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Research Output 2000 2019

2000

Prospettive e limiti dei metodi RM nello studio della funzionalita cerebrale

Translated title of the contribution: Prospects and limitations of functional magnetic resonance imaging techniques in the study of brain activityMangia, S., Macri, M. A., Garreffa, G. & Maraviglia, B., Jan 1 2000, In : Rivista di Neuroradiologia. 13, 1, p. 85-92 8 p.

Research output: Contribution to journalArticle

Magnetic Resonance Imaging
Brain
Hemodynamics
Oxygen
Statistical Data Interpretation
2001

Nuclear magnetic resonance approaches to brain function studies

Capuani, S., Garreffa, G., Macrì, M. A., Mangia, S., Di Salle, F. & Maraviglia, B., Jan 1 2001, In : Applied Magnetic Resonance. 20, 1-2, p. 85-96 12 p.

Research output: Contribution to journalArticle

brain
Brain
Nuclear magnetic resonance
Imaging techniques
nuclear magnetic resonance
2003
23 Citations (Scopus)

Issues concerning the construction of a metabolic model for neuronal activation

Mangia, S., Giove, F., Bianciardi, M., Di Salle, F., Garreffa, G. & Maraviglia, B., Feb 15 2003, In : Journal of Neuroscience Research. 71, 4, p. 463-467 5 p.

Research output: Contribution to journalShort survey

Neurons
Glucose
Lactic Acid
74 Citations (Scopus)

The aerobic brain: Lactate decrease at the onset of neural activity

Mangia, S., Garreffa, G., Bianciardi, M., Giove, F., Di Salle, F. & Maraviglia, B., Apr 25 2003, In : Neuroscience. 118, 1, p. 7-10 4 p.

Research output: Contribution to journalArticle

Lactic Acid
Brain
Photic Stimulation
Neurons
Glucose
29 Citations (Scopus)

The physiology and metabolism of neuronal activation: In vivo studies by NMR and other methods

Giove, F., Mangia, S., Bianciardi, M., Garreffa, G., Di Salle, F., Morrone, R. & Maraviglia, B., Jan 1 2003, In : Magnetic Resonance Imaging. 21, 10, p. 1283-1293 11 p.

Research output: Contribution to journalArticle

Physiology
Metabolism
Blood Vessels
Brain
Chemical activation
2004
55 Citations (Scopus)

Issues about the fMRI of the human spinal cord

Giove, F., Garreffa, G., Giulietti, G., Mangia, S., Colonnese, C. & Maraviglia, B., Jan 1 2004, In : Magnetic Resonance Imaging. 22, 10 SPEC. ISS., p. 1505-1516 12 p.

Research output: Contribution to journalArticle

Spinal Cord
Magnetic Resonance Imaging
Neurology
Magnetic resonance
Central Nervous System
3 Citations (Scopus)

Perfusion- and BOLD-based fMRI in the study of a human pathological model for task-related flow reductions

Mangia, S., Di Salle, F., Garreffa, G., Esposito, F., Giove, F., Cirillo, S., Scarabino, T., Morrone, R. & Maraviglia, B., Mar 1 2004, In : Brain Research Bulletin. 63, 1, p. 1-5 5 p.

Research output: Contribution to journalArticle

Perfusion
Magnetic Resonance Imaging
Oxygen
Cerebrovascular Circulation
Perfusion Imaging
2006

Magnetic resonance imaging (MRI) methods in Parkinson’s disease

Mangia, S., Michaeli, S. & Tuite, P. J., Jan 1 2006, Magnetic Resonance Imaging in Movement Disorders: A Guide for Clinicians and Scientists. Cambridge University Press, Vol. 9781107026360. p. 1-13 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Parkinson Disease
Magnetic Resonance Imaging
Movement Disorders
Progressive Supranuclear Palsy
Multiple System Atrophy
75 Citations (Scopus)

Sensitivity of single-voxel 1H-MRS in investigating the metabolism of the activated human visual cortex at 7 T

Mangia, S., Tkac, I., Gruetter, R., Van de Moortele, P-F., Giove, F., Maraviglia, B. & Ugurbil, K., May 1 2006, In : Magnetic Resonance Imaging. 24, 4, p. 343-348 6 p.

Research output: Contribution to journalArticle

Visual Cortex
Metabolites
Metabolism
Photic Stimulation
Magnetic resonance spectroscopy
2007
43 Citations (Scopus)
Creatine
Visual Cortex
Lactic Acid
Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging
185 Citations (Scopus)
Visual Cortex
Lactic Acid
Magnetic Resonance Spectroscopy
Aspartic Acid
Aminoacylation
2008
14 Citations (Scopus)

Characterization of the functional response in the human spinal cord: Impulse-response function and linearity

Giulietti, G., Giove, F., Garreffa, G., Colonnese, C., Mangia, S. & Maraviglia, B., Aug 15 2008, In : NeuroImage. 42, 2, p. 626-634 9 p.

Research output: Contribution to journalArticle

Spinal Cord
Brain
Magnetic Resonance Imaging
Magnetic resonance spectroscopy
Photic Stimulation
Visual Cortex
Metabolism
Aspartic Acid
4 Citations (Scopus)

Letter to the editor

Mangia, S. & Tkac, I., Jun 1 2008, In : Journal of Molecular Neuroscience. 35, 2, p. 245-246 2 p.

Research output: Contribution to journalLetter

Magnetic resonance spectroscopy
Photic Stimulation
Visual Cortex
Aspartic Acid
Electric Stimulation
2009
109 Citations (Scopus)

Metabolic and hemodynamic events after changes in neuronal activity: Current hypotheses, theoretical predictions and in vivo NMR experimental findings

Mangia, S., Giove, F., Tkac, I., Logothetis, N. K., Henry, P-G., Olman, C. A., Maraviglia, B., Di Salle, F. & Ugurbil, K., Jan 1 2009, In : Journal of Cerebral Blood Flow and Metabolism. 29, 3, p. 441-463 23 p.

Research output: Contribution to journalReview article

Magnetic Resonance Spectroscopy
Hemodynamics
Magnetic Resonance Imaging
Brain
Brain Diseases
38 Citations (Scopus)
Irradiation
Brain
Chemical shift
Magnetic resonance imaging
Rate constants
114 Citations (Scopus)

The in vivo neuron-to-astrocyte lactate shuttle in human brain: Evidence from modeling of measured lactate levels during visual stimulation

Mangia, S., Simpson, I. A., Vannucci, S. J. & Carruthers, A., May 1 2009, In : Journal of Neurochemistry. 109, SUPPL. 1, p. 55-62 8 p.

Research output: Contribution to journalArticle

Photic Stimulation
Astrocytes
Neurons
Magnetic resonance spectroscopy
Lactic Acid
2010
62 Citations (Scopus)

Changes in glucose uptake rather than lactate shuttle take center stage in subserving neuroenergetics: Evidence from mathematical modeling

Dinuzzo, M., Mangia, S., Maraviglia, B. & Giove, F., Mar 1 2010, In : Journal of Cerebral Blood Flow and Metabolism. 30, 3, p. 586-602 17 p.

Research output: Contribution to journalArticle

Lactic Acid
Glucose
Astrocytes
Neurons
Brain
64 Citations (Scopus)
Glycogenolysis
Glycogen
Astrocytes
Blood Glucose
Lactic Acid
11 Citations (Scopus)

Metabolic correlatives of brain activity in a FOS epilepsy patient

Peca, S., Carnì, M., Di Bonaventura, C., Aprile, T., Hagberg, G. E., Giallonardo, A. T., Manfredi, M., Mangia, S., Garreffa, G., Maraviglia, B. & Giove, F., Feb 1 2010, In : NMR in biomedicine. 23, 2, p. 170-178 9 p.

Research output: Contribution to journalArticle

Glutamic Acid
Epilepsy
Brain
Magnetic resonance spectroscopy
Electroencephalography
29 Citations (Scopus)

Probing slow protein dynamics by adiabatic R and R NMR experiments

Mangia, S., Traaseth, N. J., Veglia, G., Garwood, M. & Michaeli, S., Jul 28 2010, In : Journal of the American Chemical Society. 132, 29, p. 9979-9981 3 p.

Research output: Contribution to journalArticle

Nuclear magnetic resonance
Proteins
Experiments
Protein Folding
Magnetic Fields
2011
5 Citations (Scopus)
Creatine
Metabolites
Protons
Rate constants
Brain
17 Citations (Scopus)

Magnetization transfer using inversion recovery during off-resonance irradiation

Mangia, S., De Martino, F., Liimatainen, T., Garwood, M. & Michaeli, S., Dec 1 2011, In : Magnetic Resonance Imaging. 29, 10, p. 1346-1350 5 p.

Research output: Contribution to journalArticle

Magnetization
Irradiation
Recovery
Organ Specificity
Neuroimaging
20 Citations (Scopus)

Relaxation dispersion in MRI induced by fictitious magnetic fields

Liimatainen, T., Mangia, S., Ling, W., Ellermann, J., Sorce, D. J., Garwood, M. & Michaeli, S., Apr 1 2011, In : Journal of Magnetic Resonance. 209, 2, p. 269-276 8 p.

Research output: Contribution to journalArticle

Magnetic Fields
Magnetic resonance imaging
Magnetic fields
magnetic fields
Amplitude modulation
65 Citations (Scopus)

Response to comment on recent modeling studies of astrocyte-neuron metabolic interactions: Much ado about nothing

Mangia, S., Dinuzzo, M., Giove, F., Carruthers, A., Simpson, I. A. & Vannucci, S. J., Jun 1 2011, In : Journal of Cerebral Blood Flow and Metabolism. 31, 6, p. 1346-1353 8 p.

Research output: Contribution to journalReview article

Astrocytes
Lactic Acid
Neurons
Glucose
Synaptic Transmission
2012
36 Citations (Scopus)

Cortical metabolites as biomarkers in the R6/2 model of Huntington's disease

Zacharoff, L., Tkac, I., Song, Q., Tang, C., Bolan, P. J., Mangia, S., Henry, P-G., Li, T. & Dubinsky, J. M., Mar 1 2012, In : Journal of Cerebral Blood Flow and Metabolism. 32, 3, p. 502-514 13 p.

Research output: Contribution to journalArticle

Huntington Disease
Biomarkers
Disease Progression
Brain
Magnetic Resonance Spectroscopy
8 Citations (Scopus)

Heteronuclear adiabatic relaxation dispersion (hard) for quantitative analysis of conformational dynamics in proteins

Traaseth, N. J., Chao, F. A., Masterson, L. R., Mangia, S., Garwood, M., Michaeli, S., Seelig, B. & Veglia, G., Jun 1 2012, In : Journal of Magnetic Resonance. 219, p. 75-82 8 p.

Research output: Contribution to journalArticle

quantitative analysis
proteins
Chemical analysis
Proteins
Rate constants
23 Citations (Scopus)

Hypoglycemia-induced increases in thalamic cerebral blood flow are blunted in subjects with type 1 diabetes and hypoglycemia unawareness

Mangia, S., Tesfaye, N., De Martino, F., Kumar, A. F., Kollasch, P., Moheet, A., Eberly, L. E. & Seaquist, E. R., Nov 1 2012, In : Journal of Cerebral Blood Flow and Metabolism. 32, 11, p. 2084-2090 7 p.

Research output: Contribution to journalArticle

Cerebrovascular Circulation
Type 1 Diabetes Mellitus
Hypoglycemia
Thalamus
Blood Glucose
9 Citations (Scopus)
Brain Stem
Parkinson Disease
Magnetic Resonance Imaging
Mesencephalon
Pathology
43 Citations (Scopus)

Metabolic pathways and activity-dependent modulation of glutamate concentration in the human brain

Mangia, S., Giove, F. & DiNuzzo, M., Nov 1 2012, In : Neurochemical Research. 37, 11, p. 2554-2561 8 p.

Research output: Contribution to journalReview article

Metabolic Networks and Pathways
Glutamic Acid
Brain
Modulation
Neurotransmitter Agents
47 Citations (Scopus)

The role of astrocytic glycogen in supporting the energetics of neuronal activity

DiNuzzo, M., Mangia, S., Maraviglia, B. & Giove, F., Nov 1 2012, In : Neurochemical Research. 37, 11, p. 2432-2438 7 p.

Research output: Contribution to journalReview article

Glycogen
Metabolism
Astrocytes
Glucose
Neurons
15 Citations (Scopus)

Toward understanding transverse relaxation in human brain through its field dependence

Mitsumori, F., Watanabe, H., Takaya, N., Garwood, M., Auerbach, E. J., Michaeli, S. & Mangia, S., Sep 1 2012, In : Magnetic resonance in medicine. 68, 3, p. 947-953 7 p.

Research output: Contribution to journalArticle

Magnetic Fields
Brain
Ferritins
Least-Squares Analysis
Protons
2013
10 Citations (Scopus)
Carrier State
Facilitative Glucose Transport Proteins
Deoxyglucose
Metabolism
Protein Isoforms
7 Citations (Scopus)

K+ homeostasis in the Brain: A new role for glycogenolysis

Mangia, S., Giove, F. & Dinuzzo, M., Mar 1 2013, In : Neurochemical Research. 38, 3, p. 470-471 2 p.

Research output: Contribution to journalReview article

Glycogenolysis
Glycogen
Brain
Homeostasis
Astrocytes
24 Citations (Scopus)

MRI rotating frame relaxation measurements for articular cartilage assessment

Ellermann, J., Ling, W., Nissi, M. J., Arendt, E., Carlson, C. S., Garwood, M., Michaeli, S. & Mangia, S., Nov 1 2013, In : Magnetic Resonance Imaging. 31, 9, p. 1537-1543 7 p.

Research output: Contribution to journalArticle

Cartilage
Articular Cartilage
Magnetic resonance imaging
Trypsin
Magnetization
20 Citations (Scopus)

Neurochemical profile of patients with type 1 diabetes measured by 1H-MRS at 4 T

Mangia, S., Kumar, A. F., Moheet, A., Roberts, R. J., Eberly, L. E., Seaquist, E. R. & Tkac, I., May 1 2013, In : Journal of Cerebral Blood Flow and Metabolism. 33, 5, p. 754-759 6 p.

Research output: Contribution to journalArticle

Type 1 Diabetes Mellitus
Occipital Lobe
Brain
Body Mass Index
Proton Magnetic Resonance Spectroscopy
21 Citations (Scopus)

Regulatory mechanisms for glycogenolysis and K+ uptake in brain astrocytes

Dinuzzo, M., Mangia, S., Maraviglia, B. & Giove, F., Sep 11 2013, In : Neurochemistry International. 63, 5, p. 458-464 7 p.

Research output: Contribution to journalReview article

Glycogenolysis
Glycogen
Astrocytes
Brain
Ion Transport
2014
1 Citation (Scopus)

Exchange-induced relaxation in the presence of a fictitious field

Sorce, D. J., Mangia, S., Liimatainen, T., Garwood, M. & Michaeli, S., Jan 1 2014, In : Journal of Magnetic Resonance. 245, p. 12-16 5 p.

Research output: Contribution to journalArticle

Magnetic Fields
Magnetic resonance imaging
Tumors
Ion exchange
tumors
14 Citations (Scopus)
Multiple Sclerosis
Relapsing-Remitting Multiple Sclerosis
Patents
Lateral Ventricles
Magnetic Resonance Spectroscopy
27 Citations (Scopus)

Physiological bases of the K+ and the glutamate/GABA hypotheses of epilepsy

DiNuzzo, M., Mangia, S., Maraviglia, B. & Giove, F., Jan 1 2014, In : Epilepsy Research. 108, 6, p. 995-1012 18 p.

Research output: Contribution to journalReview article

gamma-Aminobutyric Acid
Glutamic Acid
Epilepsy
Seizures
Glutamate-Ammonia Ligase
2015
5 Citations (Scopus)

Assessment of dysmyelination with RAFFn MRI: Application to murine MPS I

Satzer, D., DiBartolomeo, C., Ritchie, M. M., Storino, C., Liimatainen, T., Hakkarainen, H., Idiyatullin, D., Mangia, S., Michaeli, S., Parr, A. M. & Low, W. C., Feb 13 2015, In : PLoS One. 10, 2, e0116788.

Research output: Contribution to journalArticle

mucopolysaccharidosis
Mucopolysaccharidoses
Magnetic resonance imaging
Relaxation time
myelin sheath
12 Citations (Scopus)

Does abnormal glycogen structure contribute to increased susceptibility to seizures in epilepsy?

DiNuzzo, M., Mangia, S., Maraviglia, B. & Giove, F., Feb 1 2015, In : Metabolic Brain Disease. 30, 1, p. 307-316 10 p.

Research output: Contribution to journalArticle

Glycogen
Glutamic Acid
Epilepsy
Seizures
Astrocytes
77 Citations (Scopus)

Impact of diabetes on cognitive function and brain structure

Moheet, A., Mangia, S. & Seaquist, E. R., Sep 1 2015, In : Annals of the New York Academy of Sciences. 1353, 1, p. 60-71 12 p.

Research output: Contribution to journalArticle

Medical problems
Cognition
Brain
Type 1 Diabetes Mellitus
Type 2 Diabetes Mellitus
10 Citations (Scopus)

Monoaminergic Control of Cellular Glucose Utilization by Glycogenolysis in Neocortex and Hippocampus

DiNuzzo, M., Giove, F., Maraviglia, B. & Mangia, S., Dec 1 2015, In : Neurochemical Research. 40, 12, p. 2493-2504 12 p.

Research output: Contribution to journalArticle

Glycogenolysis
Neocortex
Hippocampus
Glucose-6-Phosphate
Glycogen
19 Citations (Scopus)

MRI contrasts in high rank rotating frames

Liimatainen, T., Hakkarainen, H., Mangia, S., Huttunen, J. M. J., Storino, C., Idiyatullin, D. S., Sorce, D., Garwood, M. & Michaeli, S., Jan 1 2015, In : Magnetic resonance in medicine. 73, 1, p. 254-262 9 p.

Research output: Contribution to journalArticle

Magnetic Fields
Brain
White Matter
Gray Matter
8 Citations (Scopus)

Naltrexone for treatment of impaired awareness of hypoglycemia in type 1 diabetes: A randomized clinical trial

Moheet, A., Mangia, S., Kumar, A., Tesfaye, N., Eberly, L. E., Bai, Y., Kubisiak, K. & Seaquist, E. R., Nov 1 2015, In : Journal of Diabetes and Its Complications. 29, 8, p. 1277-1282 6 p.

Research output: Contribution to journalArticle

Naltrexone
Type 1 Diabetes Mellitus
Hypoglycemia
Randomized Controlled Trials
Therapeutics
64 Citations (Scopus)

Neurochemical and BOLD responses during neuronal activation measured in the human visual cortex at 7 Tesla

Bednarik, P., Tkac, I., Giove, F., Dinuzzo, M., Deelchand, D. K., Emir, U. E., Eberly, L. E. & Mangia, S., Mar 31 2015, In : Journal of Cerebral Blood Flow and Metabolism. 35, p. 601-610 10 p.

Research output: Contribution to journalArticle

Visual Cortex
Magnetic Resonance Imaging
Glutamic Acid
Lactic Acid
Aspartic Acid
2016
4 Citations (Scopus)

Effect of collagen cross-linking on quantitative MRI parameters of articular cartilage

Rautiainen, J., Nieminen, M. T., Salo, E. N., Kokkonen, H. T., Mangia, S., Michaeli, S., Gröhn, O., Jurvelin, J. S., Töyräs, J. & Nissi, M. J., Sep 1 2016, In : Osteoarthritis and Cartilage. 24, 9, p. 1656-1664 9 p.

Research output: Contribution to journalArticle

Cartilage
Articular Cartilage
Magnetic resonance
Collagen
Magnetic Resonance Imaging
11 Citations (Scopus)

MRI relaxation in the presence of fictitious fields correlates with myelin content in normal rat brain

Hakkarainen, H., Sierra, A., Mangia, S., Garwood, M., Michaeli, S., Gröhn, O. & Liimatainen, T., Jan 1 2016, In : Magnetic resonance in medicine. 75, 1, p. 161-168 8 p.

Research output: Contribution to journalArticle

Myelin Sheath
Brain
Iron
Cell Count
Brain Diseases