Sabita Roy

1983 …2021

Research output per year

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Research Output

2020

Opioids Impair Intestinal Epithelial Repair in HIV-Infected Humanized Mice

Meng, J., Banerjee, S., Zhang, L., Sindberg, G., Moidunny, S., Li, B., Robbins, D. J., Girotra, M., Segura, B., Ramakrishnan, S. & Roy, S., Jan 17 2020, In : Frontiers in immunology. 10, 2999.

Research output: Contribution to journalArticle

Open Access
2018

Morphine induces changes in the gut microbiome and metabolome in a morphine dependence model

Wang, F., Meng, J., Zhang, L., Johnson, T., Chen, C. & Roy, S., Dec 1 2018, In : Scientific reports. 8, 1, 3596.

Research output: Contribution to journalArticle

Open Access
25 Scopus citations

Morphine worsens the severity and prevents pancreatic regeneration in mouse models of acute pancreatitis

Barlass, U., Dutta, R., Cheema, H., George, J., Sareen, A., Dixit, A., Yuan, Z., Giri, B., Meng, J., Banerjee, S., Banerjee, S., Dudeja, V., Dawra, R. K., Roy, S. & Saluja, A. K., Apr 2018, In : Gut. 67, 4, p. 719-727 9 p.

Research output: Contribution to journalArticle

17 Scopus citations
Open Access
9 Scopus citations
2017

Enteric glial–mediated enhancement of intestinal barrier integrity is compromised by morphine

Bauman, B. D., Meng, J., Zhang, L., Louiselle, A., Zheng, E., Banerjee, S., Roy, S. & Segura, B. J., Nov 2017, In : Journal of Surgical Research. 219, p. 214-221 8 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Gut Homeostasis, Microbial Dysbiosis, and Opioids

Wang, F. & Roy, S., Jan 1 2017, In : Toxicologic Pathology. 45, 1, p. 150-156 7 p.

Research output: Contribution to journalArticle

Open Access
16 Scopus citations

Pirfenidone ameliorates murine chronic GVHD through inhibition of macrophage infiltration and TGF-β production

Du, J., Paz, K., Flynn, R., Vulic, A., Robinson, T. M., Lineburg, K. E., Alexander, K. A., Meng, J., Roy, S., Panoskaltsis-Mortari, A., Loschi, M., Hill, G. R., Serody, J. S., Maillard, I., Miklos, D., Koreth, J., Cutler, C. S., Antin, J. H., Ritz, J., MacDonald, K. P. & 3 others, Schacker, T. W., Luznik, L. & Blazar, B. R., May 4 2017, In : Blood. 129, 18, p. 2570-2580 11 p.

Research output: Contribution to journalArticle

Open Access
42 Scopus citations
2016

Cell-permeable iron inhibits vascular endothelial growth factor receptor-2 signaling and tumor angiogenesis

Kir, D., Saluja, M., Modi, S., Venkatachalam, A., Schnettler, E., Roy, S. & Ramakrishnan, S., Jan 1 2016, In : Oncotarget. 7, 40, p. 65348-65363 16 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Differential effects of gram-positive and gram-negative bacterial products on morphine induced inhibition of phagocytosis

Jana, N., Vidhu, A., Raini, D., Zhang, L., Saluja, A., Meng, J., Lisa, K., Santanu, B. & Sabita, R., Feb 19 2016, In : Scientific reports. 6, 21094.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

DNA damage-induced ephrin-B2 reverse signaling promotes chemoresistance and drives EMT in colorectal carcinoma harboring mutant p53

Alam, S. K., Yadav, V. K., Bajaj, S., Datta, A., Dutta, S. K., Bhattacharyya, M., Bhattacharya, S., Debnath, S., Roy, S., Boardman, L. A., Smyrk, T. C., Molina, J. R., Chakrabarti, S., Chowdhury, S., Mukhopadhyay, D. & Roychoudhury, S., Apr 1 2016, In : Cell Death and Differentiation. 23, 4, p. 707-722 16 p.

Research output: Contribution to journalArticle

Open Access
39 Scopus citations

Erratum: Differential effects of gram-positive and gram-negative bacterial products on morphine induced inhibition of phagocytosis (Scientific Reports (2016) 21094:6 DOI:10.1038/srep21094)

Ninkovic, J., Anand, V., Dutta, R., Zhang, L., Saluja, A., Meng, J., Koodie, L., Banerjee, S. & Roy, S., Apr 20 2016, In : Scientific reports. 6, 24011.

