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Personal profile

Research interests

My lab is interested in molecular signaling mechanisms that orchestrate daily rhythms in our brain and how their dysregulation contributes to various neurological and psychiatric diseases. We are particularly interested in the role of mammalian target of rapamycin (mTOR) signaling and mechanisms that control mRNA translation in the circadian clock.

Education/Academic qualification

MD, Fourth Military Medical University

PhD, The Ohio State University


  • circadian rhythms
  • Signalling
  • neuroscience
  • traumatic brain injury
  • stroke
  • Autism Spectrum Disorders

Fingerprint The Fingerprint is created by mining the titles and abstracts of the person's research outputs and projects/funding awards to create an index of weighted terms from discipline-specific thesauri.

  • 1 Similar Profiles
Circadian Clocks Medicine & Life Sciences
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Eukaryotic Initiation Factor-4E Medicine & Life Sciences
Light Medicine & Life Sciences
Phosphorylation Medicine & Life Sciences
Fragile X Syndrome Medicine & Life Sciences

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Projects 2016 2018

Messenger RNA

Research Output 2004 2018

1 Citations

mTOR signaling in VIP neurons regulates circadian clock synchrony and olfaction

Liu, D., Stowie, A., de Zavalia, N., Leise, T., Pathak, S. S., Drewes, L. R., Davidson, A. J., Amir, S., Sonenberg, N. & Cao, R. Apr 3 2018 In : Proceedings of the National Academy of Sciences of the United States of America. 115, 14, p. E3296-E3304

Research output: Contribution to journalArticle

Circadian Clocks
Suprachiasmatic Nucleus
1 Citations

mTOR signaling regulates central and peripheral circadian clock function

Ramanathan, C., Kathale, N. D., Liu, D., Lee, C., Freeman, D. A., Hogenesch, J. B., Cao, R. & Liu, A. C. May 1 2018 In : PLoS genetics. 14, 5, e1007369

Research output: Contribution to journalArticle

Circadian Clocks
circadian rhythm

Translational control of depression-like behavior via phosphorylation of eukaryotic translation initiation factor 4E

Aguilar-Valles, A., Haji, N., De Gregorio, D., Matta-Camacho, E., Eslamizade, M. J., Popic, J., Sharma, V., Cao, R., Rummel, C., Tanti, A., Wiebe, S., Nuñez, N., Comai, S., Nadon, R., Luheshi, G., Mechawar, N., Turecki, G., Lacaille, J. C., Gobbi, G. & Sonenberg, N. Dec 1 2018 In : Nature communications. 9, 1, 2459

Research output: Contribution to journalArticle

Eukaryotic Initiation Factor-4E
Eukaryotic Initiation Factors
19 Citations

Metformin ameliorates core deficits in a mouse model of fragile X syndrome

Gantois, I. , Khoutorsky, A. , Popic, J. , Aguilar-Valles, A. , Freemantle, E. , Cao, R. , Sharma, V. , Pooters, T. , Nagpal, A. , Skalecka, A. , Truong, V. T. , Wiebe, S. , Groves, I. A. , Jafarnejad, S. M. , Chapat, C. , McCullagh, E. A. , Gamache, K. , Nader, K. , Lacaille, J. C. , Gkogkas, C. G. & 1 others Sonenberg, N. Jun 1 2017 In : Nature medicine. 23, 6, p. 674-677 4 p.

Research output: Contribution to journalArticle

Fragile X Syndrome
Trinucleotide Repeat Expansion
Trinucleotide Repeats
23 Citations

Light-regulated translational control of circadian behavior by eIF4E phosphorylation

Cao, R., Gkogkas, C. G., De Zavalia, N., Blum, I. D., Yanagiya, A., Tsukumo, Y., Xu, H., Lee, C., Storch, K. F., Liu, A. C., Amir, S. & Sonenberg, N. Jan 1 2015 In : Nature Neuroscience. 18, 6, p. 855-862 8 p.

Research output: Contribution to journalArticle

Circadian Clocks
Behavior Control
Protein Biosynthesis