Alzheimer phenotype by alpha-synuclein in mice and primary neurons

Khan, S. S., LaCroix, M., Boyle, G., Sherman, M. A., Brown, J. L., Amar, F., Aldaco, J., Lee, M. K., Bloom, G. S. & Lesne, S. E., Oct 1 2018, In : Acta Neuropathologica. 136, 4, p. 589-605 17 p.

Research output: Contribution to journalArticle

Open Access
Alzheimer Disease
4 Citations (Scopus)

Discrete Pools of Oligomeric Amyloid-β Track with Spatial Learning Deficits in a Mouse Model of Alzheimer Amyloidosis

Chiang, A. C. A., Fowler, S. W., Reddy, R., Pletnikova, O., Troncoso, J. C., Sherman, M. A., Lesne, S. E. & Jankowsky, J. L., Mar 1 2018, In : American Journal of Pathology. 188, 3, p. 739-756 18 p.

Research output: Contribution to journalArticle

Open Access
Amyloid beta-Protein Precursor
20 Citations (Scopus)

Selective lowering of synapsins induced by oligomeric α-synuclein exacerbates memory deficits

Larson, M. E., Greimel, S. J., Amar, F., LaCroix, M., Boyle, G., Sherman, M. A., Schley, H., Miel, C., Schneider, J. A., Kayed, R., Benfenati, F., Lee, M. K., Bennett, D. A. & Lesné, S. E., Jun 6 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 23, p. E4648-E4657

Research output: Contribution to journalArticle

Open Access
Memory Disorders
Amyloidogenic Proteins
27 Citations (Scopus)

The amyloid-β oligomer Aβ∗56 induces specific alterations in neuronal signaling that lead to tau phosphorylation and aggregation

Amar, F., Sherman, M. A., Rush, T., Larson, M., Boyle, G., Chang, L., Götz, J., Buisson, A. & Lesne, S. E., May 9 2017, In : Science signaling. 10, 478, aal2021.

Research output: Contribution to journalArticle

Open Access
Alzheimer Disease