Research output: Contribution to journalComment/debate

Open Access

Inhibition of NF-kappa B pathway leads to deregulation of epithelial-mesenchymal transition and neural invasion in pancreatic cancer

Nomura, A., Majumder, K., Giri, B., Dauer, P., Dudeja, V., Roy, S., Banerjee, S. & Saluja, A. K., Dec 1 2016, In : Laboratory Investigation. 96, 12, p. 1268-1278 11 p.

Research output: Contribution to journalArticle

26 Scopus citations

Oncostatin M promotes excitotoxicity by inhibiting glutamate uptake in astrocytes: Implications in HIV-associated neurotoxicity

Moidunny, S., Matos, M., Wesseling, E., Banerjee, S., Volsky, D. J., Cunha, R. A., Agostinho, P., Boddeke, H. W. & Roy, S., Jun 10 2016, In : Journal of Neuroinflammation. 13, 1, 144.

Research output: Contribution to journalArticle

Open Access
18 Scopus citations

Opioid-induced gut microbial disruption and bile dysregulation leads to gut barrier compromise and sustained systemic inflammation

Banerjee, S., Sindberg, G., Wang, F., Meng, J., Sharma, U., Zhang, L., Dauer, P., Chen, C., Dalluge, J., Johnson, T. & Roy, S., Nov 1 2016, In : Mucosal Immunology. 9, 6, p. 1418-1428 11 p.

Research output: Contribution to journalArticle

50 Scopus citations
2015

An Infectious Murine Model for Studying the Systemic Effects of Opioids on Early HIV Pathogenesis in the Gut

Sindberg, G. M., Sharma, U., Banerjee, S., Anand, V., Dutta, R., Gu, C. J., Volsky, D. J. & Roy, S., Feb 20 2015, In : Journal of Neuroimmune Pharmacology. 10, 1, p. 74-87 14 p.

Research output: Contribution to journalArticle

20 Scopus citations
11 Scopus citations

Disruption of gut homeostasis by opioids accelerates HIV disease progression

Meng, J., Sindberg, G. M. & Roy, S., Jan 1 2015, In : Frontiers in Microbiology. 6, JUN, 643.

Research output: Contribution to journalReview article

19 Scopus citations

Hypoxia differentially regulates arterial and venous smooth muscle cell migration

Chanakira, A., Kir, D., Barke, R. A., Santilli, S. M., Ramakrishnan, S. & Roy, S., Sep 18 2015, In : PloS one. 10, 9, e0138587.

Research output: Contribution to journalArticle

12 Scopus citations

Morphine compromises bronchial epithelial TLR2/IL17R signaling crosstalk, necessary for lung IL17 homeostasis

Banerjee, S., Ninkovic, J., Meng, J., Sharma, U., Ma, J., Charboneau, R. & Roy, S., Jun 15 2015, In : Scientific reports. 5, 11384.

Research output: Contribution to journalArticle

7 Scopus citations

Morphine potentiates LPS-induced autophagy initiation but inhibits autophagosomal maturation through distinct TLR4-dependent and independent pathways

Wan, J., Ma, J., Anand, V., Ramakrishnan, S. & Roy, S., Jun 1 2015, In : Acta Physiologica. 214, 2, p. 189-199 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

Opioid exacerbation of gram-positive sepsis, induced by gut microbial modulation, is rescued by IL-17A neutralization

Meng, J., Banerjee, S., Li, D., Sindberg, G. M., Wang, F., Ma, J. & Roy, S., Jun 3 2015, In : Scientific reports. 5, 10918.

Research output: Contribution to journalArticle

31 Scopus citations
2014

Cellular interactions and signaling in neuroAIDS: Emerging issues colloquium

Al-Harthi, L., Buch, S., Geiger, J. D., Gendelman, H. E., He, J. J., Jordan-Sciutto, K. L., Kolson, D. L., Rappaport, J., Roy, S., Zheng, J. & Fox, H. S., Jun 2014, In : Journal of Neuroimmune Pharmacology. 9, 3, p. 269-276 8 p.

