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Personal profile

Research interests

My lab is interested in molecular signaling mechanisms that orchestrate daily rhythms in our brain and how their dysregulation contributes to various neurological and psychiatric diseases. We are particularly interested in the role of mammalian target of rapamycin (mTOR) signaling and mechanisms that control mRNA translation in the circadian clock.

Education/Academic qualification

MD, Fourth Military Medical University

PhD, The Ohio State University

Keywords

  • circadian rhythms
  • Signalling
  • neuroscience
  • traumatic brain injury
  • stroke
  • Autism Spectrum Disorders

Fingerprint The Fingerprint is created by mining the titles and abstracts of the person's research outputs and projects/funding awards to create an index of weighted terms from discipline-specific thesauri.

Circadian Clocks Medicine & Life Sciences
Sirolimus Medicine & Life Sciences
Suprachiasmatic Nucleus Medicine & Life Sciences
Protein Biosynthesis Medicine & Life Sciences
Eukaryotic Initiation Factor-4E Medicine & Life Sciences
Light Medicine & Life Sciences
Phosphorylation Medicine & Life Sciences
Fragile X Syndrome Medicine & Life Sciences

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Projects 2016 2018

Messenger RNA

Research Output 2004 2018

1 Citations

mTOR signaling, translational control, and the circadian clock

Cao, R., Sep 10 2018, In : Frontiers in Genetics. 9, SEP, 367.

Research output: Contribution to journalReview article

Circadian Clocks
Sirolimus
Protein Biosynthesis
Periodicity
Circadian Rhythm
3 Citations

mTOR signaling in VIP neurons regulates circadian clock synchrony and olfaction

Liu, D., Stowie, A., de Zavalia, N., Leise, T., Pathak, S. S., Drewes, L. R., Davidson, A. J., Amir, S., Sonenberg, N. & Cao, R., Apr 3 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 14, p. E3296-E3304

Research output: Contribution to journalArticle

Circadian Clocks
Smell
Sirolimus
Neurons
Suprachiasmatic Nucleus
3 Citations

mTOR signaling regulates central and peripheral circadian clock function

Ramanathan, C., Kathale, N. D., Liu, D., Lee, C., Freeman, D. A., Hogenesch, J. B., Cao, R. & Liu, A. C., May 1 2018, In : PLoS Genetics. 14, 5, e1007369.

Research output: Contribution to journalArticle

Circadian Clocks
Sirolimus
circadian rhythm
fibroblasts
metabolism

Translational control of depression-like behavior via phosphorylation of eukaryotic translation initiation factor 4E

Aguilar-Valles, A., Haji, N., De Gregorio, D., Matta-Camacho, E., Eslamizade, M. J., Popic, J., Sharma, V., Cao, R., Rummel, C., Tanti, A., Wiebe, S., Nuñez, N., Comai, S., Nadon, R., Luheshi, G., Mechawar, N., Turecki, G., Lacaille, J. C., Gobbi, G. & Sonenberg, N., Dec 1 2018, In : Nature communications. 9, 1, 2459.

Research output: Contribution to journalArticle

Eukaryotic Initiation Factor-4E
Eukaryotic Initiation Factors
phosphorylation
Phosphorylation
mice
20 Citations

Metformin ameliorates core deficits in a mouse model of fragile X syndrome

Gantois, I., Khoutorsky, A., Popic, J., Aguilar-Valles, A., Freemantle, E., Cao, R., Sharma, V., Pooters, T., Nagpal, A., Skalecka, A., Truong, V. T., Wiebe, S., Groves, I. A., Jafarnejad, S. M., Chapat, C., McCullagh, E. A., Gamache, K., Nader, K., Lacaille, J. C., Gkogkas, C. G. & 1 othersSonenberg, N., Jun 1 2017, In : Nature Medicine. 23, 6, p. 674-677 4 p.

Research output: Contribution to journalArticle

Fragile X Syndrome
Metformin
Trinucleotide Repeat Expansion
Trinucleotide Repeats
Phosphorylation