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Research Output 1967 2019

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Article
2019
1 Citation (Scopus)
Acrolein
Smoking
Lung
Tobacco Products
DNA

Effects of cessation of cigarette smoking on eicosanoid biomarkers of inflammation and oxidative damage

McElroy, J. P., Carmella, S. G., Heskin, A. K., Tang, M. K., Murphy, S. E., Reisinger, S. A., Jensen, J. A., Hatsukami, D. K., Hecht, S. S. & Shields, P. G., Jan 1 2019, In : PloS one. 14, 6, e0218386.

Research output: Contribution to journalArticle

Open Access
Dinoprost
eicosanoids
smoking (habit)
Eicosanoids
Biomarkers

Effects of immediate versus gradual nicotine reduction in cigarettes on biomarkers of biological effects

Hatsukami, D. K., Luo, X., Heskin, A. K., Tang, M. K., Carmella, S. G., Jensen, J., Robinson, J. D., Vandrey, R., Drobes, D. J., Strasser, A. A., al'Absi, M. N., Leischow, S., Cinciripini, P. M., Koopmeiners, J., Ikuemonisan, J., Benowitz, N. L., Donny, E. C. & Hecht, S. S., Jan 1 2019, In : Addiction.

Research output: Contribution to journalArticle

Nicotine
Tobacco Products
Biomarkers
Smoking
Confidence Intervals

FEMA GRAS assessment of natural flavor complexes: Citrus-derived flavoring ingredients

Cohen, S. M., Eisenbrand, G., Fukushima, S., Gooderham, N. J., Guengerich, F. P., Hecht, S. S., Rietjens, I. M. C. M., Bastaki, M., Davidsen, J. M., Harman, C. L., McGowen, M. & Taylor, S. V., Feb 1 2019, In : Food and Chemical Toxicology. 124, p. 192-218 27 p.

Research output: Contribution to journalArticle

Citrus
Flavors
flavorings
ingredients
flavor
2 Citations (Scopus)

Longitudinal stability in cigarette smokers of urinary biomarkers of exposure to the toxicants acrylonitrile and acrolein

Chen, M., Carmella, S. G., Sipe, C., Jensen, J., Luo, X., Le, C. T., Murphy, S. E., Benowitz, N. L., Joseph McClernon, F., Vandrey, R., Allen, S. S., Denlinger-Apte, R., Cinciripini, P. M., Strasser, A. A., al'Absi, M. N., Robinson, J. D., Donny, E. C., Hatsukami, D. K. & Hecht, S. S., Jan 1 2019, In : PloS one. 14, 1, e0210104.

Research output: Contribution to journalArticle

Open Access
acrolein
Acrylonitrile
Acrolein
cigarettes
Acetylcysteine
1 Citation (Scopus)

Longitudinal stability in cigarette smokers of urinary eicosanoid biomarkers of oxidative damage and inflammation

Carmella, S. G., Heskin, A. K., Tang, M. K., Jensen, J., Luo, X., Le, C. T., Murphy, S. E., Benowitz, N. L., Joseph McClernon, F., Vandrey, R., Allen, S. S., Denlinger-Apte, R., Cinciripini, P. M., Strasser, A. A., al'Absi, M. N., Robinson, J. D., Donny, E. C., Hatsukami, D. K. & Hecht, S. S., Apr 1 2019, In : PloS one. 14, 4, e0215853.

Research output: Contribution to journalArticle

Open Access
eicosanoids
Eicosanoids
cigarettes
Prostaglandins F
Biomarkers
1 Citation (Scopus)

Mass Spectrometric Quantitation of Pyridyloxobutyl DNA Phosphate Adducts in Rats Chronically Treated with N′-Nitrosonornicotine

Li, Y., Ma, B., Cao, Q., Balbo, S., Zhao, L., Upadhyaya, P. & Hecht, S. S., Apr 15 2019, In : Chemical research in toxicology. 32, 4, p. 773-783 11 p.

Research output: Contribution to journalArticle

N'-nitrosonornicotine
DNA Adducts
Rats
Phosphates
DNA

Urinary concentrations of monohydroxylated polycyclic aromatic hydrocarbons in adults from the U.S. Population Assessment of Tobacco and Health (PATH) Study Wave 1 (2013–2014)

Wang, Y., Wong, L. Y., Meng, L., Pittman, E. N., Trinidad, D. A., Hubbard, K. L., Etheredge, A., Del Valle-Pinero, A. Y., Zamoiski, R., van Bemmel, D. M., Borek, N., Patel, V., Kimmel, H. L., Conway, K. P., Lawrence, C., Edwards, K. C., Hyland, A., Goniewicz, M. L., Hatsukami, D. K., Hecht, S. S. & 1 others, Calafat, A. M., Feb 1 2019, In : Environment International. p. 201-208 8 p.

