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Research Output 1967 2019

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Review article
2019
1 Citation (Scopus)

Recent studies on DNA adducts resulting from human exposure to tobacco smoke

Ma, B., Stepanov, I. & Hecht, S. S., Jan 1 2019, In : Toxics. 7, 1, 16.

Research output: Contribution to journalReview article

Open Access
Tobacco
DNA Adducts
Smoke
Carcinogens
Nitrosamines
2018
1 Citation (Scopus)

The safety evaluation of food flavouring substances: the role of metabolic studies

Smith, R. L., Cohen, S. M., Fukushima, S., Gooderham, N. J., Hecht, S. S., Guengerich, F. P., Rietjens, I. M. C. M., Bastaki, M., Harman, C. L., McGowen, M. M. & Taylor, S. V., Jan 1 2018, In : Toxicology Research. 7, 4, p. 618-646 29 p.

Research output: Contribution to journalReview article

Food Safety
Flavors
Metabolism
Safety
Glucuronic Acid
2017
12 Citations (Scopus)

Oral cell DNA adducts as potential biomarkers for lung cancer susceptibility in cigarette smokers

Hecht, S. S., Jan 1 2017, In : Chemical research in toxicology. 30, 1, p. 367-375 9 p.

Research output: Contribution to journalReview article

Open Access
DNA Adducts
Biomarkers
Tobacco Products
Lung Neoplasms
DNA
7 Citations (Scopus)

Safety evaluation of substituted thiophenes used as flavoring ingredients

Cohen, S. M., Fukushima, S., Gooderham, N. J., Guengerich, F. P., Hecht, S. S., Rietjens, I. M. C. M., Smith, R. L., Bastaki, M., Harman, C. L., McGowen, M. M., Valerio, L. G. & Taylor, S. V., Jan 1 2017, In : Food and Chemical Toxicology. 99, p. 40-59 20 p.

Research output: Contribution to journalReview article

thiophenes
Thiophenes
flavorings
Metabolism
ingredients
8 Citations (Scopus)

Tobacco, e-cigarettes, and child health

Peterson, L. A. & Hecht, S. S., Apr 1 2017, In : Current Opinion in Pediatrics. 29, 2, p. 225-230 6 p.

Research output: Contribution to journalReview article

Tobacco
Smoke
Nicotine
National Institute of Environmental Health Sciences (U.S.)
Biomarkers
2016
1 Citation (Scopus)

FEMA expert panel review of p-mentha-1,8-dien-7-al genotoxicity testing results

Cohen, S. M., Fukushima, S., Gooderham, N. J., Guengerich, F. P., Hecht, S. S., Rietjens, I. M. C. M., Smith, R. L., Bastaki, M., Harman, C. L., McGowen, M. M. & Taylor, S. V., Dec 1 2016, In : Food and Chemical Toxicology. 98, p. 201-209 9 p.

Research output: Contribution to journalReview article

Mentha
Flavors
genotoxicity
Assays
Micronucleus Tests
122 Citations (Scopus)

Key characteristics of carcinogens as a basis for organizing data on mechanisms of carcinogenesis

Smith, M. T., Guyton, K. Z., Gibbons, C. F., Fritz, J. M., Portier, C. J., Rusyn, I., DeMarini, D. M., Caldwell, J. C., Kavlock, R. J., Lambert, P. F., Hecht, S. S., Bucher, J. R., Stewart, B. W., Baan, R. A., Cogliano, V. J. & Straif, K., Jun 1 2016, In : Environmental health perspectives. 124, 6, p. 713-721 9 p.

Research output: Contribution to journalReview article

International Agencies
Carcinogens
Carcinogenesis
Research
Neoplasms
20 Citations (Scopus)

Research on cruciferous vegetables, indole-3-carbinol, and cancer prevention: A tribute to Lee W. Wattenberg

Fujioka, N., Fritz, V., Upadhyaya, P., Kassie, F. & Hecht, S. S., Jun 1 2016, In : Molecular Nutrition and Food Research. 60, 6, p. 1228-1238 11 p.

