Projects per year
Personal profile
Research interests
My lab is interested in molecular signaling mechanisms that orchestrate daily rhythms in our brain and how their dysregulation contributes to various neurological and psychiatric diseases. We are particularly interested in the role of mammalian target of rapamycin (mTOR) signaling and mechanisms that control mRNA translation in the circadian clock.
Education/Academic qualification
MD, Fourth Military Medical University
PhD, The Ohio State University
Keywords
- circadian rhythms
- Signalling
- neuroscience
- traumatic brain injury
- stroke
- Autism Spectrum Disorders
Fingerprint The Fingerprint is created by mining the titles and abstracts of the person's research outputs and projects/funding awards to create an index of weighted terms from discipline-specific thesauri.
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Circadian Clocks
Medicine & Life Sciences
Sirolimus
Medicine & Life Sciences
Suprachiasmatic Nucleus
Medicine & Life Sciences
Protein Biosynthesis
Medicine & Life Sciences
Eukaryotic Initiation Factor-4E
Medicine & Life Sciences
Light
Medicine & Life Sciences
Phosphorylation
Medicine & Life Sciences
Fragile X Syndrome
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2016 2018
- 1 Active
Messenger RNA
Research Output 2004 2018
mTOR signaling in VIP neurons regulates circadian clock synchrony and olfaction
Liu, D., Stowie, A., de Zavalia, N., Leise, T., Pathak, S. S., Drewes, L. R., Davidson, A. J., Amir, S., Sonenberg, N. & Cao, R. Apr 3 2018 In : Proceedings of the National Academy of Sciences of the United States of America. 115, 14, p. E3296-E3304Research output: Contribution to journal › Article
Circadian Clocks
Smell
Sirolimus
Neurons
Suprachiasmatic Nucleus
mTOR signaling regulates central and peripheral circadian clock function
Ramanathan, C., Kathale, N. D., Liu, D., Lee, C., Freeman, D. A., Hogenesch, J. B., Cao, R. & Liu, A. C. May 1 2018 In : PLoS genetics. 14, 5, e1007369Research output: Contribution to journal › Article
Circadian Clocks
Sirolimus
circadian rhythm
fibroblasts
metabolism
Translational control of depression-like behavior via phosphorylation of eukaryotic translation initiation factor 4E
Aguilar-Valles, A., Haji, N., De Gregorio, D., Matta-Camacho, E., Eslamizade, M. J., Popic, J., Sharma, V., Cao, R., Rummel, C., Tanti, A., Wiebe, S., Nuñez, N., Comai, S., Nadon, R., Luheshi, G., Mechawar, N., Turecki, G., Lacaille, J. C., Gobbi, G. & Sonenberg, N. Dec 1 2018 In : Nature communications. 9, 1, 2459Research output: Contribution to journal › Article
Eukaryotic Initiation Factor-4E
Eukaryotic Initiation Factors
phosphorylation
Phosphorylation
mice
Metformin ameliorates core deficits in a mouse model of fragile X syndrome
Gantois, I. , Khoutorsky, A. , Popic, J. , Aguilar-Valles, A. , Freemantle, E. , Cao, R. , Sharma, V. , Pooters, T. , Nagpal, A. , Skalecka, A. , Truong, V. T. , Wiebe, S. , Groves, I. A. , Jafarnejad, S. M. , Chapat, C. , McCullagh, E. A. , Gamache, K. , Nader, K. , Lacaille, J. C. , Gkogkas, C. G. & 1 others Jun 1 2017 In : Nature medicine. 23, 6, p. 674-677 4 p.Research output: Contribution to journal › Article
Fragile X Syndrome
Metformin
Trinucleotide Repeat Expansion
Trinucleotide Repeats
Phosphorylation
Light-regulated translational control of circadian behavior by eIF4E phosphorylation
Cao, R., Gkogkas, C. G., De Zavalia, N., Blum, I. D., Yanagiya, A., Tsukumo, Y., Xu, H., Lee, C., Storch, K. F., Liu, A. C., Amir, S. & Sonenberg, N. Jan 1 2015 In : Nature Neuroscience. 18, 6, p. 855-862 8 p.Research output: Contribution to journal › Article
Circadian Clocks
Behavior Control
Phosphorylation
Light
Protein Biosynthesis