Sabita Roy

1983 …2020

Research output per year

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Research Output

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Morphine induced exacerbation of sepsis is mediated by tempering endotoxin tolerance through modulation of miR-146a

Banerjee, S., Meng, J., Das, S., Krishnan, A., Haworth, J., Charboneau, R., Zeng, Y., Ramakrishnan, S. & Roy, S., Jul 8 2013, In : Scientific reports. 3, 1977.

Research output: Contribution to journalArticle

34 Scopus citations
11 Scopus citations

Morphine Induces Bacterial Translocation in Mice by Compromising Intestinal Barrier Function in a TLR-Dependent Manner

Meng, J., Yu, H., Ma, J., Wang, J., Banerjee, S., Charboneau, R., Barke, R. A. & Roy, S., Jan 18 2013, In : PloS one. 8, 1, e54040.

Research output: Contribution to journalArticle

71 Scopus citations

Morphine induces CD4+ T cell IL-4 expression through an adenylyl cyclase mechanism independent of the protein kinase A pathway

Roy, S., Wang, J., Charboneau, R., Loh, H. H. & Barke, R. A., Nov 15 2005, In : Journal of Immunology. 175, 10, p. 6361-6367 7 p.

Research output: Contribution to journalArticle

57 Scopus citations

Morphine induces changes in the gut microbiome and metabolome in a morphine dependence model

Wang, F., Meng, J., Zhang, L., Johnson, T., Chen, C. & Roy, S., Dec 1 2018, In : Scientific reports. 8, 1, 3596.

Research output: Contribution to journalArticle

Open Access
31 Scopus citations

Morphine induces defects in early response of alveolar macrophages to Streptococcus pneumoniae by modulating TLR9-NF-κB signaling

Wang, J., Barke, R. A., Charboneau, R., Schwendener, R. & Roy, S., Mar 1 2008, In : Journal of Immunology. 180, 5, p. 3594-3600 7 p.

Research output: Contribution to journalArticle

70 Scopus citations

Morphine induces splenocyte trafficking into the CNS

Olin, M. R., Oh, S. U., Roy, S., Peterson, P. & Molitor, T. W., Jun 1 2012, In : Journal of Neuroimmune Pharmacology. 7, 2, p. 436-443 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Morphine inhibits Fc-mediated phagocytosis through mu and delta opioid receptors

Tomassini, N., Renaud, F., Roy, S. & Loh, H. H., Feb 2004, In : Journal of Neuroimmunology. 147, 1-2, p. 131-133 3 p.

Research output: Contribution to journalArticle

24 Scopus citations

Morphine inhibits migration of tumor-infiltrating leukocytes and suppresses angiogenesis associated with tumor growth in mice

Koodie, L., Yuan, H., Pumper, J. A., Yu, H., Charboneau, R., Ramakrishnan, S. & Roy, S., Apr 2014, In : American Journal of Pathology. 184, 4, p. 1073-1084 12 p.

Research output: Contribution to journalArticle

34 Scopus citations

Morphine inhibits murine dendritic cell IL-23 production by modulating toll-like receptor 2 and Nod2 signaling

Wang, J., Ma, J., Charboneau, R., Barke, R. A. & Roy, S., Mar 25 2011, In : Journal of Biological Chemistry. 286, 12, p. 10225-10232 8 p.

Research output: Contribution to journalArticle

30 Scopus citations

Morphine inhibits transcriptional activation of IL-2 in mouse thymocytes

Roy, S., Chapin, R. B., Cain, K. J., Charboneau, R. G., Ramakrishnan, S. & Barke, R. A., Jul 10 1997, In : Cellular Immunology. 179, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

59 Scopus citations

Morphine inhibits VEGF expression in myocardial ischemia

Roy, S., Balasubramanian, S., Wang, J., Chandrashekhar, Y., Charboneau, R. & Barke, R., Aug 1 2003, In : Surgery. 134, 2, p. 336-344 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

Morphine modulates lymph node-derived T lymphocyte function: Role of caspase-3, -8, and nitric oxide

Wang, J., Charboneau, R., Balasubramanian, S., Barke, R. A., Loh, H. H. & Roy, S., Oct 22 2001, In : Journal of Leukocyte Biology. 70, 4, p. 527-536 10 p.