Research output: Contribution to journalArticle

Open Access
tobacco
PAH
biomarker
product
health
2018
8 Citations (Scopus)

Acrolein exposure in hookah smokers and non-smokers exposed to hookah tobacco secondhand smoke: Implications for regulating hookah tobacco products

Kassem, N. O. F., Kassem, N. O., Liles, S., Zarth, A. T., Jackson, S. R., Daffa, R. M., Chatfield, D. A., Carmella, S. G., Hecht, S. S. & Hovell, M. F., Mar 6 2018, In : Nicotine and Tobacco Research. 20, 4, p. 492-501 10 p.

Research output: Contribution to journalArticle

Open Access
Acrolein
Tobacco Smoke Pollution
Tobacco Products
Tobacco
Smoking
5 Citations (Scopus)
Open Access
Tobacco
Enantiomers
DNA Adducts
Metabolites
Carcinogens
5 Citations (Scopus)

Effect of immediate vs gradual reduction in nicotine content of cigarettes on biomarkers of smoke exposure a randomized clinical trial

Hatsukami, D. K., Luo, X., Jensen, J. A., al'Absi, M. N., Allen, S. S., Carmella, S. G., Chen, M., Cinciripini, P. M., Denlinger-Apte, R., Drobes, D. J., Koopmeiners, J., Lane, T., Le, C. T., Leischow, S., Luo, K., Joseph McClernon, F., Murphy, S. E., Paiano, V., Robinson, J. D., Severson, H. & 8 others, Sipe, C., Strasser, A. A., Strayer, L. S., Tang, M. K., Vandrey, R., Hecht, S. S., Benowitz, N. L. & Donny, E. C., Sep 4 2018, In : JAMA - Journal of the American Medical Association. 320, 9, p. 880-891 12 p.

Research output: Contribution to journalArticle

Open Access
hydroxypropyl methacrylate
Nicotine
Smoke
Tobacco Products
Randomized Controlled Trials
Vegetables
Acetylcysteine
Urine
Brassica
Isothiocyanates
6 Citations (Scopus)
Nitrosamines
DNA Adducts
Tobacco
Carcinogenesis
Phosphates
Bronchiolo-Alveolar Adenocarcinoma
Enantiomers
Inbred F344 Rats
Metabolites
Pancreatic Neoplasms
7 Citations (Scopus)
Enantiomers
DNA Adducts
Metabolites
Rats
Phosphates
3 Citations (Scopus)

Relationship of the oxidative damage biomarker 8-epiprostaglandin F to risk of lung cancer development in the Shanghai Cohort Study

Yuan, J. M., Carmella, S. G., Wang, R., Tan, Y. T., Adams-Haduch, J., Gao, Y. T. & Hecht, S. S., Jul 3 2018, In : Carcinogenesis. 39, 7, p. 948-954 7 p.

Research output: Contribution to journalArticle

Dinoprost
Lung Neoplasms
Cohort Studies
Biomarkers
Smoking
3 Citations (Scopus)

Updated procedure for the safety evaluation of natural flavor complexes used as ingredients in food

Cohen, S. M., Eisenbrand, G., Fukushima, S., Gooderham, N. J., Guengerich, F. P., Hecht, S. S., Rietjens, I. M. C. M., Davidsen, J. M., Harman, C. L. & Taylor, S. V., Mar 1 2018, In : Food and Chemical Toxicology. 113, p. 171-178 8 p.

Research output: Contribution to journalArticle

Flavors
ingredients
flavor
Safety
Food
2017
1 Citation (Scopus)

A general method for detecting nitrosamide formation in the in vitro metabolism of nitrosamines by cytochrome P450s

Carlson, E. S., Upadhyaya, P. & Hecht, S. S., Sep 25 2017, In : Journal of Visualized Experiments. 2017, 127, e56312.

