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Sanaz Sedaghat

 https://orcid.org/0000-0002-8296-1811
20132023

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  • 2023

    Association of change in cardiovascular risk factors with incident dementia

    Sedaghat, S., Lutsey, P. L., Ji, Y., Empana, J. P., Sorond, F., Hughes, T. M., Mosley, T. H., Gottesman, R. F., Knopman, D. S., Walker, K. A., Gudnason, V., Launer, L. J. & van Sloten, T. T., May 2023, In: Alzheimer's and Dementia. 19, 5, p. 1821-1831 11 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    1 Scopus citations

  • Changes in Cardiovascular Health Across Midlife and Late-Life and Magnetic Resonance Imaging Markers of Cerebral Vascular Disease in Late-Life

    Sedaghat, S., Ji, Y., Empana, J. P., Hughes, T. M., Mosley, T. H., Gottesman, R. F., Griswold, M., Jack, C. R., Lutsey, P. L. & Van Sloten, T. T., May 1 2023, In: Stroke. 54, 5, p. 1280-1288 9 p.

    Research output: Contribution to journal › Article › peer-review

  • Kidney function, bone-mineral metabolism markers, and calcification of coronary arteries, aorta, and cardiac valves in older adults

    Mok, Y., Wang, F., Ballew, S. H., Menez, S., Butler, K. R., Wagenknecht, L., Sedaghat, S., Lutsey, P. L., Coresh, J., Blaha, M. J. & Matsushita, K., Mar 2023, In: Atherosclerosis. 368, p. 35-43 9 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • The Association of Kidney Function with Plasma Amyloid-β Levels and Brain Amyloid Deposition

    Sedaghat, S., Ji, Y., Hughes, T. M., Coresh, J., Grams, M. E., Folsom, A. R., Sullivan, K. J., Murray, A. M., Gottesman, R. F., Mosley, T. H. & Lutsey, P. L., 2023, In: Journal of Alzheimer's Disease. 92, 1, p. 229-239 11 p.

    Research output: Contribution to journal › Article › peer-review

  • The Burden of Dementia Spectrum Disorders and Associated Comorbid and Demographic Features

    Sabayan, B., Wyman-Chick, K. A. & Sedaghat, S., Feb 2023, In: Clinics in Geriatric Medicine. 39, 1, p. 1-14 14 p.

    Research output: Contribution to journal › Review article › peer-review

  • 2022

    Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals

    Lifelines Cohort Study, DiscovEHR/MyCode study & VA Million Veteran Program, Dec 1 2022, In: Communications biology. 5, 1, 580.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    8 Scopus citations

  • Education and Cardiovascular Health as Effect Modifiers of APOE ϵ4 on Dementia: The Atherosclerosis Risk in Communities Study

    Lee, M., Hughes, T. M., George, K. M., Griswold, M. E., Sedaghat, S., Simino, J. & Lutsey, P. L., Jun 1 2022, In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 77, 6, p. 1199-1207 9 p.

    Research output: Contribution to journal › Article › peer-review

    4 Scopus citations

  • Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies

    Lifelines Cohort Study, Sep 2022, In: Kidney international. 102, 3, p. 624-639 16 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    13 Scopus citations

  • Mid-life Epigenetic Age, Neuroimaging Brain Age, and Cognitive Function: Coronary Artery Risk Development in Young Adults (CARDIA) Study

    Zheng, Y., Habes, M., Gonzales, M., Pomponio, R., Nasrallah, I., Khan, S., Vaughan, D. E., Davatzikos, C., Seshadri, S., Launer, L., Sorond, F., Sedaghat, S., Wainwright, D., Baccarelli, A., Sidney, S., Bryan, N., Greenland, P., Lloyd-Jones, D., Yaffe, K. & Hou, L., 2022, In: Aging. 14, 4, p. 1691-1712 22 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    8 Scopus citations

  • Retinal Microvascular Caliber and Incident Depressive Symptoms: The Multi-Ethnic Study of Atherosclerosis

    Van Gennip, A. C. E., Sedaghat, S., Carnethon, M. R., Allen, N. B., Klein, B. E. K., Cotch, M. F., Chirinos, D. A., Stehouwer, C. D. A. & Van Sloten, T. T., May 1 2022, In: American journal of epidemiology. 191, 5, p. 843-855 13 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    1 Scopus citations

  • Variation in Population Attributable Fraction of Dementia Associated with Potentially Modifiable Risk Factors by Race and Ethnicity in the US

    Lee, M., Whitsel, E., Avery, C., Hughes, T. M., Griswold, M. E., Sedaghat, S., Gottesman, R. F., Mosley, T. H., Heiss, G. & Lutsey, P. L., Jul 6 2022, In: JAMA Network Open. 5, 7, p. E2219672

    Research output: Contribution to journal › Article › peer-review

    Open Access
    15 Scopus citations
  • 2021

    Blood pressure, executive function, and network connectivity in middle-aged adults at risk of dementia in late life

    Jenkins, L. M., Kogan, A., Malinab, M., Ingo, C., Sedaghat, S., Bryan, N. R., Yaffe, K., Parrish, T. B., Nemeth, A. J., Lloyd-Jones, D. M., Launer, L. J., Wang, L. & Sorond, F., Sep 14 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 37, e2024265118.

