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Research Output 1967 2019

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Article
2019
1 Citation (Scopus)
Acrolein
Smoking
Lung
Tobacco Products
DNA

FEMA GRAS assessment of natural flavor complexes: Citrus-derived flavoring ingredients

Cohen, S. M., Eisenbrand, G., Fukushima, S., Gooderham, N. J., Guengerich, F. P., Hecht, S. S., Rietjens, I. M. C. M., Bastaki, M., Davidsen, J. M., Harman, C. L., McGowen, M. & Taylor, S. V., Feb 1 2019, In : Food and Chemical Toxicology. 124, p. 192-218 27 p.

Research output: Contribution to journalArticle

Citrus
Flavors
flavorings
ingredients
flavor
1 Citation (Scopus)

Longitudinal stability in cigarette smokers of urinary biomarkers of exposure to the toxicants acrylonitrile and acrolein

Chen, M., Carmella, S. G., Sipe, C., Jensen, J., Luo, X., Le, C. T., Murphy, S. E., Benowitz, N. L., Joseph McClernon, F., Vandrey, R., Allen, S. S., Denlinger-Apte, R., Cinciripini, P. M., Strasser, A. A., al'Absi, M. N., Robinson, J. D., Donny, E. C., Hatsukami, D. K. & Hecht, S. S., Jan 1 2019, In : PloS one. 14, 1, e0210104.

Research output: Contribution to journalArticle

Open Access
acrolein
Acrylonitrile
Acrolein
cigarettes
Acetylcysteine

Longitudinal stability in cigarette smokers of urinary eicosanoid biomarkers of oxidative damage and inflammation

Carmella, S. G., Heskin, A. K., Tang, M. K., Jensen, J., Luo, X., Le, C. T., Murphy, S. E., Benowitz, N. L., Joseph McClernon, F., Vandrey, R., Allen, S. S., Denlinger-Apte, R., Cinciripini, P. M., Strasser, A. A., al'Absi, M. N., Robinson, J. D., Donny, E. C., Hatsukami, D. K. & Hecht, S. S., Apr 1 2019, In : PloS one. 14, 4, e0215853.

Research output: Contribution to journalArticle

Open Access
eicosanoids
Eicosanoids
cigarettes
Prostaglandins F
Biomarkers
1 Citation (Scopus)
N'-nitrosonornicotine
DNA Adducts
Rats
Phosphates
DNA

Urinary concentrations of monohydroxylated polycyclic aromatic hydrocarbons in adults from the U.S. Population Assessment of Tobacco and Health (PATH) Study Wave 1 (2013–2014)

Wang, Y., Wong, L. Y., Meng, L., Pittman, E. N., Trinidad, D. A., Hubbard, K. L., Etheredge, A., Del Valle-Pinero, A. Y., Zamoiski, R., van Bemmel, D. M., Borek, N., Patel, V., Kimmel, H. L., Conway, K. P., Lawrence, C., Edwards, K. C., Hyland, A., Goniewicz, M. L., Hatsukami, D. K., Hecht, S. S. & 1 othersCalafat, A. M., Feb 1 2019, In : Environment International. p. 201-208 8 p.

Research output: Contribution to journalArticle

tobacco
PAH
biomarker
product
health
2018
6 Citations (Scopus)

Acrolein exposure in hookah smokers and non-smokers exposed to hookah tobacco secondhand smoke: Implications for regulating hookah tobacco products

Kassem, N. O. F., Kassem, N. O., Liles, S., Zarth, A. T., Jackson, S. R., Daffa, R. M., Chatfield, D. A., Carmella, S. G., Hecht, S. S. & Hovell, M. F., Mar 6 2018, In : Nicotine and Tobacco Research. 20, 4, p. 492-501 10 p.

Research output: Contribution to journalArticle

Acrolein
Tobacco Smoke Pollution
Tobacco Products
Tobacco
Smoking
2 Citations (Scopus)

Effect of immediate vs gradual reduction in nicotine content of cigarettes on biomarkers of smoke exposure a randomized clinical trial

Hatsukami, D. K., Luo, X., Jensen, J. A., al'Absi, M. N., Allen, S. S., Carmella, S. G., Chen, M., Cinciripini, P. M., Denlinger-Apte, R., Drobes, D. J., Koopmeiners, J., Lane, T., Le, C. T., Leischow, S., Luo, K., Joseph McClernon, F., Murphy, S. E., Paiano, V., Robinson, J. D., Severson, H. & 8 othersSipe, C., Strasser, A. A., Strayer, L. S., Tang, M. K., Vandrey, R., Hecht, S. S., Benowitz, N. L. & Donny, E. C., Sep 4 2018, In : JAMA - Journal of the American Medical Association. 320, 9, p. 880-891 12 p.

