1967 …2024
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Research Output 1967 2019

2019
3 Citations (Scopus)
Acrolein
Smoking
Lung
Tobacco Products
DNA

Differences in exposure to toxic and/or carcinogenic volatile organic compounds between Black and White cigarette smokers

St.Helen, G., Benowitz, N. L., Ko, J., Jacob, P., Gregorich, S. E., Pérez-Stable, E. J., Murphy, S. E., Hecht, S. S., Hatsukami, D. K. & Donny, E. C., Jan 1 2019, In : Journal of Exposure Science and Environmental Epidemiology.

Research output: Contribution to journalArticle

Volatile Organic Compounds
Nicotine
Poisons
Volatile organic compounds
Tobacco Products
1 Citation (Scopus)

Dose-dependent detoxication of the airborne pollutant benzene in a randomized trial of broccoli sprout beverage in Qidong, China

Chen, J. G., Johnson, J., Egner, P., Ng, D., Zhu, J., Wang, J. B., Xue, X. F., Sun, Y., Zhang, Y. H., Lu, L. L., Chen, Y. S., Wu, Y., Zhu, Y. R., Carmella, S., Hecht, S., Jacobson, L., Muñoz, A., Kensler, K., Rule, A., Fahey, J. & 2 others, Kensler, T. & Groopman, J., Sep 1 2019, In : American Journal of Clinical Nutrition. 110, 3, p. 675-684 10 p.

Research output: Contribution to journalArticle

Open Access
Brassica
Beverages
Benzene
China
Placebos

Effects of cessation of cigarette smoking on eicosanoid biomarkers of inflammation and oxidative damage

McElroy, J. P., Carmella, S. G., Heskin, A. K., Tang, M. K., Murphy, S. E., Reisinger, S. A., Jensen, J. A., Hatsukami, D. K., Hecht, S. S. & Shields, P. G., Jan 1 2019, In : PloS one. 14, 6, e0218386.

Research output: Contribution to journalArticle

Open Access
Dinoprost
eicosanoids
smoking (habit)
Eicosanoids
Biomarkers

Effects of immediate versus gradual nicotine reduction in cigarettes on biomarkers of biological effects

Hatsukami, D. K., Luo, X., Heskin, A. K., Tang, M. K., Carmella, S. G., Jensen, J., Robinson, J. D., Vandrey, R., Drobes, D. J., Strasser, A. A., al'Absi, M., Leischow, S., Cinciripini, P. M., Koopmeiners, J., Ikuemonisan, J., Benowitz, N. L., Donny, E. C. & Hecht, S. S., Oct 1 2019, In : Addiction. 114, 10, p. 1824-1833 10 p.

Research output: Contribution to journalArticle

Nicotine
Tobacco Products
Biomarkers
Smoking
Confidence Intervals
1 Citation (Scopus)

FEMA GRAS assessment of natural flavor complexes: Citrus-derived flavoring ingredients

Cohen, S. M., Eisenbrand, G., Fukushima, S., Gooderham, N. J., Guengerich, F. P., Hecht, S. S., Rietjens, I. M. C. M., Bastaki, M., Davidsen, J. M., Harman, C. L., McGowen, M. & Taylor, S. V., Feb 2019, In : Food and Chemical Toxicology. 124, p. 192-218 27 p.

Research output: Contribution to journalArticle

Citrus
Flavors
flavorings
ingredients
flavor

FEMA GRAS assessment of natural flavor complexes: Mint, buchu, dill and caraway derived flavoring ingredients

Cohen, S. M., Eisenbrand, G., Fukushima, S., Gooderham, N. J., Guengerich, F. P., Hecht, S. S., Rietjens, I. M. C. M., Bastaki, M., Davidsen, J. M., Harman, C. L., McGowen, M. M. & Taylor, S. V., Jan 1 2019, (Accepted/In press) In : Food and Chemical Toxicology. 110870.

Research output: Contribution to journalArticle

Open Access
Agathosma betulina
Anethum graveolens
Carum
Mints
caraway
3 Citations (Scopus)

Longitudinal stability in cigarette smokers of urinary biomarkers of exposure to the toxicants acrylonitrile and acrolein

Chen, M., Carmella, S. G., Sipe, C., Jensen, J., Luo, X., Le, C. T., Murphy, S. E., Benowitz, N. L., Joseph McClernon, F., Vandrey, R., Allen, S. S., Denlinger-Apte, R., Cinciripini, P. M., Strasser, A. A., Al’Absi, M., Robinson, J. D., Donny, E. C., Hatsukami, D. & Hecht, S. S., Jan 2019, In : PloS one. 14, 1, e0210104.