Research output: Contribution to journalReview article

1 Scopus citations

Dynamin 2 along with microRNA-199a reciprocally regulate hypoxia-inducible factors and ovarian cancer metastasis

Joshi, H. P., Subramanian, I. V., Schnettler, E. K., Ghosh, G., Rupaimoole, R., Evans, C., saluja, M., Jing, Y., Cristina, I., Roy, S., Zeng, Y., Shah, V. H., Sood, A. K. & Ramakrishnan, S., Jan 1 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 14, p. 5331-5336 6 p.

Research output: Contribution to journalArticle

45 Scopus citations
4 Scopus citations

Methamphetamine induces autophagy as a pro-survival response against apoptotic endothelial cell death through the Kappa opioid receptor

Ma, J., Wan, J., Meng, J., Banerjee, S., Ramakrishnan, S. & Roy, S., Mar 2014, In : Cell Death and Disease. 5, 3, e1099.

Research output: Contribution to journalArticle

65 Scopus citations

Morphine inhibits migration of tumor-infiltrating leukocytes and suppresses angiogenesis associated with tumor growth in mice

Koodie, L., Yuan, H., Pumper, J. A., Yu, H., Charboneau, R., Ramakrishnan, S. & Roy, S., Apr 2014, In : American Journal of Pathology. 184, 4, p. 1073-1084 12 p.

Research output: Contribution to journalArticle

33 Scopus citations

Supplemental oxygen reverses hypoxia-induced smooth muscle cell proliferation by modulating HIF-alpha and VEGF levels in a rabbit arteriovenous fistula model

Wan, J., Lata, C., Santilli, A., Green, D., Roy, S. & Santilli, S., Apr 2014, In : Annals of Vascular Surgery. 28, 3, p. 725-736 12 p.

Research output: Contribution to journalArticle

16 Scopus citations

Vascular endothelial growth factor signaling in hypoxia and inflammation

Ramakrishnan, S., Anand, V. & Roy, S., Mar 2014, In : Journal of Neuroimmune Pharmacology. 9, 2, p. 142-160 19 p.

Research output: Contribution to journalReview article

98 Scopus citations
2013

Morphine and immunosuppression in the context of tumor growth and metastasis

Koodie, L. & Roy, S., Jan 1 2013, Morphine and Metastasis. Springer Netherlands, p. 31-46 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Morphine induced exacerbation of sepsis is mediated by tempering endotoxin tolerance through modulation of miR-146a

Banerjee, S., Meng, J., Das, S., Krishnan, A., Haworth, J., Charboneau, R., Zeng, Y., Ramakrishnan, S. & Roy, S., Jul 8 2013, In : Scientific reports. 3, 1977.

Research output: Contribution to journalArticle

33 Scopus citations

Morphine Induces Bacterial Translocation in Mice by Compromising Intestinal Barrier Function in a TLR-Dependent Manner

Meng, J., Yu, H., Ma, J., Wang, J., Banerjee, S., Charboneau, R., Barke, R. A. & Roy, S., Jan 18 2013, In : PloS one. 8, 1, e54040.

Research output: Contribution to journalArticle

66 Scopus citations

Role of the mu-opioid receptor in opioid modulation of immune function

Ninković, J. & Roy, S., Jul 1 2013, In : Amino Acids. 45, 1, p. 9-24 16 p.

Research output: Contribution to journalReview article

69 Scopus citations

The role of short-term oxygen administration in the prevention of intimal hyperplasia

Lata, C., Green, D. L., Wan, J., Roy, S. & Santilli, S. M., Aug 1 2013, In : Journal of vascular surgery. 58, 2, p. 452-459 8 p.

Research output: Contribution to journalArticle

5 Scopus citations
2012

Hypoxia differentially regulates arterial and venous smooth muscle cell proliferation via PDGFR-β and VEGFR-2 expression

Chanakira, A., Dutta, R., Charboneau, R., Barke, R. A., Santilli, S. M. & Roy, S., Mar 1 2012, In : American Journal of Physiology - Heart and Circulatory Physiology. 302, 5, p. H1173-H1184

Research output: Contribution to journalArticle

25 Scopus citations

Mechanism(s) involved in opioid drug abuse modulation of HAND

Dutta, R. & Roy, S., Sep 21 2012, In : Current HIV research. 10, 5, p. 469-477 9 p.