    Research output: Contribution to journal › Article › peer-review

    7 Scopus citations

  • Effect of metabolic genetic variants on long-term disease comorbidity in patients with type 2 diabetes

    Abedian, S., Abbasi, A., de Boer, A., Stricker, B. H., Bakker, S. J. L., van der Harst, P., Sedaghat, S., Darvishian, M., Ikram, M. A., Navis, G., Dehghan, A., Pen, I., Stolk, R. P., Snieder, H., Klungel, O. H., Souverein, P. & Alizadeh, B. Z., Feb 2 2021, In: Scientific reports. 11, 1, 2794.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Epigenome-wide association study of serum urate reveals insights into urate co-regulation and the SLC2A9 locus

    The Estonian Biobank Research Team & The Genetics of DNA Methylation Consortium, Dec 2021, In: Nature communications. 12, 1, 7173.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    5 Scopus citations

  • Meta-analyses identify DNA methylation associated with kidney function and damage

    Estonian Biobank Research Team & Genetics of DNA Methylation Consortium, Dec 2021, In: Nature communications. 12, 1, 7174.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    16 Scopus citations

  • Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline

    Lifelines Cohort Study & Regeneron Genetics Center, Apr 1 2021, In: Kidney international. 99, 4, p. 926-939 14 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    27 Scopus citations

  • Vascular health across young adulthood and midlife cerebral autoregulation, gait, and cognition

    Mahinrad, S., Shownkeen, M., Sedaghat, S., Yaffe, K., Hausdorff, J. M., Lloyd-Jones, D. M., Gorelick, P. B. & Sorond, F. A., May 2021, In: Alzheimer's and Dementia. 17, 5, p. 745-754 10 p.

    Research output: Contribution to journal › Article › peer-review

    3 Scopus citations
  • 2020

    Antihypertensive medications and risk for incident dementia and Alzheimer's disease: a meta-analysis of individual participant data from prospective cohort studies

    Ding, J., Davis-Plourde, K. L., Sedaghat, S., Tully, P. J., Wang, W., Phillips, C., Pase, M. P., Himali, J. J., Gwen Windham, B., Griswold, M., Gottesman, R., Mosley, T. H., White, L., Guðnason, V., Debette, S., Beiser, A. S., Seshadri, S., Ikram, M. A., Meirelles, O., Tzourio, C., & 1 othersLauner, L. J., Jan 2020, In: The Lancet Neurology. 19, 1, p. 61-70 10 p.

    Research output: Contribution to journal › Article › peer-review

    122 Scopus citations

  • Cerebral microvascular complications of type 2 diabetes: stroke, cognitive dysfunction, and depression

    van Sloten, T. T., Sedaghat, S., Carnethon, M. R., Launer, L. J. & Stehouwer, C. D. A., Apr 2020, In: The Lancet Diabetes and Endocrinology. 8, 4, p. 325-336 12 p.

    Research output: Contribution to journal › Review article › peer-review

    216 Scopus citations

  • Cumulative Blood Pressure Exposure, Basal Ganglia, and Thalamic Morphology in Midlife

    Jenkins, L. M., Garner, C. R., Kurian, S., Higgins, J. P., Parrish, T. B., Sedaghat, S., Nemeth, A. J., Lloyd-Jones, D. M., Launer, L. J., Hausdorff, J. M., Wang, L. & Sorond, F. A., May 1 2020, In: Hypertension. 75, 5, p. 1289-1295 7 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    18 Scopus citations

  • Cumulative Blood Pressure Exposure during Young Adulthood and Mobility and Cognitive Function in Midlife

    Mahinrad, S., Kurian, S., Garner, C. R., Sedaghat, S., Nemeth, A. J., Moscufo, N., Higgins, J. P., Jacobs, D. R., Hausdorff, J. M., Lloyd-Jones, D. M. & Sorond, F. A., Mar 3 2020, In: Circulation. 141, 9, p. 712-724 13 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    48 Scopus citations

  • Decline in kidney function over the course of adulthood and cognitive function in midlife

    Sedaghat, S., Sorond, F., Yaffe, K., Sidney, S., Kramer, H. J., Jacobs, D. R., Launer, L. J. & Carnethon, M. R., Oct 27 2020, In: Neurology. 95, 17, p. E2389-E2397

    Research output: Contribution to journal › Article › peer-review

    6 Scopus citations

  • Plasma tau, neurofilament light chain and amyloid-β levels and risk of dementia; a population-based cohort study

    de Wolf, F., Ghanbari, M., Licher, S., McRae-McKee, K., Gras, L., Weverling, G. J., Wermeling, P., Sedaghat, S., Kamran Ikram, M., Waziry, R., Koudstaal, W., Klap, J., Kostense, S., Hofman, A., Anderson, R., Goudsmit, J. & Arfan Ikram, M., Mar 1 2020, In: Brain. 143, 4, p. 1220-1232 13 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    151 Scopus citations

  • Telomere Length and the Risk of Alzheimer's Disease: The Rotterdam Study

    Fani, L., Hilal, S., Sedaghat, S., Broer, L., Licher, S., Arp, P. P., Van Meurs, J. B. J., Ikram, M. K. & Ikram, M. A., 2020, In: Journal of Alzheimer's Disease. 73, 2, p. 707-714 8 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    32 Scopus citations
  • 2019

    A catalog of genetic loci associated with kidney function from analyses of a million individuals

    Lifelines Cohort Study & V. A. Million Veteran Program, Jun 1 2019, In: Nature Genetics. 51, 6, p. 957-972 16 p.

