Ruifeng Cao

MD,PhD

Accepting PhD Students

20042019
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Personal profile

Research interests

My lab is interested in molecular signaling mechanisms that orchestrate daily rhythms in our brain and how their dysregulation contributes to neurological and psychiatric diseases. We are particularly interested in the role of mammalian target of rapamycin (mTOR) signaling and mechanisms that control mRNA translation in the circadian clock.

Education/Academic qualification

MD, Fourth Military Medical University

PhD, The Ohio State University

External positions

Member, Society for Research on Biological Rhythms

2010 → …

Member, Society for Neuroscience

2008 → …

Research interests

  • circadian rhythms
  • neuronal signal transduction
  • autism spectrum disorders
  • cellular stress response
  • mRNA translation
  • mTOR signaling
  • sleep
  • traumatic brain injury
  • glioma

Fingerprint The Fingerprint is created by mining the titles and abstracts of the person's research outputs and projects/funding awards to create an index of weighted terms from discipline-specific thesauri.

  • 4 Similar Profiles
Circadian Clocks Medicine & Life Sciences
Sirolimus Medicine & Life Sciences
Suprachiasmatic Nucleus Medicine & Life Sciences
Protein Biosynthesis Medicine & Life Sciences
Eukaryotic Initiation Factor-4E Medicine & Life Sciences
Phosphorylation Medicine & Life Sciences
Light Medicine & Life Sciences
Eukaryotic Initiation Factors Medicine & Life Sciences

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Projects 2016 2019

Brain Neoplasms
Phosphorylation
Messenger RNA

Research Output 2004 2019

The eIF2α Kinase GCN2 Modulates Period and Rhythmicity of the Circadian Clock by Translational Control of Atf4

Pathak, S. S., Liu, D., Li, T., de Zavalia, N., Zhu, L., Li, J., Karthikeyan, R., Alain, T., Liu, A. C., Storch, K. F., Kaufman, R. J., Jin, V. X., Amir, S., Sonenberg, N. & Cao, R., Nov 20 2019, In : Neuron. 104, 4, p. 724-735.e6

Research output: Contribution to journalArticle

Eukaryotic Initiation Factor-2
Eukaryotic Initiation Factors
Circadian Clocks
Periodicity
Phosphotransferases
9 Citations (Scopus)

mTOR signaling in VIP neurons regulates circadian clock synchrony and olfaction

Liu, D., Stowie, A., de Zavalia, N., Leise, T., Pathak, S. S., Drewes, L. R., Davidson, A. J., Amir, S., Sonenberg, N. & Cao, R., Apr 3 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 14, p. E3296-E3304

Research output: Contribution to journalArticle

Open Access
Circadian Clocks
Smell
Sirolimus
Neurons
Suprachiasmatic Nucleus
29 Citations (Scopus)

Light-regulated translational control of circadian behavior by eIF4E phosphorylation

Cao, R., Gkogkas, C. G., De Zavalia, N., Blum, I. D., Yanagiya, A., Tsukumo, Y., Xu, H., Lee, C., Storch, K. F., Liu, A. C., Amir, S. & Sonenberg, N., Jun 28 2015, In : Nature Neuroscience. 18, 6, p. 855-862 8 p.

Research output: Contribution to journalArticle

Circadian Clocks
Behavior Control
Phosphorylation
Light
Protein Biosynthesis
70 Citations (Scopus)

Translational control of entrainment and synchrony of the suprachiasmatic circadian clock by mTOR/4E-BP1 signaling

Cao, R., Robinson, B., Xu, H., Gkogkas, C., Khoutorsky, A., Alain, T., Yanagiya, A., Nevarko, T., Liu, A. C., Amir, S. & Sonenberg, N., Aug 21 2013, In : Neuron. 79, 4, p. 712-724 13 p.

Research output: Contribution to journalArticle

Tacrolimus Binding Proteins
Circadian Clocks
Suprachiasmatic Nucleus
Carrier Proteins
Eukaryotic Initiation Factor-4E

Molecular Biology and Physiology of Circadian Clocks

Cao, R., Jun 25 2019, Oxford Research Encyclopedia of Neuroscience.

Research output: Chapter in Book/Report/Conference proceedingChapter