Research output: Contribution to journalArticle

Open Access
acrolein
Acrylonitrile
Acrolein
cigarettes
Acetylcysteine
1 Citation (Scopus)

Longitudinal stability in cigarette smokers of urinary eicosanoid biomarkers of oxidative damage and inflammation

Carmella, S. G., Heskin, A. K., Tang, M. K., Jensen, J., Luo, X., Le, C. T., Murphy, S. E., Benowitz, N. L., Joseph McClernon, F., Vandrey, R., Allen, S. S., Denlinger-Apte, R., Cinciripini, P. M., Strasser, A. A., Al’Absi, M., Robinson, J. D., Donny, E. C., Hatsukami, D. K. & Hecht, S. S., Apr 2019, In : PloS one. 14, 4, e0215853.

Research output: Contribution to journalArticle

Open Access
eicosanoids
Eicosanoids
cigarettes
Prostaglandins F
Biomarkers
2 Citations (Scopus)

Mass Spectrometric Quantitation of Pyridyloxobutyl DNA Phosphate Adducts in Rats Chronically Treated with N′-Nitrosonornicotine

Li, Y., Ma, B., Cao, Q., Balbo, S., Zhao, L., Upadhyaya, P. & Hecht, S. S., Apr 15 2019, In : Chemical research in toxicology. 32, 4, p. 773-783 11 p.

Research output: Contribution to journalArticle

N'-nitrosonornicotine
DNA Adducts
Rats
Phosphates
DNA
1 Citation (Scopus)

Oral Health Effects of Combusted and Smokeless Tobacco Products

Tomar, S. L., Hecht, S. S., Jaspers, I., Gregory, R. L. & Stepanov, I., Oct 1 2019, In : Advances in dental research. 30, 1, p. 4-10 7 p.

Research output: Contribution to journalReview article

Smokeless Tobacco
Oral Health
Tobacco Products
Mouth
Dental Pharmaceutical Preparations
2 Citations (Scopus)

Prediagnostic levels of urinary 8-epi-prostaglandin F and prostaglandin E2 metabolite, biomarkers of oxidative damage and inflammation, and risk of hepatocellular carcinoma

Yuan, J. M., Grouls, M., Carmella, S. G., Wang, R., Heskin, A., Jiang, Y., Tan, Y. T., Adams-Haduch, J., Gao, Y. T. & Hecht, S. S., Aug 22 2019, In : Carcinogenesis. 40, 8, p. 989-997 9 p.

Research output: Contribution to journalArticle

Dinoprost
Dinoprostone
Hepatocellular Carcinoma
Biomarkers
Inflammation
2 Citations (Scopus)

Recent studies on DNA adducts resulting from human exposure to tobacco smoke

Ma, B., Stepanov, I. & Hecht, S. S., Jan 1 2019, In : Toxics. 7, 1, 16.

Research output: Contribution to journalReview article

Open Access
Tobacco
DNA Adducts
Smoke
Carcinogens
Nitrosamines
1 Citation (Scopus)

Urinary concentrations of monohydroxylated polycyclic aromatic hydrocarbons in adults from the U.S. Population Assessment of Tobacco and Health (PATH) Study Wave 1 (2013–2014)

Wang, Y., Wong, L. Y., Meng, L., Pittman, E. N., Trinidad, D. A., Hubbard, K. L., Etheredge, A., Del Valle-Pinero, A. Y., Zamoiski, R., van Bemmel, D. M., Borek, N., Patel, V., Kimmel, H. L., Conway, K. P., Lawrence, C., Edwards, K. C., Hyland, A., Goniewicz, M. L., Hatsukami, D. K., Hecht, S. S. & 1 others, Calafat, A. M., Feb 1 2019, In : Environment International. 123, p. 201-208 8 p.

Research output: Contribution to journalArticle

Open Access
tobacco
PAH
biomarker
product
health
2018
10 Citations (Scopus)

Acrolein exposure in hookah smokers and non-smokers exposed to hookah tobacco secondhand smoke: Implications for regulating hookah tobacco products

Kassem, N. O. F., Kassem, N. O., Liles, S., Zarth, A. T., Jackson, S. R., Daffa, R. M., Chatfield, D. A., Carmella, S. G., Hecht, S. S. & Hovell, M. F., Mar 6 2018, In : Nicotine and Tobacco Research. 20, 4, p. 492-501 10 p.