    Research output: Contribution to journal › Article › peer-review

    350 Scopus citations

  • Association of metformin, sulfonylurea and insulin use with brain structure and function and risk of dementia and Alzheimer’s disease: Pooled analysis from 5 cohorts

    Weinstein, G., Davis-Plourde, K. L., Conner, S., Himali, J. J., Beiser, A. S., Lee, A., Rawlings, A. M., Sedaghat, S., Ding, J., Moshier, E., Van Duijn, C. M., Beeri, M. S., Selvin, E., Arfan Ikram, M., Launer, L. J., Haan, M. N. & Seshadri, S., Feb 2019, In: PloS one. 14, 2, e0212293.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    56 Scopus citations

  • Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria

    Teumer, A., Li, Y., Ghasemi, S., Prins, B. P., Wuttke, M., Hermle, T., Giri, A., Sieber, K. B., Qiu, C., Kirsten, H., Tin, A., Chu, A. Y., Bansal, N., Feitosa, M. F., Wang, L., Chai, J. F., Cocca, M., Fuchsberger, C., Gorski, M., Hoppmann, A., & 166 othersHorn, K., Li, M., Marten, J., Noce, D., Nutile, T., Sedaghat, S., Sveinbjornsson, G., Tayo, B. O., van der Most, P. J., Xu, Y., Yu, Z., Gerstner, L., Ärnlöv, J., Bakker, S. J. L., Baptista, D., Biggs, M. L., Boerwinkle, E., Brenner, H., Burkhardt, R., Carroll, R. J., Chee, M. L., Chee, M. L., Chen, M., Cheng, C. Y., Cook, J. P., Coresh, J., Corre, T., Danesh, J., de Borst, M. H., De Grandi, A., de Mutsert, R., de Vries, A. P. J., Degenhardt, F., Dittrich, K., Divers, J., Eckardt, K. U., Ehret, G., Endlich, K., Felix, J. F., Franco, O. H., Franke, A., Freedman, B. I., Freitag-Wolf, S., Gansevoort, R. T., Giedraitis, V., Gögele, M., Grundner-Culemann, F., Gudbjartsson, D. F., Gudnason, V., Hamet, P., Harris, T. B., Hicks, A. A., Holm, H., Foo, V. H. X., Hwang, S. J., Ikram, M. A., Ingelsson, E., Jaddoe, V. W. V., Jakobsdottir, J., Josyula, N. S., Jung, B., Kähönen, M., Khor, C. C., Kiess, W., Koenig, W., Körner, A., Kovacs, P., Kramer, H., Krämer, B. K., Kronenberg, F., Lange, L. A., Langefeld, C. D., Lee, J. J. M., Lehtimäki, T., Lieb, W., Lim, S. C., Lind, L., Lindgren, C. M., Liu, J., Loeffler, M., Lyytikäinen, L. P., Mahajan, A., Maranville, J. C., Mascalzoni, D., McMullen, B., Meisinger, C., Meitinger, T., Miliku, K., Mook-Kanamori, D. O., Müller-Nurasyid, M., Mychaleckyj, J. C., Nauck, M., Nikus, K., Ning, B., Noordam, R., Connell, J. O., Olafsson, I., Palmer, N. D., Peters, A., Podgornaia, A. I., Ponte, B., Poulain, T., Pramstaller, P. P., Rabelink, T. J., Raffield, L. M., Reilly, D. F., Rettig, R., Rheinberger, M., Rice, K. M., Rivadeneira, F., Runz, H., Ryan, K. A., Sabanayagam, C., Saum, K. U., Schöttker, B., Shaffer, C. M., Shi, Y., Smith, A. V., Strauch, K., Stumvoll, M., Sun, B. B., Szymczak, S., Tai, E. S., Tan, N. Y. Q., Taylor, K. D., Teren, A., Tham, Y. C., Thiery, J., Thio, C. H. L., Thomsen, H., Thorsteinsdottir, U., Tönjes, A., Tremblay, J., Uitterlinden, A. G., van der Harst, P., Verweij, N., Vogelezang, S., Völker, U., Waldenberger, M., Wang, C., Wilson, O. D., Wong, C., Wong, T. Y., Yang, Q., Yasuda, M., Akilesh, S., Bochud, M., Böger, C. A., Devuyst, O., Edwards, T. L., Ho, K., Morris, A. P., Parsa, A., Pendergrass, S. A., Psaty, B. M., Rotter, J. I., Stefansson, K., Wilson, J. G., Susztak, K., Snieder, H., Heid, I. M., Scholz, M., Butterworth, A. S., Hung, A. M., Pattaro, C. & Köttgen, A., Dec 1 2019, In: Nature communications. 10, 1, 4130.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    95 Scopus citations

  • Kidney Function and Arterial Calcification in Major Vascular Beds

    Sedaghat, S., Hoorn, E. J., Ikram, M. A., Koop-Nieuwelink, C., Kavousi, M., Franco, O. H., van der Lugt, A., Vernooij, M. W. & Bos, D., May 7 2019, In: Journal of the American Heart Association. 8, 9, e010930.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    11 Scopus citations

  • Kidney Function and the Risk of Stroke and Dementia: The Rotterdam Study

    Koop-Nieuwelink, C., Sedaghat, S., Mutlu, U., Licher, S., Franco, O. H., Ikram, M. A., Geerlings, M. I., Ikram, M. K. & Bos, D., 2019, In: Journal of Alzheimer's Disease. 67, 3, p. 821-826 6 p.

