Stephen W Wietgrefe

1985 …2019

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

Filter
Article
1985

Cloning of a gene whose expression is increased in scrapie and in senile plaques in human brain

Wietgrefe, S., Zupancic, M., Haase, A., Chesebro, B., Race, R., Frey, W., Rustan, T. & Friedman, R. L., Jan 1 1985, In : Science. 230, 4730, p. 1177-1179 3 p.

Research output: Contribution to journalArticle

43 Scopus citations

Natural history of restricted synthesis and expression of measles virus genes in subacute sclerosing panencephalitis

Haase, A. T., Gantz, D., Eble, B., Walker, D., Stowring, L., Ventura, P., Blum, H., Wietgrefe, S., Zupancic, M. & Tourtellotte, W., 1985, In : Proceedings of the National Academy of Sciences of the United States of America. 82, 9, p. 3020-3024 5 p.

Research output: Contribution to journalArticle

43 Scopus citations
1986

Correlation between presence of lactate dehydrogenase-elevating virus RNA and antigens in motor neurons and paralysis in infected C58 mice

Contag, C. H., Chan, S. P. K., Wietgrefe, S. W. & Plagemann, P. G. W., Dec 1986, In : Virus research. 6, 3, p. 195-209 15 p.

Research output: Contribution to journalArticle

13 Scopus citations

Speculations on the Role of Transmissible Agents in the Pathogenesis of Alzheimer's Disease

Haase, A. T., Lewis, E., Wietgrefe, S., Zupancic, M., Jane, D., Minnigan, H. & Ball, M. J., Nov 1986, In : Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques. 13, S4, p. 449-451 3 p.

Research output: Contribution to journalArticle

3 Scopus citations
1987

The molecular pathogenesis of astrogliosis in scrapie and Alzheimer's disease

Diedrich, J., Wietgrefe, S., Zupancic, M., Staskus, K., Retzel, E., Haase, A. T. & Race, R., Jun 1987, In : Microbial Pathogenesis. 2, 6, p. 435-442 8 p.

Research output: Contribution to journalArticle

42 Scopus citations
1991

Isolation of replication-competent molecular clones of visna virus

Staskus, K. A., Retzel, E. F., Lewis, E. D., Silsby, J. L., Sheila Cyr, S. T., Rank, J. M., Wietgrefe, S. W., Haase, A. T., Cook, R., Fast, D., Geiser, P. T., Harty, J. T., Kong, S. H., Lahti, C. J., Neufeld, T. P., Porter, T. E., Shoop, E. & Zachow, K. R., Mar 1991, In : Virology. 181, 1, p. 228-240 13 p.

Research output: Contribution to journalArticle

55 Scopus citations
1992

A new in situ hybridization technique for spliced RNA species documents the bone marrow origin of pulmonary macrophages in chronic myelogenous leukemia

Ely, P., Haase, A., Wietgrefe, S., Zupancic, M., Beneke, J., Hertz, M. & Miller, W., 1992, In : Blood. 80, 9, p. 2321-2325 5 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations
1997

Kinetics of response in lymphoid tissues to antiretroviral therapy of HIV-1 infection

Cavert, W., Notermans, D. W., Staskus, K., Wietgrefe, S. W., Zupancic, M., Gebhard, K., Henry, K., Zhang, Z. Q., Mills, R., McDade, H., Goudsmit, J., Danner, S. A. & Haase, A. T., May 9 1997, In : Science. 276, 5314, p. 960-964 5 p.

Research output: Contribution to journalArticle

480 Scopus citations
1998

Kinetics of CD4+ T cell repopulation of lymphoid tissues after treatment of HIV-1 infection

Zhang, Z. Q., Notermans, D. W., Sedgewick, G., Cavert, W., Wietgrefe, S., Zupancic, M., Gebhard, K., Henry, K., Boies, L., Chen, Z., Jenkins, M., Mills, R., Mcdade, H., Goodwin, C., Schuwirth, C. M., Danner, S. A. & Haase, A. T., Feb 3 1998, In : Proceedings of the National Academy of Sciences of the United States of America. 95, 3, p. 1154-1159 6 p.

