1967 …2023
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Research Output 1967 2019

2019
1 Citation (Scopus)
Acrolein
Smoking
Lung
Tobacco Products
DNA

Effects of cessation of cigarette smoking on eicosanoid biomarkers of inflammation and oxidative damage

McElroy, J. P., Carmella, S. G., Heskin, A. K., Tang, M. K., Murphy, S. E., Reisinger, S. A., Jensen, J. A., Hatsukami, D. K., Hecht, S. S. & Shields, P. G., Jan 1 2019, In : PloS one. 14, 6, e0218386.

Research output: Contribution to journalArticle

Open Access
Dinoprost
eicosanoids
smoking (habit)
Eicosanoids
Biomarkers

Effects of immediate versus gradual nicotine reduction in cigarettes on biomarkers of biological effects

Hatsukami, D. K., Luo, X., Heskin, A. K., Tang, M. K., Carmella, S. G., Jensen, J., Robinson, J. D., Vandrey, R., Drobes, D. J., Strasser, A. A., al'Absi, M. N., Leischow, S., Cinciripini, P. M., Koopmeiners, J., Ikuemonisan, J., Benowitz, N. L., Donny, E. C. & Hecht, S. S., Jan 1 2019, In : Addiction.

Research output: Contribution to journalArticle

Nicotine
Tobacco Products
Biomarkers
Smoking
Confidence Intervals

FEMA GRAS assessment of natural flavor complexes: Citrus-derived flavoring ingredients

Cohen, S. M., Eisenbrand, G., Fukushima, S., Gooderham, N. J., Guengerich, F. P., Hecht, S. S., Rietjens, I. M. C. M., Bastaki, M., Davidsen, J. M., Harman, C. L., McGowen, M. & Taylor, S. V., Feb 1 2019, In : Food and Chemical Toxicology. 124, p. 192-218 27 p.

Research output: Contribution to journalArticle

Citrus
Flavors
flavorings
ingredients
flavor
2 Citations (Scopus)

Longitudinal stability in cigarette smokers of urinary biomarkers of exposure to the toxicants acrylonitrile and acrolein

Chen, M., Carmella, S. G., Sipe, C., Jensen, J., Luo, X., Le, C. T., Murphy, S. E., Benowitz, N. L., Joseph McClernon, F., Vandrey, R., Allen, S. S., Denlinger-Apte, R., Cinciripini, P. M., Strasser, A. A., al'Absi, M. N., Robinson, J. D., Donny, E. C., Hatsukami, D. K. & Hecht, S. S., Jan 1 2019, In : PloS one. 14, 1, e0210104.

Research output: Contribution to journalArticle

Open Access
acrolein
Acrylonitrile
Acrolein
cigarettes
Acetylcysteine
1 Citation (Scopus)

Longitudinal stability in cigarette smokers of urinary eicosanoid biomarkers of oxidative damage and inflammation

Carmella, S. G., Heskin, A. K., Tang, M. K., Jensen, J., Luo, X., Le, C. T., Murphy, S. E., Benowitz, N. L., Joseph McClernon, F., Vandrey, R., Allen, S. S., Denlinger-Apte, R., Cinciripini, P. M., Strasser, A. A., al'Absi, M. N., Robinson, J. D., Donny, E. C., Hatsukami, D. K. & Hecht, S. S., Apr 1 2019, In : PloS one. 14, 4, e0215853.

Research output: Contribution to journalArticle

Open Access
eicosanoids
Eicosanoids
cigarettes
Prostaglandins F
Biomarkers
1 Citation (Scopus)

Mass Spectrometric Quantitation of Pyridyloxobutyl DNA Phosphate Adducts in Rats Chronically Treated with N′-Nitrosonornicotine

Li, Y., Ma, B., Cao, Q., Balbo, S., Zhao, L., Upadhyaya, P. & Hecht, S. S., Apr 15 2019, In : Chemical research in toxicology. 32, 4, p. 773-783 11 p.

Research output: Contribution to journalArticle

N'-nitrosonornicotine
DNA Adducts
Rats
Phosphates
DNA

Recent studies on DNA adducts resulting from human exposure to tobacco smoke

Ma, B., Stepanov, I. & Hecht, S. S., Jan 1 2019, In : Toxics. 7, 1, 16.

