20082024
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Research Output 2008 2019

2019

Adhesive thermosensitive gels for local delivery of viral vectors

Caronia, J. M., Sorensen, D. W., Leslie, H. M., van Berlo, J. & Azarin, S. M., Sep 1 2019, In : Biotechnology and bioengineering. 116, 9, p. 2353-2363 11 p.

Research output: Contribution to journalArticle

Open Access
UCON 50-HB-5100
Poloxamer
Transition Temperature
Adhesives
Gels

Biomaterial Platform to Establish a Hypoxic Metastatic Niche in Vivo

Lee, H. R., Pelaez, F., Silbaugh, A. M., Leslie, F., Racila, E. V. & Azarin, S. M., Apr 15 2019, In : ACS Applied Bio Materials. 2, 4, p. 1549-1560 12 p.

Research output: Contribution to journalArticle

Biocompatible Materials
Biomaterials
Scaffolds
Tumors
Cells
1 Citation (Scopus)

Engineering T cell response to cancer antigens by choice of focal therapeutic conditions

Shao, Q., O'flanagan, S. D., Lam, T. S., Roy, P., Pelaez, F., Burbach, B. J., Azarin, S. M., Shimizu, Y. & Bischof, J. C., Jan 1 2019, In : International Journal of Hyperthermia. 36, 1, p. 130-138 9 p.

Research output: Contribution to journalArticle

Cryosurgery
Electroporation
Hot Temperature
T-Lymphocytes
Antigens
2018
3 Citations (Scopus)

A facile in vitro platform to study cancer cell dormancy under hypoxic microenvironments using CoCl2

Lee, H. R., Leslie, F. & Azarin, S. M., Aug 3 2018, In : Journal of Biological Engineering. 12, 1, 12.

Research output: Contribution to journalArticle

Cells
Hypoxia-Inducible Factor 1
Neoplasms
Cell Line
MCF-7 Cells
5 Citations (Scopus)

Biomaterial Scaffolds as Pre-metastatic Niche Mimics Systemically Alter the Primary Tumor and Tumor Microenvironment

Aguado, B. A., Hartfield, R. M., Bushnell, G. G., Decker, J. T., Azarin, S. M., Nanavati, D., Schipma, M. J., Rao, S. S., Oakes, R. S., Zhang, Y., Jeruss, J. S. & Shea, L. D., May 23 2018, In : Advanced Healthcare Materials. 7, 10, 1700903.

Research output: Contribution to journalArticle

Tumor Microenvironment
Biocompatible Materials
Biomaterials
Scaffolds
Tumors
2 Citations (Scopus)

Biomaterial scaffolds for non-invasive focal hyperthermia as a potential tool to ablate metastatic cancer cells

Pelaez, F., Manuchehrabadi, N., Roy, P., Natesan, H., Wang, Y., Racila, E., Fong, H., Zeng, K., Silbaugh, A. M., Bischof, J. C. & Azarin, S. M., Jun 1 2018, In : Biomaterials. 166, p. 27-37 11 p.

Research output: Contribution to journalArticle

Biocompatible Materials
Biomaterials
Scaffolds
Fever
Hot Temperature
4 Citations (Scopus)

Freezing Responses in DMSO-Based Cryopreservation of Human iPS Cells: Aggregates Versus Single Cells

Li, R., Yu, G., Azarin, S. M. & Hubel, A., May 1 2018, In : Tissue Engineering - Part C: Methods. 24, 5, p. 289-299 11 p.

Research output: Contribution to journalArticle

Cryopreservation
Dimethyl Sulfoxide
Freezing
Ice
Induced Pluripotent Stem Cells
5 Citations (Scopus)
Open Access
Adrenoleukodystrophy
Blood-Brain Barrier
Endothelial Cells
Brain
Ethylene Oxide

Work in progress: Identifying current standards and addressing the need for further process safety education in unit operations courses

Carter, T. L., Azarin, S. M., Brennan, J., Hill, E. & Karlsson, A. J., Jun 23 2018, In : ASEE Annual Conference and Exposition, Conference Proceedings. 2018-June

Research output: Contribution to journalConference article

Education
2016
1 Citation (Scopus)

An introduction to mammalian cell culture

Le, T. S., McCann, M., Azarin, S. M. & Hu, W., Apr 1 2016, Chemical Engineering Progress, 112, 4.

Research output: Contribution to specialist publicationArticle

Cell culture
Proteins
Vaccines
Cells
Tissue
4 Citations (Scopus)

Detection of extracellular matrix modification in cancer models with inverse spectroscopic optical coherence tomography

Spicer, G. L. C., Azarin, S. M., Yi, J., Young, S. T., Ellis, R., Bauer, G. M., Shea, L. D. & Backman, V., Sep 12 2016, In : Physics in Medicine and Biology. 61, 19, p. 6892-6904 13 p.