    Research output: Contribution to journal › Article › peer-review

    14 Scopus citations

  • Quantification of biological age as a determinant of age-related diseases in the Rotterdam Study: a structural equation modeling approach

    Waziry, R., Gras, L., Sedaghat, S., Tiemeier, H., Weverling, G. J., Ghanbari, M., Klap, J., de Wolf, F., Hofman, A., Ikram, M. A. & Goudsmit, J., Aug 15 2019, In: European Journal of Epidemiology. 34, 8, p. 793-799 7 p.

    Research output: Contribution to journal › Article › peer-review

    17 Scopus citations

  • Relationship of Estimated GFR and Albuminuria to Concurrent Laboratory Abnormalities: An Individual Participant Data Meta-analysis in a Global Consortium

    CKD Prognosis Consortium, Feb 1 2019, In: American Journal of Kidney Diseases. 73, 2, p. 206-217 12 p.

    Research output: Contribution to journal › Article › peer-review

    40 Scopus citations

  • Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels

    German Chronic Kidney Disease Study, Lifelines Cohort Study & V. A. Million Veteran Program, Oct 1 2019, In: Nature Genetics. 51, 10, p. 1459-1474 16 p.

    Research output: Contribution to journal › Article › peer-review

    178 Scopus citations
  • 2018

    Common carotid artery diameter and risk of cardiovascular events and mortality: Pooled analyses of four cohort studies

    Sedaghat, S., Van Sloten, T. T., Laurent, S., London, G. M., Pannier, B., Kavousi, M., Mattace-Raso, F., Franco, O. H., Boutouyrie, P., Ikram, M. A. & Stehouwer, C. D. A., Jul 1 2018, In: Hypertension. 72, 1, p. 85-92 8 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    37 Scopus citations

  • Coronary heart disease, heart failure, and the risk of dementia: A systematic review and meta-analysis

    Wolters, F. J., Segufa, R. A., Darweesh, S. K. L., Bos, D., Ikram, M. A., Sabayan, B., Hofman, A. & Sedaghat, S., Nov 2018, In: Alzheimer's and Dementia. 14, 11, p. 1493-1504 12 p.

    Research output: Contribution to journal › Review article › peer-review

    113 Scopus citations

  • Kidney function, gait pattern and fall in the general population: A cohort study

    Sedaghat, S., Darweesh, S. K. L., Verlinden, V. J. A., Van Der Geest, J. N., Dehghan, A., Franco, O. H., Hoorn, E. J. & Ikram, M. A., Dec 1 2018, In: Nephrology Dialysis Transplantation. 33, 12, p. 2165-2172 8 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    12 Scopus citations

  • Large-scale whole-exome sequencing association studies identify rare functional variants influencing serum urate levels

    Tin, A., Li, Y., Brody, J. A., Nutile, T., Chu, A. Y., Huffman, J. E., Yang, Q., Chen, M. H., Robinson-Cohen, C., Macé, A., Liu, J., Demirkan, A., Sorice, R., Sedaghat, S., Swen, M., Yu, B., Ghasemi, S., Teumer, A., Vollenweider, P., Ciullo, M., & 15 othersLi, M., Uitterlinden, A. G., Kraaij, R., Amin, N., van Rooij, J., Kutalik, Z., Dehghan, A., McKnight, B., van Duijn, C. M., Morrison, A., Psaty, B. M., Boerwinkle, E., Fox, C. S., Woodward, O. M. & Köttgen, A., Dec 1 2018, In: Nature communications. 9, 1, 4228.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    37 Scopus citations

  • The AGES-Reykjavik Study suggests that change in kidney measures is associated with subclinical brain pathology in older community-dwelling persons

    Sedaghat, S., Ding, J., Eiriksdottir, G., van Buchem, M. A., Sigurdsson, S., Ikram, M. A., Meirelles, O., Gudnason, V., Levey, A. S. & Launer, L. J., Sep 2018, In: Kidney international. 94, 3, p. 608-615 8 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    8 Scopus citations
  • 2017

    1000 Genomes-based metaanalysis identifies 10 novel loci for kidney function

    Gorski, M., Van Der Most, P. J., Teumer, A., Chu, A. Y., Li, M., Mijatovic, V., Nolte, I. M., Cocca, M., Taliun, D., Gomez, F., Li, Y., Tayo, B., Tin, A., Feitosa, M. F., Aspelund, T., Attia, J., Biffar, R., Bochud, M., Boerwinkle, E., Borecki, I., & 106 othersBottinger, E. P., Chen, M. H., Chouraki, V., Ciullo, M., Coresh, J., Cornelis, M. C., Curhan, G. C., D'Adamo, A. P., Dehghan, A., Dengler, L., Ding, J., Eiriksdottir, G., Endlich, K., Enroth, S., Esko, T., Franco, O. H., Gasparini, P., Gieger, C., Girotto, G., Gottesman, O., Gudnason, V., Gyllensten, U., Hancock, S. J., Harris, T. B., Helmer, C., Höllerer, S., Hofer, E., Hofman, A., Holliday, E. G., Homuth, G., Hu, F. B., Huth, C., Hutri-Kähönen, N., Hwang, S. J., Imboden, M., Johansson, A., Kähönen, M., König, W., Kramer, H., Krämer, B. K., Kumar, A., Kutalik, Z., Lambert, J. C., Launer, L. J., Lehtimäki, T., De Borst, M. H., Navis, G., Swertz, M., Liu, Y., Lohman, K., Loos, R. J. F., Lu, Y., Lyytikäinen, L. P., McEvoy, M. A., Meisinger, C., Meitinger, T., Metspalu, A., Metzger, M., Mihailov, E., Mitchell, P., Nauck, M., Oldehinkel, A. J., Olden, M., Penninx, B. W. J. H., Pistis, G., Pramstaller, P. P., Probst-Hensch, N., Raitakari, O. T., Rettig, R., Ridker, P. M., Rivadeneira, F., Robino, A., Rosas, S. E., Ruderfer, D., Ruggiero, D., Saba, Y., Sala, C., Schmidt, H., Schmidt, R., Scott, R. J., Sedaghat, S., Smith, A. V., Sorice, R., Stengel, B., Stracke, S., Strauch, K., Toniolo, D., Uitterlinden, A. G., Ulivi, S., Viikari, J. S., Völker, U., Vollenweider, P., Völzke, H., Vuckovic, D., Waldenberger, M., Wang, J. J., Yang, Q., Chasman, D. I., Tromp, G., Snieder, H., Heid, I. M., Fox, C. S., Köttgen, A., Pattaro, C., Böger, C. A. & Fuchsberger, C., 2017, In: Scientific reports. 7, 45040.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    79 Scopus citations