Research output: Contribution to journalReview article

Open Access
Tobacco
DNA Adducts
Smoke
Carcinogens
Nitrosamines

Urinary concentrations of monohydroxylated polycyclic aromatic hydrocarbons in adults from the U.S. Population Assessment of Tobacco and Health (PATH) Study Wave 1 (2013–2014)

Wang, Y., Wong, L. Y., Meng, L., Pittman, E. N., Trinidad, D. A., Hubbard, K. L., Etheredge, A., Del Valle-Pinero, A. Y., Zamoiski, R., van Bemmel, D. M., Borek, N., Patel, V., Kimmel, H. L., Conway, K. P., Lawrence, C., Edwards, K. C., Hyland, A., Goniewicz, M. L., Hatsukami, D. K., Hecht, S. S. & 1 others, Calafat, A. M., Feb 1 2019, In : Environment International. p. 201-208 8 p.

Research output: Contribution to journalArticle

Open Access
tobacco
PAH
biomarker
product
health
2018
8 Citations (Scopus)

Acrolein exposure in hookah smokers and non-smokers exposed to hookah tobacco secondhand smoke: Implications for regulating hookah tobacco products

Kassem, N. O. F., Kassem, N. O., Liles, S., Zarth, A. T., Jackson, S. R., Daffa, R. M., Chatfield, D. A., Carmella, S. G., Hecht, S. S. & Hovell, M. F., Mar 6 2018, In : Nicotine and Tobacco Research. 20, 4, p. 492-501 10 p.

Research output: Contribution to journalArticle

Open Access
Acrolein
Tobacco Smoke Pollution
Tobacco Products
Tobacco
Smoking
5 Citations (Scopus)
Open Access
Tobacco
Enantiomers
DNA Adducts
Metabolites
Carcinogens

A New Editorial Team for CRT

Hecht, S. S., Jan 16 2018, In : Chemical Research in Toxicology. 31, 1, 1 p.

Research output: Contribution to journalEditorial

Cathode ray tubes
5 Citations (Scopus)

Effect of immediate vs gradual reduction in nicotine content of cigarettes on biomarkers of smoke exposure a randomized clinical trial

Hatsukami, D. K., Luo, X., Jensen, J. A., al'Absi, M. N., Allen, S. S., Carmella, S. G., Chen, M., Cinciripini, P. M., Denlinger-Apte, R., Drobes, D. J., Koopmeiners, J., Lane, T., Le, C. T., Leischow, S., Luo, K., Joseph McClernon, F., Murphy, S. E., Paiano, V., Robinson, J. D., Severson, H. & 8 others, Sipe, C., Strasser, A. A., Strayer, L. S., Tang, M. K., Vandrey, R., Hecht, S. S., Benowitz, N. L. & Donny, E. C., Sep 4 2018, In : JAMA - Journal of the American Medical Association. 320, 9, p. 880-891 12 p.

Research output: Contribution to journalArticle

Open Access
hydroxypropyl methacrylate
Nicotine
Smoke
Tobacco Products
Randomized Controlled Trials
Vegetables
Acetylcysteine
Urine
Brassica
Isothiocyanates
6 Citations (Scopus)
Nitrosamines
DNA Adducts
Tobacco
Carcinogenesis
Phosphates
Bronchiolo-Alveolar Adenocarcinoma
Enantiomers
Inbred F344 Rats
Metabolites
Pancreatic Neoplasms
7 Citations (Scopus)
Enantiomers
DNA Adducts
Metabolites
Rats
Phosphates
3 Citations (Scopus)

Relationship of the oxidative damage biomarker 8-epiprostaglandin F to risk of lung cancer development in the Shanghai Cohort Study

Yuan, J. M., Carmella, S. G., Wang, R., Tan, Y. T., Adams-Haduch, J., Gao, Y. T. & Hecht, S. S., Jul 3 2018, In : Carcinogenesis. 39, 7, p. 948-954 7 p.

Research output: Contribution to journalArticle

Dinoprost
Lung Neoplasms
Cohort Studies
Biomarkers
Smoking
1 Citation (Scopus)

The safety evaluation of food flavouring substances: the role of metabolic studies

Smith, R. L., Cohen, S. M., Fukushima, S., Gooderham, N. J., Hecht, S. S., Guengerich, F. P., Rietjens, I. M. C. M., Bastaki, M., Harman, C. L., McGowen, M. M. & Taylor, S. V., Jan 1 2018, In : Toxicology Research. 7, 4, p. 618-646 29 p.

