20052021

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  • 2021

    Elements and evolutionary determinants of genomic divergence between paired primary and metastatic tumors

    Sun, R. & Nikolakopoulos, A. N., Mar 17 2021, In: PLoS computational biology. 17, 3, e1008838.

    Research output: Contribution to journalArticlepeer-review

    Open Access
  • 2020

    Characterizing the ecological and evolutionary dynamics of cancer

    Zahir, N., Sun, R., Gallahan, D., Gatenby, R. A. & Curtis, C., Aug 1 2020, In: Nature Genetics. 52, 8, p. 759-767 9 p.

    Research output: Contribution to journalArticlepeer-review

    26 Scopus citations
  • 2019

    Clonal replacement and heterogeneity in breast tumors treated with neoadjuvant HER2-targeted therapy

    Caswell-Jin, J. L., McNamara, K., Reiter, J. G., Sun, R., Hu, Z., Ma, Z., Ding, J., Suarez, C. J., Tilk, S., Raghavendra, A., Forte, V., Chin, S. F., Bardwell, H., Provenzano, E., Caldas, C., Lang, J., West, R., Tripathy, D., Press, M. F. & Curtis, C., Dec 1 2019, In: Nature communications. 10, 1, 657.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    28 Scopus citations
  • Quantitative evidence for early metastatic seeding in colorectal cancer

    Hu, Z., Ding, J., Ma, Z., Sun, R., Seoane, J. A., Scott Shaffer, J., Suarez, C. J., Berghoff, A. S., Cremolini, C., Falcone, A., Loupakis, F., Birner, P., Preusser, M., Lenz, H. J. & Curtis, C., Jul 1 2019, In: Nature Genetics. 51, 7, p. 1113-1122 10 p.

    Research output: Contribution to journalArticlepeer-review

    161 Scopus citations
  • 2018

    Big bang tumor growth and clonal evolution

    Sun, R., Hu, Z. & Curtis, C., May 2018, In: Cold Spring Harbor Perspectives in Medicine. 8, 5, a028381.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    27 Scopus citations
  • Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors

    George, J., Walter, V., Peifer, M., Alexandrov, L. B., Seidel, D., Leenders, F., Maas, L., Müller, C., Dahmen, I., Delhomme, T. M., Ardin, M., Leblay, N., Byrnes, G., Sun, R., De Reynies, A., McLeer-Florin, A., Bosco, G., Malchers, F., Menon, R., Altmüller, J. & 42 others, Becker, C., Nürnberg, P., Achter, V., Lang, U., Schneider, P. M., Bogus, M., Soloway, M. G., Wilkerson, M. D., Cun, Y., McKay, J. D., Moro-Sibilot, D., Brambilla, C. G., Lantuejoul, S., Lemaitre, N., Soltermann, A., Weder, W., Tischler, V., Brustugun, O. T., Lund-Iversen, M., Helland, Å., Solberg, S., Ansén, S., Wright, G., Solomon, B., Roz, L., Pastorino, U., Petersen, I., Clement, J. H., Sänger, J., Wolf, J., Vingron, M., Zander, T., Perner, S., Travis, W. D., Haas, S. A., Olivier, M., Foll, M., Büttner, R., Hayes, D. N., Brambilla, E., Fernandez-Cuesta, L. & Thomas, R. K., Dec 1 2018, In: Nature communications. 9, 1, 1048.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    155 Scopus citations
  • Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element

    Cho, S. W., Xu, J., Sun, R., Mumbach, M. R., Carter, A. C., Chen, Y. G., Yost, K. E., Kim, J., He, J., Nevins, S. A., Chin, S. F., Caldas, C., Liu, S. J., Horlbeck, M. A., Lim, D. A., Weissman, J. S., Curtis, C. & Chang, H. Y., May 31 2018, In: Cell. 173, 6, p. 1398-1412.e22

    Research output: Contribution to journalArticlepeer-review

    Open Access
    216 Scopus citations
  • 2017

    A population genetics perspective on the determinants of intra-tumor heterogeneity

    Hu, Z., Sun, R. & Curtis, C., Apr 2017, In: Biochimica et Biophysica Acta - Reviews on Cancer. 1867, 2, p. 109-126 18 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    31 Scopus citations
  • Between-region genetic divergence reflects the mode and tempo of tumor evolution

    Sun, R., Hu, Z., Sottoriva, A., Graham, T. A., Harpak, A., Ma, Z., Fischer, J. M., Shibata, D. & Curtis, C., Jul 1 2017, In: Nature Genetics. 49, 7, p. 1015-1024 10 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    75 Scopus citations
  • 2016

    X-exome sequencing of 405 unresolved families identifies seven novel intellectual disability genes