Research output: Contribution to journalArticle

hydroxypropyl methacrylate
Nicotine
Smoke
Tobacco Products
Randomized Controlled Trials
5 Citations (Scopus)
Nitrosamines
DNA Adducts
Tobacco
Carcinogenesis
Phosphates
Bronchiolo-Alveolar Adenocarcinoma
Enantiomers
Inbred F344 Rats
Metabolites
Pancreatic Neoplasms
4 Citations (Scopus)
Enantiomers
DNA Adducts
Metabolites
Rats
Phosphates
3 Citations (Scopus)

Relationship of the oxidative damage biomarker 8-epiprostaglandin F to risk of lung cancer development in the Shanghai Cohort Study

Yuan, J. M., Carmella, S. G., Wang, R., Tan, Y. T., Adams-Haduch, J., Gao, Y. T. & Hecht, S. S., Jul 3 2018, In : Carcinogenesis. 39, 7, p. 948-954 7 p.

Research output: Contribution to journalArticle

Prostaglandins F
Lung Neoplasms
Cohort Studies
Biomarkers
Smoking
2 Citations (Scopus)

Updated procedure for the safety evaluation of natural flavor complexes used as ingredients in food

Cohen, S. M., Eisenbrand, G., Fukushima, S., Gooderham, N. J., Guengerich, F. P., Hecht, S. S., Rietjens, I. M. C. M., Davidsen, J. M., Harman, C. L. & Taylor, S. V., Mar 1 2018, In : Food and Chemical Toxicology. 113, p. 171-178 8 p.

Research output: Contribution to journalArticle

Flavors
ingredients
flavor
Safety
Food
2017
1 Citation (Scopus)
Open Access
Nitrosamines
Cytochromes
Metabolism
Proteins
Cytochrome P-450 Enzyme System
2 Citations (Scopus)
N'-nitrosonornicotine
Enantiomers
Tandem Mass Spectrometry
Mass spectrometry
Urine
7 Citations (Scopus)

Association of CYP2A6 activity with lung cancer incidence in smokers: The Multiethnic Cohort Study

Park, S. L., Murphy, S. E., Wilkens, L. R., Stram, D. O., Hecht, S. S. & Le Marchand, L., May 1 2017, In : PLoS One. 12, 5, e0178435.

Research output: Contribution to journalArticle

nicotine
lung neoplasms
cohort studies
Nicotine
cytochrome P-450
17 Citations (Scopus)

Biomarkers of exposure to new and emerging tobacco delivery products

Schick, S. F., Blount, B. C., Jacob, P., Saliba, N. A., Bernert, J. T., El Hellani, A., Jatlow, P., Pappas, R. S., Wang, L., Foulds, J., Ghosh, A., Hecht, S. S., Gomez, J. C., Martin, J. R., Mesaros, C., Srivastava, S., St. Helen, G., Tarran, R., Lorkiewicz, P. K., Blair, I. A. & 4 othersKimmel, H. L., Doerschuk, C. M., Benowitz, N. L. & Bhatnagar, A., Sep 1 2017, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 313, 3, p. L425-L452

Research output: Contribution to journalArticle

Tobacco Products
Biomarkers
Research Personnel
Tobacco Use
Research
10 Citations (Scopus)

CYP2A6 genetic polymorphisms and biomarkers of tobacco smoke constituents in relation to risk of lung cancer in the Singapore Chinese Health Study

Yuan, J. M., Nelson, H. H., Carmella, S. G., Wang, R., Kuriger-Laber, J., Jin, A., Adams-Haduch, J., Hecht, S. S., Koh, W. P. & Murphy, S. E., Jan 1 2017, In : Carcinogenesis. 38, 4, p. 411-418 8 p.

Research output: Contribution to journalArticle

Singapore
Genetic Polymorphisms
Nicotine
Smoke
Cytochrome P-450 Enzyme System
2 Citations (Scopus)
Squamous Cell Neoplasms
Mouth Neoplasms
Head and Neck Neoplasms
Carcinogens
DNA Damage
4 Citations (Scopus)
Deoxycytidine
Carcinogens
Tobacco
DNA
Nitrosamines
Open Access
Polycyclic Aromatic Hydrocarbons
Acetylcysteine
Epoxy Compounds
Urine
Creosote
2 Citations (Scopus)

Pilot in Vivo Structure-Activity Relationship of Dihydromethysticin in Blocking 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone-Induced O6-Methylguanine and Lung Tumor in A/J Mice

Puppala, M., Narayanapillai, S. C., Leitzman, P., Sun, H., Upadhyaya, P., O'Sullivan, M. G., Hecht, S. S. & Xing, C., Jan 1 2017, In : Journal of Medicinal Chemistry. 60, 18, p. 7935-7940 6 p.