  • Corrigendum: 1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function

    Gorski, M., Most, P. J. V. D., Teumer, A., Chu, A. Y., Li, M., Mijatovic, V., Nolte, I. M., Cocca, M., Taliun, D., Gomez, F., Li, Y., Tayo, B., Tin, A., Feitosa, M. F., Aspelund, T., Attia, J., Biffar, R., Bochud, M., Boerwinkle, E., Borecki, I., & 106 othersBottinger, E. P., Chen, M. H., Chouraki, V., Ciullo, M., Coresh, J., Cornelis, M. C., Curhan, G. C., Adamo, A. P. D., Dehghan, A., Dengler, L., Ding, J., Eiriksdottir, G., Endlich, K., Enroth, S., Esko, T., Franco, O. H., Gasparini, P., Gieger, C., Girotto, G., Gottesman, O., Gudnason, V., Gyllensten, U., Hancock, S. J., Harris, T. B., Helmer, C., Höllerer, S., Hofer, E., Hofman, A., Holliday, E. G., Homuth, G., Hu, F. B., Huth, C., Hutri-Kähönen, N., Hwang, S. J., Imboden, M., Johansson, Å., Kähönen, M., König, W., Kramer, H., Krämer, B. K., Kumar, A., Kutalik, Z., Lambert, J. C., Launer, L. J., Lehtimäki, T., de Borst, M. H., Navis, G., Swertz, M., Liu, Y., Lohman, K., Loos, R. J. F., Lu, Y., Lyytikäinen, L. P., McEvoy, M. A., Meisinger, C., Meitinger, T., Metspalu, A., Metzger, M., Mihailov, E., Mitchell, P., Nauck, M., Oldehinkel, A. J., Olden, M., Wjh Penninx, B., Pistis, G., Pramstaller, P. P., Probst-Hensch, N., Raitakari, O. T., Rettig, R., Ridker, P. M., Rivadeneira, F., Robino, A., Rosas, S. E., Ruderfer, D., Ruggiero, D., Saba, Y., Sala, C., Schmidt, H., Schmidt, R., Scott, R. J., Sedaghat, S., Smith, A. V., Sorice, R., Stengel, B., Stracke, S., Strauch, K., Toniolo, D., Uitterlinden, A. G., Ulivi, S., Viikari, J. S., Völker, U., Vollenweider, P., Völzke, H., Vuckovic, D., Waldenberger, M., Wang, J. J., Yang, Q., Chasman, D. I., Tromp, G., Snieder, H., Heid, I. M., Fox, C. S., Köttgen, A., Pattaro, C., Böger, C. A. & Fuchsberger, C., May 26 2017, In: Scientific reports. 7, p. 46835 1 p., 46835.

    Research output: Contribution to journal › Comment/debate › peer-review

    Open Access
    1 Scopus citations

  • Development of a Healthy Aging Score in the Population-Based Rotterdam Study: Evaluating Age and Sex Differences

    Jaspers, L., Schoufour, J. D., Erler, N. S., Darweesh, S. K. L., Portegies, M. L. P., Sedaghat, S., Lahousse, L., Brusselle, G. G., Stricker, B. H., Tiemeier, H., Ikram, M. A., Laven, J. S. E., Franco, O. H. & Kavousi, M., Mar 1 2017, In: Journal of the American Medical Directors Association. 18, 3, p. 276.e1-276.e7

    Research output: Contribution to journal › Article › peer-review

    24 Scopus citations

  • Loss of Cardioprotective Effects at the ADAMTS7 Locus as a Result of Gene-Smoking Interactions

    Saleheen, D., Zhao, W., Young, R., Nelson, C. P., Ho, W., Ferguson, J. F., Rasheed, A., Ou, K., Nurnberg, S. T., Bauer, R. C., Goel, A., Do, R., Stewart, A. F. R., Hartiala, J., Zhang, W., Thorleifsson, G., Strawbridge, R. J., Sinisalo, J., Kanoni, S., Sedaghat, S., & 50 othersMarouli, E., Kristiansson, K., Zhao, J. H., Scott, R., Gauguier, D., Shah, S. H., Smith, A. V., Van Zuydam, N., Cox, A. J., Willenborg, C., Kessler, T., Zeng, L., Province, M. A., Ganna, A., Lind, L., Pedersen, N. L., White, C. C., Joensuu, A., Kleber, M. E., Hall, A. S., März, W., Salomaa, V., O'Donnell, C., Ingelsson, E., Feitosa, M. F., Erdmann, J., Bowden, D. W., Palmer, C. N. A., Gudnason, V., Faire, U. D., Zalloua, P., Wareham, N., Thompson, J. R., Kuulasmaa, K., Dedoussis, G., Perola, M., Dehghan, A., Chambers, J. C., Kooner, J., Allayee, H., Deloukas, P., McPherson, R., Stefansson, K., Schunkert, H., Kathiresan, S., Farrall, M., Marcel Frossard, P., Rader, D. J., Samani, N. J. & Reilly, M. P., Jun 13 2017, In: Circulation. 135, 24, p. 2336-2353 18 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    37 Scopus citations

