Keyphrases
Mycobacterium Tuberculosis (M. tb)
100%
Pyrazinoic Acid
65%
Tuberculosis
46%
Antimycobacterial Activity
41%
Prodrug
35%
Structural Characterization
32%
Functional Characterization
32%
Orally Active
32%
Nucleophilic
32%
Rifamycin Antibiotics
32%
Lactams
32%
Biological Evaluation
32%
PLP-dependent Enzymes
32%
Transacetylase
32%
Homoserine
32%
Activity-based Probes
32%
5-aminosalicylic Acid (5-ASA)
32%
Cephem
32%
Synthetic Evaluation
32%
Mycobactin
32%
Siderophore Production
32%
ADP-ribosylation
32%
Salicylic Acid Analogues
32%
Polyfluorinated
32%
Structure-activity Relationship
32%
Via Resistance
32%
Microbiome
32%
Adenylation
32%
Antibacterial Agents
32%
Metabolically Stable
32%
Biotin Ligase
32%
Salicylic Acid
27%
Warhead
26%
Rifamycin
24%
Resistant Strains
21%
β-lactamase
21%
Acyl
19%
Sulfamide
19%
Mycobacterium
18%
Infection-related Mortality
15%
Tuberculosis Drugs
14%
Tuberculosis Treatment
14%
Disease States
13%
Human Microbiome
13%
Hydrolysis
13%
Biosynthetic Pathway
11%
Non-replicating
11%
Mechanism of Action
11%
Overexpressing
11%
Electrophilic
10%
Pharmacology, Toxicology and Pharmaceutical Science
Mycobacterium Tuberculosis
98%
Pyrazinoic Acid
65%
Infection
57%
Antimycobacterial Agent
41%
Antiinfective Agent
39%
Prodrug
35%
Microbiome
35%
Antibiotics
32%
Structure Activity Relationship
32%
Aminosalicylic Acid
32%
Salicylic Acid
32%
Lactam
32%
Lysine
32%
Cephem
32%
Alkyne
32%
Rifamycin
32%
Siderophore
32%
Adenosine Diphosphate
32%
Ligase
32%
Biotin
32%
Penicillinase
21%
Sulfanilamide
19%
Iron
18%
Mycobacteria
17%
Diseases
15%
Pyrazinamide
13%
Pharmacokinetics
13%
Beta Lactam Antibiotic
10%
Acyltransferase
9%
Bioavailability
9%
Salicylic Acid Derivative
9%
Bioactivation
7%
Infectious Agent
6%
Target Activity
6%
Mycobacterium abscessus
6%
Carboxylate
6%
Minimum Inhibitory Concentration
6%
Antibacterial Activity
6%
Staphylococcus Aureus
6%
Biochemistry, Genetics and Molecular Biology
Mycobacterium Tuberculosis
68%
Enzyme
57%
Nucleophilicity
32%
ADP-ribosylation
32%
Structure Activity Relation
32%
N-Acetyltransferase
32%
Anabolism
23%
Whole Cell
14%
Lysine
12%
Loss of Function Mutation
10%
Binding Affinity
10%
Protein Catabolism
10%
Antimicrobial Activity
10%
Isothermal Titration Calorimetry
10%
Crystal Structure
10%
Coenzyme A
10%
Mycobacterium abscessus
8%
Drug Disposition
8%
Infectious Agent
8%
Bactericidal Activity
8%
Pharmacokinetics
8%
Mycobacteria
8%