Personal profile

Research interests

My lab is interested in molecular signaling mechanisms that orchestrate daily rhythms in our brain and how their dysregulation contributes to various neurological and psychiatric diseases. We are particularly interested in the role of mammalian target of rapamycin (mTOR) signaling and mechanisms that control mRNA translation in the circadian clock.

Education / Academic qualification

MD, Fourth Military Medical University

PhD, The Ohio State University


  • circadian rhythms
  • Signalling
  • neuroscience
  • traumatic brain injury
  • stroke
  • Autism Spectrum Disorders

Fingerprint The Fingerprint is created by mining the titles and abstracts of the person's research outputs and projects/funding awards to create an index of weighted terms from discipline-specific thesauri.

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Projects 2016 2018

Messenger RNA

Research Output 2004 2017

7 Citations

Metformin ameliorates core deficits in a mouse model of fragile X syndrome

Gantois, I. , Khoutorsky, A. , Popic, J. , Aguilar-Valles, A. , Freemantle, E. , Cao, R. , Sharma, V. , Pooters, T. , Nagpal, A. , Skalecka, A. , Truong, V. T. , Wiebe, S. , Groves, I. A. , Jafarnejad, S. M. , Chapat, C. , McCullagh, E. A. , Gamache, K. , Nader, K. , Lacaille, J. C. , Gkogkas, C. G. & 1 others Sonenberg, N. Jun 1 2017 In : Nature Medicine. 23, 6, p. 674-677 4 p.

Research output: Research - peer-reviewArticle

Fragile X Syndrome
Trinucleotide Repeat Expansion
Protein Biosynthesis
Matrix Metalloproteinases
12 Citations

Light-regulated translational control of circadian behavior by eIF4E phosphorylation

Cao, R., Gkogkas, C. G., De Zavalia, N., Blum, I. D., Yanagiya, A., Tsukumo, Y., Xu, H., Lee, C., Storch, K. F., Liu, A. C., Amir, S. & Sonenberg, N. Jun 28 2015 In : Nature Neuroscience. 18, 6, p. 855-862 8 p.

Research output: Research - peer-reviewArticle

Circadian Clocks
Behavior Control
Protein Biosynthesis
42 Citations

Pharmacogenetic Inhibition of eIF4E-Dependent Mmp9 mRNA Translation Reverses Fragile X Syndrome-like Phenotypes

Gkogkas, C. G., Khoutorsky, A., Cao, R., Jafarnejad, S. M., Prager-Khoutorsky, M., Giannakas, N., Kaminari, A., Fragkouli, A., Nader, K., Price, T. J., Konicek, B. W., Graff, J. R., Tzinia, A. K., Lacaille, J. C. & Sonenberg, N. Dec 11 2014 In : Cell Reports. 9, 5, p. 1742-1756 15 p.

Research output: Research - peer-reviewArticle

Eukaryotic Initiation Factor-4E
Fragile X Syndrome
Protein Biosynthesis
31 Citations

Control of synaptic plasticity and memory via suppression of poly(A)-Binding protein

Khoutorsky, A., Yanagiya, A., Gkogkas, C. G., Fabian, M. R., Prager-Khoutorsky, M., Cao, R., Gamache, K., Bouthiette, F., Parsyan, A., Sorge, R. E., Mogil, J. S., Nader, K., Lacaille, J. C. & Sonenberg, N. Apr 24 2013 In : Neuron. 78, 2, p. 298-311 14 p.

Research output: Research - peer-reviewArticle

Poly(A)-Binding Proteins
Neuronal Plasticity
Protein Biosynthesis
9 Citations

Mitogen- and stress-activated protein kinase 1 modulates photic entrainment of the suprachiasmatic circadian clock

Cao, R., Butcher, G. Q., Karelina, K., Arthur, J. S. & Obrietan, K. Jan 2013 In : European Journal of Neuroscience. 37, 1, p. 130-140 11 p.

Research output: Research - peer-reviewArticle

Circadian Clocks
mitogen and stress-activated protein kinase 1