  • NFAT5 and SLC4A10 loci associate with plasma osmolality

    Böger, C. A., Gorski, M., McMahon, G. M., Xu, H., Chang, Y. P. C., Van Der Most, P. J., Navis, G., Nolte, I. M., De Borst, M. H., Zhang, W., Lehne, B., Loh, M., Tan, S. T., Boerwinkle, E., Grams, M. E., Sekula, P., Li, M., Wilmot, B., Moon, J. G., Scheet, P., & 86 othersCucca, F., Xiao, X., Lyytikäinen, L. P., Delgado, G., Grammer, T. B., Kleber, M. E., Sedaghat, S., Rivadeneira, F., Corre, T., Kutalik, Z., Bergmann, S., Nielson, C. M., Srikanth, P., Teumer, A., Müller-Nurasyid, M., Brockhaus, A. C., Pfeufer, A., Rathmann, W., Peters, A., Matsumoto, M., De Andrade, M., Atkinson, E. J., Robinson-Cohen, C., De Boer, I. H., Hwang, S. J., Heid, I. M., Gögele, M., Concas, M. P., Tanaka, T., Bandinelli, S., Nalls, M. A., Singleton, A., Tajuddin, S. M., Adeyemo, A., Zhou, J., Doumatey, A., McWeeney, S., Murabito, J., Franceschini, N., Flessner, M., Shlipak, M., Wilson, J. G., Chen, G., Rotimi, C. N., Zonderman, A. B., Evans, M. K., Ferrucci, L., Devuyst, O., Pirastu, M., Shuldiner, A., Hicks, A. A., Pramstaller, P. P., Kestenbaum, B., Kardia, S. L. R., Turner, S. T., Study, L. C., Briske, T. E., Gieger, C., Strauch, K., Meisinger, C., Meitinger, T., Völker, U., Nauck, M., Völzke, H., Vollenweider, P., Bochud, M., Waeber, G., Kähönen, M., Lehtimäki, T., März, W., Dehghan, A., Franco, O. H., Uitterlinden, A. G., Hofman, A., Taylor, H. A., Chambers, J. C., Kooner, J. S., Fox, C. S., Hitzemann, R., Orwoll, E. S., Pattaro, C., Schlessinger, D., Köttgen, A., Snieder, H., Parsa, A. & Cohen, D. M., Aug 2017, In: Journal of the American Society of Nephrology. 28, 8, p. 2311-2321 11 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    19 Scopus citations

  • SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function

    Li, M., Li, Y., Weeks, O., Mijatovic, V., Teumer, A., Huffman, J. E., Tromp, G., Fuchsberger, C., Gorski, M., Lyytikäinen, L. P., Nutile, T., Sedaghat, S., Sorice, R., Tin, A., Yang, Q., Ahluwalia, T. S., Arking, D. E., Bihlmeyer, N. A., Böger, C. A., Carroll, R. J., & 136 othersChasman, D. I., Cornelis, M. C., Dehghan, A., Faul, J. D., Feitosa, M. F., Gambaro, G., Gasparini, P., Giulianini, F., Heid, I., Huang, J., Imboden, M., Jackson, A. U., Jeff, J., Jhun, M. A., Katz, R., Kifley, A., Kilpeläinen, T. O., Kumar, A., Laakso, M., Li-Gao, R., Lohman, K., Lu, Y., Mägi, R., Malerba, G., Mihailov, E., Mohlke, K. L., Mook-Kanamori, D. O., Robino, A., Ruderfer, D., Salvi, E., Schick, U. M., Schulz, C. A., Smith, A. V., Smith, J. A., Traglia, M., Yerges-Armstrong, L. M., Zhao, W., Goodarzi, M. O., Kraja, A. T., Liu, C., Wessel, J., Boerwinkle, E., Borecki, I. B., Bork-Jensen, J., Bottinger, E. P., Braga, D., Brandslund, I., Brody, J. A., Campbell, A., Carey, D. J., Christensen, C., Coresh, J., Crook, E., Curhan, G. C., Cusi, D., De Boer, I. H., De Vries, A. P. J., Denny, J. C., Devuyst, O., Dreisbach, A. W., Endlich, K., Esko, T., Franco, O. H., Fulop, T., Gerhard, G. S., Glümer, C., Gottesman, O., Grarup, N., Gudnason, V., Hansen, T., Harris, T. B., Hayward, C., Hocking, L., Hofman, A., Hu, F. B., Husemoen, L. L. N., Jackson, R. D., Jørgensen, T., Jørgensen, M. E., Kähönen, M., Kardia, S. L. R., König, W., Kooperberg, C., Kriebel, J., Launer, L. J., Lauritzen, T., Lehtimäki, T., Levy, D., Linksted, P., Linneberg, A., Liu, Y., Loos, R. J. F., Lupo, A., Meisinger, C., Melander, O., Metspalu, A., Mitchell, P., Nauck, M., Nürnberg, P., Orho-Melander, M., Parsa, A., Pedersen, O., Peters, A., Peters, U., Polasek, O., Porteous, D., Probst-Hensch, N. M., Psaty, B. M., Qi, L., Raitakari, O. T., Reiner, A. P., Rettig, R., Ridker, P. M., Rivadeneira, F., Rossouw, J. E., Schmidt, F., Siscovick, D., Soranzo, N., Strauch, K., Toniolo, D., Turner, S. T., Uitterlinden, A. G., Ulivi, S., Velayutham, D., Völker, U., Völzke, H., Waldenberger, M., Wang, J. J., Weir, D. R., Witte, D., Kuivaniemi, H., Fox, C. S., Franceschini, N., Goessling, W., Köttgen, A. & Chu, A. Y., Mar 2017, In: Journal of the American Society of Nephrology. 28, 3, p. 981-994 14 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    32 Scopus citations
  • 2016