Research output: Contribution to journalReview article

indoles
Vegetables
vegetables
Glucosinolates
neoplasms
2015
66 Citations (Scopus)

NIH electronic cigarette workshop: Developing a research agenda

Walton, K. M., Abrams, D. B., Bailey, W. C., Clark, D., Connolly, G. N., Djordjevic, M. V., Eissenberg, T. E., Fiore, M. C., Goniewicz, M. L., Haverkos, L., Hecht, S. S., Henningfield, J. E., Hughes, J. R., Oncken, C. A., Postow, L., Rose, J. E., Wanke, K. L., Yang, L. & Hatsukami, D. K., Feb 1 2015, In : Nicotine and Tobacco Research. 17, 2, p. 259-269 11 p.

Research output: Contribution to journalReview article

Education
Research
Nicotine
Tobacco Products
Equipment and Supplies
2014
27 Citations (Scopus)

Fifty years of tobacco carcinogenesis research: From mechanisms to early detection and prevention of lung cancer

Hecht, S. S. & Szabo, E., Jan 1 2014, In : Cancer Prevention Research. 7, 1, p. 1-8 8 p.

Research output: Contribution to journalReview article

Tobacco
Lung Neoplasms
Carcinogenesis
Research
Carcinogens
19 Citations (Scopus)

Impact of structural and metabolic variations on the toxicity and carcinogenicity of hydroxy- and alkoxy-substituted allyl- and propenylbenzenes

Rietjens, I. M. C. M., Cohen, S. M., Fukushima, S., Gooderham, N. J., Hecht, S., Marnett, L. J., Smith, R. L., Adams, T. B., Bastaki, M., Harman, C. G. & Taylor, S. V., Jul 21 2014, In : Chemical research in toxicology. 27, 7, p. 1092-1103 12 p.

Research output: Contribution to journalReview article

Toxicity
Metabolism
Food
Alkylation
Metabolic Networks and Pathways
39 Citations (Scopus)

Urinary tobacco smoke-constituent biomarkers for assessing risk of lung cancer

Yuan, J. M., Butler, L. M., Stepanov, I. & Hecht, S. S., Jan 15 2014, In : Cancer Research. 74, 2, p. 401-411 11 p.

Research output: Contribution to journalReview article

Smoke
Tobacco
Lung Neoplasms
Biomarkers
Smoking
2013
107 Citations (Scopus)

Assessing secondhand smoke using biological markers

Avila-Tang, E., Al-Delaimy, W. K., Ashley, D. L., Benowitz, N., Bernert, J. T., Kim, S., Samet, J. M. & Hecht, S. S., May 1 2013, In : Tobacco control. 22, 3, p. 164-171 8 p.

Research output: Contribution to journalReview article

Tobacco Smoke Pollution
nicotine
Biomarkers
Cotinine
medical research
2012
15 Citations (Scopus)
DNA Adducts
Head and Neck Neoplasms
Early Detection of Cancer
Carcinogens
Tobacco
2011
5 Citations (Scopus)

Evolution of research on the DNA adduct chemistry of N-nitrosopyrrolidine and related aldehydes

Hecht, S. S., Upadhyaya, P. & Wang, M., Jun 20 2011, In : Chemical Research in Toxicology. 24, 6, p. 781-790 10 p.

Research output: Contribution to journalReview article

N-Nitrosopyrrolidine
DNA Adducts
Aldehydes
Carcinogenesis
Research
2010
69 Citations (Scopus)

Applying tobacco carcinogen and toxicant biomarkers in product regulation and cancer prevention

Hecht, S. S., Yuan, J. M. & Hatsukami, D. K., Jun 21 2010, In : Chemical research in toxicology. 23, 6, p. 1001-1008 8 p.

Research output: Contribution to journalReview article

Tobacco
Biomarkers
Carcinogens
Tobacco Products
Neoplasms
69 Citations (Scopus)

Formaldehyde and leukemia: Epidemiology, potential mechanisms, and implications for risk assessment

Zhang, L., Beane Freeman, L. E., Nakamura, J., Hecht, S. S., Vandenberg, J. J., Smith, M. T. & Sonawane, B. R., Apr 1 2010, In : Environmental and Molecular Mutagenesis. 51, 3, p. 181-191 11 p.