Research output: Contribution to journalArticle

Optical Coherence Tomography
Extracellular Matrix
Neoplasms
Disease Progression
In Vitro Techniques
19 Citations (Scopus)

Enhanced survival with implantable scaffolds that capture metastatic breast cancer cells in vivo

Rao, S. S., Bushnell, G. G., Azarin, S. M., Spicer, G., Aguado, B. A., Stoehr, J. R., Jiang, E. J., Backman, V., Shea, L. D. & Jeruss, J. S., Sep 15 2016, In : Cancer Research. 76, 18, p. 5209-5218 10 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Neoplasms
Survival
Neoplasm Metastasis
Optical Coherence Tomography
21 Citations (Scopus)

Extracellular matrix mediators of metastatic cell colonization characterized using scaffold mimics of the pre-metastatic niche

Aguado, B. A., Caffe, J. R., Nanavati, D., Rao, S. S., Bushnell, G. G., Azarin, S. M. & Shea, L. D., Mar 15 2016, In : Acta Biomaterialia. 33, p. 13-24 12 p.

Research output: Contribution to journalArticle

Scaffolds
Extracellular Matrix
Tumors
Extracellular Matrix Proteins
Cells
2015
55 Citations (Scopus)

In vivo capture and label-free detection of early metastatic cells

Azarin, S. M., Yi, J., Gower, R. M., Aguado, B. A., Sullivan, M. E., Goodman, A. G., Jiang, E. J., Rao, S. S., Ren, Y., Tucker, S. L., Backman, V., Jeruss, J. S. & Shea, L. D., Sep 8 2015, In : Nature communications. 6, 8094.

Research output: Contribution to journalArticle

Scaffolds
Labels
Tumors
metastasis
cells
11 Citations (Scopus)

Secretome identification of immune cell factors mediating metastatic cell homing

Aguado, B. A., Wu, J. J., Azarin, S. M., Nanavati, D., Rao, S. S., Bushnell, G. G., Medicherla, C. B. & Shea, L. D., Dec 4 2015, In : Scientific reports. 5, 17566.

Research output: Contribution to journalArticle

Immunologic Factors
Conditioned Culture Medium
Transendothelial and Transepithelial Migration
Haptoglobins
Systems Biology
2014
153 Citations (Scopus)

A retinoic acid-enhanced, multicellular human blood-brain barrier model derived from stem cell sources

Lippmann, E. S., Al-Ahmad, A., Azarin, S. M., Palecek, S. P. & Shusta, E. V., Feb 24 2014, In : Scientific reports. 4, 4160.

Research output: Contribution to journalArticle

Tretinoin
Blood-Brain Barrier
Stem Cells
Brain
Pericytes
42 Citations (Scopus)

Modulation of leukocyte infiltration and phenotype in microporous tissue engineering scaffolds via vector induced IL-10 expression

Gower, R. M., Boehler, R. M., Azarin, S. M., Ricci, C. F., Leonard, J. N. & Shea, L. D., Feb 1 2014, In : Biomaterials. 35, 6, p. 2024-2031 8 p.

Research output: Contribution to journalArticle

Tissue Scaffolds
Macrophages
Tissue Engineering
Scaffolds (biology)
Tissue engineering
27 Citations (Scopus)

Spatially resolved optical and ultrastructural properties of colorectal and pancreatic field carcinogenesis observed by inverse spectroscopic optical coherence tomography

Yi, J., Radosevich, A. J., Stypula-Cyrus, Y., Mutyal, N. N., Azarin, S. M., Horcher, E., Goldberg, M. J., Bianchi, L. K., Bajaj, S., Roy, H. K. & Backman, V., Jan 1 2014, In : Journal of biomedical optics. 19, 3, 036013.

Research output: Contribution to journalArticle

Biopsy
Optical tomography
tomography
cancer
optical properties
2013
475 Citations (Scopus)

Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/β-catenin signaling under fully defined conditions

Lian, X., Zhang, J., Azarin, S. M., Zhu, K., Hazeltine, L. B., Bao, X., Hsiao, C., Kamp, T. J. & Palecek, S. P., Jan 1 2013, In : Nature Protocols. 8, 1, p. 162-175 14 p.

Research output: Contribution to journalArticle

Catenins
Pluripotent Stem Cells
Stem cells
Cardiac Myocytes
Flow cytometry

Engineering systems to study and control tumor progression and metastasis

Azarin, S. M., Jan 1 2013, Education Division 2013 - Core Programming Area at the 2013 AIChE Annual Meeting: Global Challenges for Engineering a Sustainable Future. AIChE, 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

systems engineering
Systems engineering
Tumors
2012
243 Citations (Scopus)

Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells

Lippmann, E. S., Azarin, S. M., Kay, J. E., Nessler, R. A., Wilson, H. K., Al-Ahmad, A., Palecek, S. P. & Shusta, E. V., Aug 1 2012, In : Nature biotechnology. 30, 8, p. 783-791 9 p.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Endothelial cells
Stem cells
Blood-Brain Barrier
Endothelial Cells
13 Citations (Scopus)

Effects of 3D microwell culture on growth kinetics and metabolism of human embryonic stem cells

Azarin, S. M., Larson, E. A., Almodõvar-Cruz, J. M., De Pablo, J. J. & Palecek, S. P., Mar 1 2012, In : Biotechnology and Applied Biochemistry. 59, 2, p. 88-96 9 p.