Research output: Contribution to journalArticle

Lactones
Structure-Activity Relationship
Adenoma
Lung Neoplasms
Lung
5 Citations (Scopus)
Nitrosamines
Tobacco
Enantiomers
DNA Adducts
Metabolites
12 Citations (Scopus)

Reduced nicotine content cigarettes and use of alternative nicotine products: exploratory trial

Hatsukami, D. K., Luo, X., Dick, L., Kangkum, M., Allen, S. S., Murphy, S. E., Hecht, S. S., Shields, P. G. & al'Absi, M., Jan 1 2017, In : Addiction. 112, 1, p. 156-167 12 p.

Research output: Contribution to journalArticle

Nicotine
Tobacco Products
Confidence Intervals
Smoking
Biomarkers
5 Citations (Scopus)
DNA Adducts
Benzo(a)pyrene
Carcinogens
Liquid chromatography
DNA
2016
10 Citations (Scopus)
2-butenal
Smoke
Acrolein
Carcinogens
Tobacco
8 Citations (Scopus)
N'-nitrosonornicotine
Deoxyguanosine
DNA Adducts
Rats
Inbred F344 Rats
12 Citations (Scopus)

A randomized controlled trial of progressively reduced nicotine content cigarettes on smoking behaviors, biomarkers of exposure, and subjective ratings

Mercincavage, M., Souprountchouk, V., Tang, K. Z., Dumont, R. L., Wileyto, E. P., Carmella, S. G., Hecht, S. S. & Strasser, A. A., Jul 1 2016, In : Cancer Epidemiology Biomarkers and Prevention. 25, 7, p. 1125-1133 9 p.

Research output: Contribution to journalArticle

Nicotine
Randomized Controlled Trials
Biomarkers
Smoking
Tobacco Products
9 Citations (Scopus)

Benzene uptake and glutathione S-transferase T1 status as determinants of S-phenylmercapturic acid in cigarette smokers in the multiethnic cohort

Haiman, C. A., Patel, Y. M., Stram, D. O., Carmella, S. G., Chen, M., Wilkens, L. R., Le Marchand, L. & Hecht, S. S., Mar 1 2016, In : PloS one. 11, 3, e0150641.

Research output: Contribution to journalArticle

cigarettes
benzene
Benzene
glutathione transferase
Tobacco Products
22 Citations (Scopus)
Tobacco Products
Carcinogens
Tobacco
Clinical Trials
Lung
18 Citations (Scopus)

Dietary consumption of black raspberries or their anthocyanin constituents alters innate immune cell trafficking in esophageal cancer

Peiffer, D. S., Wang, L. S., Zimmerman, N. P., Ransom, B. W. S., Carmella, S. G., Kuo, C. T., Chen, J. H., Oshima, K., Huang, Y. W., Hecht, S. S. & Stoner, G. D., Jan 1 2016, In : Cancer Immunology Research. 4, 1, p. 72-82 11 p.

Research output: Contribution to journalArticle

Anthocyanins
Esophageal Neoplasms
Esophagus
Cytokines
Diet
2 Citations (Scopus)
Lung
Lung Neoplasms
Carcinogenesis
DNA Adducts
4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol
11 Citations (Scopus)
N'-nitrosonornicotine
Hydroxylation
Tobacco
DNA Adducts
Carcinogens
7 Citations (Scopus)

Evaluation of Nitrosamide Formation in the Cytochrome P450-Mediated Metabolism of Tobacco-Specific Nitrosamines

Carlson, E. S., Upadhyaya, P. & Hecht, S. S., Dec 19 2016, In : Chemical research in toxicology. 29, 12, p. 2194-2205 12 p.

Research output: Contribution to journalArticle

N'-nitrosonornicotine
Nitrosamines
Tobacco
Metabolism
Cytochrome P-450 Enzyme System
37 Citations (Scopus)
N'-nitrosonornicotine
Nitrosamines
Tobacco
Biomarkers
Chemical activation
15 Citations (Scopus)

Genetic determinants of cytochrome P450 2A6 activity and biomarkers of tobacco smoke exposure in relation to risk of lung cancer development in the Shanghai cohort study

Yuan, J. M., Nelson, H. H., Butler, L. M., Carmella, S. G., Wang, R., Kuriger-Laber, J. K., Adams-Haduch, J., Hecht, S. S., Gao, Y. T. & Murphy, S. E., May 1 2016, In : International Journal of Cancer. 138, 9, p. 2161-2171 11 p.