Research output: Contribution to journalReview article

Formaldehyde
Leukemia
Epidemiology
DNA Adducts
Toxicogenetics
43 Citations (Scopus)

Tobacco and cancer: An American Association for Cancer Research policy statement

Viswanath, K., Herbst, R. S., Land, S. R., Leischow, S. J., Shields, P. G., Brandon, T. H., Fiore, M. C., Gritz, E. R., Hecht, S. S., Lerman, C., Minna, J. D. & Sidransky, D., May 1 2010, In : Cancer Research. 70, 9, p. 3419-3430 12 p.

Research output: Contribution to journalReview article

Tobacco
Tobacco Use
Neoplasms
Tobacco Products
Public Health
2009
73 Citations (Scopus)

Chemoprevention of lung carcinogenesis in addicted smokers and ex-smokers

Hecht, S. S., Kassie, F. & Hatsukami, D. K., Jul 1 2009, In : Nature Reviews Cancer. 9, 7, p. 476-488 13 p.

Research output: Contribution to journalReview article

Chemoprevention
Carcinogens
Carcinogenesis
Lung
Smoke
2008
197 Citations (Scopus)

Progress and challenges in selected areas of tobacco carcinogenesis

Hecht, S. S., Jan 1 2008, In : Chemical research in toxicology. 21, 1, p. 160-171 12 p.

Research output: Contribution to journalReview article

Tobacco
Carcinogenesis
Tobacco Use
Lung Neoplasms
Carcinogens
339 Citations (Scopus)

Smokeless tobacco and cancer

Boffetta, P., Hecht, S., Gray, N., Gupta, P. & Straif, K., Jan 1 2008, In : The Lancet Oncology. 9, 7, p. 667-675 9 p.

Research output: Contribution to journalReview article

Smokeless Tobacco
Mouth Neoplasms
Tobacco Products
Neoplasms
Esophageal Neoplasms
2007
124 Citations (Scopus)

Cancer prevention with freeze-dried berries and berry components

Stoner, G. D., Wang, L. S., Zikri, N., Chen, T., Hecht, S. S., Huang, C., Sardo, C. & Lechner, J. F., Oct 1 2007, In : Seminars in Cancer Biology. 17, 5, p. 403-410 8 p.

Research output: Contribution to journalReview article

Fruit
Esophageal Neoplasms
Neoplasms
Carcinogens
Colonic Neoplasms
44 Citations (Scopus)

Developing the science base for reducing tobacco harm

Hatsukami, D., Joseph, A., LeSage, M., Jensen, J., Murphy, S., Pentel, P., Kotlyar, M., Borgida, E., Le, C. & Hecht, S., Dec 1 2007, In : Nicotine and Tobacco Research. 9, SUPPL. 4, p. 537-553 17 p.

Research output: Contribution to journalReview article

Tobacco
Harm Reduction
Tobacco Use
Research
Individuality
2006
89 Citations (Scopus)

Biomarkers to assess the utility of potential reduced exposure tobacco products

Hatsukami, D. K., Benowitz, N. L., Rennard, S. I., Oncken, C. & Hecht, S. S., Apr 1 2006, In : Nicotine and Tobacco Research. 8, 2, p. 169-191 23 p.

Research output: Contribution to journalReview article

Tobacco Products
Biomarkers
Tobacco
Proxy
Lung Diseases
20 Citations (Scopus)

Biomarkers to assess the utility of potential reduced exposure tobacco products.

Hatsukami, D. K., Benowitz, N. L., Rennard, S. I., Oncken, C. & Hecht, S. S., Jan 1 2006, In : Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. 8, 4, p. 600-622 23 p.

Research output: Contribution to journalReview article

Tobacco Products
Biomarkers
Tobacco
Proxy
Lung Diseases
2005
122 Citations (Scopus)
Pyridines
Species Specificity
Nitrosamines
Microsomes
Catalysis
2004
55 Citations (Scopus)

Carcinogen derived biomarkers: Applications in studies of human exposure to secondhand tobacco smoke

Hecht, S. S., Mar 1 2004, In : Tobacco control. 13, SUPPL. 1

Research output: Contribution to journalReview article

Tobacco Smoke Pollution
Carcinogens
nicotine
Tobacco
Biomarkers
2003
147 Citations (Scopus)

Analysis of DNA and protein adducts of benzo[a]pyrene in human tissues using structure-specific methods

Boysen, G. & Hecht, S. S., Jan 1 2003, In : Mutation Research - Reviews in Mutation Research. 543, 1, p. 17-30 14 p.