Research output: Contribution to journalArticle

Growth kinetics
Stem cells
Metabolism
Cell culture
Growth
49 Citations (Scopus)

Modulation of Wnt/β-catenin signaling in human embryonic stem cells using a 3-D microwell array

Azarin, S. M., Lian, X., Larson, E. A., Popelka, H. M., de Pablo, J. J. & Palecek, S. P., Mar 1 2012, In : Biomaterials. 33, 7, p. 2041-2049 9 p.

Research output: Contribution to journalArticle

Catenins
Stem cells
Modulation
Cadherins
Embryoid Bodies
648 Citations (Scopus)

Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling

Lian, X., Hsiao, C., Wilson, G., Zhu, K., Hazeltine, L. B., Azarin, S. M., Raval, K. K., Zhang, J., Kamp, T. J. & Palecek, S. P., Jul 3 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 27

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Cardiac Myocytes
Glycogen Synthase Kinase 3
Catenins
Small Interfering RNA
2011
37 Citations (Scopus)

Fabrication and selective functionalization of amine-reactive polymer multilayers on topographically patterned microwell cell culture arrays

Broderick, A. H., Azarin, S. M., Buck, M. E., Palecek, S. P. & Lynn, D. M., Jun 13 2011, In : Biomacromolecules. 12, 6, p. 1998-2007 10 p.

Research output: Contribution to journalArticle

Functional polymers
Cell culture
Amines
Multilayers
Fabrication

Fabrication of amine-reactive polymer multilayers on microwell cell culture arrays: Combining methods for the topographic patterning of cell substrates with approaches to facile surface functionalization

Broderick, A. H., Azarin, S. M., Buck, M. E., Palecek, S. P. & Lynn, D. M., Jan 1 2011, Materials Engineering and Sciences Division - Core Programming Topic at the 2011 AIChE Annual Meeting. AIChE, Vol. 1. p. 72-73 2 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Functional polymers
Cell culture
Amines
Multilayers
Fabrication
2010
43 Citations (Scopus)

Development of scalable culture systems for human embryonic stem cells

Azarin, S. M. & Palecek, S. P., Feb 15 2010, In : Biochemical Engineering Journal. 48, 3, p. 378-384 7 p.

Research output: Contribution to journalReview article

Stem cells
Cell culture
Induced Pluripotent Stem Cells
Pluripotent Stem Cells
Bioreactors
28 Citations (Scopus)

Human embryonic stem cell-derived keratinocytes exhibit an epidermal transcription program and undergo epithelial morphogenesis in engineered tissue constructs

Metallo, C. M., Azarin, S. M., Moses, L. E., Ji, L., De Pablo, J. J. & Palecek, S. P., Jan 1 2010, In : Tissue Engineering - Part A. 16, 1, p. 213-223 11 p.

Research output: Contribution to journalArticle

Transcription
Stem cells
Morphogenesis
Keratinocytes
Tissue
12 Citations (Scopus)

Matrix revolutions: A trinity of defined substrates for long-term expansion of human ESCs

Azarin, S. M. & Palecek, S. P., Jan 1 2010, In : Cell Stem Cell. 7, 1, p. 7-8 2 p.

Research output: Contribution to journalShort survey

126 Citations (Scopus)

The microwell control of embryoid body size in order to regulate cardiac differentiation of human embryonic stem cells

Mohr, J. C., Zhang, J., Azarin, S. M., Soerens, A. G., de Pablo, J. J., Thomson, J. A., Lyons, G. E., Palecek, S. P. & Kamp, T. J., Mar 1 2010, In : Biomaterials. 31, 7, p. 1885-1893 9 p.

Research output: Contribution to journalArticle

Embryoid Bodies
Body Size
Stem cells
Myosin Light Chains
Cardiac Myocytes
2008
35 Citations (Scopus)

Engineering tissue from human embryonic stem cells: Tissue Engineering Review Series

Metallo, C. M., Azarin, S. M., Ji, L., De Pablo, J. J. & Palecek, S. P., Jun 1 2008, In : Journal of Cellular and Molecular Medicine. 12, 3, p. 709-729 21 p.

Research output: Contribution to journalArticle

Cell engineering
Cell Engineering
Tissue Engineering
Stem cells
Tissue engineering
76 Citations (Scopus)

Tumor-targeted gene delivery using molecularly engineered hybrid polymers functionalized with a tumor-homing peptide

Wood, K. C., Azarin, S. M., Arap, W., Pasqualini, R., Langer, R. & Hammond, P. T., Feb 1 2008, In : Bioconjugate Chemistry. 19, 2, p. 403-405 3 p.

Research output: Contribution to journalArticle

Peptides
Tumors
Polymers
Genes
Gene Transfer Techniques
7 Citations (Scopus)

Work in progress - A first-year Introduction-to-Engineering course on Society's Engineering Grand Challenges

Azarin, S., Ferrier, N., Kennedy, S. M., Klingenberg, D., Masters, K., McMahon, K. D., Russell, J. & Hagness, S. C., Dec 1 2008, In : Proceedings - Frontiers in Education Conference, FIE. 4720379.

Research output: Contribution to journalArticle

engineering
society
Students
megacity
Planets