Sergio Gradilone

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Cilia Medicine & Life Sciences
Aquaporins Medicine & Life Sciences
Cholangiocarcinoma Medicine & Life Sciences
Hepatocytes Medicine & Life Sciences
Polycystic Kidney Diseases Medicine & Life Sciences
Liver Medicine & Life Sciences
Autosomal Recessive Polycystic Kidney Medicine & Life Sciences
Histone Deacetylases Medicine & Life Sciences

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Projects 2015 2020


HDAC6 and Pancreas Cancer

Gradilone, S.



Project: Research project

Pancreatic Neoplasms

Research Output 1998 2019

Characterization of Novel Murine and Human PDAC Cell Models: Identifying the Role of Intestine Specific Homeobox Gene ISX in Hypoxia and Disease Progression

Ganaie, A. A., Parray, A., Hussain, T., Shabaneh, A., Jamroze, A., Ferrari, M. G., Wang, L., Liao, D. J., Koocheckpour, S., Nanda, S., Wang, J., Deng, Y., Gradilone, S., Hinchcliffe, E. H., Konety, B. R. & Bhat, M. S., Aug 1 2019, In : Translational Oncology. 12, 8, p. 1056-1071 16 p.

Research output: Contribution to journalArticle

Open Access
Homeobox Genes
Disease Progression
Aurora Kinases
3 Citations (Scopus)

The Chemosensory Function of Primary Cilia Regulates Cholangiocyte Migration, Invasion, and Tumor Growth

Mansini, A. P., Peixoto, E., Jin, S., Richard, S. & Gradilone, S., Apr 1 2019, In : Hepatology. 69, 4, p. 1582-1598 17 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Combination of a Histone Deacetylase 6 Inhibitor and a Somatostatin Receptor Agonist Synergistically Reduces Hepatorenal Cystogenesis in an Animal Model of Polycystic Liver Disease

Lorenzo Pisarello, M., Masyuk, T. V., Gradilone, S., Masyuk, A. I., Ding, J. F., Lee, P. Y. & LaRusso, N. F., Apr 1 2018, In : American Journal of Pathology. 188, 4, p. 981-994 14 p.

Research output: Contribution to journalArticle

Somatostatin Receptors
Histone Deacetylase Inhibitors
Polycystic Kidney Diseases
Histone Deacetylases
Animal Models
7 Citations (Scopus)

MicroRNA (miR)-433 and miR-22 dysregulations induce histone-deacetylase-6 overexpression and ciliary loss in cholangiocarcinoma

Mansini, A. P., Lorenzo Pisarello, M. J., Thelen, K. M., Cruz-Reyes, M., Peixoto, E., Jin, S., Howard, B. N., Trussoni, C. E., Gajdos, G. B., LaRusso, N. F., Perugorria, M. J., Banales, J. M. & Gradilone, S. A., Aug 1 2018, In : Hepatology. 68, 2, p. 561-573 13 p.

Research output: Contribution to journalArticle

Open Access
Histone Deacetylases
9 Citations (Scopus)

The cholangiocyte primary cilium in health and disease

Mansini, A., Peixoto, E., Thelen, K. M., Gaspari, C., Jin, S. & Gradilone, S., Apr 2018, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1864, 4, p. 1245-1253 9 p.

Research output: Contribution to journalReview article

Open Access
Fluids and Secretions