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Research Output 1989 2019

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Article
2019

Distinct dual antiviral mechanism that enhances hepatitis B virus mutagenesis and reduces viral DNA synthesis

McDaniel, Y. Z., Patterson, S. & Mansky, L. M., Oct 1 2019, In : Antiviral Research. 170, 104540.

Research output: Contribution to journalArticle

Viral DNA
Hepatitis B virus
Mutagenesis
Antiviral Agents
Mutagens
2018
3 Citations (Scopus)
Dengue Virus
Nucleosides
Mutagenesis
Antiviral Agents
Dengue
2017
8 Citations (Scopus)

An official American Thoracic Society Workshop Report: Chemical inhalational disasters biology of lung injury, development of novel therapeutics, and medical preparedness

Summerhill, E. M., Hoyle, G. W., Jordt, S. E., Jugg, B. J., Martin, J. G., Matalon, S., Patterson, S., Prezant, D. J., Sciuto, A. M., Svendsen, E. R., White, C. W. & Veress, L. A., Jun 1 2017, In : Annals of the American Thoracic Society. 14, 6, p. 1060-1072 13 p.

Research output: Contribution to journalArticle

Irritants
Lung Injury
Disasters
Phosgene
Mustard Gas
1 Citation (Scopus)

In-vitro mercaptopyruvate sulfurtransferase species comparison in humans and common laboratory animals

Moeller, B. M., Crankshaw, D. L., Briggs, J., Nagasawa, H. T. & Patterson, S., May 15 2017, In : Toxicology Letters. 274, p. 64-68 5 p.

Research output: Contribution to journalArticle

Laboratory Animals
Cyanides
Animals
Liver
Mass Casualty Incidents
2016
2 Citations (Scopus)

5-Azacytidine enhances the mutagenesis of HIV-1 by reduction to 5-aza-2'-deoxycytidine

Rawson, J. M. O., Daly, M. B., Xie, J., Clouser, C. L., Landman, S. R., Reilly, C. S., Bonnac, L., Kim, B., Patterson, S. & Mansky, L. M., Apr 1 2016, In : Antimicrobial Agents and Chemotherapy. 60, 4, p. 2318-2325 8 p.

Research output: Contribution to journalArticle

decitabine
Azacitidine
Mutagenesis
HIV-1
Reverse Transcription
7 Citations (Scopus)

Development of sulfanegen for mass cyanide casualties

Patterson, S., Moeller, B., Nagasawa, H. T., Vince, R., Crankshaw, D. L., Briggs, J., Stutelberg, M. W., Vinnakota, C. V. & Logue, B. A., Jan 1 2016, In : Annals of the New York Academy of Sciences. 1374, 1, p. 202-209 8 p.

Research output: Contribution to journalArticle

Mass Casualty Incidents
Cyanides
Antidotes
Occupational Accidents
Detoxification
2 Citations (Scopus)

Dual anti-HIV mechanism of clofarabine

Daly, M. B., Roth, M. E., Bonnac, L., Maldonado, J. O., Xie, J., Clouser, C. L., Patterson, S. E., Kim, B. & Mansky, L. M., Mar 24 2016, In : Retrovirology. 13, 1, 20.

Research output: Contribution to journalArticle

HIV-1
HIV
Macrophages
Viral DNA
T-Lymphocytes
5 Citations (Scopus)

Simultaneous determination of 3-mercaptopyruvate and cobinamide in plasma by liquid chromatography-tandem mass spectrometry

Stutelberg, M. W., Dzisam, J. K., Monteil, A. R., Petrikovics, I., Boss, G. R., Patterson, S., Rockwood, G. A. & Logue, B. A., Jan 1 2016, In : Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 1008, p. 181-188 8 p.

Research output: Contribution to journalArticle

Liquid chromatography
Tandem Mass Spectrometry
Liquid Chromatography
Mass spectrometry
Plasmas
2 Citations (Scopus)

Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase

Rawson, J. M. O., Roth, M. E., Xie, J., Daly, M. B., Clouser, C. L., Landman, S. R., Reilly, C. S., Bonnac, L., Kim, B., Patterson, S. & Mansky, L. M., Jun 1 2016, In : Bioorganic and Medicinal Chemistry. 24, 11, p. 2410-2422 13 p.