Research output: Contribution to journalArticle

176 Scopus citations
1999

Sexual transmission and propagation of SIV and HIV in resting and activated CD4+ T cells

Zhang, Z. Q., Schuler, T., Zupancic, M., Wietgrefe, S. W., Staskus, K. A., Reimann, K. A., Reinhart, T. A., Rogan, M., Cavert, W., Miller, C. J., Veazey, R. S., Notermans, D., Little, S., Danner, S. A., Richman, D. D., Havlir, D., Wong, J., Jordan, H. L., Schacker, T. W., Racz, P. & 4 others, Tenner-Racz, K., Letvin, N. L., Wolinsky, S. & Haase, A. T., Nov 12 1999, In : Science. 286, 5443, p. 1353-1357 5 p.

Research output: Contribution to journalArticle

694 Scopus citations
2002

The clustering of infected SIV cells in lymphatic tissue

Reilly, C., Schacker, T., Haase, A. T., Wietgrefe, S. & Krason, D., Dec 1 2002, In : Journal of the American Statistical Association. 97, 460, p. 943-954 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

Transendothelial migration of leukocytes carrying infectious HIV-1: An indicator of adverse prognosis

Birdsall, H. H., Siwak, E. B., Trial, J. A., Rodriguez-Barradas, M., White, A. C., Wietgrefe, S. & Rossen, R. D., Jan 4 2002, In : AIDS. 16, 1, p. 5-12 8 p.

Research output: Contribution to journalArticle

9 Scopus citations
2004
168 Scopus citations
2005

Propagation and dissemination of infection after vaginal transmission of simian immunodeficiency virus

Miller, C. J., Li, Q., Abel, K., Kim, E. Y., Ma, Z. M., Wietgrefe, S. W., La Franco-Scheuch, L., Compton, L., Duan, L., Shore, M. D., Zupancic, M., Busch, M., Carlis, J. V., Wolinksy, S. & Haase, A. T., Jul 2005, In : Journal of virology. 79, 14, p. 9217-9227 11 p.

Research output: Contribution to journalArticle

337 Scopus citations
2006

Premature induction of an immunosuppressive regulatory T cell response during acute simian immunodeficiency virus infection

Estes, J. D., Li, Q., Reynolds, M. R., Wietgrefe, S., Duan, L., Schacker, T., Picker, L. J., Watkins, D. I., Lifson, J. D., Reilly, C., Carlis, J. & Haase, A. T., Mar 1 2006, In : Journal of Infectious Diseases. 193, 5, p. 703-712 10 p.

Research output: Contribution to journalArticle

197 Scopus citations
2007

Determination of simian immunodeficiency virus production by infected activated and resting cells

Reilly, C., Wietgrefe, S., Sedgewick, G. & Haase, A., Jan 2007, In : AIDS. 21, 2, p. 163-168 6 p.

Research output: Contribution to journalArticle

34 Scopus citations

Simian immunodeficiency virus-induced lymphatic tissue fibrosis is mediated by transforming growth factor β1-positive regulatory T cells and begins in early infection

Estes, J. D., Wietgrefe, S., Schacker, T., Southern, P., Beilman, G., Reilly, C., Milush, J. M., Lifson, J. D., Sodora, D. L., Carlis, J. V. & Haase, A. T., Feb 15 2007, In : Journal of Infectious Diseases. 195, 4, p. 551-561 11 p.

Research output: Contribution to journalArticle

128 Scopus citations
2008

Simian immunodeficiency virus-induced intestinal cell apoptosis is the underlying mechanism of the regenerative enteropathy of early infection

Li, Q., Estes, J. D., Duan, L., Jessurun, J., Pambuccian, S., Forster, C., Wietgrefe, S., Zupancic, M., Schacker, T., Reilly, C., Carlis, J. V. & Haase, A. T., Feb 1 2008, In : Journal of Infectious Diseases. 197, 3, p. 420-429 10 p.

