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Sergio Gradilone

19982020
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Autosomal Recessive Polycystic Kidney Medicine & Life Sciences
Histone Deacetylases Medicine & Life Sciences

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Projects 2015 2020

The cholangiocyte primary cilium as a tumor suppressor o

Gradilone, S.

NIH NATIONAL CANCER INSTITUTE (NCI)

7/1/15 → 6/30/20

Project: Research project

Cilia
Organelles
Neoplasms

HDAC6 and Pancreas Cancer

Gradilone, S.

MAYO CLINIC - JACKSONVILLE

6/1/16 → 5/31/17

Project: Research project

Pancreatic Neoplasms

Primary cilia and malignant transformation

Gradilone, S.

NIH NATIONAL CANCER INSTITUTE (NCI)

1/27/15 → 9/30/15

Project: Research project

Research Output 1998 2019

Characterization of Novel Murine and Human PDAC Cell Models: Identifying the Role of Intestine Specific Homeobox Gene ISX in Hypoxia and Disease Progression

Ganaie, A. A., Parray, A., Hussain, T., Shabaneh, A., Jamroze, A., Ferrari, M. G., Wang, L., Liao, D. J., Koocheckpour, S., Nanda, S., Wang, J., Deng, Y., Gradilone, S., Hinchcliffe, E. H., Konety, B. R. & Bhat, M. S., Aug 2019, In : Translational Oncology. 12, 8, p. 1056-1071 16 p.

Research output: Contribution to journal › Article

Open Access
Homeobox Genes
Intestines
Disease Progression
Neoplasms
Aurora Kinases
3 Citations (Scopus)

The Chemosensory Function of Primary Cilia Regulates Cholangiocyte Migration, Invasion, and Tumor Growth

Mansini, A. P., Peixoto, E., Jin, S., Richard, S. & Gradilone, S., Apr 2019, In : Hepatology. 69, 4, p. 1582-1598 17 p.

Research output: Contribution to journal › Article

Cilia
Cholangiocarcinoma
Chalcone
Phosphotransferases
Growth
3 Citations (Scopus)

Combination of a Histone Deacetylase 6 Inhibitor and a Somatostatin Receptor Agonist Synergistically Reduces Hepatorenal Cystogenesis in an Animal Model of Polycystic Liver Disease

Lorenzo Pisarello, M., Masyuk, T. V., Gradilone, S., Masyuk, A. I., Ding, J. F., Lee, P. Y. & LaRusso, N. F., Apr 2018, In : American Journal of Pathology. 188, 4, p. 981-994 14 p.

Research output: Contribution to journal › Article

Somatostatin Receptors
Histone Deacetylase Inhibitors
Polycystic Kidney Diseases
Histone Deacetylases
Animal Models
7 Citations (Scopus)

MicroRNA (miR)-433 and miR-22 dysregulations induce histone-deacetylase-6 overexpression and ciliary loss in cholangiocarcinoma

Mansini, A. P., Lorenzo Pisarello, M. J., Thelen, K. M., Cruz-Reyes, M., Peixoto, E., Jin, S., Howard, B. N., Trussoni, C. E., Gajdos, G. B., LaRusso, N. F., Perugorria, M. J., Banales, J. M. & Gradilone, S. A., Aug 2018, In : Hepatology. 68, 2, p. 561-573 13 p.

Research output: Contribution to journal › Article

Open Access
Histone Deacetylases
Cholangiocarcinoma
MicroRNAs
Karyopherins
Cilia
10 Citations (Scopus)

The cholangiocyte primary cilium in health and disease

Mansini, A., Peixoto, E., Thelen, K. M., Gaspari, C., Jin, S. & Gradilone, S., Apr 2018, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1864, 4, p. 1245-1253 9 p.

Research output: Contribution to journal › Review article

Open Access
Cilia
Cholangiocarcinoma
Health
Organelles
Fluids and Secretions