Research output: Contribution to journalArticle

Open Access
Nitrosamines
Cytochromes
Metabolism
Proteins
Cytochrome P-450 Enzyme System
2 Citations (Scopus)
Open Access
N'-nitrosonornicotine
Enantiomers
Tandem Mass Spectrometry
Mass spectrometry
Urine
7 Citations (Scopus)

Association of CYP2A6 activity with lung cancer incidence in smokers: The Multiethnic Cohort Study

Park, S. L., Murphy, S. E., Wilkens, L. R., Stram, D. O., Hecht, S. S. & Le Marchand, L., May 1 2017, In : PLoS One. 12, 5, e0178435.

Research output: Contribution to journalArticle

nicotine
lung neoplasms
cohort studies
Nicotine
cytochrome P-450
18 Citations (Scopus)

Biomarkers of exposure to new and emerging tobacco delivery products

Schick, S. F., Blount, B. C., Jacob, P., Saliba, N. A., Bernert, J. T., El Hellani, A., Jatlow, P., Pappas, R. S., Wang, L., Foulds, J., Ghosh, A., Hecht, S. S., Gomez, J. C., Martin, J. R., Mesaros, C., Srivastava, S., St. Helen, G., Tarran, R., Lorkiewicz, P. K., Blair, I. A. & 4 others, Kimmel, H. L., Doerschuk, C. M., Benowitz, N. L. & Bhatnagar, A., Sep 1 2017, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 313, 3, p. L425-L452

Research output: Contribution to journalArticle

Tobacco Products
Biomarkers
Research Personnel
Tobacco Use
Research
10 Citations (Scopus)

CYP2A6 genetic polymorphisms and biomarkers of tobacco smoke constituents in relation to risk of lung cancer in the Singapore Chinese Health Study

Yuan, J. M., Nelson, H. H., Carmella, S. G., Wang, R., Kuriger-Laber, J., Jin, A., Adams-Haduch, J., Hecht, S. S., Koh, W. P. & Murphy, S. E., Jan 1 2017, In : Carcinogenesis. 38, 4, p. 411-418 8 p.

Research output: Contribution to journalArticle

Open Access
Singapore
Genetic Polymorphisms
Nicotine
Smoke
Cytochrome P-450 Enzyme System
2 Citations (Scopus)
Open Access
Squamous Cell Neoplasms
Mouth Neoplasms
Head and Neck Neoplasms
Carcinogens
DNA Damage
5 Citations (Scopus)
Deoxycytidine
Carcinogens
Tobacco
DNA
Nitrosamines
Open Access
Polycyclic Aromatic Hydrocarbons
Acetylcysteine
Epoxy Compounds
Urine
Creosote
3 Citations (Scopus)

Pilot in Vivo Structure-Activity Relationship of Dihydromethysticin in Blocking 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone-Induced O6-Methylguanine and Lung Tumor in A/J Mice

Puppala, M., Narayanapillai, S. C., Leitzman, P., Sun, H., Upadhyaya, P., O'Sullivan, M. G., Hecht, S. S. & Xing, C., Jan 1 2017, In : Journal of Medicinal Chemistry. 60, 18, p. 7935-7940 6 p.

Research output: Contribution to journalArticle

Lactones
Structure-Activity Relationship
Adenoma
Lung Neoplasms
Lung
7 Citations (Scopus)
Nitrosamines
Tobacco
Enantiomers
DNA Adducts
Metabolites
15 Citations (Scopus)

Reduced nicotine content cigarettes and use of alternative nicotine products: exploratory trial

Hatsukami, D. K., Luo, X., Dick, L., Kangkum, M., Allen, S. S., Murphy, S. E., Hecht, S. S., Shields, P. G. & al'Absi, M., Jan 1 2017, In : Addiction. 112, 1, p. 156-167 12 p.

Research output: Contribution to journalArticle

Open Access
Nicotine
Tobacco Products
Confidence Intervals
Smoking
Biomarkers
7 Citations (Scopus)
DNA Adducts
Benzo(a)pyrene
Carcinogens
Liquid chromatography
DNA
2016
11 Citations (Scopus)
2-butenal
Smoke
Acrolein
Carcinogens
Tobacco
8 Citations (Scopus)
N'-nitrosonornicotine
Deoxyguanosine
DNA Adducts
Rats
Inbred F344 Rats
12 Citations (Scopus)

A randomized controlled trial of progressively reduced nicotine content cigarettes on smoking behaviors, biomarkers of exposure, and subjective ratings

Mercincavage, M., Souprountchouk, V., Tang, K. Z., Dumont, R. L., Wileyto, E. P., Carmella, S. G., Hecht, S. S. & Strasser, A. A., Jul 1 2016, In : Cancer Epidemiology Biomarkers and Prevention. 25, 7, p. 1125-1133 9 p.