Research output: Contribution to journalArticle

91 Scopus citations
2009

Simultaneous cell-to-cell transmission of human immunodeficiency virus to multiple targets through polysynapses

Rudnicka, D., Feldmann, J., Porrot, F., Wietgrefe, S., Guadagnini, S., Prévost, M. C., Estaquier, J., Haase, A. T., Sol-Foulon, N. & Schwartz, O., Jun 2009, In : Journal of virology. 83, 12, p. 6234-6246 13 p.

Research output: Contribution to journalArticle

169 Scopus citations
2010

Host genes associated with HIV-1 replication in lymphatic tissue

Smith, A. J., Li, Q., Wietgrefe, S. W., Schacker, T. W., Reilly, C. S. & Haase, A. T., Nov 1 2010, In : Journal of Immunology. 185, 9, p. 5417-5424 8 p.

Research output: Contribution to journalArticle

30 Scopus citations
2011

Cumulative mechanisms of lymphoid tissue fibrosis and T cell depletion in HIV-1 and SIV infections

Zeng, M., Smith, A. J., Wietgrefe, S. W., Southern, P. J., Schacker, T. W., Reilly, C. S., Estes, J. D., Burton, G. F., Silvestri, G., Lifson, J. D., Carlis, J. V. & Haase, A. T., Mar 1 2011, In : Journal of Clinical Investigation. 121, 3, p. 998-1008 11 p.

Research output: Contribution to journalArticle

193 Scopus citations

The immunosuppressive role of IL-32 in lymphatic tissue during HIV-1 infection

Smith, A. J., Toledo, C. M., Wietgrefe, S. W., Duan, L., Schacker, T. W., Reilly, C. S. & Haase, A. T., Jun 1 2011, In : Journal of Immunology. 186, 11, p. 6576-6584 9 p.

Research output: Contribution to journalArticle

33 Scopus citations
2014

Live simian immunodeficiency virus vaccine correlate of protection: Local antibody production and concentration on the path of virus entry

Li, Q., Zeng, M., Duan, L., Voss, J. E., Smith, A. J., Pambuccian, S., Shang, L., Wietgrefe, S., Southern, P. J., Reilly, C. S., Skinner, P. J., Zupancic, M. L., Carlis, J. V., Piatak, M., Waterman, D., Reeves, R. K., Masek-Hammerman, K., Derdeyn, C. A., Alpert, M. D., Evans, D. T. & 7 others, Kohler, H., Müller, S., Robinson, J., Lifson, J. D., Burton, D. R., Johnson, R. P. & Haase, A. T., Sep 15 2014, In : Journal of Immunology. 193, 6, p. 3113-3125 13 p.

Research output: Contribution to journalArticle

47 Scopus citations

Live simian immunodeficiency virus vaccine correlate of protection: Immune complex-inhibitory fc receptor interactions that reduce target cell availability

Smith, A. J., Wietgrefe, S. W., Shang, L., Reilly, C. S., Southern, P. J., Perkey, K. E., Duan, L., Kohler, H., Müller, S., Robinson, J., Carlis, J. V., Li, Q., Johnson, R. P. & Haase, A. T., Sep 15 2014, In : Journal of Immunology. 193, 6, p. 3126-3133 8 p.

Research output: Contribution to journalArticle

27 Scopus citations

NK cell responses to simian immunodeficiency virus vaginal exposure in naive and vaccinated rhesus macaques

Shang, L., Smith, A. J., Duan, L., Perkey, K. E., Qu, L., Wietgrefe, S., Zupancic, M., Southern, P. J., Masek-Hammerman, K., Reeves, R. K., Johnson, R. P. & Haase, A. T., Jul 1 2014, In : Journal of Immunology. 193, 1, p. 277-284 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues

Fletcher, C. V., Staskus, K., Wietgrefe, S. W., Rothenberger, M., Reilly, C., Chipman, J. G., Beilman, G. J., Khoruts, A., Thorkelson, A., Schmidt, T. E., Anderson, J., Perkey, K., Stevenson, M., Perelson, A. S., Douek, D. C., Haase, A. T. & Schacker, T. W., Feb 11 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 6, p. 2307-2312 6 p.