    Hu, H., Haas, S. A., Chelly, J., Van Esch, H., Raynaud, M., De Brouwer, A. P. M., Weinert, S., Froyen, G., Frints, S. G. M., Laumonnier, F., Zemojtel, T., Love, M. I., Richard, H., Emde, A. K., Bienek, M., Jensen, C., Hambrock, M., Fischer, U., Langnick, C., Feldkamp, M. & 64 others, Wissink-Lindhout, W., Lebrun, N., Castelnau, L., Rucci, J., Montjean, R., Dorseuil, O., Billuart, P., Stuhlmann, T., Shaw, M., Corbett, M. A., Gardner, A., Willis-Owen, S., Tan, C., Friend, K. L., Belet, S., Van Roozendaal, K. E. P., Jimenez-Pocquet, M., Moizard, M. P., Ronce, N., Sun, R., O'Keeffe, S., Chenna, R., Van Bömmel, A., Göke, J., Hackett, A., Field, M., Christie, L., Boyle, J., Haan, E., Nelson, J., Turner, G., Baynam, G., Gillessen-Kaesbach, G., Müller, U., Steinberger, D., Budny, B., Badura-Stronka, M., Latos-Bieleńska, A., Ousager, L. B., Wieacker, P., Rodríguez Criado, G., Bondeson, M. L., Annerén, G., Dufke, A., Cohen, M., Van Maldergem, L., Vincent-Delorme, C., Echenne, B., Simon-Bouy, B., Kleefstra, T., Willemsen, M., Fryns, J. P., Devriendt, K., Ullmann, R., Vingron, M., Wrogemann, K., Wienker, T. F., Tzschach, A., Van Bokhoven, H., Gecz, J., Jentsch, T. J., Chen, W., Ropers, H. H. & Kalscheuer, V. M., Jan 1 2016, In: Molecular psychiatry. 21, 1, p. 133-148 16 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    167 Scopus citations
  • 2015

    Identification of novel fusion genes in lung cancer using breakpoint assembly of transcriptome sequencing data

    Fernandez-Cuesta, L., Sun, R., Menon, R., George, J., Lorenz, S., Meza-Zepeda, L. A., Peifer, M., Plenker, D., Heuckmann, J. M., Leenders, F., Zander, T., Dahmen, I., Koker, M., Schöttle, J., Ullrich, R. T., Altmüller, J., Becker, C., Nürnberg, P., Seidel, H., Böhm, D. & 20 others, Göke, F., Ansén, S., Russell, P. A., Wright, G. M., Wainer, Z., Solomon, B., Petersen, I., Clement, J. H., Sänger, J., Brustugun, O. T., Helland, Å., Solberg, S., Lund-Iversen, M., Buettner, R., Wolf, J., Brambilla, E., Vingron, M., Perner, S., Haas, S. A. & Thomas, R. K., Jan 5 2015, In: Genome biology. 16, 1, 7.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    36 Scopus citations
  • 2014

    CD74-NRG1 fusions in lung adenocarcinoma

    Fernandez-Cuesta, L., Plenker, D., Osada, H., Sun, R., Menon, R., Leenders, F., Ortiz-Cuaran, S., Peifer, M., Bos, M., Daßler, J., Malchers, F., Schöttle, J., Vogel, W., Dahmen, I., Koker, M., Ullrich, R. T., Wright, G. M., Russell, P. A., Wainer, Z., Solomon, B. & 31 others, Brambilla, E., Nagy-Mignotte, H., Moro-Sibilot, D., Brambilla, C. G., Lantuejoul, S., Altmüller, J., Becker, C., Nürnberg, P., Heuckmann, J. M., Stoelben, E., Petersen, I., Clement, J. H., Sänger, J., Muscarella, L. A., la Torre, A., Fazio, V. M., Lahortiga, I., Perera, T., Ogata, S., Parade, M., Brehmer, D., Vingron, M., Heukamp, L. C., Buettner, R., Zander, T., Wolf, J., Perner, S., Ansén, S., Haas, S. A., Yatabe, Y. & Thomas, R. K., Apr 2014, In: Cancer discovery. 4, 4, p. 415-422 8 p.

    Research output: Contribution to journalArticlepeer-review

    177 Scopus citations
  • Frequent mutations in chromatin-remodelling genes in pulmonary carcinoids

    Fernandez-Cuesta, L., Peifer, M., Lu, X., Sun, R., Ozretić, L., Seidel, D., Zander, T., Leenders, F., George, J., Müller, C., Dahmen, I., Pinther, B., Bosco, G., Konrad, K., Altmüller, J., Nürnberg, P., Achter, V., Lang, U., Schneider, P. M., Bogus, M. & 26 others, Soltermann, A., Brustugun, O. T. E., Helland, Å., Solberg, S., Lund-Iversen, M., Ansén, S., Stoelben, E., Wright, G. M., Russell, P., Wainer, Z., Solomon, B., Field, J. K., Hyde, R., Davies, M. P. A., Heukamp, L. C., Petersen, I., Perner, S., Lovly, C. M., Cappuzzo, F., Travis, W. D., Wolf, J., Vingron, M., Brambilla, E., Haas, S. A., Buettner, R. & Thomas, R. K., 2014, In: Nature communications. 5, p. 3518 1 p., 3518.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    186 Scopus citations
  • 2012

    Breakpointer: Using local mapping artifacts to support sequence breakpoint discovery from single-end reads