Research output: Contribution to journalArticle

Nicotine
Randomized Controlled Trials
Biomarkers
Smoking
Tobacco Products
10 Citations (Scopus)

Benzene uptake and glutathione S-transferase T1 status as determinants of S-phenylmercapturic acid in cigarette smokers in the multiethnic cohort

Haiman, C. A., Patel, Y. M., Stram, D. O., Carmella, S. G., Chen, M., Wilkens, L. R., Le Marchand, L. & Hecht, S. S., Mar 1 2016, In : PloS one. 11, 3, e0150641.

Research output: Contribution to journalArticle

cigarettes
benzene
Benzene
glutathione transferase
Tobacco Products
24 Citations (Scopus)

Clinical trial of 2-phenethyl isothiocyanate as an inhibitor of metabolic activation of a tobacco-specific lung carcinogen in cigarette smokers

Yuan, J. M., Stepanov, I., Murphy, S. E., Wang, R., Allen, S., Jensen, J., Strayer, L., Adams-Haduch, J., Upadhyaya, P., Le, C., Kurzer, M. S., Nelson, H. H., Yu, M. C., Hatsukami, D. & Hecht, S. S., May 1 2016, In : Cancer Prevention Research. 9, 5, p. 396-405 10 p.

Research output: Contribution to journalArticle

Tobacco Products
Carcinogens
Tobacco
Clinical Trials
Lung
20 Citations (Scopus)

Dietary consumption of black raspberries or their anthocyanin constituents alters innate immune cell trafficking in esophageal cancer

Peiffer, D. S., Wang, L. S., Zimmerman, N. P., Ransom, B. W. S., Carmella, S. G., Kuo, C. T., Chen, J. H., Oshima, K., Huang, Y. W., Hecht, S. S. & Stoner, G. D., Jan 1 2016, In : Cancer Immunology Research. 4, 1, p. 72-82 11 p.

Research output: Contribution to journalArticle

Anthocyanins
Esophageal Neoplasms
Esophagus
Cytokines
Diet
3 Citations (Scopus)

Dietary Dihydromethysticin Increases Glucuronidation of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in A/J Mice, Potentially Enhancing Its Detoxification

Chanickal Narayanapillai, S., von Weymarn, L. B., Carmella, S. G., Leitzman, P., Paladino, J., Upadhyaya, P., Hecht, S. S., Murphy, S. E. & Xing, C., Mar 1 2016, In : Drug Metabolism and Disposition. 44, 3, p. 422-427 6 p.

Research output: Contribution to journalArticle

Lung
Lung Neoplasms
Carcinogenesis
DNA Adducts
4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol
11 Citations (Scopus)

DNA Adduct Formation from Metabolic 5′-Hydroxylation of the Tobacco-Specific Carcinogen N′-Nitrosonornicotine in Human Enzyme Systems and in Rats

Zarth, A. T., Upadhyaya, P., Yang, J. & Hecht, S. S., Mar 21 2016, In : Chemical research in toxicology. 29, 3, p. 380-389 10 p.

Research output: Contribution to journalArticle

N'-nitrosonornicotine
Hydroxylation
Tobacco
DNA Adducts
Carcinogens
7 Citations (Scopus)

Evaluation of Nitrosamide Formation in the Cytochrome P450-Mediated Metabolism of Tobacco-Specific Nitrosamines

Carlson, E. S., Upadhyaya, P. & Hecht, S. S., Dec 19 2016, In : Chemical research in toxicology. 29, 12, p. 2194-2205 12 p.

Research output: Contribution to journalArticle

N'-nitrosonornicotine
Nitrosamines
Tobacco
Metabolism
Cytochrome P-450 Enzyme System
37 Citations (Scopus)
N'-nitrosonornicotine
Nitrosamines
Tobacco
Biomarkers
Chemical activation
16 Citations (Scopus)

Genetic determinants of cytochrome P450 2A6 activity and biomarkers of tobacco smoke exposure in relation to risk of lung cancer development in the Shanghai cohort study

Yuan, J. M., Nelson, H. H., Butler, L. M., Carmella, S. G., Wang, R., Kuriger-Laber, J. K., Adams-Haduch, J., Hecht, S. S., Gao, Y. T. & Murphy, S. E., May 1 2016, In : International Journal of Cancer. 138, 9, p. 2161-2171 11 p.

