Personal profile

Research interests

My lab is interested in molecular signaling mechanisms that orchestrate daily rhythms in our brain and how their dysregulation contributes to various neurological and psychiatric diseases. We are particularly interested in the role of mammalian target of rapamycin (mTOR) signaling and mechanisms that control mRNA translation in the circadian clock.

Education / Academic qualification

MD, Fourth Military Medical University

PhD, The Ohio State University


  • circadian rhythms
  • Signalling
  • neuroscience
  • traumatic brain injury
  • stroke
  • Autism Spectrum Disorders

Fingerprint The Fingerprint is created by mining the titles and abstracts of the person's research outputs and projects/funding awards to create an index of weighted terms from discipline-specific thesauri.

Circadian Clocks Medicine & Life Sciences
Sirolimus Medicine & Life Sciences
Suprachiasmatic Nucleus Medicine & Life Sciences
Protein Biosynthesis Medicine & Life Sciences
Light Medicine & Life Sciences
Fragile X Syndrome Medicine & Life Sciences
Eukaryotic Initiation Factor-4E Medicine & Life Sciences
Phosphorylation Medicine & Life Sciences

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Projects 2016 2018

Messenger RNA

Research Output 2004 2018

mTOR signaling in VIP neurons regulates circadian clock synchrony and olfaction

Liu, D., Stowie, A., de Zavalia, N., Leise, T., Pathak, S. S., Drewes, L. R., Davidson, A. J., Amir, S., Sonenberg, N. & Cao, R. Apr 3 2018 In : Proceedings of the National Academy of Sciences of the United States of America. 115, 14, p. E3296-E3304

Research output: Contribution to journalArticle

Circadian Clocks
Suprachiasmatic Nucleus
13 Citations

Metformin ameliorates core deficits in a mouse model of fragile X syndrome

Gantois, I. , Khoutorsky, A. , Popic, J. , Aguilar-Valles, A. , Freemantle, E. , Cao, R. , Sharma, V. , Pooters, T. , Nagpal, A. , Skalecka, A. , Truong, V. T. , Wiebe, S. , Groves, I. A. , Jafarnejad, S. M. , Chapat, C. , McCullagh, E. A. , Gamache, K. , Nader, K. , Lacaille, J. C. , Gkogkas, C. G. & 1 others Sonenberg, N. Jun 1 2017 In : Nature medicine. 23, 6, p. 674-677 4 p.

Research output: Contribution to journalArticle

Fragile X Syndrome
Trinucleotide Repeat Expansion
Trinucleotide Repeats
18 Citations

Light-regulated translational control of circadian behavior by eIF4E phosphorylation

Cao, R., Gkogkas, C. G., De Zavalia, N., Blum, I. D., Yanagiya, A., Tsukumo, Y., Xu, H., Lee, C., Storch, K. F., Liu, A. C., Amir, S. & Sonenberg, N. Jan 1 2015 In : Nature Neuroscience. 18, 6, p. 855-862 8 p.

Research output: Contribution to journalArticle

Circadian Clocks
Behavior Control
Protein Biosynthesis
46 Citations

Pharmacogenetic Inhibition of eIF4E-Dependent Mmp9 mRNA Translation Reverses Fragile X Syndrome-like Phenotypes

Gkogkas, C. G., Khoutorsky, A., Cao, R., Jafarnejad, S. M., Prager-Khoutorsky, M., Giannakas, N., Kaminari, A., Fragkouli, A., Nader, K., Price, T. J., Konicek, B. W., Graff, J. R., Tzinia, A. K., Lacaille, J. C. & Sonenberg, N. Jan 1 2014 In : Cell Reports. 9, 5, p. 1742-1756 15 p.

Research output: Contribution to journalArticle

Eukaryotic Initiation Factor-4E
Fragile X Syndrome
Protein Biosynthesis
31 Citations

Control of synaptic plasticity and memory via suppression of poly(A)-Binding protein

Khoutorsky, A., Yanagiya, A., Gkogkas, C. G., Fabian, M. R., Prager-Khoutorsky, M., Cao, R., Gamache, K., Bouthiette, F., Parsyan, A., Sorge, R. E., Mogil, J. S., Nader, K., Lacaille, J. C. & Sonenberg, N. Apr 24 2013 In : Neuron. 78, 2, p. 298-311 14 p.

Research output: Contribution to journalArticle

Poly(A)-Binding Proteins
Neuronal Plasticity
Protein Biosynthesis