Research output: Contribution to journalReview article

Food Safety
Flavors
Metabolism
Safety
Glucuronic Acid
3 Citations (Scopus)

Updated procedure for the safety evaluation of natural flavor complexes used as ingredients in food

Cohen, S. M., Eisenbrand, G., Fukushima, S., Gooderham, N. J., Guengerich, F. P., Hecht, S. S., Rietjens, I. M. C. M., Davidsen, J. M., Harman, C. L. & Taylor, S. V., Mar 1 2018, In : Food and Chemical Toxicology. 113, p. 171-178 8 p.

Research output: Contribution to journalArticle

Flavors
ingredients
flavor
Safety
Food
2017
1 Citation (Scopus)

A general method for detecting nitrosamide formation in the in vitro metabolism of nitrosamines by cytochrome P450s

Carlson, E. S., Upadhyaya, P. & Hecht, S. S., Sep 25 2017, In : Journal of Visualized Experiments. 2017, 127, e56312.

Research output: Contribution to journalArticle

Open Access
Nitrosamines
Cytochromes
Metabolism
Proteins
Cytochrome P-450 Enzyme System
2 Citations (Scopus)
Open Access
N'-nitrosonornicotine
Enantiomers
Tandem Mass Spectrometry
Mass spectrometry
Urine

A special issue of CRT: Celebrating volume 30

Hecht, S. S., Jan 1 2017, In : Chemical Research in Toxicology. 30, 1, 1 p.

Research output: Contribution to journalEditorial

Cathode ray tubes
Toxicology
7 Citations (Scopus)

Association of CYP2A6 activity with lung cancer incidence in smokers: The Multiethnic Cohort Study

Park, S. L., Murphy, S. E., Wilkens, L. R., Stram, D. O., Hecht, S. S. & Le Marchand, L., May 1 2017, In : PLoS One. 12, 5, e0178435.

Research output: Contribution to journalArticle

nicotine
lung neoplasms
cohort studies
Nicotine
cytochrome P-450
18 Citations (Scopus)

Biomarkers of exposure to new and emerging tobacco delivery products

Schick, S. F., Blount, B. C., Jacob, P., Saliba, N. A., Bernert, J. T., El Hellani, A., Jatlow, P., Pappas, R. S., Wang, L., Foulds, J., Ghosh, A., Hecht, S. S., Gomez, J. C., Martin, J. R., Mesaros, C., Srivastava, S., St. Helen, G., Tarran, R., Lorkiewicz, P. K., Blair, I. A. & 4 others, Kimmel, H. L., Doerschuk, C. M., Benowitz, N. L. & Bhatnagar, A., Sep 1 2017, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 313, 3, p. L425-L452

Research output: Contribution to journalArticle

Tobacco Products
Biomarkers
Research Personnel
Tobacco Use
Research
1 Citation (Scopus)

Carcinogenic Effects of Cigarette Smoke on the Respiratory Tract

Peterson, L. A., Urban, A. M. & Hecht, S. S., Dec 15 2017, Respiratory Toxicology. Elsevier Inc., Vol. 15-15. p. 228-253 26 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Smoke
Tobacco Products
Respiratory System
Lung Neoplasms
Carcinogens
10 Citations (Scopus)

CYP2A6 genetic polymorphisms and biomarkers of tobacco smoke constituents in relation to risk of lung cancer in the Singapore Chinese Health Study

Yuan, J. M., Nelson, H. H., Carmella, S. G., Wang, R., Kuriger-Laber, J., Jin, A., Adams-Haduch, J., Hecht, S. S., Koh, W. P. & Murphy, S. E., Jan 1 2017, In : Carcinogenesis. 38, 4, p. 411-418 8 p.