Research output: Contribution to journalArticle

Open Access
Acrolein
Tobacco Smoke Pollution
Tobacco Products
Tobacco
Smoking
6 Citations (Scopus)
Open Access
Tobacco
Enantiomers
DNA Adducts
Metabolites
Carcinogens

A New Editorial Team for CRT

Hecht, S. S., Jan 16 2018, In : Chemical research in toxicology. 31, 1, 1 p.

Research output: Contribution to journalEditorial

Cathode ray tubes
21 Citations (Scopus)

Comparison of Nicotine and Toxicant Exposure in Users of Electronic Cigarettes and Combustible Cigarettes

Goniewicz, M. L., Smith, D. M., Edwards, K. C., Blount, B. C., Caldwell, K. L., Feng, J., Wang, L., Christensen, C., Ambrose, B., Borek, N., van Bemmel, D., Konkel, K., Erives, G., Stanton, C. A., Lambert, E., Kimmel, H. L., Hatsukami, D. K., Hecht, S. S., Niaura, R. S., Travers, M. & 2 others, Lawrence, C. & Hyland, A. J., Dec 7 2018, In : JAMA Network Open. 1, 8, p. e185937

Research output: Contribution to journalArticle

Open Access
Nicotine
Tobacco Products
Tobacco
Volatile Organic Compounds
Biomarkers
9 Citations (Scopus)

Effect of immediate vs gradual reduction in nicotine content of cigarettes on biomarkers of smoke exposure a randomized clinical trial

Hatsukami, D. K., Luo, X., Jensen, J. A., al'Absi, M. N., Allen, S. S., Carmella, S. G., Chen, M., Cinciripini, P. M., Denlinger-Apte, R., Drobes, D. J., Koopmeiners, J., Lane, T., Le, C. T., Leischow, S., Luo, K., Joseph McClernon, F., Murphy, S. E., Paiano, V., Robinson, J. D., Severson, H. & 8 others, Sipe, C., Strasser, A. A., Strayer, L. S., Tang, M. K., Vandrey, R., Hecht, S. S., Benowitz, N. L. & Donny, E. C., Sep 4 2018, In : JAMA - Journal of the American Medical Association. 320, 9, p. 880-891 12 p.

Research output: Contribution to journalArticle

Open Access
hydroxypropyl methacrylate
Nicotine
Smoke
Tobacco Products
Randomized Controlled Trials
Vegetables
Acetylcysteine
Urine
Brassica
Isothiocyanates
7 Citations (Scopus)
Open Access
Nitrosamines
DNA Adducts
Tobacco
Carcinogenesis
Phosphates
Open Access
Bronchiolo-Alveolar Adenocarcinoma
Enantiomers
Inbred F344 Rats
Metabolites
Pancreatic Neoplasms
7 Citations (Scopus)
Open Access
Enantiomers
DNA Adducts
Metabolites
Rats
Phosphates
6 Citations (Scopus)

Relationship of the oxidative damage biomarker 8-epiprostaglandin F to risk of lung cancer development in the Shanghai Cohort Study

Yuan, J. M., Carmella, S. G., Wang, R., Tan, Y. T., Adams-Haduch, J., Gao, Y. T. & Hecht, S. S., Jul 3 2018, In : Carcinogenesis. 39, 7, p. 948-954 7 p.

Research output: Contribution to journalArticle

Dinoprost
Lung Neoplasms
Cohort Studies
Biomarkers
Smoking
2 Citations (Scopus)

The safety evaluation of food flavouring substances: the role of metabolic studies

Smith, R. L., Cohen, S. M., Fukushima, S., Gooderham, N. J., Hecht, S. S., Guengerich, F. P., Rietjens, I. M. C. M., Bastaki, M., Harman, C. L., McGowen, M. M. & Taylor, S. V., Jan 1 2018, In : Toxicology Research. 7, 4, p. 618-646 29 p.

Research output: Contribution to journalReview article

Food Safety
Flavors
Metabolism
Safety
Glucuronic Acid
5 Citations (Scopus)

Updated procedure for the safety evaluation of natural flavor complexes used as ingredients in food

Cohen, S. M., Eisenbrand, G., Fukushima, S., Gooderham, N. J., Guengerich, F. P., Hecht, S. S., Rietjens, I. M. C. M., Davidsen, J. M., Harman, C. L. & Taylor, S. V., Mar 2018, In : Food and Chemical Toxicology. 113, p. 171-178 8 p.