Research output: Contribution to journalArticle

Ribonucleotide Reductases
Azacitidine
HIV-1
Ribonucleosides
Mutagenesis
2015
8 Citations (Scopus)

Lack of mutational hot spots during decitabine-mediated HIV-1 mutagenesis

Rawson, J. M. O., Landman, S. R., Reilly, C. S., Bonnac, L., Patterson, S. & Mansky, L. M., Nov 1 2015, In : Antimicrobial Agents and Chemotherapy. 59, 11, p. 6834-6843 10 p.

Research output: Contribution to journalArticle

decitabine
Mutagenesis
HIV-1
Mutation Rate
Guanine
2014
9 Citations (Scopus)
decitabine
gemcitabine
Prodrugs
HIV-1
Permeability
10 Citations (Scopus)

Determination of 3-mercaptopyruvate in rabbit plasma by high performance liquid chromatography tandem mass spectrometry

Stutelberg, M. W., Vinnakota, C. V., Mitchell, B. L., Monteil, A. R., Patterson, S. & Logue, B. A., Jan 1 2014, In : Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 949-950, p. 94-98 5 p.

Research output: Contribution to journalArticle

High performance liquid chromatography
Tandem Mass Spectrometry
Cyanides
Antidotes
Mass spectrometry
10 Citations (Scopus)

Discovery of novel ribonucleoside analogs with activity against human immunodeficiency virus type 1

Dapp, M. J., Bonnac, L., Patterson, S. & Mansky, L. M., Jan 1 2014, In : Journal of virology. 88, 1, p. 354-363 10 p.

Research output: Contribution to journalArticle

ribonucleosides
Ribonucleosides
Human immunodeficiency virus 1
reverse transcription
HIV-1
7 Citations (Scopus)

Noninvasive optical cytochrome c oxidase redox state measurements using diffuse optical spectroscopy

Lee, J., Kim, J. G., Mahon, S. B., Mukai, D., Yoon, D., Boss, G. R., Patterson, S., Rockwood, G., Isom, G. & Brenner, M., Jan 1 2014, In : Journal of Biomedical Optics. 19, 5, 055001.

Research output: Contribution to journalArticle

oxidase
cytochromes
Electron Transport Complex IV
Cyanides
hemorrhages
16 Citations (Scopus)

Novel inhibitors of human immunodeficiency virus type 2 infectivity

Beach, L. B., Rawson, J. M., Kim, B., Patterson, S. & Mansky, L. M., Dec 1 2014, In : Journal of General Virology. 95, p. 2778-2783 6 p.

Research output: Contribution to journalArticle

HIV-2
Azacitidine
gemcitabine
Mutagenesis
Pharmaceutical Preparations
2013
15 Citations (Scopus)

5,6-Dihydro-5-aza-2′-deoxycytidine potentiates the anti-HIV-1 activity of ribonucleotide reductase inhibitors

Rawson, J. M., Heineman, R. H., Beach, L. B., Martin, J. L., Schnettler, E. K., Dapp, M. J., Patterson, S. E. & Mansky, L. M., Nov 15 2013, In : Bioorganic and Medicinal Chemistry. 21, 22, p. 7222-7228 7 p.

Research output: Contribution to journalArticle

Ribonucleotide Reductases
Viruses
HIV-1
Mutagens
gemcitabine
19 Citations (Scopus)

Cyanide antidotes for mass casualties: Water-soluble salts of the dithiane (sulfanegen) from 3-mercaptopyruvate for intramuscular administration

Patterson, S., Monteil, A. R., Cohen, J. F., Crankshaw, D. L., Vince, R. & Nagasawa, H. T., Feb 14 2013, In : Journal of Medicinal Chemistry. 56, 3, p. 1346-1349 4 p.

Research output: Contribution to journalArticle

Mass Casualty Incidents
Antidotes
Cyanides
Salts
Water
58 Citations (Scopus)

Seasonal pasture myopathy/atypical myopathy in North America associated with ingestion of hypoglycin A within seeds of the box elder tree

Valberg, S. J., Sponseller, B. T., Hegeman, A. D., Earing, J., Bender, J. B., Martinson, K. L., Patterson, S. & Sweetman, L., Jul 1 2013, In : Equine veterinary journal. 45, 4, p. 419-426 8 p.

