Fingerprint The Fingerprint is created by mining the titles and abstracts of the person's research outputs and projects/funding awards to create an index of weighted terms from discipline-specific thesauri.

Lipopolysaccharides Medicine & Life Sciences
Endotoxins Medicine & Life Sciences
Lipid A Medicine & Life Sciences
Structure-Activity Relationship Medicine & Life Sciences
Toll-Like Receptor 8 Medicine & Life Sciences
Toll-Like Receptor 7 Medicine & Life Sciences
Amines Medicine & Life Sciences
Vaccines Medicine & Life Sciences

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Projects 2015 2019

Adjuvant Discovery Program

David, S. A.

University of Kansas

8/1/159/29/19

Project: Research project

Research Output 1992 2018

Potent anti-viral vaccine adjuvant based on pH-degradable nanogels with covalently linked small molecule imidazoquinoline TLR7/8 agonist

Nuhn, L., Van Hoecke, L., Deswarte, K., Schepens, B., Li, Y., Lambrecht, B. N., De Koker, S., David, S. A., Saelens, X. & De Geest, B. G. Jan 1 2018 (Accepted/In press) In : Biomaterials.

Research output: Contribution to journalArticle

Viral Vaccines
Vaccines
Cancer Vaccines
Subunit Vaccines
Molecules

Transiently Thermoresponsive Acetal Polymers for Safe and Effective Administration of Amphotericin B as a Vaccine Adjuvant

Van Herck, S., Van Hoecke, L., Louage, B., Lybaert, L., De Coen, R., Kasmi, S., Esser-Kahn, A. P., David, S. A., Nuhn, L., Schepens, B., Saelens, X. & De Geest, B. G. Mar 21 2018 In : Bioconjugate Chemistry. 29, 3, p. 748-760 13 p.

Research output: Contribution to journalArticle

Acetals
Vaccines
Toll-Like Receptors
Amphotericin B
Polymers
1 Citations

Identification of High-Potency Human TLR8 and Dual TLR7/TLR8 Agonists in Pyrimidine-2,4-diamines

Beesu, M., Salyer, A. C. D., Brush, M. J. H., Trautman, K. L., Hill, J. K. & David, S. A. Mar 9 2017 In : Journal of Medicinal Chemistry. 60, 5, p. 2084-2098 15 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 7
Diamines
Dendritic Cells
Interferon-gamma
Tumor Necrosis Factor-alpha
1 Citations

Syntheses of human TLR8-specific small-molecule agonists

Beesu, M., Kokatla, H. P. & David, S. A. Jan 1 2017 Methods in Molecular Biology. Humana Press Inc., p. 29-44 16 p. (Methods in Molecular Biology; vol. 1494)

Research output: Chapter in Book/Report/Conference proceedingChapter

Dendritic Cells
Th1 Cells
Myeloid Cells
Structure-Activity Relationship
Monocytes

Total Synthesis and Structure-Activity Relationship Studies of the Cytotoxic Anhydrophytosphingosine Jaspine B (Pachastrissamine)

Pashikanti, S., Ukani, R., David, S. A. & Datta, A. May 3 2017 In : Synthesis (Germany). 49, 9, p. 2088-2100 13 p., ss-2016-m0623-op

Research output: Contribution to journalArticle

Biological Products
Lactones
Cytotoxicity
Serine
pachastrissamine