Fingerprint The Fingerprint is created by mining the titles and abstracts of the person's research outputs and projects/funding awards to create an index of weighted terms from discipline-specific thesauri.

  • 4 Similar Profiles
Carboxylic Acids Medicine & Life Sciences
Naphthyridines Medicine & Life Sciences
Indazoles Medicine & Life Sciences
gamendazole Medicine & Life Sciences
Cyclin-Dependent Kinases Medicine & Life Sciences
Sertoli Cells Medicine & Life Sciences
Male Contraceptive Agents Medicine & Life Sciences
hydrazine Medicine & Life Sciences

Research Output 1996 2015

4 Citations

Scalable syntheses of the BET bromodomain inhibitor JQ1

Syeda, S. S., Jakkaraj, S. & Georg, G. I. May 25 2015 In : Tetrahedron Letters. 56, 23, p. 3454-3457 4 p.

Research output: Research - peer-reviewArticle

Triazoles
2,4-bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane-2,4-disulfide
Thioamides
Poisons
Benzodiazepines
23 Citations

Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases

Schonbrunn, E., Betzi, S., Alam, R., Martin, M. P., Becker, A., Han, H., Francis, R., Chakrasali, R., Jakkaraj, S., Kazi, A., Sebti, S. M., Cubitt, C. L., Gebhard, A. W., Hazlehurst, L. A., Tash, J. S. & Georg, G. I. May 23 2013 In : Journal of Medicinal Chemistry. 56, 10, p. 3768-3782 15 p.

Research output: Research - peer-reviewArticle

Cyclin-Dependent Kinases
Retinoblastoma
Protein-Serine-Threonine Kinases
Cell Cycle
Phosphotransferases
69 Citations

Discovery of a potential allosteric ligand binding site in CDK2

Betzi, S., Alam, R., Martin, M., Lubbers, D. J., Han, H., Jakkaraj, S. R., Georg, G. I. & Schönbrunn, E. May 20 2011 In : ACS Chemical Biology. 6, 5, p. 492-501 10 p.

Research output: Research - peer-reviewArticle

Binding Sites
Ligands
naphthalene
Cyclin-Dependent Kinases
Cyclin A
48 Citations

A novel potent indazole carboxylic acid derivative blocks spermatogenesis and is contraceptive in rats after a single oral dose

Tash, J. S., Attardi, B., Hild, S. A., Chakrasali, R., Jakkaraj, S. R. & Georg, G. I. Jun 1 2008 In : Biology of Reproduction. 78, 6, p. 1127-1138 12 p.

Research output: Research - peer-reviewArticle

Indazoles
Spermatogenesis
Contraceptive Agents
Carboxylic Acids
gamendazole
45 Citations

Gamendazole, an orally active indazole carboxylic acid male contraceptive agent, targets HSP90AB1 (HSP90BETA) and EEF1A1 (eEF1A), and stimulates Il1a transcription in rat sertoli cells

Tash, J. S., Chakrasali, R., Jakkaraj, S. R., Hughes, J., Smith, S. K., Hornbaker, K., Heckert, L. L., Ozturk, S. B., Hadden, M. K., Kinzy, T. G., Blagg, B. S. J. & Georg, G. I. Jun 1 2008 In : Biology of Reproduction. 78, 6, p. 1139-1152 14 p.

Research output: Research - peer-reviewArticle

Male Contraceptive Agents
Indazoles
Sertoli Cells
Carboxylic Acids
gamendazole