    Sun, R., Love, M. I., Zemojtel, T., Emde, A. K., Chung, H. R., Vingron, M. & Haas, S. A., Apr 2012, In: Bioinformatics. 28, 7, p. 1024-1025 2 p., bts064.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    17 Scopus citations
  • Detecting genomic indel variants with exact breakpoints in single- and paired-end sequencing data using splazers

    Emde, A. K., Schulz, M. H., Weese, D., Sun, R., Vingron, M., Kalscheuer, V. M., Haas, S. A. & Reinert, K., Mar 2012, In: Bioinformatics. 28, 5, p. 619-627 9 p., bts019.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    52 Scopus citations
  • Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer

    Peifer, M., Fernández-Cuesta, L., Sos, M. L., George, J., Seidel, D., Kasper, L. H., Plenker, D., Leenders, F., Sun, R., Zander, T., Menon, R., Koker, M., Dahmen, I., Müller, C., Di Cerbo, V., Schildhaus, H. U., Altmüller, J., Baessmann, I., Becker, C., De Wilde, B. & 73 others, Vandesompele, J., Böhm, D., Ansén, S., Gabler, F., Wilkening, I., Heynck, S., Heuckmann, J. M., Lu, X., Carter, S. L., Cibulskis, K., Banerji, S., Getz, G., Park, K. S., Rauh, D., Grütter, C., Fischer, M., Pasqualucci, L., Wright, G., Wainer, Z., Russell, P., Petersen, I., Chen, Y., Stoelben, E., Ludwig, C., Schnabel, P., Hoffmann, H., Muley, T., Brockmann, M., Engel-Riedel, W., Muscarella, L. A., Fazio, V. M., Groen, H., Timens, W., Sietsma, H., Thunnissen, E., Smit, E., Heideman, D. A. M., Snijders, P. J. F., Cappuzzo, F., Ligorio, C., Damiani, S., Field, J., Solberg, S., Brustugun, O. T., Lund-Iversen, M., Sänger, J., Clement, J. H., Soltermann, A., Moch, H., Weder, W., Solomon, B., Soria, J. C., Validire, P., Besse, B., Brambilla, E., Brambilla, C., Lantuejoul, S., Lorimier, P., Schneider, P. M., Hallek, M., Pao, W., Meyerson, M., Sage, J., Shendure, J., Schneider, R., Büttner, R., Wolf, J., Nürnberg, P., Perner, S., Heukamp, L. C., Brindle, P. K., Haas, S. & Thomas, R. K., Oct 2012, In: Nature Genetics. 44, 10, p. 1104-1110 7 p.

    Research output: Contribution to journalArticlepeer-review

    925 Scopus citations
  • 2011

    Modeling read counts for CNV detection in exome sequencing data

    Love, M. I., Myišičková, A., Sun, R., Kalscheuer, V., Vingron, M. & Haas, S. A., 2011, In: Statistical Applications in Genetics and Molecular Biology. 10, 1, 52.

    Research output: Contribution to journalArticlepeer-review

    47 Scopus citations
  • 2009

    A strategy for meta-analysis of short time series microarray datasets

    Sun, R., Fu, X., Guo, F., Ma, Z., Goulbourne, C., Jiang, M., Li, Y., Xie, Y. & Mao, Y., Jan 1 2009, In: Frontiers in Bioscience. 14, 11, p. 4058-4070 13 p.

    Research output: Contribution to journalArticlepeer-review

    1 Scopus citations
  • Global gene expression analysis reveals reduced abundance of putative microRNA targets in human prostate tumours

    Sun, R., Fu, X., Li, Y., Xie, Y. & Mao, Y., Feb 26 2009, In: BMC Genomics. 10, 93.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    37 Scopus citations
  • 2008

    Simultaneously detection of genomic and expression alterations in prostate cancer using cDNA microarray

    Jiang, M., Li, M., Fu, X., Huang, Y., Qian, H., Sun, R., Mao, Y., Xie, Y. & Li, Y., Oct 1 2008, In: Prostate. 68, 14, p. 1496-1509 14 p.

    Research output: Contribution to journalArticlepeer-review

    19 Scopus citations
  • 2007

    Identification of genes differentially regulated by transcription factor, AP-2Delta

    Sun, L., Huang, S., Wu, Q., Gu, S., Fu, X., Yu, K., Lu, F., Ji, C., Feng, C., Sun, R., Xie, Y. & Mao, Y., 2007, In: Frontiers in Bioscience. 12, 5, p. 1699-1706 8 p.

    Research output: Contribution to journalArticlepeer-review

    3 Scopus citations
  • 2005

    Molecular cloning and characterization of AAAS-V2, a novel splice variant of human AAAS

    Li, X., Ji, C., Gu, J., Xu, J., Jin, Z., Sun, L., Zou, X., Lin, Y., Sun, R., Wang, P., Gu, S. & Mao, Y., Jun 2005, In: Molecular Biology Reports. 32, 2, p. 127-131 5 p.

    Research output: Contribution to journalArticlepeer-review

    9 Scopus citations