Research output: Contribution to journalArticle

Flavors
ingredients
flavor
Safety
Food
2017
1 Citation (Scopus)

A general method for detecting nitrosamide formation in the in vitro metabolism of nitrosamines by cytochrome P450s

Carlson, E. S., Upadhyaya, P. & Hecht, S. S., Sep 25 2017, In : Journal of Visualized Experiments. 2017, 127, e56312.

Research output: Contribution to journalArticle

Open Access
Nitrosamines
Cytochromes
Metabolism
Proteins
Cytochrome P-450 Enzyme System
2 Citations (Scopus)
Open Access
N'-nitrosonornicotine
Enantiomers
Tandem Mass Spectrometry
Mass spectrometry
Urine

A special issue of CRT: Celebrating volume 30

Hecht, S. S., Jan 1 2017, In : Chemical research in toxicology. 30, 1, 1 p.

Research output: Contribution to journalEditorial

Cathode ray tubes
Toxicology
13 Citations (Scopus)

Association of CYP2A6 activity with lung cancer incidence in smokers: The Multiethnic Cohort Study

Park, S. L., Murphy, S. E., Wilkens, L. R., Stram, D. O., Hecht, S. S. & Le Marchand, L., May 1 2017, In : PloS one. 12, 5, e0178435.

Research output: Contribution to journalArticle

Open Access
nicotine
lung neoplasms
cohort studies
Nicotine
cytochrome P-450
22 Citations (Scopus)

Biomarkers of exposure to new and emerging tobacco delivery products

Schick, S. F., Blount, B. C., Jacob, P., Saliba, N. A., Bernert, J. T., El Hellani, A., Jatlow, P., Pappas, R. S., Wang, L., Foulds, J., Ghosh, A., Hecht, S. S., Gomez, J. C., Martin, J. R., Mesaros, C., Srivastava, S., St. Helen, G., Tarran, R., Lorkiewicz, P. K., Blair, I. A. & 4 others, Kimmel, H. L., Doerschuk, C. M., Benowitz, N. L. & Bhatnagar, A., Sep 2017, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 313, 3, p. L425-L452

Research output: Contribution to journalArticle

Tobacco Products
Biomarkers
Research Personnel
Tobacco Use
Research
1 Citation (Scopus)

Carcinogenic Effects of Cigarette Smoke on the Respiratory Tract

Peterson, L. A., Urban, A. M. & Hecht, S. S., Dec 15 2017, Respiratory Toxicology. Elsevier Inc., Vol. 15-15. p. 228-253 26 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Smoke
Tobacco Products
Respiratory System
Lung Neoplasms
Carcinogens
14 Citations (Scopus)

CYP2A6 genetic polymorphisms and biomarkers of tobacco smoke constituents in relation to risk of lung cancer in the Singapore Chinese Health Study

Yuan, J. M., Nelson, H. H., Carmella, S. G., Wang, R., Kuriger-Laber, J., Jin, A., Adams-Haduch, J., Hecht, S. S., Koh, W. P. & Murphy, S. E., Jan 1 2017, In : Carcinogenesis. 38, 4, p. 411-418 8 p.

Research output: Contribution to journalArticle

Open Access
Singapore
Genetic Polymorphisms
Nicotine
Smoke
Cytochrome P-450 Enzyme System
2 Citations (Scopus)

Experimental nasal cavity tumors induced by tobacco-specific nitrosamines (TSNA)

Rivenson, A., Furuya, K., Hecht, S. S. & Hoffman, D., Jan 1 2017, Nasal Tumors in Animals and Man Volume III: Experimental Nasal Carcinogenesis. CRC Press, p. 79-114 36 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Nitrosamines
Nasal Cavity
Smoke
Tobacco
Tobacco Products
3 Citations (Scopus)
Open Access
Squamous Cell Neoplasms
Mouth Neoplasms
Head and Neck Neoplasms
Carcinogens
DNA Damage
6 Citations (Scopus)
Open Access
Deoxycytidine
Carcinogens
Tobacco
DNA
Nitrosamines
Open Access
Polycyclic Aromatic Hydrocarbons
Acetylcysteine
Epoxy Compounds
Urine
Creosote
4 Citations (Scopus)

Nasal cavity carcinogens: Possible routes of metabolic activation

Hecht, S. S., Castonguay, A. & Hoffmann, D., Jan 1 2017, Nasal Tumors in Animals and Man Volume III: Experimental Nasal Carcinogenesis. CRC Press, p. 201-232 32 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Nasal Cavity
Carcinogens
Nose Neoplasms
Phenacetin
Nitrosamines
13 Citations (Scopus)

Oral cell DNA adducts as potential biomarkers for lung cancer susceptibility in cigarette smokers

Hecht, S. S., Jan 1 2017, In : Chemical research in toxicology. 30, 1, p. 367-375 9 p.

