Sarah Greising

Accepting PhD Students

20092021
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Personal profile

Research Interests

Current research interests and long-term scientific goals of the laboratory revolve around the plasticity and regeneration of skeletal muscle, in efforts to mitigate the devastating functional limitations of limb salvage and traumatic muscle injuries. The laboratory examines the musculoskeletal and neuromuscular systems in efforts to understand and develop effective strategies to address the deleterious effects complex traumatic muscle injuries, namely volumetric muscle loss. Ongoing work broadly encompasses investigating muscle and nerve interactions, metabolic and fibrotic comorbidities, regenerative rehabilitation treatment strategies, and the combination of these in more complex orthopaedic injuries.

Fingerprint The Fingerprint is created by mining the titles and abstracts of the person's research outputs and projects/funding awards to create an index of weighted terms from discipline-specific thesauri.

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Muscles Medicine & Life Sciences
Diaphragm Medicine & Life Sciences
Skeletal Muscle Medicine & Life Sciences
Wounds and Injuries Medicine & Life Sciences
Muscle Strength Medicine & Life Sciences
Muscle Chemical Compounds
Sarcopenia Medicine & Life Sciences
Estradiol Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2018 2021

Research Output 2009 2019

Oxidative pathophysiology following volumetric muscle loss injury in a porcine model

Chao, T., Burmeister, D. M., Corona, B. T. & Greising, S., Jan 1 2019, In : Journal of applied physiology. 126, 6, p. 1541-1549 9 p.

Research output: Contribution to journalArticle

Swine
Muscles
Wounds and Injuries
Skeletal Muscle
Respiration
1 Citation (Scopus)

PGC-1α overexpression partially rescues impaired oxidative and contractile pathophysiology following volumetric muscle loss injury

Southern, W. M., Nichenko, A. S., Tehrani, K. F., McGranahan, M. J., Krishnan, L., Qualls, A. E., Jenkins, N. T., Mortensen, L. J., Yin, H., Yin, A., Guldberg, R. E., Greising, S. & Call, J. A., Dec 1 2019, In : Scientific reports. 9, 1, 4079.

Research output: Contribution to journalArticle

Open Access
Muscles
Wounds and Injuries
Rehabilitation
Exercise
Regenerative Medicine
5 Citations (Scopus)

A moderate oestradiol level enhances neutrophil number and activity in muscle after traumatic injury but strength recovery is accelerated

Le, G. C., Novotny, S. A., Mader, T. L., Greising, S., Chan, S., Kyba, M., Lowe, D. A. & Warren, G. L., Oct 1 2018, In : Journal of Physiology. 596, 19, p. 4665-4680 16 p.

Research output: Contribution to journalArticle

Estradiol
Estrogens
Neutrophils
Muscles
Wounds and Injuries

Correction: Multiscale analysis of a regenerative therapy for treatment of volumetric muscle loss injury (Cell Death Discovery, (2018), 4, 1, (33), 10.1038/s41420-018-0027-8)

Aguilar, C. A., Greising, S., Watts, A., Goldman, S. M., Peragallo, C., Zook, C., Larouche, J. & Corona, B. T., Dec 1 2018, In : Cell Death Discovery. 4, 1, 78.

Research output: Contribution to journalComment/debate

Open Access
Publications
Cell Death
Muscles
Wounds and Injuries
Chromatin
2 Citations (Scopus)

Diaphragm plasticity in aging and disease: therapies for muscle weakness go from strength to strength

Greising, S., Ottenheijm, C. A. C., O’Halloran, K. D. & Barreiro, E., Aug 1 2018, In : Journal of applied physiology. 125, 2, p. 243-253 11 p.

Research output: Contribution to journalReview article

Muscle Weakness
Diaphragm
Muscles
Therapeutics
Sarcopenia