Research output: Contribution to journalArticle

48 Scopus citations

Morphine modulates NFκB activation in macrophages

Roy, S., Cain, K. J., Chapin, R. B., Charboneau, R. G. & Barke, R. A., Apr 17 1998, In : Biochemical and Biophysical Research Communications. 245, 2, p. 392-396 5 p.

Research output: Contribution to journalArticle

129 Scopus citations

Morphine modulation of Toll-like receptors in microglial cells potentiates neuropathogenesis in a HIV-1 model of coinfection with pneumococcal pneumoniae

Dutta, R., Krishnan, A., Meng, J., Das, S., Ma, J., Banerjee, S., Wang, J., Charboneau, R., Prakash, O., Barke, R. A. & Roy, S., Jul 18 2012, In : Journal of Neuroscience. 32, 29, p. 9917-9930 14 p.

Research output: Contribution to journalArticle

23 Scopus citations

Morphine negatively regulates interferon-γ promoter activity in activated murine T cells through two distinct cyclic AMP-dependent pathways

Wang, J., Barke, R. A., Charboneau, R., Loh, H. H. & Roy, S., Sep 26 2003, In : Journal of Biological Chemistry. 278, 39, p. 37622-37631 10 p.

Research output: Contribution to journalArticle

70 Scopus citations

Morphine potentiates LPS-induced autophagy initiation but inhibits autophagosomal maturation through distinct TLR4-dependent and independent pathways

Wan, J., Ma, J., Anand, V., Ramakrishnan, S. & Roy, S., Jun 1 2015, In : Acta Physiologica. 214, 2, p. 189-199 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

Morphine sulfate inhibits hypoxia-induced vascular endothelial growth factor expression in endothelial cells and cardiac myocytes

Balasubramanian, S., Ramakrishnan, S., Charboneau, R., Wang, J., Barke, R. A. & Roy, S., Jan 1 2001, In : Journal of Molecular and Cellular Cardiology. 33, 12, p. 2179-2187 9 p.

Research output: Contribution to journalArticle

45 Scopus citations

Morphine suppresses tumor angiogenesis through a HIF-1α/p38MAPK pathway

Koodie, L., Ramakrishnan, S. & Roy, S., Aug 2010, In : American Journal of Pathology. 177, 2, p. 984-997 14 p.

Research output: Contribution to journalArticle

70 Scopus citations

Morphine synergizes with lipopolysaccharide in a chronic endotoxemia model

Roy, S., Charboneau, R. G. & Barke, R. A., Mar 1 1999, In : Journal of Neuroimmunology. 95, 1-2, p. 107-114 8 p.

Research output: Contribution to journalArticle

65 Scopus citations

Morphine withdrawal contributes to Th cell differentiation by biasing cells toward the Th2 lineage

Kelschenbach, J., Barke, R. A. & Roy, S., Aug 15 2005, In : Journal of Immunology. 175, 4, p. 2655-2665 11 p.

Research output: Contribution to journalArticle

23 Scopus citations

Morphine withdrawal inhibits IL-12 induction in a macrophage cell line through a mechanism that involves cAMP

Kelschenbach, J., Ninkovic, J., Wang, J., Krishnan, A., Charboneau, R., Barke, R. A. & Roy, S., Mar 15 2008, In : Journal of Immunology. 180, 6, p. 3670-3679 10 p.

Research output: Contribution to journalArticle

13 Scopus citations
14 Scopus citations

Morphine worsens the severity and prevents pancreatic regeneration in mouse models of acute pancreatitis

Barlass, U., Dutta, R., Cheema, H., George, J., Sareen, A., Dixit, A., Yuan, Z., Giri, B., Meng, J., Banerjee, S., Banerjee, S., Dudeja, V., Dawra, R. K., Roy, S. & Saluja, A. K., Apr 2018, In : Gut. 67, 4, p. 719-727 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

Mu and delta receptors mediate morphine effects on phagocytosis by murine peritoneal macrophages

Tomassini, N., Renaud, F. L., Roy, S. & Loh, H. H., Mar 2003, In : Journal of Neuroimmunology. 136, 1-2, p. 9-16 8 p.