Research output: Contribution to journalReview article

Open Access
DNA Adducts
Biomarkers
Tobacco Products
Lung Neoplasms
DNA
3 Citations (Scopus)

Pilot in Vivo Structure-Activity Relationship of Dihydromethysticin in Blocking 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone-Induced O6-Methylguanine and Lung Tumor in A/J Mice

Puppala, M., Narayanapillai, S. C., Leitzman, P., Sun, H., Upadhyaya, P., O'Sullivan, M. G., Hecht, S. S. & Xing, C., Jan 1 2017, In : Journal of Medicinal Chemistry. 60, 18, p. 7935-7940 6 p.

Research output: Contribution to journalArticle

Open Access
Lactones
Structure-Activity Relationship
Adenoma
Lung Neoplasms
Lung
7 Citations (Scopus)
Open Access
Nitrosamines
Tobacco
Enantiomers
DNA Adducts
Metabolites
18 Citations (Scopus)

Reduced nicotine content cigarettes and use of alternative nicotine products: exploratory trial

Hatsukami, D. K., Luo, X., Dick, L., Kangkum, M., Allen, S. S., Murphy, S. E., Hecht, S. S., Shields, P. G. & al'Absi, M., Jan 1 2017, In : Addiction. 112, 1, p. 156-167 12 p.

Research output: Contribution to journalArticle

Open Access
Nicotine
Tobacco Products
Confidence Intervals
Smoking
Biomarkers
8 Citations (Scopus)

Safety evaluation of substituted thiophenes used as flavoring ingredients

Cohen, S. M., Fukushima, S., Gooderham, N. J., Guengerich, F. P., Hecht, S. S., Rietjens, I. M. C. M., Smith, R. L., Bastaki, M., Harman, C. L., McGowen, M. M., Valerio, L. G. & Taylor, S. V., Jan 1 2017, In : Food and Chemical Toxicology. 99, p. 40-59 20 p.

Research output: Contribution to journalReview article

thiophenes
Thiophenes
flavorings
Metabolism
ingredients
9 Citations (Scopus)

Tobacco, e-cigarettes, and child health

Peterson, L. A. & Hecht, S. S., Apr 1 2017, In : Current Opinion in Pediatrics. 29, 2, p. 225-230 6 p.

Research output: Contribution to journalReview article

Open Access
Tobacco
Smoke
Nicotine
National Institute of Environmental Health Sciences (U.S.)
Biomarkers
10 Citations (Scopus)
DNA Adducts
Benzo(a)pyrene
Carcinogens
Liquid chromatography
DNA
2016
12 Citations (Scopus)
2-butenal
Smoke
Acrolein
Carcinogens
Tobacco
10 Citations (Scopus)
N'-nitrosonornicotine
Deoxyguanosine
DNA Adducts
Rats
Inbred F344 Rats
5 Citations (Scopus)

Analytical Assessment of e-Cigarettes: From Contents to Chemical and Particle Exposure Profiles

Farsalinos, K. E., Gillman, I. G., Hecht, S. S., Polosa, R. & Thornburg, J., Nov 14 2016, Elsevier Inc. 150 p.

Research output: Book/ReportBook

Tobacco Products
Aerosols
Industry
Medical Marijuana
Information Science
14 Citations (Scopus)

A randomized controlled trial of progressively reduced nicotine content cigarettes on smoking behaviors, biomarkers of exposure, and subjective ratings

Mercincavage, M., Souprountchouk, V., Tang, K. Z., Dumont, R. L., Wileyto, E. P., Carmella, S. G., Hecht, S. S. & Strasser, A. A., Jul 1 2016, In : Cancer Epidemiology Biomarkers and Prevention. 25, 7, p. 1125-1133 9 p.

Research output: Contribution to journalArticle

Nicotine
Randomized Controlled Trials
Biomarkers
Smoking
Tobacco Products
11 Citations (Scopus)

Benzene uptake and glutathione S-transferase T1 status as determinants of S-phenylmercapturic acid in cigarette smokers in the multiethnic cohort

Haiman, C. A., Patel, Y. M., Stram, D. O., Carmella, S. G., Chen, M., Wilkens, L. R., Le Marchand, L. & Hecht, S. S., Mar 2016, In : PloS one. 11, 3, e0150641.

Research output: Contribution to journalArticle

cigarettes
benzene
Benzene
glutathione transferase
Tobacco Products