Research output: Contribution to journalReview article

17 Scopus citations
37 Scopus citations

Morphine induces splenocyte trafficking into the CNS

Olin, M. R., Oh, S. U., Roy, S., Peterson, P. & Molitor, T. W., Jun 1 2012, In : Journal of Neuroimmune Pharmacology. 7, 2, p. 436-443 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Morphine modulation of Toll-like receptors in microglial cells potentiates neuropathogenesis in a HIV-1 model of coinfection with pneumococcal pneumoniae

Dutta, R., Krishnan, A., Meng, J., Das, S., Ma, J., Banerjee, S., Wang, J., Charboneau, R., Prakash, O., Barke, R. A. & Roy, S., Jul 18 2012, In : Journal of Neuroscience. 32, 29, p. 9917-9930 14 p.

Research output: Contribution to journalArticle

23 Scopus citations

The effects of opioids on immune cells, functions and diseases

Ninković, J. & Roy, S., Jan 1 2012, Nerve-Driven Immunity: Neurotransmitters and Neuropeptides in the Immune System. Springer-Verlag Wien, p. 175-202 28 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations
2011

Drugs of abuse effects on immunity and microbial pathogenesis

Roy, S., Dec 1 2011, In : Journal of Neuroimmune Pharmacology. 6, 4, p. 435-438 4 p.

Research output: Contribution to journalReview article

1 Scopus citations

Morphine inhibits murine dendritic cell IL-23 production by modulating toll-like receptor 2 and Nod2 signaling

Wang, J., Ma, J., Charboneau, R., Barke, R. A. & Roy, S., Mar 25 2011, In : Journal of Biological Chemistry. 286, 12, p. 10225-10232 8 p.

Research output: Contribution to journalArticle

30 Scopus citations
14 Scopus citations

Opioid drug abuse and modulation of immune function: Consequences in the susceptibility to opportunistic infections

Roy, S., Ninkovic, J., Banerjee, S., Charboneau, R. G., Das, S., Dutta, R., Kirchner, V., Koodie, L., Ma, J., Meng, J. & Barke, R. A., Dec 1 2011, In : Journal of Neuroimmune Pharmacology. 6, 4, p. 442-465 24 p.

Research output: Contribution to journalReview article

121 Scopus citations
2010

Chronic morphine administration delays wound healing by inhibiting immune cell recruitment to the wound site

Martin, J. L., Koodie, L., Krishnan, A. G., Charboneau, R., Barke, R. A. & Roy, S., Feb 2010, In : American Journal of Pathology. 176, 2, p. 786-799 14 p.

Research output: Contribution to journalArticle

62 Scopus citations

Chronic morphine's role on innate immunity, bacterial susceptibility and implications in wound healing

Martin, J. & Roy, S., Jan 1 2010, Chemokine Receptors and NeuroAIDS: Beyond Co-Receptor Function and Links to Other Neuropathologies. Springer New York, p. 337-352 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Chronic morphine treatment inhibits LPS-induced angiogenesis: Implications in wound healing

Martin, J. L., Charboneau, R., Barke, R. A. & Roy, S., Sep 15 2010, In : Cellular Immunology. 265, 2, p. 139-145 7 p.

Research output: Contribution to journalArticle

44 Scopus citations

Hypoxia-induced microRNA-424 expression in human endothelial cells regulates HIF-α isoforms and promotes angiogenesis

Ghosh, G., Subramanian, I. V., Adhikari, N., Zhang, X., Joshi, H. P., Basi, D., Chandrashekhar, Y. S., Hall, J. L., Roy, S., Zeng, Y. & Ramakrishnan, S., Nov 1 2010, In : Journal of Clinical Investigation. 120, 11, p. 4141-4154 14 p.

Research output: Contribution to journalArticle

281 Scopus citations
5 Scopus citations

Morphine disrupts interleukin-23 (IL-23)/IL-17-mediated pulmonary mucosal host defense against Streptococcus pneumoniae infection

Ma, J., Wang, J., Wan, J., Charboneau, R., Chang, Y., Barke, R. A. & Roy, S., Feb 1 2010, In : Infection and immunity. 78, 2, p. 830-837 8 p.

Research output: Contribution to journalArticle

40 Scopus citations

Morphine suppresses tumor angiogenesis through a HIF-1α/p38MAPK pathway

Koodie, L., Ramakrishnan, S. & Roy, S., Aug 2010, In : American Journal of Pathology. 177, 2, p. 984-997 14 p.

Research output: Contribution to journalArticle

69 Scopus citations