Research output: Contribution to journalArticle

Nicotine
Smoke
Cytochrome P-450 Enzyme System
Tobacco
Lung Neoplasms
12 Citations (Scopus)

Harnessing the power of cruciferous vegetables: Developing a biomarker for brassica vegetable consumption using urinary 3,3'-diindolylmethane

Fujioka, N., Ransom, B. W., Carmella, S. G., Upadhyaya, P., Lindgren, B. R., Roper-Batker, A., Hatsukami, D. K., Fritz, V. A., Rohwer, C. & Hecht, S. S., Oct 1 2016, In : Cancer Prevention Research. 9, 10, p. 788-793 6 p.

Research output: Contribution to journalArticle

Brassica
Vegetables
Biomarkers
3,3'-diindolylmethane
glucobrassicin
8 Citations (Scopus)

Metabolites of the polycyclic aromatic hydrocarbon phenanthrene in the urine of cigarette smokers from five ethnic groups with differing risks for lung cancer

Patel, Y. M., Park, S. L., Carmella, S. G., Paiano, V., Olvera, N., Stram, D. O., Haiman, C. A., Le Marchand, L. & Hecht, S. S., Jun 1 2016, In : PLoS One. 11, 6, e0156203.

Research output: Contribution to journalArticle

phenanthrene
cigarettes
Polycyclic Aromatic Hydrocarbons
polycyclic aromatic hydrocarbons
lung neoplasms
16 Citations (Scopus)

Randomised clinical trial of snus versus medicinal nicotine among smokers interested in product switching

Hatsukami, D. K., Severson, H., Anderson, A., Vogel, R. I., Jensen, J., Broadbent, B., Murphy, S. E., Carmella, S. G. & Hecht, S. S., May 1 2016, In : Tobacco control. 25, 3, p. 267-274 8 p.

Research output: Contribution to journalArticle

Nicotine
nicotine
Tobacco Products
Randomized Controlled Trials
N'-nitrosonornicotine
5 Citations (Scopus)

Tobacco-specific N-nitrosamines and polycyclic aromatic hydrocarbons in cigarettes smoked by the participants of the Shanghai Cohort Study

Yershova, K., Yuan, J. M., Wang, R., Valentin, L., Watson, C., Gao, Y. T., Hecht, S. S. & Stepanov, I., Sep 15 2016, In : International Journal of Cancer. 139, 6, p. 1261-1269 9 p.

Research output: Contribution to journalArticle

Nitrosamines
Polycyclic Aromatic Hydrocarbons
Tobacco Products
Tobacco
Cohort Studies
2 Citations (Scopus)
N'-nitrosonornicotine
Gene Expression Profiling
Esophagus
Mouth
Carcinogenesis
2015
5 Citations (Scopus)

Associations between genetic ancestries and nicotine metabolism biomarkers in the multiethnic cohort study

Wang, H., Park, S. L., Stram, D. O., Haiman, C. A., Wilkens, L. R., Hecht, S. S., Kolonel, L. N., Murphy, S. E. & Marchand, L. L., Jan 1 2015, In : American Journal of Epidemiology. 182, 11, p. 945-951 7 p.

Research output: Contribution to journalArticle

Cotinine
Nicotine
Cohort Studies
Biomarkers
Oceanic Ancestry Group
5 Citations (Scopus)

Benzene oxide is a substrate for glutathione S-transferases

Zarth, A. T., Murphy, S. E. & Hecht, S. S., Dec 5 2015, In : Chemico-Biological Interactions. 242, p. 390-395 6 p.

Research output: Contribution to journalArticle

Glutathione Transferase
Substrates
Kinetic parameters
Glutathione
Detoxification
8 Citations (Scopus)
N'-nitrosonornicotine
Tobacco Products
Urine
nornicotine
Nitrosation
5 Citations (Scopus)

Combined analysis of the tobacco metabolites cotinine and 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol in human urine

Kotandeniya, D., Carmella, S. G., Ming, X., Murphy, S. E. & Hecht, S. S., Feb 3 2015, In : Analytical chemistry. 87, 3, p. 1514-1517 4 p.

Research output: Contribution to journalArticle

Cotinine
Tobacco
Metabolites
Glucuronides
Electrospray ionization
15 Citations (Scopus)
Tobacco
DNA Adducts
Carcinogens
Phosphates
Lung