Research output: Contribution to journalReview article

7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
Carcinogens
DNA
Proteins
DNA Adducts
32 Citations (Scopus)

Biomakers of tobacco exposure or harm: Application to clinical and epidemiological studies

Hatsukami, D. K., Hecht, S. S., Hennrikus, D. J., Joseph, A. M. & Pentel, P. R., Jun 1 2003, In : Nicotine and Tobacco Research. 5, 3, p. 387-396 10 p.

Research output: Contribution to journalReview article

Tobacco
Epidemiologic Studies
Biomarkers
Tobacco Use
Health
42 Citations (Scopus)

Effects of benzyl isothiocyanate and 2-phenethyl isothiocyanate on benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolism in F-344 rats

Boysen, G., Kenney, P. M. J., Upadhyaya, P., Wang, M. & Hecht, S. S., Mar 1 2003, In : Carcinogenesis. 24, 3, p. 517-525 9 p.

Research output: Contribution to journalReview article

Benzo(a)pyrene
DNA Adducts
Lung
Diet
Hemoglobins
854 Citations (Scopus)

Tobacco carcinogens, their biomarkers and tobacco-induced cancer

Hecht, S. S., Jan 1 2003, In : Nature Reviews Cancer. 3, 10, p. 733-744 12 p.

Research output: Contribution to journalReview article

Carcinogens
Tobacco
Biomarkers
Nicotine
Tobacco Products
2002
357 Citations (Scopus)

Cigarette smoking and lung cancer: Chemical mechanisms and approaches to prevention

Hecht, S. S., Jan 1 2002, In : Lancet Oncology. 3, 8, p. 461-469 9 p.

Research output: Contribution to journalReview article

Carcinogens
Lung Neoplasms
Smoking
DNA Adducts
DNA
302 Citations (Scopus)

Human urinary carcinogen metabolites: Biomarkers for investigating tobacco and cancer

Hecht, S. S., Jan 1 2002, In : Carcinogenesis. 23, 6, p. 907-922 16 p.

Research output: Contribution to journalReview article

Carcinogens
Tobacco
Biomarkers
Smoke
Neoplasms
1999
1406 Citations (Scopus)

Tobacco smoke carcinogens and lung cancer

Hecht, S. S., Jul 21 1999, In : Journal of the National Cancer Institute. 91, 14, p. 1194-1210 17 p.

Research output: Contribution to journalReview article

Smoke
Carcinogens
Tobacco
Lung Neoplasms
Laboratory Animals
1998
850 Citations (Scopus)

Biochemistry, biology, and carcinogenicity of tobacco-specific N- nitrosamines

Hecht, S. S., Jul 1 1998, In : Chemical research in toxicology. 11, 6, p. 559-603 45 p.

Research output: Contribution to journalReview article

Nitrosamines
Biochemistry
Tobacco
DNA Adducts
Carcinogens
1997
59 Citations (Scopus)

Tobacco addiction: Implications for treatment and cancer prevention

Cinciripini, P. M., Hecht, S. S., Henningfield, J. E., Manley, M. W. & Kramer, B. S., Dec 17 1997, In : Journal of the National Cancer Institute. 89, 24, p. 1852-1867 16 p.

Research output: Contribution to journalReview article

Tobacco
Tobacco Use Disorder
Neoplasms
National Cancer Institute (U.S.)
American Medical Association
1996
30 Citations (Scopus)

Liver tumorigenesis by Helicobacter hepaticus: Considerations of mechanism

Canella, K. A., Diwan, B. A., Gorelick, P. L., Donovan, P. J., Sipowicz, M. A., Kasprzak, K. S., Weghorst, C. M., Snyderwine, E. G., Davis, C. D., Keefer, L. K., Kyrtopoulos, S. A., Hecht, S. S., Wang, M., Anderson, L. M. & Rice, J. M., Jul 3 1996, In : In Vivo. 10, 3, p. 285-292 8 p.