Research output: Contribution to journalArticle

Acer negundo
Acer
muscular diseases
Muscular Diseases
North America
2012
13 Citations (Scopus)

Activity of a novel combined antiretroviral therapy of gemcitabine and decitabine in a mouse model for HIV-1

Clouser, C. L., Holtz, C. M., Mullett, M., Crankshaw, D. L., Briggs, J. E., O'Sullivan, G., Patterson, S. & Mansky, L. M., Apr 1 2012, In : Antimicrobial Agents and Chemotherapy. 56, 4, p. 1942-1948 7 p.

Research output: Contribution to journalArticle

decitabine
gemcitabine
HIV-1
Murine Leukemia Viruses
Murine Acquired Immunodeficiency Syndrome
51 Citations (Scopus)

Anti-HIV-1 activity of resveratrol derivatives and synergistic inhibition of HIV-1 by the combination of resveratrol and decitabine

Clouser, C. L., Chauhan, J., Bess, M. A., Oploo, J. L. V., Zhou, D., Dimick-Gray, S., Mansky, L. M. & Patterson, S., Nov 1 2012, In : Bioorganic and Medicinal Chemistry Letters. 22, 21, p. 6642-6646 5 p.

Research output: Contribution to journalArticle

decitabine
HIV-1
Ribonucleotide Reductases
Derivatives
Nucleosides
17 Citations (Scopus)

Cyanide toxicity in juvenile pigs and its reversal by a new prodrug, sulfanegen sodium

Belani, K. G., Singh, H., Beebe, D. S., George, P., Patterson, S., Nagasawa, H. T. & Vince, R., May 1 2012, In : Anesthesia and Analgesia. 114, 5, p. 956-961 6 p.

Research output: Contribution to journalArticle

Prodrugs
Cyanides
Swine
Sodium
Nitroprusside
14 Citations (Scopus)

Discovery of drugs that possess activity against feline leukemia virus

Greggs, W. M., Clouser, C. L., Patterson, S. & Mansky, L. M., Apr 1 2012, In : Journal of General Virology. 93, 4, p. 900-905 6 p.

Research output: Contribution to journalArticle

Feline Leukemia Virus
Drug Discovery
HIV-1
Gammaretrovirus
Pharmaceutical Preparations
10 Citations (Scopus)

IP-FCM Measures Physiologic Protein-Protein Interactions Modulated by Signal Transduction and Small-Molecule Drug Inhibition

Smith, S. E. P., Bida, A. T., Davis, T. R., Sicotte, H., Patterson, S., Gil, D. & Schrum, A. G., Sep 21 2012, In : PloS one. 7, 9, e45722.

Research output: Contribution to journalArticle

Signal transduction
Flow cytometry
protein-protein interactions
Immunoprecipitation
flow cytometry
8 Citations (Scopus)

Noninvasive monitoring of treatment response in a rabbit cyanide toxicity model reveals differences in brain and muscle metabolism

Kim, J. G., Lee, J., Mahon, S. B., Mukai, D., Patterson, S., Boss, G. R., Tromberg, B. J. & Brenner, M., Oct 1 2012, In : Journal of biomedical optics. 17, 10, 105005.

Research output: Contribution to journalArticle

rabbits
Cyanides
cyanides
metabolism
muscles
2011
15 Citations (Scopus)

Analysis of the ex vivo and in vivo antiretroviral activity of gemcitabine

Clouser, C. L., Holtz, C. M., Mullett, M., Crankshaw, D. L., Briggs, J. E., Chauhan, J., Vanhoutan, I. M., Patterson, S. & Mansky, L. M., Feb 1 2011, In : PLoS One. 6, 1, e15840.

Research output: Contribution to journalArticle

gemcitabine
ribonucleotide reductase
hydroxyurea
mice
toxicity
20 Citations (Scopus)

The combination of cobinamide and sulfanegen is highly effective in mouse models of cyanide poisoning

Chan, A., Crankshaw, D. L., Monteil, A., Patterson, S., Nagasawa, H. T., Briggs, J. E., Kozocas, J. A., Mahon, S. B., Brenner, M., Pilz, R. B., Bigby, T. D. & Boss, G. R., Jun 1 2011, In : Clinical Toxicology. 49, 5, p. 366-373 8 p.

Research output: Contribution to journalArticle

Cyanides
Poisoning
Antidotes
Inhalation
Pharmaceutical Preparations
2010
56 Citations (Scopus)

Exploiting drug repositioning for discovery of a novel HIV combination therapy

Clouser, C. L., Patterson, S. & Mansky, L. M., Jan 1 2010, In : Journal of Virology. 84, 18, p. 9301-9309 9 p.

Research output: Contribution to journalArticle

Drug Repositioning
decitabine
Drug Discovery
HIV
Ribonucleotide Reductases
39 Citations (Scopus)

Intramuscular Cobinamide Sulfite in a Rabbit Model of Sublethal Cyanide Toxicity

Brenner, M., Kim, J. G., Mahon, S. B., Lee, J., Kreuter, K. A., Blackledge, W., Mukai, D., Patterson, S., Mohammad, O., Sharma, V. S. & Boss, G. R., Apr 1 2010, In : Annals of Emergency Medicine. 55, 4, p. 352-363 12 p.

Research output: Contribution to journalArticle

Sulfites
Cyanides
Rabbits
Mass Casualty Incidents
Vitamin B 12
13 Citations (Scopus)

Phosphonoxins III: Synthesis of α-aminophosphonate analogs of antifungal polyoxins with anti-Giardia activity

Staake, M., Chauhan, J., Zhou, D., Shanker, A., De Chatterjee, A., Das, S. & Patterson, S., Oct 15 2010, In : Organic Letters. 12, 20, p. 4596-4599 4 p.

Research output: Contribution to journalArticle

Giardia
Giardia lamblia
Azides
Palladium
Lithium
28 Citations (Scopus)

Sulfanegen sodium treatment in a rabbit model of sub-lethal cyanide toxicity

Brenner, M., Kim, J. G., Lee, J., Mahon, S. B., Lemor, D., Ahdout, R., Boss, G. R., Blackledge, W., Jann, L., Nagasawa, H. T. & Patterson, S., Nov 1 2010, In : Toxicology and Applied Pharmacology. 248, 3, p. 269-276 8 p.

Research output: Contribution to journalArticle

Cyanides
Toxicity
Sodium
Rabbits
Sulfur
3 Citations (Scopus)

Synthesis of novel benzo[ b ]furans and benzo[ b ]thiophenes: Analogs of combretastatin and resveratrol

Chauhan, J., Monteil, A. R. & Patterson, S., Dec 1 2010, In : Heterocyclic Communications. 16, 4-6, p. 241-244 4 p.

Research output: Contribution to journalArticle

Benzofurans
Antineoplastic Agents
benzothiophene
resveratrol
benzofuran
2009
64 Citations (Scopus)

5-Azacytidine can induce lethal mutagenesis in human immunodeficiency virus type 1

Dapp, M. J., Clouser, C. L., Patterson, S. & Mansky, L. M., Nov 1 2009, In : Journal of Virology. 83, 22, p. 11950-11958 9 p.

Research output: Contribution to journalArticle

Azacitidine
Human immunodeficiency virus 1
reverse transcription
lethal genes
mutagenesis
2008
7 Citations (Scopus)

Phosphonoxins II: Diastereoselective synthesis of phosphonic acid analogues of polyoxins

Zhou, D., Staake, M. & Patterson, S., Jun 5 2008, In : Organic Letters. 10, 11, p. 2179-2182 4 p.

Research output: Contribution to journalArticle

analogs
acids
synthesis
configurations
polyoxin
2007
24 Citations (Scopus)

A novel paradigm for assessing efficacies of potential antidotes against neurotoxins in mice

Crankshaw, D. L., Goon, D. J. W., Briggs, J. E., DeLong, D., Kuskowski, M., Patterson, S. E. & Nagasawa, H. T., Dec 10 2007, In : Toxicology Letters. 175, 1-3, p. 111-117 7 p.

Research output: Contribution to journalArticle

Antidotes
Neurotoxins
Cyanides
Righting Reflex
Animals
6 Citations (Scopus)

Efficient synthesis of benzamide riboside, a potential anticancer agent

Bonnac, L., Gao, G. Y., Chen, L., Patterson, S., Jayaram, H. N. & Pankiewicz, K. W., Oct 1 2007, In : Nucleosides, Nucleotides and Nucleic Acids. 26, 10-12, p. 1249-1253 5 p.

Research output: Contribution to journalArticle

Antineoplastic Agents
3-(1-deoxyribofuranosyl)benzamide
Clinical Studies
12 Citations (Scopus)

Fujita-Ban QSAR analysis and CoMFA study of quinoline antagonists of immunostimulatory CpG-oligodeoxynucleotides

Paliakov, E., Henary, M., Say, M., Patterson, S., Parker, A., Manzel, L., Macfarlane, D. E., Bojarski, A. J. & Strekowski, L., Jan 1 2007, In : Bioorganic and Medicinal Chemistry. 15, 1, p. 324-332 9 p.

Research output: Contribution to journalArticle

Quantitative Structure-Activity Relationship
Oligodeoxyribonucleotides
Amines
Coulomb interactions
Bioactivity
35 Citations (Scopus)

Novel, orally effective cyanide antidotes

Nagasawa, H. T., Goon, D. J. W., Crankshaw, D. L., Vince, R. & Patterson, S., Dec 27 2007, In : Journal of Medicinal Chemistry. 50, 26, p. 6462-6464 3 p.

Research output: Contribution to journalArticle

Antidotes
Cyanides
Prodrugs
Enzymes
3-mercaptopyruvic acid
20 Citations (Scopus)

Phosphonoxins: Rational design and discovery of a potent nucleotide anti-Giardia agent

Suk, D. H., Rejman, D., Dykstra, C. C., Pohl, R., Pankiewicz, K. W. & Patterson, S., May 15 2007, In : Bioorganic and Medicinal Chemistry Letters. 17, 10, p. 2811-2816 6 p.

Research output: Contribution to journalArticle

Giardia
Trophozoites
Anti-Infective Agents
Nucleotides
Growth
24 Citations (Scopus)

Probing binding requirements of NAD kinase with modified substrate (NAD) analogues

Bonnac, L., Chen, L., Pathak, R., Gao, G., Ming, Q., Bennett, E., Felczak, K. Z., Kullberg, M., Patterson, S., Mazzola, F., Magni, G. & Pankiewicz, K. W., Mar 15 2007, In : Bioorganic and Medicinal Chemistry Letters. 17, 6, p. 1512-1515 4 p.

Research output: Contribution to journalArticle

NAD
Substrates
Fluorine
Adenine
Mycobacterium tuberculosis
22 Citations (Scopus)

Probing binding requirements of type I and type II isoforms of inosine monophosphate dehydrogenase with adenine-modified nicotinamide adenine dinucleotide analogues

Chen, L., Gao, G., Felczak, K. Z., Bonnac, L., Patterson, S., Wilson, D., Bennett, E. M., Jayaram, H. N., Hedstrom, L. & Pankiewicz, K. W., Nov 15 2007, In : Journal of Medicinal Chemistry. 50, 23, p. 5743-5751 9 p.

Research output: Contribution to journalArticle

Inosine Monophosphate
Adenine
tiazofurin
NAD
Inhibitory Concentration 50
7 Citations (Scopus)

Rational design and synthesis of novel nucleotide anti-Giardia agents

Suk, D. H., Bonnac, L., Dykstra, C. C., Pankiewicz, K. W. & Patterson, S., Apr 1 2007, In : Bioorganic and Medicinal Chemistry Letters. 17, 7, p. 2064-2067 4 p.

Research output: Contribution to journalArticle

Giardia
Nucleotides
Trophozoites
Growth
2006
20 Citations (Scopus)

Novel methylenephosphophosphonate analogues of mycophenolic adenine dinucleotide. Inhibition of inosine monophosphate dehydrogenase

Rejman, D., Olesiak, M., Chen, L., Patterson, S., Wilson, D., Jayaram, H. N., Hedstrom, L. & Pankiewicz, K. W., Aug 10 2006, In : Journal of Medicinal Chemistry. 49, 16, p. 5018-5022 5 p.

