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Sarah Greising

Accepting PhD Students

20092021

Research output per year

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Research Interests

Current research interests and long-term scientific goals of the laboratory revolve around the plasticity and regeneration of skeletal muscle, in efforts to mitigate the devastating functional limitations of limb salvage and traumatic muscle injuries. The laboratory examines the musculoskeletal and neuromuscular systems in efforts to understand and develop effective strategies to address the deleterious effects complex traumatic muscle injuries, namely volumetric muscle loss. Ongoing work broadly encompasses investigating muscle and nerve interactions, metabolic and fibrotic comorbidities, regenerative rehabilitation treatment strategies, and the combination of these in more complex orthopaedic injuries.

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Projects

Neurocentric Enhancement of Skeletal Muscle Function for the Treatment of Volumetric Muscle Loss

Greising, S.

US ARMY MED RESEARCH & MATERIEL COMMAND

3/1/19 → 2/28/21

Project: Research project

    • Aligned Nanofibrillar Scaffold Activated with HGF-mmRNA in Combination with Minced Muscle Graft for Treating Volumetric Muscle Loss (VML) Injury

    Greising, S.

    FIBRALIGN CORPORATION

    2/7/19 → 2/6/21

    Project: Research project

    • Early interventions to address functional limitations and comorbidities to volumetric muscle loss

    Greising, S.

    University of Georgia

    9/15/18 → 9/14/21

    Project: Research project

    • Research Output

    Oxidative pathophysiology following volumetric muscle loss injury in a porcine model

    Chao, T., Burmeister, D. M., Corona, B. T. & Greising, S. M., Jan 1 2019, In : Journal of applied physiology. 126, 6, p. 1541-1549 9 p.

    Research output: Contribution to journal › Article

    • PGC-1α overexpression partially rescues impaired oxidative and contractile pathophysiology following volumetric muscle loss injury

    Southern, W. M., Nichenko, A. S., Tehrani, K. F., McGranahan, M. J., Krishnan, L., Qualls, A. E., Jenkins, N. T., Mortensen, L. J., Yin, H., Yin, A., Guldberg, R. E., Greising, S. M. & Call, J. A., Dec 1 2019, In : Scientific reports. 9, 1, 4079.

    Research output: Contribution to journal › Article

    Open Access
    • 3 Scopus citations

    Therapeutic Approaches for Volumetric Muscle Loss Injury: A Systematic Review and Meta-Analysis

    Greising, S. M., Corona, B. T., McGann, C., Frankum, J. K. & Warren, G. L., Dec 2019, In : Tissue Engineering - Part B: Reviews. 25, 6, p. 510-525 16 p.

    Research output: Contribution to journal › Review article

    Open Access

    • A moderate oestradiol level enhances neutrophil number and activity in muscle after traumatic injury but strength recovery is accelerated

    Le, G. C., Novotny, S. A., Mader, T. L., Greising, S., Chan, S., Kyba, M., Lowe, D. A. & Warren, G. L., Oct 1 2018, In : Journal of Physiology. 596, 19, p. 4665-4680 16 p.

    Research output: Contribution to journal › Article

    Open Access
    • 5 Scopus citations

    Correction: Multiscale analysis of a regenerative therapy for treatment of volumetric muscle loss injury (Cell Death Discovery, (2018), 4, 1, (33), 10.1038/s41420-018-0027-8)

    Aguilar, C. A., Greising, S. M., Watts, A., Goldman, S. M., Peragallo, C., Zook, C., Larouche, J. & Corona, B. T., Dec 1 2018, In : Cell Death Discovery. 4, 1, 78.

    Research output: Contribution to journal › Comment/debate

    Open Access