Projects per year
Personal profile
Research interests
My lab is interested in molecular signaling mechanisms that orchestrate daily rhythms in our brain and how their dysregulation contributes to neurological and psychiatric diseases. We are particularly interested in the role of mammalian target of rapamycin (mTOR) signaling and mechanisms that control mRNA translation in the circadian clock.
Education/Academic qualification
MD, Fourth Military Medical University
PhD, The Ohio State University
External Positions
Member, Society for Research on Biological Rhythms
2010 → …Member, Society for Neuroscience
2008 → …Research interests
- circadian rhythms
- neuronal signal transduction
- autism spectrum disorders
- cellular stress response
- mRNA translation
- mTOR signaling
- sleep
- traumatic brain injury
- glioma
Fingerprint The Fingerprint is created by mining the titles and abstracts of the person's research outputs and projects/funding awards to create an index of weighted terms from discipline-specific thesauri.
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Projects
- 2 Finished
Targeting eIF4E phosphorylation to treat brain cancer
Whiteside Inst. for Clinical Research
1/1/19 → 12/31/19
Project: Research project
Research Output
The eIF2α Kinase GCN2 Modulates Period and Rhythmicity of the Circadian Clock by Translational Control of Atf4
Pathak, S. S., Liu, D., Li, T., de Zavalia, N., Zhu, L., Li, J., Karthikeyan, R., Alain, T., Liu, A. C., Storch, K. F., Kaufman, R. J., Jin, V. X., Amir, S., Sonenberg, N. & Cao, R., Nov 20 2019, In : Neuron. 104, 4, p. 724-735.e6Research output: Contribution to journal › Article
mTOR signaling in VIP neurons regulates circadian clock synchrony and olfaction
Liu, D., Stowie, A., de Zavalia, N., Leise, T., Pathak, S. S., Drewes, L. R., Davidson, A. J., Amir, S., Sonenberg, N. & Cao, R., Apr 3 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 14, p. E3296-E3304Research output: Contribution to journal › Article
Open Access
15
Scopus
citations
Light-regulated translational control of circadian behavior by eIF4E phosphorylation
Cao, R., Gkogkas, C. G., De Zavalia, N., Blum, I. D., Yanagiya, A., Tsukumo, Y., Xu, H., Lee, C., Storch, K. F., Liu, A. C., Amir, S. & Sonenberg, N., Jun 28 2015, In : Nature neuroscience. 18, 6, p. 855-862 8 p.Research output: Contribution to journal › Article
31
Scopus
citations
Translational control of entrainment and synchrony of the suprachiasmatic circadian clock by mTOR/4E-BP1 signaling
Cao, R., Robinson, B., Xu, H., Gkogkas, C., Khoutorsky, A., Alain, T., Yanagiya, A., Nevarko, T., Liu, A. C., Amir, S. & Sonenberg, N., Aug 21 2013, In : Neuron. 79, 4, p. 712-724 13 p.Research output: Contribution to journal › Article
78
Scopus
citations
Wakefulness/sleep architecture and electroencephalographic activity in mice lacking the translational repressor 4E-BP1 or 4E-BP2
Areal, C. C., Cao, R., Sonenberg, N. & Mongrain, V., Feb 13 2020, In : Sleep. 43, 2Research output: Contribution to journal › Article