Projects per year
Personal profile
Research interests
My lab is interested in molecular signaling mechanisms that orchestrate daily rhythms in our brain and how their dysregulation contributes to neurological and psychiatric diseases. We are particularly interested in the role of mammalian target of rapamycin (mTOR) signaling and mechanisms that control mRNA translation in the circadian clock.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
MD, Fourth Military Medical University
PhD, The Ohio State University
External Positions
Member, Society for Research on Biological Rhythms
2010 → …
Member, Society for Neuroscience
2008 → …
Research Interest Keywords
- circadian rhythms
- neuronal signal transduction
- autism spectrum disorders
- cellular stress response
- mRNA translation
- mTOR signaling
- sleep
- traumatic brain injury
- glioma
Fingerprint
The Fingerprint is created by mining the titles and abstracts of the person's research outputs and projects/funding awards to create an index of weighted terms from discipline-specific thesauri.
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Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Integrated stress response and the circadian clock
NIH NIGMS NATL INST OF GENERAL
9/10/22 → 6/30/27
Project: Research project
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Cao Subaward - Rutgers Rebudget, Homeostatic Responses to Amino Acid Insufficiency
7/1/21 → 6/30/24
Project: Research project
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Mammalian target of rapamycin (mTOR) signaling and the suprachiasmatic circadian clock - New R01 Submission
NIH NAT INST OF NEURO DISORDERS & STROKE
9/15/20 → 6/30/25
Project: Research project
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Dysfunction of the cerebellar circadian clock and ataxia
Winston & Maxine Wallin Neuro Disc Fund
1/1/21 → 12/31/21
Project: Research project
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Targeting eIF4E phosphorylation to treat brain cancer
Whiteside Inst. for Clinical Research
1/1/19 → 12/31/19
Project: Research project
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The eIF2α Kinase GCN2 Modulates Period and Rhythmicity of the Circadian Clock by Translational Control of Atf4
Pathak, S. S., Liu, D., Li, T., de Zavalia, N., Zhu, L., Li, J., Karthikeyan, R., Alain, T., Liu, A. C., Storch, K. F., Kaufman, R. J., Jin, V. X., Amir, S., Sonenberg, N. & Cao, R., Nov 20 2019, In: Neuron. 104, 4, p. 724-735.e6Research output: Contribution to journal › Article › peer-review
Open Access31 Scopus citations -
mTOR signaling in VIP neurons regulates circadian clock synchrony and olfaction
Liu, D., Stowie, A., de Zavalia, N., Leise, T., Pathak, S. S., Drewes, L. R., Davidson, A. J., Amir, S., Sonenberg, N. & Cao, R., Apr 3 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 14, p. E3296-E3304Research output: Contribution to journal › Article › peer-review
Open Access32 Scopus citations -
Light-regulated translational control of circadian behavior by eIF4E phosphorylation
Cao, R., Gkogkas, C. G., De Zavalia, N., Blum, I. D., Yanagiya, A., Tsukumo, Y., Xu, H., Lee, C., Storch, K. F., Liu, A. C., Amir, S. & Sonenberg, N., Jun 28 2015, In: Nature neuroscience. 18, 6, p. 855-862 8 p.Research output: Contribution to journal › Article › peer-review
60 Scopus citations -
Translational control of entrainment and synchrony of the suprachiasmatic circadian clock by mTOR/4E-BP1 signaling
Cao, R., Robinson, B., Xu, H., Gkogkas, C., Khoutorsky, A., Alain, T., Yanagiya, A., Nevarko, T., Liu, A. C., Amir, S. & Sonenberg, N., Aug 21 2013, In: Neuron. 79, 4, p. 712-724 13 p.Research output: Contribution to journal › Article › peer-review
Open Access112 Scopus citations -
Autistic-like behavior and cerebellar dysfunction in Bmal1 mutant mice ameliorated by mTORC1 inhibition
Liu, D., Perez de Nanclares Fernandez, C., Simbriger, K., Fang, K., Lorsung, E., Le, N., Amorim, I. S., Chalkiadaki, K., Pathak, S. S., Li, J., Gewirtz, J. C., Jin, V. X., Kofuji, P., Araque, A., Orr, H. T., Gkogkas, C. G. & Cao, R., 2022, (Accepted/In press) In: Molecular psychiatry.Research output: Contribution to journal › Article › peer-review
11 Scopus citations