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Sylvain E Lesne

PhD

 https://orcid.org/0000-0001-9411-1868

Accepting PhD Students

20002024

Research output per year

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Fingerprint The Fingerprint is created by mining the titles and abstracts of the person's research outputs and projects/funding awards to create an index of weighted terms from discipline-specific thesauri.

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Projects

Alpha-synculein/tau coupling in Alzheimer's disease

Lesne, S. E.

NIH NAT'L INSTITUTE ON AGING (NIA)

2/1/20 → 11/30/21

Project: Research project

Gender-specific alterations of synuclein isoforms in aging and Alzheimer's disease-related dementias

Lesne, S. E.

Winston & Maxine Wallin Neuro Disc Fund

1/1/20 → 12/31/20

Project: Research project

    • Role of alpha-synuclein dependent network hyperexcitability in Lewy Body Dementia

    Lee, M. K. & Lesne, S. E.

    NIH NAT INST OF NEURO DISORDERS & STROKE

    9/15/19 → 7/31/20

    Project: Research project

    • Soluble aSyn is a modulator of AD pathophysiology

    Lesne, S. E., Araque, A. & Lee, M. K.

    NIH NAT'L INSTITUTE ON AGING (NIA)

    8/15/19 → 3/31/24

    Project: Research project

    AMP-Kinase as a target for neuroprotection in AD

    Lee, M. K., Lesne, S. E. & Liao, D.

    NIH NAT'L INSTITUTE ON AGING (NIA)

    2/15/19 → 1/31/24

    Project: Research project

    Research Output

    Tau is required for progressive synaptic and memory deficits in a transgenic mouse model of α-synucleinopathy

    Singh, B., Covelo, A., Martell-Martínez, H., Nanclares, C., Sherman, M. A., Okematti, E., Meints, J., Teravskis, P. J., Gallardo, C., Savonenko, A. V., Benneyworth, M. A., Lesne, S. E., Liao, D., Araque, A. & Lee, M. K., Oct 1 2019, In : Acta Neuropathologica. 138, 4, p. 551-574 24 p.

    Research output: Contribution to journal › Article

    Open Access
    • 2 Scopus citations

    Bidirectional modulation of Alzheimer phenotype by alpha-synuclein in mice and primary neurons

    Khan, S. S., LaCroix, M., Boyle, G., Sherman, M. A., Brown, J. L., Amar, F., Aldaco, J., Lee, M. K., Bloom, G. S. & Lesné, S. E., Oct 1 2018, In : Acta Neuropathologica. 136, 4, p. 589-605 17 p.

    Research output: Contribution to journal › Article

    Open Access
    • 5 Scopus citations

    Discrete Pools of Oligomeric Amyloid-β Track with Spatial Learning Deficits in a Mouse Model of Alzheimer Amyloidosis

    Chiang, A. C. A., Fowler, S. W., Reddy, R., Pletnikova, O., Troncoso, J. C., Sherman, M. A., Lesne, S. E. & Jankowsky, J. L., Mar 2018, In : American Journal of Pathology. 188, 3, p. 739-756 18 p.

    Research output: Contribution to journal › Article

    Open Access
    • 4 Scopus citations

    Selective lowering of synapsins induced by oligomeric α-synuclein exacerbates memory deficits

    Larson, M. E., Greimel, S. J., Amar, F., LaCroix, M., Boyle, G., Sherman, M. A., Schley, H., Miel, C., Schneider, J. A., Kayed, R., Benfenati, F., Lee, M. K., Bennett, D. A. & Lesné, S. E., Jun 6 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 23, p. E4648-E4657

    Research output: Contribution to journal › Article

    Open Access
    • 20 Scopus citations

    The amyloid-β oligomer Aβ∗56 induces specific alterations in neuronal signaling that lead to tau phosphorylation and aggregation

    Amar, F., Sherman, M. A., Rush, T., Larson, M., Boyle, G., Chang, L., Götz, J., Buisson, A. & Lesné, S. E., May 9 2017, In : Science signaling. 10, 478, aal2021.

    Research output: Contribution to journal › Article

    Open Access
    • 30 Scopus citations