Research output: Contribution to journalArticle

Nicotine
Smoke
Cytochrome P-450 Enzyme System
Tobacco
Lung Neoplasms
12 Citations (Scopus)
Brassica
Vegetables
Biomarkers
3,3'-diindolylmethane
glucobrassicin
7 Citations (Scopus)

Metabolites of the polycyclic aromatic hydrocarbon phenanthrene in the urine of cigarette smokers from five ethnic groups with differing risks for lung cancer

Patel, Y. M., Park, S. L., Carmella, S. G., Paiano, V., Olvera, N., Stram, D. O., Haiman, C. A., Le Marchand, L. & Hecht, S. S., Jun 1 2016, In : PLoS One. 11, 6, e0156203.

Research output: Contribution to journalArticle

phenanthrene
cigarettes
Polycyclic Aromatic Hydrocarbons
polycyclic aromatic hydrocarbons
lung neoplasms
16 Citations (Scopus)

Randomised clinical trial of snus versus medicinal nicotine among smokers interested in product switching

Hatsukami, D. K., Severson, H., Anderson, A., Vogel, R. I., Jensen, J., Broadbent, B., Murphy, S. E., Carmella, S. G. & Hecht, S. S., May 1 2016, In : Tobacco control. 25, 3, p. 267-274 8 p.

Research output: Contribution to journalArticle

Nicotine
nicotine
Tobacco Products
Randomized Controlled Trials
N'-nitrosonornicotine
5 Citations (Scopus)

Tobacco-specific N-nitrosamines and polycyclic aromatic hydrocarbons in cigarettes smoked by the participants of the Shanghai Cohort Study

Yershova, K., Yuan, J. M., Wang, R., Valentin, L., Watson, C., Gao, Y. T., Hecht, S. S. & Stepanov, I., Sep 15 2016, In : International Journal of Cancer. 139, 6, p. 1261-1269 9 p.

Research output: Contribution to journalArticle

Nitrosamines
Polycyclic Aromatic Hydrocarbons
Tobacco Products
Tobacco
Cohort Studies
2 Citations (Scopus)
N'-nitrosonornicotine
Gene Expression Profiling
Esophagus
Mouth
Carcinogenesis
2015
5 Citations (Scopus)

Associations between genetic ancestries and nicotine metabolism biomarkers in the multiethnic cohort study

Wang, H., Park, S. L., Stram, D. O., Haiman, C. A., Wilkens, L. R., Hecht, S. S., Kolonel, L. N., Murphy, S. E. & Marchand, L. L., Jan 1 2015, In : American Journal of Epidemiology. 182, 11, p. 945-951 7 p.

Research output: Contribution to journalArticle

Cotinine
Nicotine
Cohort Studies
Biomarkers
Oceanic Ancestry Group
4 Citations (Scopus)

Benzene oxide is a substrate for glutathione S-transferases

Zarth, A. T., Murphy, S. E. & Hecht, S. S., Dec 5 2015, In : Chemico-Biological Interactions. 242, p. 390-395 6 p.

Research output: Contribution to journalArticle

Glutathione Transferase
Substrates
Kinetic parameters
Glutathione
Detoxification
8 Citations (Scopus)
N'-nitrosonornicotine
Tobacco Products
Urine
nornicotine
Nitrosation
5 Citations (Scopus)

Combined analysis of the tobacco metabolites cotinine and 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol in human urine

Kotandeniya, D., Carmella, S. G., Ming, X., Murphy, S. E. & Hecht, S. S., Feb 3 2015, In : Analytical Chemistry. 87, 3, p. 1514-1517 4 p.

Research output: Contribution to journalArticle

Cotinine
Tobacco
Metabolites
Glucuronides
Electrospray ionization
15 Citations (Scopus)
Tobacco
DNA Adducts
Carcinogens
Phosphates
Lung
5 Citations (Scopus)

Elevated levels of mercapturic acids of acrolein and crotonaldehyde in the urine of Chinese women in Singapore who regularly cook at home

Hecht, S. S., Koh, W. P., Wang, R., Chen, M., Carmella, S. G., Murphy, S. E. & Yuan, J. M., Mar 25 2015, In : PloS one. 10, 3, e0120023.

Research output: Contribution to journalArticle

2-butenal
acrolein
Acrolein
Singapore
Cooking
96 Citations (Scopus)

Evaluation of toxicant and carcinogen metabolites in the urine of e-cigarette users versus cigarette smokers

Hecht, S. S., Carmella, S. G., Kotandeniya, D., Pillsbury, M. E., Chen, M., Ransom, B. W. S., Vogel, R. I., Thompson, E., Murphy, S. E. & Hatsukami, D. K., Jan 1 2015, In : Nicotine and Tobacco Research. 17, 6, p. 704-709 6 p.

Research output: Contribution to journalArticle

Tobacco Products
Carcinogens
Urine
Cotinine
Nicotine