Research output: Contribution to journalReview article

Helicobacter hepaticus
Liver
Tumors
Carcinogenesis
DNA
100 Citations (Scopus)
Detoxification
Tobacco
DNA Adducts
Carcinogens
Cytochrome P-450 Enzyme System
29 Citations (Scopus)

Synthesis of tobacco-specific N-nitrosamines and their metabolites and results of related bioassays

Amin, S., Desai, D., Hecht, S. S. & Hoffmann, D., Jan 1 1996, In : Critical Reviews in Toxicology. 26, 2, p. 139-147 9 p.

Research output: Contribution to journalReview article

N'-nitrosonornicotine
Nitrosamines
Tobacco
Bioassay
Metabolites
106 Citations (Scopus)

The biological significance of tobacco-specific N-nitrosamines: Smoking and adenocarcinoma of the lung

Hoffmann, D., Rivenson, A. & Hecht, S. S., Jan 1 1996, In : Critical Reviews in Toxicology. 26, 2, p. 199-211 13 p.

Research output: Contribution to journalReview article

Nitrosamines
Tobacco
Tobacco Products
Smoke
Smoking
1994
11 Citations (Scopus)

Tobacco-specific nitrosamines.

Hecht, S. S., Peterson, L. A. & Spratt, T. E., Dec 1 1994, In : IARC scientific publications. 125, p. 91-106 16 p.

Research output: Contribution to journalReview article

Toxic Plants
Nitrosamines
DNA Adducts
Carcinogens
Tobacco
1993
59 Citations (Scopus)

Cigarette smoking and adenocarcinoma of the lung: The relevance of nicotine-derived N-nitrosamines

Hoffmann, D., Rivenson, A., Murphy, S. E., Chung, F. L., Amin, S. & Hecht, S. S., Jan 1 1993, In : Journal of Smoking-Related Disorders. 4, 3, p. 165-189 25 p.

Research output: Contribution to journalReview article

Nitrosamines
Nicotine
Tobacco
Tobacco Products
Smoking
1989
271 Citations (Scopus)

The relevance of tobacco-specific nitrosamines to human cancer

Hecht, S. S. & Hoffmann, D., Dec 1 1989, In : Cancer Surveys. 8, 2, p. 273-294 22 p.

Research output: Contribution to journalReview article

Drug Dose Response Relationship
Nose Neoplasms
Carcinogenicity Tests
Toxic Plants
Smokeless Tobacco
1985
1 Citation (Scopus)

Chemical carcinogenesis: An overview

Hecht, S. S., Jan 1 1985, In : Clinical Physiology and Biochemistry. 3, 2-3, p. 89-97 9 p.

Research output: Contribution to journalReview article

Toxic Plants
Environmental Carcinogens
Nitrosamines
Tobacco
Carcinogenesis
1984
18 Citations (Scopus)

Carcinogenicity and metabolic activation of tobacco-specific nitrosamines: current status and future prospects.

Hecht, S. S., Castonguay, A., Chung, F. L. & Hoffmann, D., Dec 1 1984, In : IARC scientific publications. 57, p. 763-778 16 p.

Research output: Contribution to journalReview article

Nitrosamines
Tobacco
Research
Smokeless Tobacco
Metabolic Activation
64 Citations (Scopus)

Formation and analysis of N-nitrosamines in tobacco products and their endogenous formation in consumers.

Hoffmann, D., Brunnemann, K. D., Adams, J. D. & Hecht, S. S., Dec 1 1984, In : IARC scientific publications. 57, p. 743-762 20 p.

Research output: Contribution to journalReview article

Toxic Plants
Smokeless Tobacco
Nitrosamines
Tobacco Smoke Pollution
Smoke
1979
20 Citations (Scopus)

Model studies in tobacco carcinogenesis with the Syrian golden hamster.

Hoffmann, D., Rivenson, A., Hecht, S. S., Hilfrich, J., Kobayashi, N. & Wynder, E. L., Dec 1 1979, In : Progress in experimental tumor research. Fortschritte der experimentellen Tumorforschung. Progres de la recherche experimentale des tumeurs. 24, p. 370-390 21 p.

Research output: Contribution to journalReview article

Respiratory Tract Neoplasms
Cocarcinogenesis
Experimental Neoplasms
Ethanolamines
Toxic Plants