Research output: Contribution to journalArticle

30 Scopus citations

Mu-opioid receptor is associated with phosphatase activity

Roy, S., Lee, N. M. & Loh, H. H., Oct 30 1986, In : Biochemical and Biophysical Research Communications. 140, 2, p. 660-665 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

MU-opioid receptor-knockout mice: Role of μ-opioid receptor in morphine mediated immune functions

Roy, S., Barke, R. A. & Loh, H. H., Oct 30 1998, In : Molecular Brain Research. 61, 1-2, p. 190-194 5 p.

Research output: Contribution to journalArticle

125 Scopus citations

Oncostatin M promotes excitotoxicity by inhibiting glutamate uptake in astrocytes: Implications in HIV-associated neurotoxicity

Moidunny, S., Matos, M., Wesseling, E., Banerjee, S., Volsky, D. J., Cunha, R. A., Agostinho, P., Boddeke, H. W. & Roy, S., Jun 10 2016, In : Journal of Neuroinflammation. 13, 1, 144.

Research output: Contribution to journalArticle

Open Access
18 Scopus citations

Opioid exacerbation of gram-positive sepsis, induced by gut microbial modulation, is rescued by IL-17A neutralization

Meng, J., Banerjee, S., Li, D., Sindberg, G. M., Wang, F., Ma, J. & Roy, S., Jun 3 2015, In : Scientific reports. 5, 10918.

Research output: Contribution to journalArticle

35 Scopus citations

Opioid-induced gut microbial disruption and bile dysregulation leads to gut barrier compromise and sustained systemic inflammation

Banerjee, S., Sindberg, G., Wang, F., Meng, J., Sharma, U., Zhang, L., Dauer, P., Chen, C., Dalluge, J., Johnson, T. & Roy, S., Nov 1 2016, In : Mucosal Immunology. 9, 6, p. 1418-1428 11 p.

Research output: Contribution to journalArticle

55 Scopus citations

Opioids Impair Intestinal Epithelial Repair in HIV-Infected Humanized Mice

Meng, J., Banerjee, S., Zhang, L., Sindberg, G., Moidunny, S., Li, B., Robbins, D. J., Girotra, M., Segura, B., Ramakrishnan, S. & Roy, S., Jan 17 2020, In : Frontiers in immunology. 10, 2999.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Pirfenidone ameliorates murine chronic GVHD through inhibition of macrophage infiltration and TGF-β production

Du, J., Paz, K., Flynn, R., Vulic, A., Robinson, T. M., Lineburg, K. E., Alexander, K. A., Meng, J., Roy, S., Panoskaltsis-Mortari, A., Loschi, M., Hill, G. R., Serody, J. S., Maillard, I., Miklos, D., Koreth, J., Cutler, C. S., Antin, J. H., Ritz, J., MacDonald, K. P. & 3 others, Schacker, T. W., Luznik, L. & Blazar, B. R., May 4 2017, In : Blood. 129, 18, p. 2570-2580 11 p.

Research output: Contribution to journalArticle

Open Access
46 Scopus citations

PPARγ gene C161T substitution alters lipid profile in Chinese patients with coronary artery disease and type 2 diabetes mellitus

Wan, J., Xiong, S., Chao, S., Xiao, J., Ma, Y., Wang, J. & Roy, S., Mar 24 2010, In : Cardiovascular Diabetology. 9, 13.

Research output: Contribution to journalArticle

34 Scopus citations

Prenatal opiate exposure attenuates LPS-induced fever in adult rats: Role of interleukin-1β

Hamilton, K. L., Franklin, L. T. M., Roy, S. & Schrott, L. M., Jan 16 2007, In : Brain Research. 1133, 1, p. 92-99 8 p.

Research output: Contribution to journalArticle

8 Scopus citations
Open Access
10 Scopus citations

Regulation of the transcription factor c/ebpα following peritoneal sepsis

Chapin, R. B., Roy, S., Charboneau, R., Cain, K., Brady, P. S., Brady, L. J. & Barke, R. A., Oct 1995, In : Journal of Surgical Research. 59, 4, p. 460-467 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Role of hypothalamic-pituitary axis in morphine-induced alteration in thymic cell distribution using mu-opioid receptor knockout mice

Roy, S., Wang, J. H., Balasubramanian, S., Sumandeep, Charboneau, R., Barke, R. & Loh, H. H., Jun 1 2001, In : Journal of Neuroimmunology. 116, 2, p. 147-155 9 p.