Research output: Contribution to journalArticle

Open Access
Singapore
Genetic Polymorphisms
Nicotine
Smoke
Cytochrome P-450 Enzyme System
2 Citations (Scopus)

Experimental nasal cavity tumors induced by tobacco-specific nitrosamines (TSNA)

Rivenson, A., Furuya, K., Hecht, S. S. & Hoffman, D., Jan 1 2017, Nasal Tumors in Animals and Man Volume III: Experimental Nasal Carcinogenesis. CRC Press, p. 79-114 36 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Nitrosamines
Nasal Cavity
Smoke
Tobacco
Tobacco Products
2 Citations (Scopus)
Open Access
Squamous Cell Neoplasms
Mouth Neoplasms
Head and Neck Neoplasms
Carcinogens
DNA Damage
5 Citations (Scopus)
Deoxycytidine
Carcinogens
Tobacco
DNA
Nitrosamines
Open Access
Polycyclic Aromatic Hydrocarbons
Acetylcysteine
Epoxy Compounds
Urine
Creosote
4 Citations (Scopus)

Nasal cavity carcinogens: Possible routes of metabolic activation

Hecht, S. S., Castonguay, A. & Hoffmann, D., Jan 1 2017, Nasal Tumors in Animals and Man Volume III: Experimental Nasal Carcinogenesis. CRC Press, p. 201-232 32 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Nasal Cavity
Carcinogens
Nose Neoplasms
Phenacetin
Nitrosamines
12 Citations (Scopus)

Oral cell DNA adducts as potential biomarkers for lung cancer susceptibility in cigarette smokers

Hecht, S. S., Jan 1 2017, In : Chemical research in toxicology. 30, 1, p. 367-375 9 p.

Research output: Contribution to journalReview article

Open Access
DNA Adducts
Biomarkers
Tobacco Products
Lung Neoplasms
DNA
3 Citations (Scopus)

Pilot in Vivo Structure-Activity Relationship of Dihydromethysticin in Blocking 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone-Induced O6-Methylguanine and Lung Tumor in A/J Mice

Puppala, M., Narayanapillai, S. C., Leitzman, P., Sun, H., Upadhyaya, P., O'Sullivan, M. G., Hecht, S. S. & Xing, C., Jan 1 2017, In : Journal of Medicinal Chemistry. 60, 18, p. 7935-7940 6 p.

Research output: Contribution to journalArticle

Lactones
Structure-Activity Relationship
Adenoma
Lung Neoplasms
Lung
7 Citations (Scopus)
Nitrosamines
Tobacco
Enantiomers
DNA Adducts
Metabolites
15 Citations (Scopus)

Reduced nicotine content cigarettes and use of alternative nicotine products: exploratory trial

Hatsukami, D. K., Luo, X., Dick, L., Kangkum, M., Allen, S. S., Murphy, S. E., Hecht, S. S., Shields, P. G. & al'Absi, M., Jan 1 2017, In : Addiction. 112, 1, p. 156-167 12 p.

Research output: Contribution to journalArticle

Open Access
Nicotine
Tobacco Products
Confidence Intervals
Smoking
Biomarkers
6 Citations (Scopus)

Safety evaluation of substituted thiophenes used as flavoring ingredients

Cohen, S. M., Fukushima, S., Gooderham, N. J., Guengerich, F. P., Hecht, S. S., Rietjens, I. M. C. M., Smith, R. L., Bastaki, M., Harman, C. L., McGowen, M. M., Valerio, L. G. & Taylor, S. V., Jan 1 2017, In : Food and Chemical Toxicology. 99, p. 40-59 20 p.

Research output: Contribution to journalReview article

thiophenes
Thiophenes
flavorings
Metabolism
ingredients
8 Citations (Scopus)

Tobacco, e-cigarettes, and child health

Peterson, L. A. & Hecht, S. S., Apr 1 2017, In : Current Opinion in Pediatrics. 29, 2, p. 225-230 6 p.

Research output: Contribution to journalReview article

Tobacco
Smoke
Nicotine
National Institute of Environmental Health Sciences (U.S.)
Biomarkers
7 Citations (Scopus)
DNA Adducts
Benzo(a)pyrene
Carcinogens
Liquid chromatography
DNA
2016
11 Citations (Scopus)
2-butenal
Smoke
Acrolein
Carcinogens
Tobacco
8 Citations (Scopus)
N'-nitrosonornicotine
Deoxyguanosine
DNA Adducts
Rats
Inbred F344 Rats
4 Citations (Scopus)

Analytical Assessment of e-Cigarettes: From Contents to Chemical and Particle Exposure Profiles

Farsalinos, K. E., Gillman, I. G., Hecht, S. S., Polosa, R. & Thornburg, J., Nov 14 2016, Elsevier Inc. 150 p.