Research output: Contribution to journalArticle

360 Scopus citations

Targeted Cytotoxic Therapy Kills Persisting HIV Infected Cells During ART

Denton, P. W., Long, J. M., Wietgrefe, S. W., Sykes, C., Spagnuolo, R. A., Snyder, O. D., Perkey, K., Archin, N. M., Choudhary, S. K., Yang, K., Hudgens, M. G., Pastan, I., Haase, A. T., Kashuba, A. D., Berger, E. A., Margolis, D. M. & Garcia, J. V., Jan 2014, In : PLoS pathogens. 10, 1, e1003872.

Research output: Contribution to journalArticle

77 Scopus citations
2015

Large number of rebounding/founder HIV variants emerge from multifocal infection in lymphatic tissues after treatment interruption

Rothenberger, M. K., Keele, B. F., Wietgrefe, S. W., Fletcher, C. V., Beilman, G. J., Chipman, J. G., Khoruts, A., Estes, J. D., Anderson, J., Callisto, S. P., Schmidt, T. E., Thorkelson, A., Reilly, C., Perkey, K., Reimann, T. G., Utay, N. S., Makamdop, K. N., Stevenson, M., Douek, D. C., Haase, A. T. & 1 others, Schacker, T. W., Mar 10 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 10, p. E1126-E1134

Research output: Contribution to journalArticle

141 Scopus citations
2016

Macrophages sustain HIV replication in vivo independently of T cells

Honeycutt, J. B., Wahl, A., Baker, C., Spagnuolo, R. A., Foster, J., Zakharova, O., Wietgrefe, S., Caro-Vegas, C., Madden, V., Sharpe, G., Haase, A. T., Eron, J. J. & Garcia, J. V., Apr 1 2016, In : Journal of Clinical Investigation. 126, 4, p. 1353-1366 14 p.

Research output: Contribution to journalArticle

Open Access
118 Scopus citations

Mucosal humoral immune response to SIVmac239Δnef vaccination and vaginal challenge

Zeng, M., Smith, A. J., Shang, L., Wietgrefe, S. W., Voss, J. E., Carlis, J. V., Li, Q., Piatak, M., Lifson, J. D., Johnson, R. P. & Haase, A. T., Mar 15 2016, In : Journal of Immunology. 196, 6, p. 2809-2818 10 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations
2017

Brain macrophages in simian immunodeficiency virus-infected, antiretroviral-suppressed macaques: A functional latent reservoir

Avalos, C. R., Abreu, C. M., Queen, S. E., Li, M., Price, S., Shirk, E. N., Engle, E. L., Forsyth, E., Bullock, B. T., Gabhann, F. M., Wietgrefe, S. W., Haase, A. T., Zink, M. C., Mankowski, J. L., Clements, J. E. & Gama, L., Jul 1 2017, In : mBio. 8, 4, e01186-17.

Research output: Contribution to journalArticle

Open Access
59 Scopus citations

Defining total-body AIDS-virus burden with implications for curative strategies

Estes, J. D., Kityo, C., Ssali, F., Swainson, L., Makamdop, K. N., Del Prete, G. Q., Deeks, S. G., Luciw, P. A., Chipman, J. G., Beilman, G. J., Hoskuldsson, T., Khoruts, A., Anderson, J., Deleage, C., Jasurda, J., Schmidt, T. E., Hafertepe, M., Callisto, S. P., Pearson, H., Reimann, T. & 12 others, Schuster, J., Schoephoerster, J., Southern, P., Perkey, K., Shang, L., Wietgrefe, S. W., Fletcher, C. V., Lifson, J. D., Douek, D. C., McCune, J. M., Haase, A. T. & Schacker, T. W., Nov 1 2017, In : Nature Medicine. 23, 11, p. 1271-1276 6 p.

Research output: Contribution to journalArticle

Open Access
132 Scopus citations

Epithelium-innate immune cell axis in mucosal responses to SIV

Shang, L., Duan, L., Perkey, K. E., Wietgrefe, S., Zupancic, M., Smith, A. J., Southern, P. J., Johnson, R. P. & Haase, A. T., Mar 1 2017, In : Mucosal Immunology. 10, 2, p. 508-519 12 p.