Research output: Contribution to journalArticle

IMP Dehydrogenase
Inosine Monophosphate
Organophosphonates
Adenosine
Oxidoreductases
Diphosphates
Nucleosides
Flavin-Adenine Dinucleotide
NAD
Phosphates
Organophosphonates
Diphosphates
Nucleosides
Flavin-Adenine Dinucleotide
Phosphoric Diester Hydrolases
2005
156 Citations (Scopus)

Design, synthesis, and antiviral activity of 2′-deoxy-2′- fluoro-2′-C-methylcytidine, a potent inhibitor of hepatitis C virus replication

Clark, J. L., Hollecker, L., Mason, J. C., Stuyver, L. J., Tharnish, P. M., Lostia, S., McBrayer, T. R., Schinazi, R. F., Watanabe, K. A., Otto, M. J., Furman, P. A., Stec, W. J., Patterson, S. & Pankiewicz, K. W., Aug 25 2005, In : Journal of Medicinal Chemistry. 48, 17, p. 5504-5508 5 p.

Research output: Contribution to journalArticle

Virus Replication
Hepacivirus
Antiviral Agents
Replicon
Halogenation
44 Citations (Scopus)

Synthesis and anti-viral activity of a series of D- and l-2′-deoxy-2′-fluororibonucleosides in the subgenomic HCV replicon system

Shi, J., Du, J., Ma, T., Pankiewicz, K. W., Patterson, S., Tharnish, P. M., McBrayer, T. R., Stuyver, L. J., Otto, M. J., Chu, C. K., Schinazi, R. F. & Watanabe, K. A., Mar 1 2005, In : Bioorganic and Medicinal Chemistry. 13, 5, p. 1641-1652 12 p.

Research output: Contribution to journalArticle

Replicon
Viruses
Hepacivirus
Bovine Viral Diarrhea Viruses
Ribosomal RNA
4 Citations (Scopus)

Synthesis and in vitro anti-HCV activity of β-D- and L-2′-deoxy-2′-fluororibonucleosides

Shi, J., Du, J., Ma, T., Pankiewicz, K. W., Patterson, S., Hassan, A. E. A., Tharnish, P. M., McBrayer, T. R., Lostia, S., Stuyver, L. J., Watanabe, K. A., Chu, C. K., Schinazi, R. F. & Otto, M. J., Oct 20 2005, In : Nucleosides, Nucleotides and Nucleic Acids. 24, 5-7, p. 875-879 5 p.

Research output: Contribution to journalArticle

Viruses
Hepacivirus
Bovine Viral Diarrhea Viruses
Halogenation
gemcitabine
7 Citations (Scopus)

Synthesis of N3,5′-cyclo-4-(β-D-ribofuranosyl)-vic- triazolo[4,5-b]pyridin-5-one and its 3′-deoxysugar analogue as potential anti-hepatitis C virus agents

Wang, P., Hollecker, L., Pankiewicz, K. W., Patterson, S., Whitaker, T., McBrayer, T. R., Tharnish, P. M., Stuyver, L. J., Schinazi, R. F., Otto, M. J. & Watanabe, K. A., Oct 20 2005, In : Nucleosides, Nucleotides and Nucleic Acids. 24, 5-7, p. 957-960 4 p.

Research output: Contribution to journalArticle

Viruses
Hepacivirus
Deoxy Sugars
Replicon
N3,5'-cyclo-4-ribofuranosyl-vic-triazolo(4,5-b)pyridin-5-one
2004
2 Citations (Scopus)

Synthesis of 5′-C-methyl-1′,3′-dioxolan-4′-yl nucleosides

Du, J., Patterson, S., Shi, J., Chun, B. K., Stuyver, L. J. & Watanabe, K. A., Mar 8 2004, In : Bioorganic and Medicinal Chemistry Letters. 14, 5, p. 1243-1245 3 p.

Research output: Contribution to journalArticle

Nucleosides
Lactic Acid
formal glycol