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Projects 2015 2019

Adjuvant Discovery Program

David, S. A.

University of Kansas

8/1/159/29/19

Project: Research project

Research Output 1992 2017

1 Citations

Identification of High-Potency Human TLR8 and Dual TLR7/TLR8 Agonists in Pyrimidine-2,4-diamines

Beesu, M., Salyer, A. C. D., Brush, M. J. H., Trautman, K. L., Hill, J. K. & David, S. A. Mar 9 2017 In : Journal of Medicinal Chemistry. 60, 5, p. 2084-2098 15 p.

Research output: Research - peer-reviewArticle

Toll-Like Receptor 7
Diamines
pyrimidine
Dendritic Cells
Interferon-gamma
1 Citations

Syntheses of human TLR8-specific small-molecule agonists

Beesu, M., Kokatla, H. P. & David, S. A. Jan 1 2017 Methods in Molecular Biology. Humana Press Inc., Vol. 1494, p. 29-44 16 p. (Methods in Molecular Biology; vol. 1494)

Research output: ResearchChapter

Dendritic Cells
Th1 Cells
Myeloid Cells
Structure-Activity Relationship
Monocytes

Total Synthesis and Structure-Activity Relationship Studies of the Cytotoxic Anhydrophytosphingosine Jaspine B (Pachastrissamine)

Pashikanti, S., Ukani, R., David, S. A. & Datta, A. May 3 2017 In : Synthesis (Germany). 49, 9, p. 2088-2100 13 p., ss-2016-m0623-op

Research output: Research - peer-reviewArticle

Biological Products
pachastrissamine
Lactones
Cytotoxicity
Serine

Transiently Thermoresponsive Acetal Polymers for Safe and Effective Administration of Amphotericin B as Vaccine Adjuvant

Van Herck, S., Van Hoecke, L., Louage, B., Lybaert, L., De Coen, R., Kasmi, S., Esser-Kahn, A. P., David, S. A., Nuhn, L., Schepens, B., Saelens, X. & De Geest, B. G. Oct 23 2017 (Accepted/In press) In : Unknown Journal.

Research output: Research - peer-reviewArticle

Acetals
Toll-Like Receptors
Amphotericin B
Polymers
Vaccines
3 Citations

Human Toll-like Receptor (TLR) 8-Specific Agonistic Activity in Substituted Pyrimidine-2,4-diamines

Beesu, M., Salyer, A. C. D., Trautman, K. L., Hill, J. K. & David, S. A. Sep 8 2016 In : Journal of Medicinal Chemistry. 59, 17, p. 8082-8093 12 p.

Research output: Research - peer-reviewArticle

Toll-Like Receptor 8
Diamines
Cytokines
pyrimidine
human TLR8 protein