    Cystatin C and Cardiovascular Disease: A Mendelian Randomization Study

    van der Laan, S. W., Fall, T., Soumaré, A., Teumer, A., Sedaghat, S., Baumert, J., Zabaneh, D., van Setten, J., Isgum, I., Galesloot, T. E., Arpegård, J., Amouyel, P., Trompet, S., Waldenberger, M., Dörr, M., Magnusson, P. K., Giedraitis, V., Larsson, A., Morris, A. P., Felix, J. F., & 52 othersMorrison, A. C., Franceschini, N., Bis, J. C., Kavousi, M., O'Donnell, C., Drenos, F., Tragante, V., Munroe, P. B., Malik, R., Dichgans, M., Worrall, B. B., Erdmann, J., Nelson, C. P., Samani, N. J., Schunkert, H., Marchini, J., Patel, R. S., Hingorani, A. D., Lind, L., Pedersen, N. L., de Graaf, J., Kiemeney, L. A. L. M., Baumeister, S. E., Franco, O. H., Hofman, A., Uitterlinden, A. G., Koenig, W., Meisinger, C., Peters, A., Thorand, B., Jukema, J. W., Eriksen, B. O., Toft, I., Wilsgaard, T., Onland-Moret, N. C., van der Schouw, Y. T., Debette, S., Kumari, M., Svensson, P., van der Harst, P., Kivimaki, M., Keating, B. J., Sattar, N., Dehghan, A., Reiner, A. P., Ingelsson, E., den Ruijter, H. M., de Bakker, P. I. W., Pasterkamp, G., Ärnlöv, J., Holmes, M. V. & Asselbergs, F. W., Aug 30 2016, In: Journal of the American College of Cardiology. 68, 9, p. 934-945 12 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    90 Scopus citations

  • Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

    Pattaro, C., Teumer, A., Gorski, M., Chu, A. Y., Li, M., Mijatovic, V., Garnaas, M., Tin, A., Sorice, R., Li, Y., Taliun, D., Olden, M., Foster, M., Yang, Q., Chen, M. H., Pers, T. H., Johnson, A. D., Ko, Y. A., Fuchsberger, C., Tayo, B., & 678 othersNalls, M., Feitosa, M. F., Isaacs, A., Dehghan, A., D'Adamo, P., Adeyemo, A., Dieffenbach, A. K., Zonderman, A. B., Nolte, I. M., Van Der Most, P. J., Wright, A. F., Shuldiner, A. R., Morrison, A. C., Hofman, A., Smith, A. V., Dreisbach, A. W., Franke, A., Uitterlinden, A. G., Metspalu, A., Tonjes, A., Lupo, A., Robino, A., Johansson, Å., Demirkan, A., Kollerits, B., Freedman, B. I., Ponte, B., Oostra, B. A., Paulweber, B., Krämer, B. K., Mitchell, B. D., Buckley, B. M., Peralta, C. A., Hayward, C., Helmer, C., Rotimi, C. N., Shaffer, C. M., Müller, C., Sala, C., Van Duijn, C. M., Saint-Pierre, A., Ackermann, D., Shriner, D., Ruggiero, D., Toniolo, D., Lu, Y., Cusi, D., Czamara, D., Ellinghaus, D., Siscovick, D. S., Ruderfer, D., Gieger, C., Grallert, H., Rochtchina, E., Atkinson, E. J., Holliday, E. G., Boerwinkle, E., Salvi, E., Bottinger, E. P., Murgia, F., Rivadeneira, F., Ernst, F., Kronenberg, F., Hu, F. B., Navis, G. J., Curhan, G. C., Ehret, G. B., Homuth, G., Coassin, S., Thun, G. A., Pistis, G., Gambaro, G., Malerba, G., Montgomery, G. W., Eiriksdottir, G., Jacobs, G., Li, G., Wichmann, H. E., Campbell, H., Schmidt, H., Wallaschofski, H., Völzke, H., Brenner, H., Kroemer, H. K., Kramer, H., Lin, H., Leach, I. M., Ford, I., Guessous, I., Rudan, I., Prokopenko, I., Borecki, I., Heid, I. M., Kolcic, I., Persico, I., Jukema, J. W., Wilson, J. F., Felix, J. F., Divers, J., Lambert, J. C., Stafford, J. M., Gaspoz, J. M., Smith, J. A., Faul, J. D., Wang, J. J., Ding, J., Hirschhorn, J. N., Attia, J., Whitfield, J. B., Chalmers, J., Viikari, J., Coresh, J., Denny, J. C., Karjalainen, J., Fernandes, J. K., Endlich, K., Butterbach, K., Keene, K. L., Lohman, K., Portas, L., Launer, L. 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E., Chen, S., Katsuya, T., Isono, M., Albrecht, E., Yamamoto, K., Kubo, M., Nakamura, Y., Kamatani, N., Kato, N., He, J., Chen, Y. T., Tanaka, T., Reilly, M. P., Schunkert, H., Assimes, T. L., Hall, A., Hengstenberg, C., König, I. R., Laaksonen, R., McPherson, R., Thompson, J. R., Thorsteinsdottir, U., Ziegler, A., Absher, D., Chen, L., Cupples, L. A., Halperin, E., Li, M., Musunuru, K., Preuss, M., Schillert, A., Thorleifsson, G., Wells, G. A., Holm, H., Roberts, R., Stewart, A. F. R., Fortmann, S., Go, A., Hlatky, M., Iribarren, C., Knowles, J., Myers, R., Quertermous, T., Sidney, S., Risch, N., Tang, H., Blankenberg, S., Schnabel, R., Sinning, C., Lackner, K. J., Tiret, L., Nicaud, V., Cambien, F., Bickel, C., Rupprecht, H. J., Perret, C., Proust, C., Münzel, T. F., Barbalic, M., Chen, I. Y. D., Demissie-Banjaw, S., Folsom, A., Lumley, T., Marciante, K., Taylor, K. D., Volcik, K., Gretarsdottir, S., Gulcher, J. 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B., Watzinger, N., Aragam, J., Zweiker, R., Lind, L., Rodeheffer, R. J., Greiser, K. H., Deckers, J. W., Stritzke, J., Ingelsson, E., Kullo, I., Haerting, J., Reffelmann, T., Redfield, M. M., Werdan, K., Mitchell, G. F., Arnett, D. K., Gottdiener, J. S., Blettner, M., Friedrich, N., Kovacs, P., Wild, P. S., Froguel, P., Rettig, R., Mägi, R., Biffar, R., Schmidt, R., Middelberg, R. P. S., Carroll, R. J., Penninx, B. W., Scott, R. J., Katz, R., Sedaghat, S., Wild, S. H., Kardia, S. L. R., Ulivi, S., Hwang, S. J., Enroth, S., Kloiber, S., Trompet, S., Stengel, B., Hancock, S. J., Turner, S. T., Rosas, S. E., Stracke, S., Harris, T. B., Zeller, T., Zemunik, T., Lehtimäki, T., Illig, T., Aspelund, T., Nikopensius, T., Esko, T., Tanaka, T., Gyllensten, U., Völker, U., Emilsson, V., Vitart, V., Aalto, V., Gudnason, V., Chouraki, V., Chen, W. M., Igl, W., März, W., Koenig, W., Lieb, W., Loos, R. J. F., Liu, Y., Snieder, H., Pramstaller, P. P., Parsa, A., O'Connell, J. R., Susztak, K., Hamet, P., Tremblay, J., De Boer, I. H., Böger, C. A., Goessling, W., Chasman, D. I., Köttgen, A., Kao, W. H. L. & Fox, C. S., Jan 21 2016, In: Nature communications. 7, 10023.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    329 Scopus citations

  • Kidney function and cerebral blood flow: The Rotterdam study

    Sedaghat, S., Vernooij, M. W., Loehrer, E., Mattace-Raso, F. U. S., Hofman, A., Van Der Lugt, A., Franco, O. H., Dehghan, A. & Ikram, M. A., Mar 2016, In: Journal of the American Society of Nephrology. 27, 3, p. 715-721 7 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    46 Scopus citations

  • Lower microstructural integrity of brain white matter is related to higher mortality

    Sedaghat, S., Cremers, L. G. M., De Groot, M., Hofman, A., Van Der Lugt, A., Niessen, W. J., Franco, O. H., Dehghan, A., Ikram, M. A. & Vernooij, M. W., Aug 30 2016, In: Neurology. 87, 9, p. 927-934 8 p.

    Research output: Contribution to journal › Article › peer-review

    18 Scopus citations

  • The association of thyroid function and the risk of kidney function decline: A population-based cohort study

    Chaker, L., Sedaghat, S., Hoorn, E. J., Den Elzen, W. P. J., Gussekloo, J., Hofman, A., Ikram, M. A., Franco, O. H., Dehghan, A. & Peeters, R. P., Dec 2016, In: European Journal of Endocrinology. 175, 6, p. 653-660 8 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    22 Scopus citations

  • von Willebrand Factor, ADAMTS13 Activity, and Decline in Kidney Function: A Population-Based Cohort Study

    Sedaghat, S., de Vries, P. S., Boender, J., Sonneveld, M. A. H., Hoorn, E. J., Hofman, A., de Maat, M. P. M., Franco, O. H., Ikram, M. A., Leebeek, F. W. G. & Dehghan, A., Nov 1 2016, In: American Journal of Kidney Diseases. 68, 5, p. 726-732 7 p.

    Research output: Contribution to journal › Article › peer-review

    11 Scopus citations
  • 2015

    Arterial stiffness and decline in kidney function

    Sedaghat, S., Mattace-Raso, F. U. S., Hoorn, E. J., Uitterlinden, A. G., Hofman, A., Ikram, M. A., Franco, O. H. & Dehghan, A., Dec 7 2015, In: Clinical Journal of the American Society of Nephrology. 10, 12, p. 2190-2197 8 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    102 Scopus citations