Ruifeng Cao


Accepting PhD Students

If you made any changes in Pure, your changes will be visible here soon.

Personal profile

Research interests

My lab is interested in molecular signaling mechanisms that orchestrate daily rhythms in our brain and how their dysregulation contributes to various neurological and psychiatric diseases. We are particularly interested in the role of mammalian target of rapamycin (mTOR) signaling and mechanisms that control mRNA translation in the circadian clock.

Education/Academic qualification

MD, Fourth Military Medical University

PhD, The Ohio State University

Research interests

  • circadian rhythms
  • Signalling
  • neuroscience
  • traumatic brain injury
  • stroke
  • Autism Spectrum Disorders

Fingerprint The Fingerprint is created by mining the titles and abstracts of the person's research outputs and projects/funding awards to create an index of weighted terms from discipline-specific thesauri.

  • 8 Similar Profiles
Circadian Clocks Medicine & Life Sciences
Sirolimus Medicine & Life Sciences
Suprachiasmatic Nucleus Medicine & Life Sciences
Protein Biosynthesis Medicine & Life Sciences
Eukaryotic Initiation Factor-4E Medicine & Life Sciences
Light Medicine & Life Sciences
Phosphorylation Medicine & Life Sciences
Fragile X Syndrome Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2016 2019

Brain Neoplasms
Messenger RNA

Research Output 2004 2018

2 Citations (Scopus)

mTOR signaling, translational control, and the circadian clock

Cao, R., Sep 10 2018, In : Frontiers in Genetics. 9, SEP, 367.

Research output: Contribution to journalReview article

Open Access
Circadian Clocks
Protein Biosynthesis
Circadian Rhythm
9 Citations (Scopus)

mTOR signaling in VIP neurons regulates circadian clock synchrony and olfaction

Liu, D., Stowie, A., de Zavalia, N., Leise, T., Pathak, S. S., Drewes, L. R., Davidson, A. J., Amir, S., Sonenberg, N. & Cao, R., Apr 3 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 14, p. E3296-E3304

Research output: Contribution to journalArticle

Open Access
Circadian Clocks
Suprachiasmatic Nucleus
20 Citations (Scopus)

mTOR signaling regulates central and peripheral circadian clock function

Ramanathan, C., Kathale, N. D., Liu, D., Lee, C., Freeman, D. A., Hogenesch, J. B., Cao, R. & Liu, A. C., May 1 2018, In : PLoS Genetics. 14, 5, e1007369.

Research output: Contribution to journalArticle

Circadian Clocks
circadian rhythm
7 Citations (Scopus)

Translational control of depression-like behavior via phosphorylation of eukaryotic translation initiation factor 4E

Aguilar-Valles, A., Haji, N., De Gregorio, D., Matta-Camacho, E., Eslamizade, M. J., Popic, J., Sharma, V., Cao, R., Rummel, C., Tanti, A., Wiebe, S., Nuñez, N., Comai, S., Nadon, R., Luheshi, G., Mechawar, N., Turecki, G., Lacaille, J. C., Gobbi, G. & Sonenberg, N., Dec 1 2018, In : Nature communications. 9, 1, 2459.

Research output: Contribution to journalArticle

Open Access
Eukaryotic Initiation Factor-4E
Eukaryotic Initiation Factors
43 Citations (Scopus)

Metformin ameliorates core deficits in a mouse model of fragile X syndrome

Gantois, I., Khoutorsky, A., Popic, J., Aguilar-Valles, A., Freemantle, E., Cao, R., Sharma, V., Pooters, T., Nagpal, A., Skalecka, A., Truong, V. T., Wiebe, S., Groves, I. A., Jafarnejad, S. M., Chapat, C., McCullagh, E. A., Gamache, K., Nader, K., Lacaille, J. C., Gkogkas, C. G. & 1 others, Sonenberg, N., Jun 1 2017, In : Nature Medicine. 23, 6, p. 674-677 4 p.

Research output: Contribution to journalArticle

Fragile X Syndrome
Trinucleotide Repeat Expansion
Trinucleotide Repeats