Research output: Book/ReportBook

Tobacco Products
Aerosols
Industry
Medical Marijuana
Information Science
12 Citations (Scopus)

A randomized controlled trial of progressively reduced nicotine content cigarettes on smoking behaviors, biomarkers of exposure, and subjective ratings

Mercincavage, M., Souprountchouk, V., Tang, K. Z., Dumont, R. L., Wileyto, E. P., Carmella, S. G., Hecht, S. S. & Strasser, A. A., Jul 1 2016, In : Cancer Epidemiology Biomarkers and Prevention. 25, 7, p. 1125-1133 9 p.

Research output: Contribution to journalArticle

Nicotine
Randomized Controlled Trials
Biomarkers
Smoking
Tobacco Products
10 Citations (Scopus)

Benzene uptake and glutathione S-transferase T1 status as determinants of S-phenylmercapturic acid in cigarette smokers in the multiethnic cohort

Haiman, C. A., Patel, Y. M., Stram, D. O., Carmella, S. G., Chen, M., Wilkens, L. R., Le Marchand, L. & Hecht, S. S., Mar 1 2016, In : PloS one. 11, 3, e0150641.

Research output: Contribution to journalArticle

cigarettes
benzene
Benzene
glutathione transferase
Tobacco Products

Biomarkers for Assessment of Chemical Exposures From e-Cigarette Emissions

Hecht, S. S., Nov 14 2016, Analytical Assessment of e-Cigarettes: From Contents to Chemical and Particle Exposure Profiles. Elsevier Inc., p. 59-73 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Tobacco Products
Biomarkers
Nicotine
Urine
Cotinine
Toxicology
Research
24 Citations (Scopus)

Clinical trial of 2-phenethyl isothiocyanate as an inhibitor of metabolic activation of a tobacco-specific lung carcinogen in cigarette smokers

Yuan, J. M., Stepanov, I., Murphy, S. E., Wang, R., Allen, S., Jensen, J., Strayer, L., Adams-Haduch, J., Upadhyaya, P., Le, C., Kurzer, M. S., Nelson, H. H., Yu, M. C., Hatsukami, D. & Hecht, S. S., May 1 2016, In : Cancer Prevention Research. 9, 5, p. 396-405 10 p.

Research output: Contribution to journalArticle

Tobacco Products
Carcinogens
Tobacco
Clinical Trials
Lung
20 Citations (Scopus)

Dietary consumption of black raspberries or their anthocyanin constituents alters innate immune cell trafficking in esophageal cancer

Peiffer, D. S., Wang, L. S., Zimmerman, N. P., Ransom, B. W. S., Carmella, S. G., Kuo, C. T., Chen, J. H., Oshima, K., Huang, Y. W., Hecht, S. S. & Stoner, G. D., Jan 1 2016, In : Cancer Immunology Research. 4, 1, p. 72-82 11 p.

Research output: Contribution to journalArticle

Anthocyanins
Esophageal Neoplasms
Esophagus
Cytokines
Diet
3 Citations (Scopus)

Dietary Dihydromethysticin Increases Glucuronidation of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in A/J Mice, Potentially Enhancing Its Detoxification

Chanickal Narayanapillai, S., von Weymarn, L. B., Carmella, S. G., Leitzman, P., Paladino, J., Upadhyaya, P., Hecht, S. S., Murphy, S. E. & Xing, C., Mar 1 2016, In : Drug Metabolism and Disposition. 44, 3, p. 422-427 6 p.

Research output: Contribution to journalArticle

Lung
Lung Neoplasms
Carcinogenesis
DNA Adducts
4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol
11 Citations (Scopus)

DNA Adduct Formation from Metabolic 5′-Hydroxylation of the Tobacco-Specific Carcinogen N′-Nitrosonornicotine in Human Enzyme Systems and in Rats

Zarth, A. T., Upadhyaya, P., Yang, J. & Hecht, S. S., Mar 21 2016, In : Chemical research in toxicology. 29, 3, p. 380-389 10 p.

Research output: Contribution to journalArticle

N'-nitrosonornicotine
Hydroxylation
Tobacco
DNA Adducts
Carcinogens