Research output: Contribution to journalArticle

Open Access
19 Scopus citations

Extensive virologic and immunologic characterization in an HIV-infected individual following allogeneic stem cell transplant and analytic cessation of antiretroviral therapy: A case study

Cummins, N. W., Rizza, S., Litzow, M. R., Hua, S., Lee, G. Q., Einkauf, K., Chun, T. W., Rhame, F., Baker, J. V., Busch, M. P., Chomont, N., Dean, P. G., Fromentin, R., Haase, A. T., Hampton, D., Keating, S. M., Lada, S. M., Lee, T. H., Natesampillai, S., Richman, D. D. & 7 others, Schacker, T. W., Wietgrefe, S., Yu, X. G., Yao, J. D., Zeuli, J., Lichterfeld, M. & Badley, A. D., Nov 2017, In : PLoS Medicine. 14, 11, e1002461.

Research output: Contribution to journalArticle

Open Access
23 Scopus citations

Reactivation of simian immunodeficiency virus reservoirs in the brain of virally suppressed macaques

Gama, L., Abreu, C. M., Shirk, E. N., Price, S. L., Li, M., Laird, G. M., Metcalf Pate, K. A., Wietgrefe, S. W., O'Connor, S. L., Pianowski, L., Haase, A. T., Van Lint, C. & Siliciano, R. F., 2017, In : AIDS. 31, 1, p. 5-14 10 p.

Research output: Contribution to journalArticle

Open Access
63 Scopus citations
2018

Transplantation of CCR5∆32 homozygous umbilical cord blood in a child with acute lymphoblastic leukemia and perinatally acquired HIV infection

Rothenberger, M. K., Wagner, J. E., Haase, A., Richman, D., Grzywacz, B. J., Strain, M., Lada, S., Estes, J., Fletcher, C. V., Podany, A. T., Anderson, J., Schmidt, T., Wietgrefe, S. W., Schacker, T. W. & Verneris, M. R., 2018, In : Open Forum Infectious Diseases. 5, 5

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Vaccine-associated maintenance of epithelial integrity correlated with protection against virus entry

Shang, L., Smith, A. J., Duan, L., Perkey, K. E., Wietgrefe, S., Zupancic, M., Southern, P. J., Johnson, R. P., Carlis, J. V. & Haase, A. T., Sep 8 2018, In : Journal of Infectious Diseases. 218, 8, p. 1272-1283 12 p.

Research output: Contribution to journalArticle

Open Access

Vaccine-modified NF-kB and GR signaling in cervicovaginal epithelium correlates with protection

Shang, L., Smith, A. J., Reilly, C. S., Duan, L., Perkey, K. E., Wietgrefe, S., Zupancic, M., Southern, P. J., Johnson, R. P., Carlis, J. V. & Haase, A. T., Mar 1 2018, In : Mucosal Immunology. 11, 2, p. 512-522 11 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2019

Humanized mouse model of HIV-1 latency with enrichment of latent virus in PD-1+ and TIGIT+ CD4 T cells

Llewellyn, G. N., Seclén, E., Wietgrefe, S. W., Liu, S., Chateau, M., Pei, H., Perkey, K., Marsden, M. D., Hinkley, S. J., Paschon, D. E., Holmes, M. C., Zack, J. A., Louie, S. G., Haase, A. T. & Cannona, P. M., May 1 2019, In : Journal of virology. 93, 10, e02086-18.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Impact of Integrase Inhibition Compared with Nonnucleoside Inhibition on HIV Reservoirs in Lymphoid Tissues

Rothenberger, M., Nganou-Makamdop, K., Kityo, C., Ssali, F., Chipman, J. G., Beilman, G. J., Hoskuldsson, T., Anderson, J., Jasurda, J., Schmidt, T. E., Calisto, S. P., Pearson, H., Reimann, T., David, C., Perkey, K., Southern, P., Wietgrefe, S., Helgeson, E., Reilly, C., Haase, A. T. & 3 others, Douek, D. C., Fletcher, C. V. & Schacker, T. W., Jul 1 2019, In : Journal of Acquired Immune Deficiency Syndromes. 81, 3, p. 355-360 6 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations