Projects per year
Personal profile
Research interests
My research focuses on understanding the role of complex exposures in cancer formation. How do exposures originating from diet, alcohol and tobacco use, the microbiome, chemotherapy drugs, and environmental contamination interact with cellular targets and disrupt normal cellular growth functions?
Employing approaches based on High Resolution Mass Spectrometry, we are developing methods to measure these exposures, assess their molecular effects, and investigate how they may result in an increase in cancer risk. Ultimately my goal is to develop tools to support preventive strategies, identify susceptible populations, allow early cancer detection and predict cancer treatment efficacy and outcome.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research Interest Keywords
- Mass Spectrometry
- DNA adductomics
- Alcohol
- Acetaldehyde
- Microbiome
- Colibactin
- Tobacco
- Metabolomics
- DNA damage
- Genotoxicity
- Alkylating drugs
- Exposures
Fingerprint
The Fingerprint is created by mining the titles and abstracts of the person's research outputs and projects/funding awards to create an index of weighted terms from discipline-specific thesauri.
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Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Dissecting the role of acetaldehyde in oral carcinogenesis
Balbo, S., Johnson, A. J., Rendahl, A. & Walmsley, S. J.
NIH Nat'l Inst. on Alcohol Abuse & Alcoh
9/20/22 → 8/31/27
Project: Research project
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The role of colibactin in CF-associated colon cancer
Khoruts, A., Balbo, S., Ishii, S. & Staley, C.
9/1/22 → 8/31/23
Project: Research project
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Midwest Consortium for Hazardous Waste Worker Training
NIH NATL INST OF ENVIRON HEALTH SCIENCES
8/13/20 → 5/31/25
Project: Research project
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A small molecule inhibitor prevents gut bacterial genotoxin production
Volpe, M. R., Velilla, J. A., Daniel-Ivad, M., Yao, J. J., Stornetta, A., Villalta, P. W., Huang, H. C., Bachovchin, D. A., Balbo, S., Gaudet, R. & Balskus, E. P., Feb 2023, In: Nature Chemical Biology. 19, 2, p. 159-167 9 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Characterization and quantitation of busulfan DNA adducts in the blood of patients receiving busulfan therapy
Guidolin, V., Li, Y., Jacobs, F. C., MacMillan, M. L., Villalta, P. W., Hecht, S. S. & Balbo, S., Mar 16 2023, In: Molecular Therapy - Oncolytics. 28, p. 197-210 14 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Mass Spectrometry-Based Metabolic Profiling of Urinary Metabolites of N′-Nitrosonornicotine (NNN) in the Rat
Li, Y., Dator, R. P., Maertens, L. A., Balbo, S. & Hecht, S. S., 2023, (Accepted/In press) In: Chemical research in toxicology.Research output: Contribution to journal › Article › peer-review
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Metabolic Activation of Benzo[a]pyrene by Human Tissue Organoid Cultures
Caipa Garcia, A. L., Kucab, J. E., Al-Serori, H., Beck, R. S. S., Fischer, F., Hufnagel, M., Hartwig, A., Floeder, A. C., Balbo, S., Francies, H., Garnett, M., Huch, M., Drost, J., Zilbauer, M., Arlt, V. M. & Phillips, D. H., Jan 2023, In: International journal of molecular sciences. 24, 1, 606.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Quantitation by Liquid Chromatography-Nanoelectrospray Ionization-High-Resolution Tandem Mass Spectrometry of Multiple DNA Adducts Related to Cigarette Smoking in Oral Cells in the Shanghai Cohort Study
Cheng, G., Guo, J., Wang, R., Yuan, J. M., Balbo, S. & Hecht, S. S., Feb 20 2023, In: Chemical research in toxicology. 36, 2, p. 305-312 8 p.Research output: Contribution to journal › Article › peer-review