Research output: Contribution to journalArticle

32 Scopus citations

Role of mu-opioid receptor in immune function

Roy, S., Charboneau, R. G., Barke, R. A. & Loh, H. H., Dec 1 2001, In : Advances in Experimental Medicine and Biology. 493, p. 117-126 10 p.

Research output: Contribution to journalArticle

18 Scopus citations

Sepsis-induced release of interleukin-6 may activate the immediate-early gene program through a hypothalamic-hypophyseal mechanism

Barke, R. A., Roy, S., Chapin, R. B., Charboneau, R., Brady, P. S., Brady, L. J., Townsend, C. M., Hauser, C. & Beauchamp, R. D., Jan 1 1994, In : Surgery. 116, 2, p. 141-149 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Supplemental oxygen reverses hypoxia-induced smooth muscle cell proliferation by modulating HIF-alpha and VEGF levels in a rabbit arteriovenous fistula model

Wan, J., Lata, C., Santilli, A., Green, D., Roy, S. & Santilli, S., Apr 2014, In : Annals of Vascular Surgery. 28, 3, p. 725-736 12 p.

Research output: Contribution to journalArticle

17 Scopus citations

Targeting the tumor vasculature: Inhibition of tumor growth by a vascular endothelial growth factor-toxin conjugate

Olson, T. A., Mohanraj, D., Roy, S. & Ramakrishnan, S., Dec 10 1997, In : International Journal of Cancer. 73, 6, p. 865-870 6 p.

Research output: Contribution to journalArticle

84 Scopus citations

The central response to ovarian carcinoma simulates the response to sepsis

Carson, L. F., Roy, S., Cain, K., Charboneau, R., Deturris, S., Ramakrishin, S. & Barke, R. A., Mar 1998, In : Journal of Surgical Research. 75, 2, p. 97-102 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

The effect of surgical treatment following peritoneal sepsis on hepatic gene expression

Barke, R. A., Birklid, S., Chapin, R. B., Roy, S., Brady, P. S. & Brady, L. J., Jan 1996, In : Journal of Surgical Research. 60, 1, p. 101-106 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

The immunosuppressive effects of chronic morphine treatment are partially dependent on corticosterone and mediated by the μ-opioid receptor

Wang, J., Charboneau, R., Balasubramanian, S., Barke, R. A., Loh, H. H. & Roy, S., May 1 2002, In : Journal of Leukocyte Biology. 71, 5, p. 782-790 9 p.

Research output: Contribution to journalArticle

77 Scopus citations

The possible inhibitory role of the leucine-zipper DNA binding protein c-fos in the regulation of hepatic gene expression after sepsis

Barke, R. A., Brady, P. S., Roy, S., Charboneau, R. & Brady, L. J., Aug 1992, In : Surgery. 112, 2, p. 412-418 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

The Possible Role of a Central Nervous System Dopaminergic Mechanism in Hepatic c-fos Protein Expression Following Peritoneal Sepsis

Roy, S., Charboneau, R., Cain, K. J., Chapin, R. B. & Barke, R. A., Nov 1995, In : Archives of Surgery. 130, 11, p. 1209-1216 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

The role of arginine vasopressin and its receptors in the normal and failing rat heart

Chandrashekhar, Y., Prahash, A. J., Sen, S., Gupta, S., Roy, S. & Anand, I. S., May 1 2003, In : Journal of Molecular and Cellular Cardiology. 35, 5, p. 495-504 10 p.

Research output: Contribution to journalArticle

29 Scopus citations

The Role of Programmed Cell Death (Apoptosis) in Thymic Involution Following Sepsis

Barke, R. A., Roy, S., Chapin, R. B. & Charboneau, R., Dec 1994, In : Archives of Surgery. 129, 12, p. 1256-1262 7 p.

Research output: Contribution to journalArticle

34 Scopus citations

The role of short-term oxygen administration in the prevention of intimal hyperplasia

Lata, C., Green, D. L., Wan, J., Roy, S. & Santilli, S. M., Aug 1 2013, In : Journal of vascular surgery. 58, 2, p. 452-459 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Transcriptional and epigenetic regulation of interleukin-2 gene in activated T cells by morphine

Wang, J., Barke, R. A. & Roy, S., Mar 2 2007, In : Journal of Biological Chemistry. 282, 10, p. 7164-7171 8 p.

Research output: Contribution to journalArticle

28 Scopus citations